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Fusion gene ID: 35504 |
FusionGeneSummary for SP4_GPNMB |
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Fusion gene information | Fusion gene name: SP4_GPNMB | Fusion gene ID: 35504 | Hgene | Tgene | Gene symbol | SP4 | GPNMB | Gene ID | 6671 | 10457 |
Gene name | Sp4 transcription factor | glycoprotein nmb | |
Synonyms | HF1B|SPR-1 | HGFIN|NMB|PLCA3 | |
Cytomap | 7p15.3 | 7p15.3 | |
Type of gene | protein-coding | protein-coding | |
Description | transcription factor Sp4 | transmembrane glycoprotein NMBglycoprotein (transmembrane) nmbglycoprotein nmb-like proteinglycoprotein nonmetastatic melanoma protein Bhematopoietic growth factor inducible neurokinin-1osteoactivintransmembrane glycoprotein HGFIN | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q02446 | Q14956 | |
Ensembl transtripts involved in fusion gene | ENST00000222584, | ENST00000258733, ENST00000381990, ENST00000409458, ENST00000539136, ENST00000453162, ENST00000478451, | |
Fusion gene scores | * DoF score | 1 X 2 X 1=2 | 3 X 3 X 3=27 |
# samples | 1 | 3 | |
** MAII score | log2(1/2*10)=2.32192809488736 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: SP4 [Title/Abstract] AND GPNMB [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | SP4 | GO:0006357 | regulation of transcription by RNA polymerase II | 12560508 |
Tgene | GPNMB | GO:0001818 | negative regulation of cytokine production | 19350579 |
Tgene | GPNMB | GO:0001934 | positive regulation of protein phosphorylation | 22891158 |
Tgene | GPNMB | GO:0030335 | positive regulation of cell migration | 20711474 |
Tgene | GPNMB | GO:0031954 | positive regulation of protein autophosphorylation | 19350579 |
Tgene | GPNMB | GO:0034103 | regulation of tissue remodeling | 25010402 |
Tgene | GPNMB | GO:0042130 | negative regulation of T cell proliferation | 19350579 |
Tgene | GPNMB | GO:2000134 | negative regulation of G1/S transition of mitotic cell cycle | 19350579 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | GBM | TCGA-28-1747-01C | SP4 | chr7 | 21468410 | + | GPNMB | chr7 | 23313140 | + |
TCGA | LD | GBM | TCGA-28-1747-01C | SP4 | chr7 | 21469210 | + | GPNMB | chr7 | 23313140 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000222584 | ENST00000258733 | SP4 | chr7 | 21468410 | + | GPNMB | chr7 | 23313140 | + |
Frame-shift | ENST00000222584 | ENST00000381990 | SP4 | chr7 | 21468410 | + | GPNMB | chr7 | 23313140 | + |
5CDS-intron | ENST00000222584 | ENST00000409458 | SP4 | chr7 | 21468410 | + | GPNMB | chr7 | 23313140 | + |
