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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 35522

FusionGeneSummary for SPAG5_SYTL1

check button Fusion gene summary
Fusion gene informationFusion gene name: SPAG5_SYTL1
Fusion gene ID: 35522
HgeneTgene
Gene symbol

SPAG5

SYTL1

Gene ID

10615

84958

Gene namesperm associated antigen 5synaptotagmin like 1
SynonymsDEEPEST|MAP126|hMAP126JFC1|SLP1
Cytomap

17q11.2

1p36.11

Type of geneprotein-codingprotein-coding
Descriptionsperm-associated antigen 5astrinmitotic spindle associated protein p126mitotic spindle coiled-coil related proteinsynaptotagmin-like protein 1NADPH oxidase-related, C2 domain-containing proteinexophilin-7
Modification date2018052220180523
UniProtAcc

Q96R06

Q8IYJ3

Ensembl transtripts involved in fusion geneENST00000321765, ENST00000318074, 
ENST00000543823, ENST00000490170, 
Fusion gene scores* DoF score6 X 6 X 4=1447 X 7 X 5=245
# samples 87
** MAII scorelog2(8/144*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/245*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SPAG5 [Title/Abstract] AND SYTL1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSYTL1

GO:0006887

exocytosis

18266782


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-62-A471-01ASPAG5chr17

26911168

-SYTL1chr1

27680204

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000321765ENST00000318074SPAG5chr17

26911168

-SYTL1chr1

27680204

+
In-frameENST00000321765ENST00000543823SPAG5chr17

26911168

-SYTL1chr1

27680204

+
5CDS-3UTRENST00000321765ENST00000490170SPAG5chr17

26911168

-SYTL1chr1

27680204

+

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FusionProtFeatures for SPAG5_SYTL1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SPAG5

Q96R06

SYTL1

Q8IYJ3

Essential component of the mitotic spindle required fornormal chromosome segregation and progression into anaphase(PubMed:11724960, PubMed:12356910, PubMed:27462074). Required forchromosome alignment, normal timing of sister chromatidsegregation, and maintenance of spindle pole architecture(PubMed:17664331, PubMed:27462074). In complex with SKAP, promotesstable microtubule-kinetochore attachments. May contribute to theregulation of separase activity. May regulate AURKA localizationto mitotic spindle, but not to centrosomes and CCNB1 localizationto both mitotic spindle and centrosomes (PubMed:18361916,PubMed:21402792). Involved in centriole duplication. Required forCDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization andpromotes the centrosomal localization of CDK2 (PubMed:26297806).In non-mitotic cells, upon stress induction, inhibits mammaliantarget of rapamycin complex 1 (mTORC1) association and recruitsthe mTORC1 component RPTOR to stress granules (SGs), therebypreventing mTORC1 hyperactivation-induced apoptosis(PubMed:23953116). May enhance GSK3B-mediated phosphorylation ofother substrates, such as MAPT/TAU (PubMed:18055457).{ECO:0000269|PubMed:12356910, ECO:0000269|PubMed:17664331,ECO:0000269|PubMed:18055457, ECO:0000269|PubMed:18361916,ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:23953116,ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:27462074,ECO:0000305|PubMed:11724960}. May play a role in vesicle trafficking (By similarity).Binds phosphatidylinositol 3,4,5-trisphosphate. Acts as a RAB27Aeffector protein and may play a role in cytotoxic granuleexocytosis in lymphocytes (By similarity). {ECO:0000250,ECO:0000269|PubMed:11278853, ECO:0000269|PubMed:18266782}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSPAG5chr17:26911168chr1:27680204ENST00000321765-1324545_6088041194Coiled coilOntology_term=ECO:0000255
HgeneSPAG5chr17:26911168chr1:27680204ENST00000321765-1324617_7898041194Compositional biasNote=Gln-rich

- In-frame and not-retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSPAG5chr17:26911168chr1:27680204ENST00000321765-1324759_8688041194Coiled coilOntology_term=ECO:0000255
HgeneSPAG5chr17:26911168chr1:27680204ENST00000321765-1324979_11748041194Coiled coilOntology_term=ECO:0000255
TgeneSYTL1chr17:26911168chr1:27680204ENST00000318074+1315237_258504551Compositional biasNote=Ser-rich
TgeneSYTL1chr17:26911168chr1:27680204ENST00000543823+1214237_258516563Compositional biasNote=Ser-rich
TgeneSYTL1chr17:26911168chr1:27680204ENST00000318074+1315268_368504551DomainC2 1
TgeneSYTL1chr17:26911168chr1:27680204ENST00000318074+131531_87504551DomainRabBD
TgeneSYTL1chr17:26911168chr1:27680204ENST00000318074+1315409_511504551DomainC2 2
TgeneSYTL1chr17:26911168chr1:27680204ENST00000543823+1214268_368516563DomainC2 1
TgeneSYTL1chr17:26911168chr1:27680204ENST00000543823+121431_87516563DomainRabBD
TgeneSYTL1chr17:26911168chr1:27680204ENST00000543823+1214409_511516563DomainC2 2


