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Fusion gene ID: 35522 |
FusionGeneSummary for SPAG5_SYTL1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SPAG5_SYTL1 | Fusion gene ID: 35522 | Hgene | Tgene | Gene symbol | SPAG5 | SYTL1 | Gene ID | 10615 | 84958 |
| Gene name | sperm associated antigen 5 | synaptotagmin like 1 | |
| Synonyms | DEEPEST|MAP126|hMAP126 | JFC1|SLP1 | |
| Cytomap | 17q11.2 | 1p36.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | sperm-associated antigen 5astrinmitotic spindle associated protein p126mitotic spindle coiled-coil related protein | synaptotagmin-like protein 1NADPH oxidase-related, C2 domain-containing proteinexophilin-7 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q96R06 | Q8IYJ3 | |
| Ensembl transtripts involved in fusion gene | ENST00000321765, | ENST00000318074, ENST00000543823, ENST00000490170, | |
| Fusion gene scores | * DoF score | 6 X 6 X 4=144 | 7 X 7 X 5=245 |
| # samples | 8 | 7 | |
| ** MAII score | log2(8/144*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/245*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SPAG5 [Title/Abstract] AND SYTL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SYTL1 | GO:0006887 | exocytosis | 18266782 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUAD | TCGA-62-A471-01A | SPAG5 | chr17 | 26911168 | - | SYTL1 | chr1 | 27680204 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000321765 | ENST00000318074 | SPAG5 | chr17 | 26911168 | - | SYTL1 | chr1 | 27680204 | + |
| In-frame | ENST00000321765 | ENST00000543823 | SPAG5 | chr17 | 26911168 | - | SYTL1 | chr1 | 27680204 | + |
| 5CDS-3UTR | ENST00000321765 | ENST00000490170 | SPAG5 | chr17 | 26911168 | - | SYTL1 | chr1 | 27680204 | + |
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FusionProtFeatures for SPAG5_SYTL1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SPAG5 | SYTL1 |
| Essential component of the mitotic spindle required fornormal chromosome segregation and progression into anaphase(PubMed:11724960, PubMed:12356910, PubMed:27462074). Required forchromosome alignment, normal timing of sister chromatidsegregation, and maintenance of spindle pole architecture(PubMed:17664331, PubMed:27462074). In complex with SKAP, promotesstable microtubule-kinetochore attachments. May contribute to theregulation of separase activity. May regulate AURKA localizationto mitotic spindle, but not to centrosomes and CCNB1 localizationto both mitotic spindle and centrosomes (PubMed:18361916,PubMed:21402792). Involved in centriole duplication. Required forCDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization andpromotes the centrosomal localization of CDK2 (PubMed:26297806).In non-mitotic cells, upon stress induction, inhibits mammaliantarget of rapamycin complex 1 (mTORC1) association and recruitsthe mTORC1 component RPTOR to stress granules (SGs), therebypreventing mTORC1 hyperactivation-induced apoptosis(PubMed:23953116). May enhance GSK3B-mediated phosphorylation ofother substrates, such as MAPT/TAU (PubMed:18055457).{ECO:0000269|PubMed:12356910, ECO:0000269|PubMed:17664331,ECO:0000269|PubMed:18055457, ECO:0000269|PubMed:18361916,ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:23953116,ECO:0000269|PubMed:26297806, ECO:0000269|PubMed:27462074,ECO:0000305|PubMed:11724960}. | May play a role in vesicle trafficking (By similarity).Binds phosphatidylinositol 3,4,5-trisphosphate. Acts as a RAB27Aeffector protein and may play a role in cytotoxic granuleexocytosis in lymphocytes (By similarity). {ECO:0000250,ECO:0000269|PubMed:11278853, ECO:0000269|PubMed:18266782}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | SPAG5 | chr17:26911168 | chr1:27680204 | ENST00000321765 | - | 13 | 24 | 545_608 | 804 | 1194 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | SPAG5 | chr17:26911168 | chr1:27680204 | ENST00000321765 | - | 13 | 24 | 617_789 | 804 | 1194 | Compositional bias | Note=Gln-rich |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >SPAG5 | chr17:26911168 | chr1:27680204 | ENST00000321765 | - | 13 | 24 | 759_868 | 804 | 1194 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >SPAG5 | chr17:26911168 | chr1:27680204 | ENST00000321765 | - | 13 | 24 | 979_1174 | 804 | 1194 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | SYTL1 | chr17:26911168 | chr1:27680204 | ENST00000318074 | + | 13 | 15 | 237_258 | 504 | 551 | Compositional bias | Note=Ser-rich |
| Tgene | SYTL1 | chr17:26911168 | chr1:27680204 | ENST00000543823 | + | 12 | 14 | 237_258 | 516 | 563 | Compositional bias | Note=Ser-rich |
| Tgene | SYTL1 | chr17:26911168 | chr1:27680204 | ENST00000318074 | + | 13 | 15 | 268_368 | 504 | 551 | Domain | C2 1 |
| Tgene | SYTL1 | chr17:26911168 | chr1:27680204 | ENST00000318074 | + | 13 | 15 | 31_87 | 504 | 551 | Domain | RabBD |
| Tgene | SYTL1 | chr17:26911168 | chr1:27680204 | ENST00000318074 | + | 13 | 15 | 409_511 | 504 | 551 | Domain | C2 2 |