5CDS-intron | ENST00000222584 | ENST00000539136 | SP4 | chr7 | 21468410 | + | GPNMB | chr7 | 23313140 | + |
5CDS-intron | ENST00000222584 | ENST00000453162 | SP4 | chr7 | 21468410 | + | GPNMB | chr7 | 23313140 | + |
5CDS-3UTR | ENST00000222584 | ENST00000478451 | SP4 | chr7 | 21468410 | + | GPNMB | chr7 | 23313140 | + |
In-frame | ENST00000222584 | ENST00000258733 | SP4 | chr7 | 21469210 | + | GPNMB | chr7 | 23313140 | + |
In-frame | ENST00000222584 | ENST00000381990 | SP4 | chr7 | 21469210 | + | GPNMB | chr7 | 23313140 | + |
5CDS-intron | ENST00000222584 | ENST00000409458 | SP4 | chr7 | 21469210 | + | GPNMB | chr7 | 23313140 | + |
5CDS-intron | ENST00000222584 | ENST00000539136 | SP4 | chr7 | 21469210 | + | GPNMB | chr7 | 23313140 | + |
5CDS-intron | ENST00000222584 | ENST00000453162 | SP4 | chr7 | 21469210 | + | GPNMB | chr7 | 23313140 | + |
5CDS-3UTR | ENST00000222584 | ENST00000478451 | SP4 | chr7 | 21469210 | + | GPNMB | chr7 | 23313140 | + |
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FusionProtFeatures for SP4_GPNMB |
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Hgene | Tgene |
SP4 | GPNMB |
Binds to GT and GC boxes promoters elements. Probabletranscriptional activator. | Could be a melanogenic enzyme. {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | >GPNMB | chr7:21469210 | chr7:23313140 | ENST00000258733 | + | 8 | 11 | 508_572 | 476 | 561 | Topological domain | Cytoplasmic |
Tgene | >GPNMB | chr7:21469210 | chr7:23313140 | ENST00000381990 | + | 8 | 11 | 508_572 | 488 | 573 | Topological domain | Cytoplasmic |
Tgene | >GPNMB | chr7:21469210 | chr7:23313140 | ENST00000258733 | + | 8 | 11 | 487_507 | 476 | 561 | Transmembrane | Helical |
Tgene | >GPNMB | chr7:21469210 | chr7:23313140 | ENST00000381990 | + | 8 | 11 | 487_507 | 488 | 573 | Transmembrane | Helical |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >SP4 | chr7:21469210 | chr7:23313140 | ENST00000222584 | + | 1 | 6 | 122_130 | -73 | 785 | Compositional bias | Note=Poly-Ser |
Hgene | >SP4 | chr7:21469210 | chr7:23313140 | ENST00000222584 | + | 1 | 6 | 12_19 | -73 | 785 | Compositional bias | Note=Poly-Ala |
Hgene | >SP4 | chr7:21469210 | chr7:23313140 | ENST00000222584 | + | 1 | 6 | 185_188 | -73 | 785 | Compositional bias | Note=Poly-Ser |
Hgene | >SP4 | chr7:21469210 | chr7:23313140 | ENST00000222584 | + | 1 | 6 | 7_11 | -73 | 785 | Compositional bias | Note=Poly-Glu |
Hgene | >SP4 | chr7:21469210 | chr7:23313140 | ENST00000222584 | + | 1 | 6 | 647_671 | -73 | 785 | Zinc finger | C2H2-type 1 |