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FusionGeneSequence for SPAG5_SYTL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_SPAG5_ENST00000321765_chr17_26911168_-_SYTL1_ENST00000318074_chr1_27680204_+_850aa
MWRVKKLSLSLSPSPQTGKPSMRTPLRELTLQPGALTNSGKRSPACSSLTPSLCKLGLQEGSNNSSPVDFVNNKRTDLSSEHFSHSSKWL
ETCQHESDEQPLDPIPQISSTPKTSEEAVDPLGNYMVKTIVLVPSPLGQQQDMIFEARLDTMAETNSISLNGPLRTDDLVREEVAPCMGD
RFSEVAAVSEKPIFQESPSHLLEESPPNPCSEQLHCSKESLSSRTEAVREDLVPSESNAFLPSSVLWLSPSTALAADFRVNHVDPEEEIV
EHGAMEEREMRFPTHPKESETEDQALVSSVEDILSTCLTPNLVEMESQEAPGPAVEDVGRILGSDTESWMSPLAWLEKGVNTSVMLENLR
QSLSLPSMLRDAAIGTTPFSTCSVGTWFTPSAPQEKSTNTSQTGLVGTKHSTSETEQLLCGRPPDLTALSRHDLEDNLLSSLVILEVLSR
QLRDWKSQLAVPHPETQDSSTQTDTSHSGITNKLQHLKESHEMGQALQQARNVMQSWVLISKELISLLHLSLLHLEEDKTTVSQESRRAE
TLVCCCFDLLKKLRAKLQSLKAEREEARHREEMALRGKDAAEIVLEAFCAHASQRISQLEQDLASMREFRGLLKDAQTQLVGLHAKQEEL
VQQTVSLTSTLQQDWRSMQLDYTTWTALLSRSRQLTEKLTVKSQQALQERDVAIEEKQEVSRVLEQVSAQLEECKGQTEQLELENSRLAT
DLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQWQKEEMALKHMQAELQQQQAVLAKEVRDLKETLEAAAMGC

>In-frame_SPAG5_ENST00000321765_chr17_26911168_-_SYTL1_ENST00000543823_chr1_27680204_+_850aa
MWRVKKLSLSLSPSPQTGKPSMRTPLRELTLQPGALTNSGKRSPACSSLTPSLCKLGLQEGSNNSSPVDFVNNKRTDLSSEHFSHSSKWL
ETCQHESDEQPLDPIPQISSTPKTSEEAVDPLGNYMVKTIVLVPSPLGQQQDMIFEARLDTMAETNSISLNGPLRTDDLVREEVAPCMGD
RFSEVAAVSEKPIFQESPSHLLEESPPNPCSEQLHCSKESLSSRTEAVREDLVPSESNAFLPSSVLWLSPSTALAADFRVNHVDPEEEIV
EHGAMEEREMRFPTHPKESETEDQALVSSVEDILSTCLTPNLVEMESQEAPGPAVEDVGRILGSDTESWMSPLAWLEKGVNTSVMLENLR
QSLSLPSMLRDAAIGTTPFSTCSVGTWFTPSAPQEKSTNTSQTGLVGTKHSTSETEQLLCGRPPDLTALSRHDLEDNLLSSLVILEVLSR
QLRDWKSQLAVPHPETQDSSTQTDTSHSGITNKLQHLKESHEMGQALQQARNVMQSWVLISKELISLLHLSLLHLEEDKTTVSQESRRAE
TLVCCCFDLLKKLRAKLQSLKAEREEARHREEMALRGKDAAEIVLEAFCAHASQRISQLEQDLASMREFRGLLKDAQTQLVGLHAKQEEL
VQQTVSLTSTLQQDWRSMQLDYTTWTALLSRSRQLTEKLTVKSQQALQERDVAIEEKQEVSRVLEQVSAQLEECKGQTEQLELENSRLAT
DLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQWQKEEMALKHMQAELQQQQAVLAKEVRDLKETLEAAAMGC