| Tgene | SYTL1 | chr17:26911168 | chr1:27680204 | ENST00000543823 | + | 12 | 14 | 268_368 | 516 | 563 | Domain | C2 1 |
| Tgene | SYTL1 | chr17:26911168 | chr1:27680204 | ENST00000543823 | + | 12 | 14 | 31_87 | 516 | 563 | Domain | RabBD |
| Tgene | SYTL1 | chr17:26911168 | chr1:27680204 | ENST00000543823 | + | 12 | 14 | 409_511 | 516 | 563 | Domain | C2 2 |
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FusionGeneSequence for SPAG5_SYTL1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SPAG5_ENST00000321765_chr17_26911168_-_SYTL1_ENST00000318074_chr1_27680204_+_850aa MWRVKKLSLSLSPSPQTGKPSMRTPLRELTLQPGALTNSGKRSPACSSLTPSLCKLGLQEGSNNSSPVDFVNNKRTDLSSEHFSHSSKWL ETCQHESDEQPLDPIPQISSTPKTSEEAVDPLGNYMVKTIVLVPSPLGQQQDMIFEARLDTMAETNSISLNGPLRTDDLVREEVAPCMGD RFSEVAAVSEKPIFQESPSHLLEESPPNPCSEQLHCSKESLSSRTEAVREDLVPSESNAFLPSSVLWLSPSTALAADFRVNHVDPEEEIV EHGAMEEREMRFPTHPKESETEDQALVSSVEDILSTCLTPNLVEMESQEAPGPAVEDVGRILGSDTESWMSPLAWLEKGVNTSVMLENLR QSLSLPSMLRDAAIGTTPFSTCSVGTWFTPSAPQEKSTNTSQTGLVGTKHSTSETEQLLCGRPPDLTALSRHDLEDNLLSSLVILEVLSR QLRDWKSQLAVPHPETQDSSTQTDTSHSGITNKLQHLKESHEMGQALQQARNVMQSWVLISKELISLLHLSLLHLEEDKTTVSQESRRAE TLVCCCFDLLKKLRAKLQSLKAEREEARHREEMALRGKDAAEIVLEAFCAHASQRISQLEQDLASMREFRGLLKDAQTQLVGLHAKQEEL VQQTVSLTSTLQQDWRSMQLDYTTWTALLSRSRQLTEKLTVKSQQALQERDVAIEEKQEVSRVLEQVSAQLEECKGQTEQLELENSRLAT DLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQWQKEEMALKHMQAELQQQQAVLAKEVRDLKETLEAAAMGC >In-frame_SPAG5_ENST00000321765_chr17_26911168_-_SYTL1_ENST00000543823_chr1_27680204_+_850aa MWRVKKLSLSLSPSPQTGKPSMRTPLRELTLQPGALTNSGKRSPACSSLTPSLCKLGLQEGSNNSSPVDFVNNKRTDLSSEHFSHSSKWL ETCQHESDEQPLDPIPQISSTPKTSEEAVDPLGNYMVKTIVLVPSPLGQQQDMIFEARLDTMAETNSISLNGPLRTDDLVREEVAPCMGD RFSEVAAVSEKPIFQESPSHLLEESPPNPCSEQLHCSKESLSSRTEAVREDLVPSESNAFLPSSVLWLSPSTALAADFRVNHVDPEEEIV EHGAMEEREMRFPTHPKESETEDQALVSSVEDILSTCLTPNLVEMESQEAPGPAVEDVGRILGSDTESWMSPLAWLEKGVNTSVMLENLR QSLSLPSMLRDAAIGTTPFSTCSVGTWFTPSAPQEKSTNTSQTGLVGTKHSTSETEQLLCGRPPDLTALSRHDLEDNLLSSLVILEVLSR QLRDWKSQLAVPHPETQDSSTQTDTSHSGITNKLQHLKESHEMGQALQQARNVMQSWVLISKELISLLHLSLLHLEEDKTTVSQESRRAE TLVCCCFDLLKKLRAKLQSLKAEREEARHREEMALRGKDAAEIVLEAFCAHASQRISQLEQDLASMREFRGLLKDAQTQLVGLHAKQEEL VQQTVSLTSTLQQDWRSMQLDYTTWTALLSRSRQLTEKLTVKSQQALQERDVAIEEKQEVSRVLEQVSAQLEECKGQTEQLELENSRLAT DLRAQLQILANMDSQLKELQSQHTHCAQDLAMKDELLCQLTQSNEEQAAQWQKEEMALKHMQAELQQQQAVLAKEVRDLKETLEAAAMGC |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SPAG5_ENST00000321765_chr17_26911168_-_SYTL1_ENST00000318074_chr1_27680204_+_2552nt ATGTGGCGAGTGAAAAAACTGAGCCTCAGCCTGTCGCCTTCGCCCCAGACGGGAAAACCATCTATGAGAACTCCTCTCCGTGAACTTACC