Hgene | >SP4 | chr7:21469210 | chr7:23313140 | ENST00000222584 | + | 1 | 6 | 677_701 | -73 | 785 | Zinc finger | C2H2-type 2 |
Hgene | >SP4 | chr7:21469210 | chr7:23313140 | ENST00000222584 | + | 1 | 6 | 707_729 | -73 | 785 | Zinc finger | C2H2-type 3 |
Tgene | GPNMB | chr7:21469210 | chr7:23313140 | ENST00000258733 | + | 8 | 11 | 320_332 | 476 | 561 | Compositional bias | Note=Poly-Pro |
Tgene | GPNMB | chr7:21469210 | chr7:23313140 | ENST00000381990 | + | 8 | 11 | 320_332 | 488 | 573 | Compositional bias | Note=Poly-Pro |
Tgene | GPNMB | chr7:21469210 | chr7:23313140 | ENST00000258733 | + | 8 | 11 | 240_327 | 476 | 561 | Domain | PKD |
Tgene | GPNMB | chr7:21469210 | chr7:23313140 | ENST00000381990 | + | 8 | 11 | 240_327 | 488 | 573 | Domain | PKD |
Tgene | GPNMB | chr7:21469210 | chr7:23313140 | ENST00000258733 | + | 8 | 11 | 64_66 | 476 | 561 | Motif | Cell attachment site |
Tgene | GPNMB | chr7:21469210 | chr7:23313140 | ENST00000381990 | + | 8 | 11 | 64_66 | 488 | 573 | Motif | Cell attachment site |
Tgene | GPNMB | chr7:21469210 | chr7:23313140 | ENST00000258733 | + | 8 | 11 | 22_486 | 476 | 561 | Topological domain | Extracellular |
Tgene | GPNMB | chr7:21469210 | chr7:23313140 | ENST00000381990 | + | 8 | 11 | 22_486 | 488 | 573 | Topological domain | Extracellular |
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FusionGeneSequence for SP4_GPNMB |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_SP4_ENST00000222584_chr7_21469210_+_GPNMB_ENST00000258733_chr7_23313140_+_644aa MSDQKKEEEEEAAAAAAMATEGGKTSEPENNNKKPKTSGSQDSQPSPLALLAATCSKIGTPGENQATGQQQIIIDPSQGLVQLQNQPQQL ELVTTQLAGNAWQLVASTPPASKENNVSQPASSSSSSSSSNNGSASPTKTKSGNSSTPGQFQVIQVQNPSGSVQYQVIPQLQTVEGQQIQ INPTSSSSLQDLQGQIQLISAGNNQAILTAANRTASGNILAQNLANQTVPVQIRPGVSIPLQLQTLPGTQAQVVTTLPINIGGVTLALPV INNVAAGGGTGQVGQPAATADSGTSNGNQLVSTPTNTTTSASTMPESPSSSTTCTTTASTSLTSSDTLVSSADTGQYASTSASSSERTIE ESQTPAATESEAQSSSQLQPNGMQNAQDQSNSLQQVQIVGQPILQQIQIQQPQQQIIQAIPPQSFQLQSGQTIQTIQQQPLQNVQLQAVN PTQVLIRAPTLTPSGQISWQTVQVQNIQSLSNLQVQNAGLSQQLTITPVSSSGGTTLAQIAPVAVAGAPITLNTAQLASVPNLQTVSVAN LGAAGVQVQGVPVTITSVADPASPLRMANSALISVGCLAIFVTVISLLVYKKHKEYNPIENSPGNVVRSKGLSVFLNRAKAVFFPGNQEK >In-frame_SP4_ENST00000222584_chr7_21469210_+_GPNMB_ENST00000381990_chr7_23313140_+_644aa MSDQKKEEEEEAAAAAAMATEGGKTSEPENNNKKPKTSGSQDSQPSPLALLAATCSKIGTPGENQATGQQQIIIDPSQGLVQLQNQPQQL ELVTTQLAGNAWQLVASTPPASKENNVSQPASSSSSSSSSNNGSASPTKTKSGNSSTPGQFQVIQVQNPSGSVQYQVIPQLQTVEGQQIQ INPTSSSSLQDLQGQIQLISAGNNQAILTAANRTASGNILAQNLANQTVPVQIRPGVSIPLQLQTLPGTQAQVVTTLPINIGGVTLALPV