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_SPAG5_ENST00000321765_chr17_26911168_-_SYTL1_ENST00000318074_chr1_27680204_+_2552nt
ATGTGGCGAGTGAAAAAACTGAGCCTCAGCCTGTCGCCTTCGCCCCAGACGGGAAAACCATCTATGAGAACTCCTCTCCGTGAACTTACC
CTGCAGCCCGGTGCCCTCACCAACTCTGGAAAAAGATCCCCCGCTTGCTCCTCGCTGACCCCATCACTGTGCAAGCTGGGGCTGCAGGAA
GGCAGCAACAACTCATCTCCAGTGGATTTTGTAAATAACAAGAGGACAGACTTATCTTCAGAACATTTCAGTCATTCCTCAAAGTGGCTA
GAAACTTGTCAGCATGAATCAGATGAGCAGCCTCTAGATCCAATTCCCCAAATTAGCTCTACTCCTAAAACGTCTGAGGAAGCAGTAGAC
CCACTGGGCAATTATATGGTTAAAACCATCGTCCTTGTACCATCTCCACTGGGGCAGCAACAAGACATGATATTTGAGGCCCGTTTAGAT
ACCATGGCAGAGACAAACAGCATATCTTTAAATGGACCTTTGAGAACAGACGATCTGGTGAGAGAGGAGGTGGCACCCTGCATGGGAGAC
AGGTTTTCAGAAGTTGCTGCTGTATCTGAGAAACCTATCTTTCAGGAATCTCCGTCCCATCTCTTAGAGGAGTCTCCACCAAATCCCTGT
TCTGAACAACTACATTGCTCCAAGGAAAGCCTGAGCAGTAGAACTGAGGCTGTGCGTGAGGACTTAGTACCTTCTGAAAGTAACGCCTTC
TTGCCTTCCTCTGTTCTCTGGCTTTCCCCTTCAACTGCCTTGGCAGCAGATTTCCGTGTCAATCATGTGGACCCAGAGGAGGAAATTGTA
GAGCATGGAGCTATGGAGGAAAGAGAAATGAGGTTTCCCACACATCCTAAGGAGTCTGAAACAGAAGATCAAGCACTTGTCTCAAGTGTG
GAAGATATTCTGTCCACATGCCTGACACCAAATCTAGTAGAAATGGAATCCCAAGAAGCTCCAGGCCCAGCAGTAGAAGATGTTGGTAGG
ATTCTTGGCTCTGATACAGAGTCTTGGATGTCCCCACTGGCCTGGCTGGAAAAAGGTGTAAATACCTCCGTCATGCTGGAAAATCTCCGC
CAAAGCTTATCCCTTCCCTCGATGCTTCGGGATGCTGCAATTGGCACTACCCCTTTCTCTACTTGCTCGGTGGGGACTTGGTTTACTCCT
TCAGCACCACAGGAAAAGAGTACAAACACATCCCAGACAGGCCTGGTTGGCACCAAGCACAGTACTTCTGAGACAGAGCAGCTCCTGTGT
GGCCGGCCTCCAGATCTGACTGCCTTGTCTCGACATGACTTGGAAGATAACCTGCTGAGCTCTCTTGTCATTCTGGAGGTTCTCTCCCGC
CAGCTTCGGGACTGGAAGAGCCAGCTGGCTGTCCCTCACCCAGAAACCCAGGACAGTAGCACACAGACTGACACATCTCACAGTGGGATA
ACTAATAAACTTCAGCATCTTAAGGAGAGCCATGAGATGGGACAGGCCCTACAGCAGGCCAGAAATGTCATGCAATCATGGGTGCTTATC
TCTAAAGAGCTGATATCCTTGCTTCACCTATCCCTGTTGCATTTAGAAGAAGATAAGACTACTGTGAGTCAGGAGTCTCGGCGTGCAGAA
ACATTGGTCTGTTGCTGTTTTGATTTGCTGAAGAAATTGAGGGCAAAGCTCCAGAGCCTCAAAGCAGAAAGGGAGGAGGCAAGGCACAGA
GAGGAAATGGCTCTCAGAGGCAAGGATGCGGCAGAGATAGTGTTGGAGGCTTTCTGTGCACACGCCAGCCAGCGCATCAGCCAGCTGGAA
CAGGACCTAGCATCCATGCGGGAATTCAGAGGCCTTCTGAAGGATGCCCAGACCCAACTGGTAGGGCTTCATGCCAAGCAAGAAGAGCTG
GTTCAGCAGACAGTGAGTCTTACTTCTACCTTGCAACAAGACTGGAGGTCCATGCAACTGGATTATACAACATGGACAGCTTTGCTGAGT
CGGTCCCGACAACTCACAGAGAAACTCACAGTCAAGAGCCAGCAAGCCCTGCAGGAACGTGATGTGGCAATTGAGGAAAAGCAGGAGGTT
TCTAGGGTGCTGGAACAAGTCTCTGCCCAGTTAGAGGAGTGCAAAGGCCAAACAGAACAACTGGAGTTGGAAAACAGTCGTCTAGCAACA
GATCTCCGGGCTCAGTTGCAGATTCTGGCCAACATGGACAGCCAGCTAAAAGAGCTACAGAGTCAGCATACCCATTGTGCCCAGGACCTG
GCTATGAAGGATGAGTTACTCTGCCAGCTTACCCAGAGCAATGAGGAGCAGGCTGCTCAATGGCAAAAGGAAGAGATGGCACTAAAACAC
ATGCAGGCAGAACTGCAGCAGCAACAAGCTGTCCTGGCCAAAGAGGTGCGGGACCTGAAAGAGACCTTGGAGGCAGCAGCTATGGGCTGC
AGGTGCCCTGGATGGATTCCACACCTGAGGAGAAGCAGCTGTGGCAAGCCCTCCTGGAGCAGCCGTGCGAATGGGTGGATGGCCTTCTAC