CTGCAGCCCGGTGCCCTCACCAACTCTGGAAAAAGATCCCCCGCTTGCTCCTCGCTGACCCCATCACTGTGCAAGCTGGGGCTGCAGGAA GGCAGCAACAACTCATCTCCAGTGGATTTTGTAAATAACAAGAGGACAGACTTATCTTCAGAACATTTCAGTCATTCCTCAAAGTGGCTA GAAACTTGTCAGCATGAATCAGATGAGCAGCCTCTAGATCCAATTCCCCAAATTAGCTCTACTCCTAAAACGTCTGAGGAAGCAGTAGAC CCACTGGGCAATTATATGGTTAAAACCATCGTCCTTGTACCATCTCCACTGGGGCAGCAACAAGACATGATATTTGAGGCCCGTTTAGAT ACCATGGCAGAGACAAACAGCATATCTTTAAATGGACCTTTGAGAACAGACGATCTGGTGAGAGAGGAGGTGGCACCCTGCATGGGAGAC AGGTTTTCAGAAGTTGCTGCTGTATCTGAGAAACCTATCTTTCAGGAATCTCCGTCCCATCTCTTAGAGGAGTCTCCACCAAATCCCTGT TCTGAACAACTACATTGCTCCAAGGAAAGCCTGAGCAGTAGAACTGAGGCTGTGCGTGAGGACTTAGTACCTTCTGAAAGTAACGCCTTC TTGCCTTCCTCTGTTCTCTGGCTTTCCCCTTCAACTGCCTTGGCAGCAGATTTCCGTGTCAATCATGTGGACCCAGAGGAGGAAATTGTA GAGCATGGAGCTATGGAGGAAAGAGAAATGAGGTTTCCCACACATCCTAAGGAGTCTGAAACAGAAGATCAAGCACTTGTCTCAAGTGTG GAAGATATTCTGTCCACATGCCTGACACCAAATCTAGTAGAAATGGAATCCCAAGAAGCTCCAGGCCCAGCAGTAGAAGATGTTGGTAGG ATTCTTGGCTCTGATACAGAGTCTTGGATGTCCCCACTGGCCTGGCTGGAAAAAGGTGTAAATACCTCCGTCATGCTGGAAAATCTCCGC CAAAGCTTATCCCTTCCCTCGATGCTTCGGGATGCTGCAATTGGCACTACCCCTTTCTCTACTTGCTCGGTGGGGACTTGGTTTACTCCT TCAGCACCACAGGAAAAGAGTACAAACACATCCCAGACAGGCCTGGTTGGCACCAAGCACAGTACTTCTGAGACAGAGCAGCTCCTGTGT GGCCGGCCTCCAGATCTGACTGCCTTGTCTCGACATGACTTGGAAGATAACCTGCTGAGCTCTCTTGTCATTCTGGAGGTTCTCTCCCGC CAGCTTCGGGACTGGAAGAGCCAGCTGGCTGTCCCTCACCCAGAAACCCAGGACAGTAGCACACAGACTGACACATCTCACAGTGGGATA ACTAATAAACTTCAGCATCTTAAGGAGAGCCATGAGATGGGACAGGCCCTACAGCAGGCCAGAAATGTCATGCAATCATGGGTGCTTATC TCTAAAGAGCTGATATCCTTGCTTCACCTATCCCTGTTGCATTTAGAAGAAGATAAGACTACTGTGAGTCAGGAGTCTCGGCGTGCAGAA ACATTGGTCTGTTGCTGTTTTGATTTGCTGAAGAAATTGAGGGCAAAGCTCCAGAGCCTCAAAGCAGAAAGGGAGGAGGCAAGGCACAGA GAGGAAATGGCTCTCAGAGGCAAGGATGCGGCAGAGATAGTGTTGGAGGCTTTCTGTGCACACGCCAGCCAGCGCATCAGCCAGCTGGAA CAGGACCTAGCATCCATGCGGGAATTCAGAGGCCTTCTGAAGGATGCCCAGACCCAACTGGTAGGGCTTCATGCCAAGCAAGAAGAGCTG GTTCAGCAGACAGTGAGTCTTACTTCTACCTTGCAACAAGACTGGAGGTCCATGCAACTGGATTATACAACATGGACAGCTTTGCTGAGT CGGTCCCGACAACTCACAGAGAAACTCACAGTCAAGAGCCAGCAAGCCCTGCAGGAACGTGATGTGGCAATTGAGGAAAAGCAGGAGGTT TCTAGGGTGCTGGAACAAGTCTCTGCCCAGTTAGAGGAGTGCAAAGGCCAAACAGAACAACTGGAGTTGGAAAACAGTCGTCTAGCAACA GATCTCCGGGCTCAGTTGCAGATTCTGGCCAACATGGACAGCCAGCTAAAAGAGCTACAGAGTCAGCATACCCATTGTGCCCAGGACCTG GCTATGAAGGATGAGTTACTCTGCCAGCTTACCCAGAGCAATGAGGAGCAGGCTGCTCAATGGCAAAAGGAAGAGATGGCACTAAAACAC ATGCAGGCAGAACTGCAGCAGCAACAAGCTGTCCTGGCCAAAGAGGTGCGGGACCTGAAAGAGACCTTGGAGGCAGCAGCTATGGGCTGC AGGTGCCCTGGATGGATTCCACACCTGAGGAGAAGCAGCTGTGGCAAGCCCTCCTGGAGCAGCCGTGCGAATGGGTGGATGGCCTTCTAC >In-frame_SPAG5_ENST00000321765_chr17_26911168_-_SYTL1_ENST00000543823_chr1_27680204_+_2552nt ATGTGGCGAGTGAAAAAACTGAGCCTCAGCCTGTCGCCTTCGCCCCAGACGGGAAAACCATCTATGAGAACTCCTCTCCGTGAACTTACC CTGCAGCCCGGTGCCCTCACCAACTCTGGAAAAAGATCCCCCGCTTGCTCCTCGCTGACCCCATCACTGTGCAAGCTGGGGCTGCAGGAA GGCAGCAACAACTCATCTCCAGTGGATTTTGTAAATAACAAGAGGACAGACTTATCTTCAGAACATTTCAGTCATTCCTCAAAGTGGCTA GAAACTTGTCAGCATGAATCAGATGAGCAGCCTCTAGATCCAATTCCCCAAATTAGCTCTACTCCTAAAACGTCTGAGGAAGCAGTAGAC CCACTGGGCAATTATATGGTTAAAACCATCGTCCTTGTACCATCTCCACTGGGGCAGCAACAAGACATGATATTTGAGGCCCGTTTAGAT ACCATGGCAGAGACAAACAGCATATCTTTAAATGGACCTTTGAGAACAGACGATCTGGTGAGAGAGGAGGTGGCACCCTGCATGGGAGAC AGGTTTTCAGAAGTTGCTGCTGTATCTGAGAAACCTATCTTTCAGGAATCTCCGTCCCATCTCTTAGAGGAGTCTCCACCAAATCCCTGT TCTGAACAACTACATTGCTCCAAGGAAAGCCTGAGCAGTAGAACTGAGGCTGTGCGTGAGGACTTAGTACCTTCTGAAAGTAACGCCTTC TTGCCTTCCTCTGTTCTCTGGCTTTCCCCTTCAACTGCCTTGGCAGCAGATTTCCGTGTCAATCATGTGGACCCAGAGGAGGAAATTGTA GAGCATGGAGCTATGGAGGAAAGAGAAATGAGGTTTCCCACACATCCTAAGGAGTCTGAAACAGAAGATCAAGCACTTGTCTCAAGTGTG GAAGATATTCTGTCCACATGCCTGACACCAAATCTAGTAGAAATGGAATCCCAAGAAGCTCCAGGCCCAGCAGTAGAAGATGTTGGTAGG ATTCTTGGCTCTGATACAGAGTCTTGGATGTCCCCACTGGCCTGGCTGGAAAAAGGTGTAAATACCTCCGTCATGCTGGAAAATCTCCGC CAAAGCTTATCCCTTCCCTCGATGCTTCGGGATGCTGCAATTGGCACTACCCCTTTCTCTACTTGCTCGGTGGGGACTTGGTTTACTCCT TCAGCACCACAGGAAAAGAGTACAAACACATCCCAGACAGGCCTGGTTGGCACCAAGCACAGTACTTCTGAGACAGAGCAGCTCCTGTGT GGCCGGCCTCCAGATCTGACTGCCTTGTCTCGACATGACTTGGAAGATAACCTGCTGAGCTCTCTTGTCATTCTGGAGGTTCTCTCCCGC CAGCTTCGGGACTGGAAGAGCCAGCTGGCTGTCCCTCACCCAGAAACCCAGGACAGTAGCACACAGACTGACACATCTCACAGTGGGATA ACTAATAAACTTCAGCATCTTAAGGAGAGCCATGAGATGGGACAGGCCCTACAGCAGGCCAGAAATGTCATGCAATCATGGGTGCTTATC TCTAAAGAGCTGATATCCTTGCTTCACCTATCCCTGTTGCATTTAGAAGAAGATAAGACTACTGTGAGTCAGGAGTCTCGGCGTGCAGAA ACATTGGTCTGTTGCTGTTTTGATTTGCTGAAGAAATTGAGGGCAAAGCTCCAGAGCCTCAAAGCAGAAAGGGAGGAGGCAAGGCACAGA GAGGAAATGGCTCTCAGAGGCAAGGATGCGGCAGAGATAGTGTTGGAGGCTTTCTGTGCACACGCCAGCCAGCGCATCAGCCAGCTGGAA CAGGACCTAGCATCCATGCGGGAATTCAGAGGCCTTCTGAAGGATGCCCAGACCCAACTGGTAGGGCTTCATGCCAAGCAAGAAGAGCTG GTTCAGCAGACAGTGAGTCTTACTTCTACCTTGCAACAAGACTGGAGGTCCATGCAACTGGATTATACAACATGGACAGCTTTGCTGAGT CGGTCCCGACAACTCACAGAGAAACTCACAGTCAAGAGCCAGCAAGCCCTGCAGGAACGTGATGTGGCAATTGAGGAAAAGCAGGAGGTT TCTAGGGTGCTGGAACAAGTCTCTGCCCAGTTAGAGGAGTGCAAAGGCCAAACAGAACAACTGGAGTTGGAAAACAGTCGTCTAGCAACA GATCTCCGGGCTCAGTTGCAGATTCTGGCCAACATGGACAGCCAGCTAAAAGAGCTACAGAGTCAGCATACCCATTGTGCCCAGGACCTG GCTATGAAGGATGAGTTACTCTGCCAGCTTACCCAGAGCAATGAGGAGCAGGCTGCTCAATGGCAAAAGGAAGAGATGGCACTAAAACAC