INNVAAGGGTGQVGQPAATADSGTSNGNQLVSTPTNTTTSASTMPESPSSSTTCTTTASTSLTSSDTLVSSADTGQYASTSASSSERTIE ESQTPAATESEAQSSSQLQPNGMQNAQDQSNSLQQVQIVGQPILQQIQIQQPQQQIIQAIPPQSFQLQSGQTIQTIQQQPLQNVQLQAVN PTQVLIRAPTLTPSGQISWQTVQVQNIQSLSNLQVQNAGLSQQLTITPVSSSGGTTLAQIAPVAVAGAPITLNTAQLASVPNLQTVSVAN LGAAGVQVQGVPVTITSVADPASPLRMANSALISVGCLAIFVTVISLLVYKKHKEYNPIENSPGNVVRSKGLSVFLNRAKAVFFPGNQEK |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_SP4_ENST00000222584_chr7_21469210_+_GPNMB_ENST00000258733_chr7_23313140_+_1932nt ATGAGCGATCAGAAGAAGGAGGAGGAGGAGGAGGCGGCAGCGGCAGCGGCGATGGCTACAGAAGGAGGGAAAACCTCTGAGCCAGAGAAT AACAATAAAAAACCCAAAACCTCAGGCTCCCAGGACTCTCAGCCCTCTCCTCTGGCTTTACTGGCAGCTACTTGCAGCAAAATAGGGACT CCTGGTGAAAATCAAGCAACTGGACAACAACAAATTATTATAGATCCAAGTCAAGGATTGGTGCAACTTCAAAATCAACCACAACAGCTA GAACTGGTAACAACGCAACTTGCTGGAAACGCTTGGCAACTTGTTGCCTCCACTCCTCCTGCTTCAAAAGAGAATAACGTTTCTCAACCA GCCTCTAGTTCGTCTAGTTCTTCCAGCAGTAATAACGGGAGTGCATCTCCTACAAAAACTAAATCAGGTAATTCTTCCACCCCTGGTCAA TTTCAAGTCATACAAGTACAAAATCCAAGTGGTAGTGTACAGTACCAAGTAATTCCACAACTTCAGACAGTGGAAGGTCAACAAATTCAA ATCAATCCAACTAGTAGTTCATCTCTACAGGATTTGCAGGGTCAAATTCAGCTCATTTCTGCAGGTAATAATCAAGCTATACTCACAGCT GCTAACAGGACAGCTTCTGGGAATATTCTTGCTCAAAACCTGGCAAATCAGACAGTTCCGGTCCAAATTAGACCTGGTGTTTCAATACCA CTGCAGTTACAGACTCTTCCTGGTACTCAGGCTCAAGTTGTAACAACCCTACCAATTAACATTGGAGGAGTGACTCTAGCTTTGCCAGTG ATAAACAACGTGGCTGCCGGAGGAGGGACTGGGCAGGTTGGCCAGCCTGCTGCTACTGCTGATAGTGGGACTTCCAATGGGAATCAATTA GTTTCCACACCCACCAACACCACTACTTCTGCCAGTACTATGCCAGAATCTCCCTCCTCCTCCACTACCTGCACAACCACTGCTTCAACG TCTTTGACAAGCAGTGACACATTAGTGAGCTCAGCAGATACTGGCCAGTATGCAAGCACATCAGCCAGTAGTTCTGAACGCACCATTGAA GAATCTCAAACACCTGCTGCTACTGAGTCTGAAGCCCAGAGCTCCAGTCAGCTTCAGCCTAATGGAATGCAGAATGCACAGGATCAATCA AATTCTCTTCAGCAGGTGCAAATTGTAGGCCAACCTATCTTACAGCAGATCCAGATCCAACAGCCTCAGCAACAGATCATTCAGGCTATT CCACCACAGTCGTTTCAACTCCAGTCAGGGCAGACGATTCAGACCATCCAGCAGCAGCCTTTACAGAATGTTCAACTTCAAGCAGTAAAT CCGACTCAGGTGCTTATCAGGGCTCCAACTTTAACACCTTCAGGGCAAATCAGTTGGCAAACTGTACAGGTTCAGAATATTCAGAGTCTT TCAAATTTGCAAGTTCAGAATGCTGGGTTATCCCAACAATTAACCATCACCCCAGTGTCTTCAAGTGGTGGCACAACTCTTGCTCAGATT GCTCCTGTGGCTGTTGCTGGTGCCCCAATAACTTTGAATACTGCCCAGCTTGCATCAGTGCCTAACCTTCAGACAGTGAGCGTTGCCAAC CTGGGTGCTGCAGGTGTTCAAGTGCAGGGAGTTCCCGTTACAATCACTAGTGTTGCAGACCCAGCCTCGCCTTTAAGGATGGCAAACAGT GCCCTGATCTCCGTTGGCTGCTTGGCCATATTTGTCACTGTGATCTCCCTCTTGGTGTACAAAAAACACAAGGAATACAACCCAATAGAA AATAGTCCTGGGAATGTGGTCAGAAGCAAAGGCCTGAGTGTCTTTCTCAACCGTGCAAAAGCCGTGTTCTTCCCGGGAAACCAGGAAAAG >In-frame_SP4_ENST00000222584_chr7_21469210_+_GPNMB_ENST00000381990_chr7_23313140_+_1932nt