>In-frame_SPAG5_ENST00000321765_chr17_26911168_-_SYTL1_ENST00000543823_chr1_27680204_+_2552nt
ATGTGGCGAGTGAAAAAACTGAGCCTCAGCCTGTCGCCTTCGCCCCAGACGGGAAAACCATCTATGAGAACTCCTCTCCGTGAACTTACC
CTGCAGCCCGGTGCCCTCACCAACTCTGGAAAAAGATCCCCCGCTTGCTCCTCGCTGACCCCATCACTGTGCAAGCTGGGGCTGCAGGAA
GGCAGCAACAACTCATCTCCAGTGGATTTTGTAAATAACAAGAGGACAGACTTATCTTCAGAACATTTCAGTCATTCCTCAAAGTGGCTA
GAAACTTGTCAGCATGAATCAGATGAGCAGCCTCTAGATCCAATTCCCCAAATTAGCTCTACTCCTAAAACGTCTGAGGAAGCAGTAGAC
CCACTGGGCAATTATATGGTTAAAACCATCGTCCTTGTACCATCTCCACTGGGGCAGCAACAAGACATGATATTTGAGGCCCGTTTAGAT
ACCATGGCAGAGACAAACAGCATATCTTTAAATGGACCTTTGAGAACAGACGATCTGGTGAGAGAGGAGGTGGCACCCTGCATGGGAGAC
AGGTTTTCAGAAGTTGCTGCTGTATCTGAGAAACCTATCTTTCAGGAATCTCCGTCCCATCTCTTAGAGGAGTCTCCACCAAATCCCTGT
TCTGAACAACTACATTGCTCCAAGGAAAGCCTGAGCAGTAGAACTGAGGCTGTGCGTGAGGACTTAGTACCTTCTGAAAGTAACGCCTTC
TTGCCTTCCTCTGTTCTCTGGCTTTCCCCTTCAACTGCCTTGGCAGCAGATTTCCGTGTCAATCATGTGGACCCAGAGGAGGAAATTGTA
GAGCATGGAGCTATGGAGGAAAGAGAAATGAGGTTTCCCACACATCCTAAGGAGTCTGAAACAGAAGATCAAGCACTTGTCTCAAGTGTG
GAAGATATTCTGTCCACATGCCTGACACCAAATCTAGTAGAAATGGAATCCCAAGAAGCTCCAGGCCCAGCAGTAGAAGATGTTGGTAGG
ATTCTTGGCTCTGATACAGAGTCTTGGATGTCCCCACTGGCCTGGCTGGAAAAAGGTGTAAATACCTCCGTCATGCTGGAAAATCTCCGC
CAAAGCTTATCCCTTCCCTCGATGCTTCGGGATGCTGCAATTGGCACTACCCCTTTCTCTACTTGCTCGGTGGGGACTTGGTTTACTCCT
TCAGCACCACAGGAAAAGAGTACAAACACATCCCAGACAGGCCTGGTTGGCACCAAGCACAGTACTTCTGAGACAGAGCAGCTCCTGTGT
GGCCGGCCTCCAGATCTGACTGCCTTGTCTCGACATGACTTGGAAGATAACCTGCTGAGCTCTCTTGTCATTCTGGAGGTTCTCTCCCGC
CAGCTTCGGGACTGGAAGAGCCAGCTGGCTGTCCCTCACCCAGAAACCCAGGACAGTAGCACACAGACTGACACATCTCACAGTGGGATA
ACTAATAAACTTCAGCATCTTAAGGAGAGCCATGAGATGGGACAGGCCCTACAGCAGGCCAGAAATGTCATGCAATCATGGGTGCTTATC
TCTAAAGAGCTGATATCCTTGCTTCACCTATCCCTGTTGCATTTAGAAGAAGATAAGACTACTGTGAGTCAGGAGTCTCGGCGTGCAGAA
ACATTGGTCTGTTGCTGTTTTGATTTGCTGAAGAAATTGAGGGCAAAGCTCCAGAGCCTCAAAGCAGAAAGGGAGGAGGCAAGGCACAGA
GAGGAAATGGCTCTCAGAGGCAAGGATGCGGCAGAGATAGTGTTGGAGGCTTTCTGTGCACACGCCAGCCAGCGCATCAGCCAGCTGGAA
CAGGACCTAGCATCCATGCGGGAATTCAGAGGCCTTCTGAAGGATGCCCAGACCCAACTGGTAGGGCTTCATGCCAAGCAAGAAGAGCTG
GTTCAGCAGACAGTGAGTCTTACTTCTACCTTGCAACAAGACTGGAGGTCCATGCAACTGGATTATACAACATGGACAGCTTTGCTGAGT
CGGTCCCGACAACTCACAGAGAAACTCACAGTCAAGAGCCAGCAAGCCCTGCAGGAACGTGATGTGGCAATTGAGGAAAAGCAGGAGGTT
TCTAGGGTGCTGGAACAAGTCTCTGCCCAGTTAGAGGAGTGCAAAGGCCAAACAGAACAACTGGAGTTGGAAAACAGTCGTCTAGCAACA
GATCTCCGGGCTCAGTTGCAGATTCTGGCCAACATGGACAGCCAGCTAAAAGAGCTACAGAGTCAGCATACCCATTGTGCCCAGGACCTG
GCTATGAAGGATGAGTTACTCTGCCAGCTTACCCAGAGCAATGAGGAGCAGGCTGCTCAATGGCAAAAGGAAGAGATGGCACTAAAACAC
ATGCAGGCAGAACTGCAGCAGCAACAAGCTGTCCTGGCCAAAGAGGTGCGGGACCTGAAAGAGACCTTGGAGGCAGCAGCTATGGGCTGC
AGGTGCCCTGGATGGATTCCACACCTGAGGAGAAGCAGCTGTGGCAAGCCCTCCTGGAGCAGCCGTGCGAATGGGTGGATGGCCTTCTAC