ATGCAGGCAGAACTGCAGCAGCAACAAGCTGTCCTGGCCAAAGAGGTGCGGGACCTGAAAGAGACCTTGGAGGCAGCAGCTATGGGCTGC AGGTGCCCTGGATGGATTCCACACCTGAGGAGAAGCAGCTGTGGCAAGCCCTCCTGGAGCAGCCGTGCGAATGGGTGGATGGCCTTCTAC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SPAG5_ENST00000321765_chr17_26911168_-_SYTL1_ENST00000318074_chr1_27680204_+_2963nt CAGGAGGGATGGACTCCTGGACTCTCCAGCTACCTGCGTGGTCCTCCCCGGTGTGAGGACAGAAGACCGGTCCTGGGCCGGGCCCGCATC CAGCCCTACCGCCGGTGTCTGAGGTGAGGGCTCCGTCAGCGGAAAACGCTCGACAACGGAGGGGCAGGCAGGGCCGGGGGCGTGGTCAAC GCGGGCCCCGCCCCCCGGGCTCTACCCCCGAGCGTACGCGCGCGCCTGAAGCAGCCAACCAGGAAGCGCAGAGCAGGTTCAAACACAGAC GGCGGGTGAACATGGCGTCCTCGACTTGGTCTGAGACGTGATAGGCCTGCCTTCTGGTTGAAGATGTGGCGAGTGAAAAAACTGAGCCTC AGCCTGTCGCCTTCGCCCCAGACGGGAAAACCATCTATGAGAACTCCTCTCCGTGAACTTACCCTGCAGCCCGGTGCCCTCACCAACTCT GGAAAAAGATCCCCCGCTTGCTCCTCGCTGACCCCATCACTGTGCAAGCTGGGGCTGCAGGAAGGCAGCAACAACTCATCTCCAGTGGAT TTTGTAAATAACAAGAGGACAGACTTATCTTCAGAACATTTCAGTCATTCCTCAAAGTGGCTAGAAACTTGTCAGCATGAATCAGATGAG CAGCCTCTAGATCCAATTCCCCAAATTAGCTCTACTCCTAAAACGTCTGAGGAAGCAGTAGACCCACTGGGCAATTATATGGTTAAAACC ATCGTCCTTGTACCATCTCCACTGGGGCAGCAACAAGACATGATATTTGAGGCCCGTTTAGATACCATGGCAGAGACAAACAGCATATCT TTAAATGGACCTTTGAGAACAGACGATCTGGTGAGAGAGGAGGTGGCACCCTGCATGGGAGACAGGTTTTCAGAAGTTGCTGCTGTATCT GAGAAACCTATCTTTCAGGAATCTCCGTCCCATCTCTTAGAGGAGTCTCCACCAAATCCCTGTTCTGAACAACTACATTGCTCCAAGGAA AGCCTGAGCAGTAGAACTGAGGCTGTGCGTGAGGACTTAGTACCTTCTGAAAGTAACGCCTTCTTGCCTTCCTCTGTTCTCTGGCTTTCC CCTTCAACTGCCTTGGCAGCAGATTTCCGTGTCAATCATGTGGACCCAGAGGAGGAAATTGTAGAGCATGGAGCTATGGAGGAAAGAGAA ATGAGGTTTCCCACACATCCTAAGGAGTCTGAAACAGAAGATCAAGCACTTGTCTCAAGTGTGGAAGATATTCTGTCCACATGCCTGACA CCAAATCTAGTAGAAATGGAATCCCAAGAAGCTCCAGGCCCAGCAGTAGAAGATGTTGGTAGGATTCTTGGCTCTGATACAGAGTCTTGG ATGTCCCCACTGGCCTGGCTGGAAAAAGGTGTAAATACCTCCGTCATGCTGGAAAATCTCCGCCAAAGCTTATCCCTTCCCTCGATGCTT CGGGATGCTGCAATTGGCACTACCCCTTTCTCTACTTGCTCGGTGGGGACTTGGTTTACTCCTTCAGCACCACAGGAAAAGAGTACAAAC ACATCCCAGACAGGCCTGGTTGGCACCAAGCACAGTACTTCTGAGACAGAGCAGCTCCTGTGTGGCCGGCCTCCAGATCTGACTGCCTTG TCTCGACATGACTTGGAAGATAACCTGCTGAGCTCTCTTGTCATTCTGGAGGTTCTCTCCCGCCAGCTTCGGGACTGGAAGAGCCAGCTG GCTGTCCCTCACCCAGAAACCCAGGACAGTAGCACACAGACTGACACATCTCACAGTGGGATAACTAATAAACTTCAGCATCTTAAGGAG AGCCATGAGATGGGACAGGCCCTACAGCAGGCCAGAAATGTCATGCAATCATGGGTGCTTATCTCTAAAGAGCTGATATCCTTGCTTCAC CTATCCCTGTTGCATTTAGAAGAAGATAAGACTACTGTGAGTCAGGAGTCTCGGCGTGCAGAAACATTGGTCTGTTGCTGTTTTGATTTG CTGAAGAAATTGAGGGCAAAGCTCCAGAGCCTCAAAGCAGAAAGGGAGGAGGCAAGGCACAGAGAGGAAATGGCTCTCAGAGGCAAGGAT GCGGCAGAGATAGTGTTGGAGGCTTTCTGTGCACACGCCAGCCAGCGCATCAGCCAGCTGGAACAGGACCTAGCATCCATGCGGGAATTC