* Fusion transcript sequences (Full-length transcript).
>In-frame_SPAG5_ENST00000321765_chr17_26911168_-_SYTL1_ENST00000318074_chr1_27680204_+_2963nt
CAGGAGGGATGGACTCCTGGACTCTCCAGCTACCTGCGTGGTCCTCCCCGGTGTGAGGACAGAAGACCGGTCCTGGGCCGGGCCCGCATC
CAGCCCTACCGCCGGTGTCTGAGGTGAGGGCTCCGTCAGCGGAAAACGCTCGACAACGGAGGGGCAGGCAGGGCCGGGGGCGTGGTCAAC
GCGGGCCCCGCCCCCCGGGCTCTACCCCCGAGCGTACGCGCGCGCCTGAAGCAGCCAACCAGGAAGCGCAGAGCAGGTTCAAACACAGAC
GGCGGGTGAACATGGCGTCCTCGACTTGGTCTGAGACGTGATAGGCCTGCCTTCTGGTTGAAGATGTGGCGAGTGAAAAAACTGAGCCTC
AGCCTGTCGCCTTCGCCCCAGACGGGAAAACCATCTATGAGAACTCCTCTCCGTGAACTTACCCTGCAGCCCGGTGCCCTCACCAACTCT
GGAAAAAGATCCCCCGCTTGCTCCTCGCTGACCCCATCACTGTGCAAGCTGGGGCTGCAGGAAGGCAGCAACAACTCATCTCCAGTGGAT
TTTGTAAATAACAAGAGGACAGACTTATCTTCAGAACATTTCAGTCATTCCTCAAAGTGGCTAGAAACTTGTCAGCATGAATCAGATGAG
CAGCCTCTAGATCCAATTCCCCAAATTAGCTCTACTCCTAAAACGTCTGAGGAAGCAGTAGACCCACTGGGCAATTATATGGTTAAAACC
ATCGTCCTTGTACCATCTCCACTGGGGCAGCAACAAGACATGATATTTGAGGCCCGTTTAGATACCATGGCAGAGACAAACAGCATATCT
TTAAATGGACCTTTGAGAACAGACGATCTGGTGAGAGAGGAGGTGGCACCCTGCATGGGAGACAGGTTTTCAGAAGTTGCTGCTGTATCT
GAGAAACCTATCTTTCAGGAATCTCCGTCCCATCTCTTAGAGGAGTCTCCACCAAATCCCTGTTCTGAACAACTACATTGCTCCAAGGAA
AGCCTGAGCAGTAGAACTGAGGCTGTGCGTGAGGACTTAGTACCTTCTGAAAGTAACGCCTTCTTGCCTTCCTCTGTTCTCTGGCTTTCC
CCTTCAACTGCCTTGGCAGCAGATTTCCGTGTCAATCATGTGGACCCAGAGGAGGAAATTGTAGAGCATGGAGCTATGGAGGAAAGAGAA
ATGAGGTTTCCCACACATCCTAAGGAGTCTGAAACAGAAGATCAAGCACTTGTCTCAAGTGTGGAAGATATTCTGTCCACATGCCTGACA
CCAAATCTAGTAGAAATGGAATCCCAAGAAGCTCCAGGCCCAGCAGTAGAAGATGTTGGTAGGATTCTTGGCTCTGATACAGAGTCTTGG
ATGTCCCCACTGGCCTGGCTGGAAAAAGGTGTAAATACCTCCGTCATGCTGGAAAATCTCCGCCAAAGCTTATCCCTTCCCTCGATGCTT
CGGGATGCTGCAATTGGCACTACCCCTTTCTCTACTTGCTCGGTGGGGACTTGGTTTACTCCTTCAGCACCACAGGAAAAGAGTACAAAC
ACATCCCAGACAGGCCTGGTTGGCACCAAGCACAGTACTTCTGAGACAGAGCAGCTCCTGTGTGGCCGGCCTCCAGATCTGACTGCCTTG
TCTCGACATGACTTGGAAGATAACCTGCTGAGCTCTCTTGTCATTCTGGAGGTTCTCTCCCGCCAGCTTCGGGACTGGAAGAGCCAGCTG
GCTGTCCCTCACCCAGAAACCCAGGACAGTAGCACACAGACTGACACATCTCACAGTGGGATAACTAATAAACTTCAGCATCTTAAGGAG
AGCCATGAGATGGGACAGGCCCTACAGCAGGCCAGAAATGTCATGCAATCATGGGTGCTTATCTCTAAAGAGCTGATATCCTTGCTTCAC
CTATCCCTGTTGCATTTAGAAGAAGATAAGACTACTGTGAGTCAGGAGTCTCGGCGTGCAGAAACATTGGTCTGTTGCTGTTTTGATTTG
CTGAAGAAATTGAGGGCAAAGCTCCAGAGCCTCAAAGCAGAAAGGGAGGAGGCAAGGCACAGAGAGGAAATGGCTCTCAGAGGCAAGGAT
GCGGCAGAGATAGTGTTGGAGGCTTTCTGTGCACACGCCAGCCAGCGCATCAGCCAGCTGGAACAGGACCTAGCATCCATGCGGGAATTC
AGAGGCCTTCTGAAGGATGCCCAGACCCAACTGGTAGGGCTTCATGCCAAGCAAGAAGAGCTGGTTCAGCAGACAGTGAGTCTTACTTCT
ACCTTGCAACAAGACTGGAGGTCCATGCAACTGGATTATACAACATGGACAGCTTTGCTGAGTCGGTCCCGACAACTCACAGAGAAACTC
ACAGTCAAGAGCCAGCAAGCCCTGCAGGAACGTGATGTGGCAATTGAGGAAAAGCAGGAGGTTTCTAGGGTGCTGGAACAAGTCTCTGCC
CAGTTAGAGGAGTGCAAAGGCCAAACAGAACAACTGGAGTTGGAAAACAGTCGTCTAGCAACAGATCTCCGGGCTCAGTTGCAGATTCTG
GCCAACATGGACAGCCAGCTAAAAGAGCTACAGAGTCAGCATACCCATTGTGCCCAGGACCTGGCTATGAAGGATGAGTTACTCTGCCAG
CTTACCCAGAGCAATGAGGAGCAGGCTGCTCAATGGCAAAAGGAAGAGATGGCACTAAAACACATGCAGGCAGAACTGCAGCAGCAACAA
GCTGTCCTGGCCAAAGAGGTGCGGGACCTGAAAGAGACCTTGGAGGCAGCAGCTATGGGCTGCAGGTGCCCTGGATGGATTCCACACCTG
AGGAGAAGCAGCTGTGGCAAGCCCTCCTGGAGCAGCCGTGCGAATGGGTGGATGGCCTTCTACCCCTCAGAACCAACCTGGCCCCCAGGA