AGAGGCCTTCTGAAGGATGCCCAGACCCAACTGGTAGGGCTTCATGCCAAGCAAGAAGAGCTGGTTCAGCAGACAGTGAGTCTTACTTCT ACCTTGCAACAAGACTGGAGGTCCATGCAACTGGATTATACAACATGGACAGCTTTGCTGAGTCGGTCCCGACAACTCACAGAGAAACTC ACAGTCAAGAGCCAGCAAGCCCTGCAGGAACGTGATGTGGCAATTGAGGAAAAGCAGGAGGTTTCTAGGGTGCTGGAACAAGTCTCTGCC CAGTTAGAGGAGTGCAAAGGCCAAACAGAACAACTGGAGTTGGAAAACAGTCGTCTAGCAACAGATCTCCGGGCTCAGTTGCAGATTCTG GCCAACATGGACAGCCAGCTAAAAGAGCTACAGAGTCAGCATACCCATTGTGCCCAGGACCTGGCTATGAAGGATGAGTTACTCTGCCAG CTTACCCAGAGCAATGAGGAGCAGGCTGCTCAATGGCAAAAGGAAGAGATGGCACTAAAACACATGCAGGCAGAACTGCAGCAGCAACAA GCTGTCCTGGCCAAAGAGGTGCGGGACCTGAAAGAGACCTTGGAGGCAGCAGCTATGGGCTGCAGGTGCCCTGGATGGATTCCACACCTG AGGAGAAGCAGCTGTGGCAAGCCCTCCTGGAGCAGCCGTGCGAATGGGTGGATGGCCTTCTACCCCTCAGAACCAACCTGGCCCCCAGGA >In-frame_SPAG5_ENST00000321765_chr17_26911168_-_SYTL1_ENST00000543823_chr1_27680204_+_2963nt CAGGAGGGATGGACTCCTGGACTCTCCAGCTACCTGCGTGGTCCTCCCCGGTGTGAGGACAGAAGACCGGTCCTGGGCCGGGCCCGCATC CAGCCCTACCGCCGGTGTCTGAGGTGAGGGCTCCGTCAGCGGAAAACGCTCGACAACGGAGGGGCAGGCAGGGCCGGGGGCGTGGTCAAC GCGGGCCCCGCCCCCCGGGCTCTACCCCCGAGCGTACGCGCGCGCCTGAAGCAGCCAACCAGGAAGCGCAGAGCAGGTTCAAACACAGAC GGCGGGTGAACATGGCGTCCTCGACTTGGTCTGAGACGTGATAGGCCTGCCTTCTGGTTGAAGATGTGGCGAGTGAAAAAACTGAGCCTC AGCCTGTCGCCTTCGCCCCAGACGGGAAAACCATCTATGAGAACTCCTCTCCGTGAACTTACCCTGCAGCCCGGTGCCCTCACCAACTCT GGAAAAAGATCCCCCGCTTGCTCCTCGCTGACCCCATCACTGTGCAAGCTGGGGCTGCAGGAAGGCAGCAACAACTCATCTCCAGTGGAT TTTGTAAATAACAAGAGGACAGACTTATCTTCAGAACATTTCAGTCATTCCTCAAAGTGGCTAGAAACTTGTCAGCATGAATCAGATGAG CAGCCTCTAGATCCAATTCCCCAAATTAGCTCTACTCCTAAAACGTCTGAGGAAGCAGTAGACCCACTGGGCAATTATATGGTTAAAACC ATCGTCCTTGTACCATCTCCACTGGGGCAGCAACAAGACATGATATTTGAGGCCCGTTTAGATACCATGGCAGAGACAAACAGCATATCT TTAAATGGACCTTTGAGAACAGACGATCTGGTGAGAGAGGAGGTGGCACCCTGCATGGGAGACAGGTTTTCAGAAGTTGCTGCTGTATCT GAGAAACCTATCTTTCAGGAATCTCCGTCCCATCTCTTAGAGGAGTCTCCACCAAATCCCTGTTCTGAACAACTACATTGCTCCAAGGAA AGCCTGAGCAGTAGAACTGAGGCTGTGCGTGAGGACTTAGTACCTTCTGAAAGTAACGCCTTCTTGCCTTCCTCTGTTCTCTGGCTTTCC CCTTCAACTGCCTTGGCAGCAGATTTCCGTGTCAATCATGTGGACCCAGAGGAGGAAATTGTAGAGCATGGAGCTATGGAGGAAAGAGAA ATGAGGTTTCCCACACATCCTAAGGAGTCTGAAACAGAAGATCAAGCACTTGTCTCAAGTGTGGAAGATATTCTGTCCACATGCCTGACA CCAAATCTAGTAGAAATGGAATCCCAAGAAGCTCCAGGCCCAGCAGTAGAAGATGTTGGTAGGATTCTTGGCTCTGATACAGAGTCTTGG ATGTCCCCACTGGCCTGGCTGGAAAAAGGTGTAAATACCTCCGTCATGCTGGAAAATCTCCGCCAAAGCTTATCCCTTCCCTCGATGCTT CGGGATGCTGCAATTGGCACTACCCCTTTCTCTACTTGCTCGGTGGGGACTTGGTTTACTCCTTCAGCACCACAGGAAAAGAGTACAAAC ACATCCCAGACAGGCCTGGTTGGCACCAAGCACAGTACTTCTGAGACAGAGCAGCTCCTGTGTGGCCGGCCTCCAGATCTGACTGCCTTG