>In-frame_SPAG5_ENST00000321765_chr17_26911168_-_SYTL1_ENST00000543823_chr1_27680204_+_2963nt
CAGGAGGGATGGACTCCTGGACTCTCCAGCTACCTGCGTGGTCCTCCCCGGTGTGAGGACAGAAGACCGGTCCTGGGCCGGGCCCGCATC
CAGCCCTACCGCCGGTGTCTGAGGTGAGGGCTCCGTCAGCGGAAAACGCTCGACAACGGAGGGGCAGGCAGGGCCGGGGGCGTGGTCAAC
GCGGGCCCCGCCCCCCGGGCTCTACCCCCGAGCGTACGCGCGCGCCTGAAGCAGCCAACCAGGAAGCGCAGAGCAGGTTCAAACACAGAC
GGCGGGTGAACATGGCGTCCTCGACTTGGTCTGAGACGTGATAGGCCTGCCTTCTGGTTGAAGATGTGGCGAGTGAAAAAACTGAGCCTC
AGCCTGTCGCCTTCGCCCCAGACGGGAAAACCATCTATGAGAACTCCTCTCCGTGAACTTACCCTGCAGCCCGGTGCCCTCACCAACTCT
GGAAAAAGATCCCCCGCTTGCTCCTCGCTGACCCCATCACTGTGCAAGCTGGGGCTGCAGGAAGGCAGCAACAACTCATCTCCAGTGGAT
TTTGTAAATAACAAGAGGACAGACTTATCTTCAGAACATTTCAGTCATTCCTCAAAGTGGCTAGAAACTTGTCAGCATGAATCAGATGAG
CAGCCTCTAGATCCAATTCCCCAAATTAGCTCTACTCCTAAAACGTCTGAGGAAGCAGTAGACCCACTGGGCAATTATATGGTTAAAACC
ATCGTCCTTGTACCATCTCCACTGGGGCAGCAACAAGACATGATATTTGAGGCCCGTTTAGATACCATGGCAGAGACAAACAGCATATCT
TTAAATGGACCTTTGAGAACAGACGATCTGGTGAGAGAGGAGGTGGCACCCTGCATGGGAGACAGGTTTTCAGAAGTTGCTGCTGTATCT
GAGAAACCTATCTTTCAGGAATCTCCGTCCCATCTCTTAGAGGAGTCTCCACCAAATCCCTGTTCTGAACAACTACATTGCTCCAAGGAA
AGCCTGAGCAGTAGAACTGAGGCTGTGCGTGAGGACTTAGTACCTTCTGAAAGTAACGCCTTCTTGCCTTCCTCTGTTCTCTGGCTTTCC
CCTTCAACTGCCTTGGCAGCAGATTTCCGTGTCAATCATGTGGACCCAGAGGAGGAAATTGTAGAGCATGGAGCTATGGAGGAAAGAGAA
ATGAGGTTTCCCACACATCCTAAGGAGTCTGAAACAGAAGATCAAGCACTTGTCTCAAGTGTGGAAGATATTCTGTCCACATGCCTGACA
CCAAATCTAGTAGAAATGGAATCCCAAGAAGCTCCAGGCCCAGCAGTAGAAGATGTTGGTAGGATTCTTGGCTCTGATACAGAGTCTTGG
ATGTCCCCACTGGCCTGGCTGGAAAAAGGTGTAAATACCTCCGTCATGCTGGAAAATCTCCGCCAAAGCTTATCCCTTCCCTCGATGCTT
CGGGATGCTGCAATTGGCACTACCCCTTTCTCTACTTGCTCGGTGGGGACTTGGTTTACTCCTTCAGCACCACAGGAAAAGAGTACAAAC
ACATCCCAGACAGGCCTGGTTGGCACCAAGCACAGTACTTCTGAGACAGAGCAGCTCCTGTGTGGCCGGCCTCCAGATCTGACTGCCTTG
TCTCGACATGACTTGGAAGATAACCTGCTGAGCTCTCTTGTCATTCTGGAGGTTCTCTCCCGCCAGCTTCGGGACTGGAAGAGCCAGCTG
GCTGTCCCTCACCCAGAAACCCAGGACAGTAGCACACAGACTGACACATCTCACAGTGGGATAACTAATAAACTTCAGCATCTTAAGGAG
AGCCATGAGATGGGACAGGCCCTACAGCAGGCCAGAAATGTCATGCAATCATGGGTGCTTATCTCTAAAGAGCTGATATCCTTGCTTCAC
CTATCCCTGTTGCATTTAGAAGAAGATAAGACTACTGTGAGTCAGGAGTCTCGGCGTGCAGAAACATTGGTCTGTTGCTGTTTTGATTTG
CTGAAGAAATTGAGGGCAAAGCTCCAGAGCCTCAAAGCAGAAAGGGAGGAGGCAAGGCACAGAGAGGAAATGGCTCTCAGAGGCAAGGAT
GCGGCAGAGATAGTGTTGGAGGCTTTCTGTGCACACGCCAGCCAGCGCATCAGCCAGCTGGAACAGGACCTAGCATCCATGCGGGAATTC
AGAGGCCTTCTGAAGGATGCCCAGACCCAACTGGTAGGGCTTCATGCCAAGCAAGAAGAGCTGGTTCAGCAGACAGTGAGTCTTACTTCT
ACCTTGCAACAAGACTGGAGGTCCATGCAACTGGATTATACAACATGGACAGCTTTGCTGAGTCGGTCCCGACAACTCACAGAGAAACTC
ACAGTCAAGAGCCAGCAAGCCCTGCAGGAACGTGATGTGGCAATTGAGGAAAAGCAGGAGGTTTCTAGGGTGCTGGAACAAGTCTCTGCC
CAGTTAGAGGAGTGCAAAGGCCAAACAGAACAACTGGAGTTGGAAAACAGTCGTCTAGCAACAGATCTCCGGGCTCAGTTGCAGATTCTG
GCCAACATGGACAGCCAGCTAAAAGAGCTACAGAGTCAGCATACCCATTGTGCCCAGGACCTGGCTATGAAGGATGAGTTACTCTGCCAG
CTTACCCAGAGCAATGAGGAGCAGGCTGCTCAATGGCAAAAGGAAGAGATGGCACTAAAACACATGCAGGCAGAACTGCAGCAGCAACAA
GCTGTCCTGGCCAAAGAGGTGCGGGACCTGAAAGAGACCTTGGAGGCAGCAGCTATGGGCTGCAGGTGCCCTGGATGGATTCCACACCTG
AGGAGAAGCAGCTGTGGCAAGCCCTCCTGGAGCAGCCGTGCGAATGGGTGGATGGCCTTCTACCCCTCAGAACCAACCTGGCCCCCAGGA


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FusionGenePPI for SPAG5_SYTL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SPAG5SNAPIN, CDK1, CEBPD, ATN1, HECW2, ARNT2, FMR1, IQCE, BARD1, DCX, POLR2L, SMARCE1, EIF4E2, FBXO28, ORC6, AMOTL2, CCHCR1, CHCHD3, C1orf109, RBM41, LGALS14, TSHZ3, SH2D4A, TTC23, ZC2HC1C, CCDC33, LINGO1, HAUS1, SNAP47, ZMAT2, CDC20B, ZFC3H1, KANSL1, GOLGA8EP, GOLGA8F, CEP170, SRGAP3, DTNBP1, IFT57, C17orf59, CCDC67, KIAA0753, CCDC14, MED4, RPGRIP1L, OFD1, SPICE1, CEP44, DCTN1, ZNF385C, ZFYVE26, ENKD1, ZGPAT, DYNLL1, MAPRE1, MID1, MID2, NLGN3, RINT1, COPS7B, RIC8A, SYCE3, TSPYL1, CCDC89, MED21, RHPN1, BFSP2, EMILIN1, CCDC22, TSKS, KIAA1467, COG6, PLK1, SLC9C1, TUBA3C, MED1, NEURL4SYTL1RAB27A, NCF2, NCF1, RAB27B, RAB8A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSPAG5chr17:26911168chr1:27680204ENST00000321765-1324482_8508041194KNSTRN


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SPAG5_SYTL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SPAG5_SYTL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSPAG5C0000786Spontaneous abortion1CTD_human