TCTCGACATGACTTGGAAGATAACCTGCTGAGCTCTCTTGTCATTCTGGAGGTTCTCTCCCGCCAGCTTCGGGACTGGAAGAGCCAGCTG GCTGTCCCTCACCCAGAAACCCAGGACAGTAGCACACAGACTGACACATCTCACAGTGGGATAACTAATAAACTTCAGCATCTTAAGGAG AGCCATGAGATGGGACAGGCCCTACAGCAGGCCAGAAATGTCATGCAATCATGGGTGCTTATCTCTAAAGAGCTGATATCCTTGCTTCAC CTATCCCTGTTGCATTTAGAAGAAGATAAGACTACTGTGAGTCAGGAGTCTCGGCGTGCAGAAACATTGGTCTGTTGCTGTTTTGATTTG CTGAAGAAATTGAGGGCAAAGCTCCAGAGCCTCAAAGCAGAAAGGGAGGAGGCAAGGCACAGAGAGGAAATGGCTCTCAGAGGCAAGGAT GCGGCAGAGATAGTGTTGGAGGCTTTCTGTGCACACGCCAGCCAGCGCATCAGCCAGCTGGAACAGGACCTAGCATCCATGCGGGAATTC AGAGGCCTTCTGAAGGATGCCCAGACCCAACTGGTAGGGCTTCATGCCAAGCAAGAAGAGCTGGTTCAGCAGACAGTGAGTCTTACTTCT ACCTTGCAACAAGACTGGAGGTCCATGCAACTGGATTATACAACATGGACAGCTTTGCTGAGTCGGTCCCGACAACTCACAGAGAAACTC ACAGTCAAGAGCCAGCAAGCCCTGCAGGAACGTGATGTGGCAATTGAGGAAAAGCAGGAGGTTTCTAGGGTGCTGGAACAAGTCTCTGCC CAGTTAGAGGAGTGCAAAGGCCAAACAGAACAACTGGAGTTGGAAAACAGTCGTCTAGCAACAGATCTCCGGGCTCAGTTGCAGATTCTG GCCAACATGGACAGCCAGCTAAAAGAGCTACAGAGTCAGCATACCCATTGTGCCCAGGACCTGGCTATGAAGGATGAGTTACTCTGCCAG CTTACCCAGAGCAATGAGGAGCAGGCTGCTCAATGGCAAAAGGAAGAGATGGCACTAAAACACATGCAGGCAGAACTGCAGCAGCAACAA GCTGTCCTGGCCAAAGAGGTGCGGGACCTGAAAGAGACCTTGGAGGCAGCAGCTATGGGCTGCAGGTGCCCTGGATGGATTCCACACCTG AGGAGAAGCAGCTGTGGCAAGCCCTCCTGGAGCAGCCGTGCGAATGGGTGGATGGCCTTCTACCCCTCAGAACCAACCTGGCCCCCAGGA |
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FusionGenePPI for SPAG5_SYTL1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SPAG5 | SNAPIN, CDK1, CEBPD, ATN1, HECW2, ARNT2, FMR1, IQCE, BARD1, DCX, POLR2L, SMARCE1, EIF4E2, FBXO28, ORC6, AMOTL2, CCHCR1, CHCHD3, C1orf109, RBM41, LGALS14, TSHZ3, SH2D4A, TTC23, ZC2HC1C, CCDC33, LINGO1, HAUS1, SNAP47, ZMAT2, CDC20B, ZFC3H1, KANSL1, GOLGA8EP, GOLGA8F, CEP170, SRGAP3, DTNBP1, IFT57, C17orf59, CCDC67, KIAA0753, CCDC14, MED4, RPGRIP1L, OFD1, SPICE1, CEP44, DCTN1, ZNF385C, ZFYVE26, ENKD1, ZGPAT, DYNLL1, MAPRE1, MID1, MID2, NLGN3, RINT1, COPS7B, RIC8A, SYCE3, TSPYL1, CCDC89, MED21, RHPN1, BFSP2, EMILIN1, CCDC22, TSKS, KIAA1467, COG6, PLK1, SLC9C1, TUBA3C, MED1, NEURL4 | SYTL1 | RAB27A, NCF2, NCF1, RAB27B, RAB8A |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | SPAG5 | chr17:26911168 | chr1:27680204 | ENST00000321765 | - | 13 | 24 | 482_850 | 804 | 1194 | KNSTRN |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SPAG5_SYTL1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SPAG5_SYTL1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SPAG5 | C0000786 | Spontaneous abortion | 1 | CTD_human |
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