ATGAGCGATCAGAAGAAGGAGGAGGAGGAGGAGGCGGCAGCGGCAGCGGCGATGGCTACAGAAGGAGGGAAAACCTCTGAGCCAGAGAAT AACAATAAAAAACCCAAAACCTCAGGCTCCCAGGACTCTCAGCCCTCTCCTCTGGCTTTACTGGCAGCTACTTGCAGCAAAATAGGGACT CCTGGTGAAAATCAAGCAACTGGACAACAACAAATTATTATAGATCCAAGTCAAGGATTGGTGCAACTTCAAAATCAACCACAACAGCTA GAACTGGTAACAACGCAACTTGCTGGAAACGCTTGGCAACTTGTTGCCTCCACTCCTCCTGCTTCAAAAGAGAATAACGTTTCTCAACCA GCCTCTAGTTCGTCTAGTTCTTCCAGCAGTAATAACGGGAGTGCATCTCCTACAAAAACTAAATCAGGTAATTCTTCCACCCCTGGTCAA TTTCAAGTCATACAAGTACAAAATCCAAGTGGTAGTGTACAGTACCAAGTAATTCCACAACTTCAGACAGTGGAAGGTCAACAAATTCAA ATCAATCCAACTAGTAGTTCATCTCTACAGGATTTGCAGGGTCAAATTCAGCTCATTTCTGCAGGTAATAATCAAGCTATACTCACAGCT GCTAACAGGACAGCTTCTGGGAATATTCTTGCTCAAAACCTGGCAAATCAGACAGTTCCGGTCCAAATTAGACCTGGTGTTTCAATACCA CTGCAGTTACAGACTCTTCCTGGTACTCAGGCTCAAGTTGTAACAACCCTACCAATTAACATTGGAGGAGTGACTCTAGCTTTGCCAGTG ATAAACAACGTGGCTGCCGGAGGAGGGACTGGGCAGGTTGGCCAGCCTGCTGCTACTGCTGATAGTGGGACTTCCAATGGGAATCAATTA GTTTCCACACCCACCAACACCACTACTTCTGCCAGTACTATGCCAGAATCTCCCTCCTCCTCCACTACCTGCACAACCACTGCTTCAACG TCTTTGACAAGCAGTGACACATTAGTGAGCTCAGCAGATACTGGCCAGTATGCAAGCACATCAGCCAGTAGTTCTGAACGCACCATTGAA GAATCTCAAACACCTGCTGCTACTGAGTCTGAAGCCCAGAGCTCCAGTCAGCTTCAGCCTAATGGAATGCAGAATGCACAGGATCAATCA AATTCTCTTCAGCAGGTGCAAATTGTAGGCCAACCTATCTTACAGCAGATCCAGATCCAACAGCCTCAGCAACAGATCATTCAGGCTATT CCACCACAGTCGTTTCAACTCCAGTCAGGGCAGACGATTCAGACCATCCAGCAGCAGCCTTTACAGAATGTTCAACTTCAAGCAGTAAAT CCGACTCAGGTGCTTATCAGGGCTCCAACTTTAACACCTTCAGGGCAAATCAGTTGGCAAACTGTACAGGTTCAGAATATTCAGAGTCTT TCAAATTTGCAAGTTCAGAATGCTGGGTTATCCCAACAATTAACCATCACCCCAGTGTCTTCAAGTGGTGGCACAACTCTTGCTCAGATT GCTCCTGTGGCTGTTGCTGGTGCCCCAATAACTTTGAATACTGCCCAGCTTGCATCAGTGCCTAACCTTCAGACAGTGAGCGTTGCCAAC CTGGGTGCTGCAGGTGTTCAAGTGCAGGGAGTTCCCGTTACAATCACTAGTGTTGCAGACCCAGCCTCGCCTTTAAGGATGGCAAACAGT GCCCTGATCTCCGTTGGCTGCTTGGCCATATTTGTCACTGTGATCTCCCTCTTGGTGTACAAAAAACACAAGGAATACAACCCAATAGAA AATAGTCCTGGGAATGTGGTCAGAAGCAAAGGCCTGAGTGTCTTTCTCAACCGTGCAAAAGCCGTGTTCTTCCCGGGAAACCAGGAAAAG |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_SP4_ENST00000222584_chr7_21469210_+_GPNMB_ENST00000258733_chr7_23313140_+_3124nt GGCTGGGCGGGGCCGGGAAGCGGCAGTGGCGGCTACGCGCGCGGGGGTGCGCGCGGGAACGACCGGGAAACACCGCGAGGGCCGGGGTGG GCCAGGCTGTGGGGACGACGGGCTGCGACGATGGCCGCAGCGGCGGGCGGCGGCGGGCCGGGGACAGCGGTAGGCGCCACGGGCTCGGGG ATTGCGGCGGCAGCCGCAGGCCTAGCTGTTTATCGACGGAAGGATGGGGGCCCGGCCACCAAGTTTTGGGAGAGCCCGGAGACGGTGTCC CAGCTGGATTCGGTGCGGGTCTGGCTGGGCAAGCACTACAAGAAGATCAGAAGAAGGAGGAGGAGGAGGAGGCGGCAGCGGCAGCGGCGA TGGCTACAGAAGGAGGGAAAACCTCTGAGCCAGAGAATAACAATAAAAAACCCAAAACCTCAGGCTCCCAGGACTCTCAGCCCTCTCCTC TGGCTTTACTGGCAGCTACTTGCAGCAAAATAGGGACTCCTGGTGAAAATCAAGCAACTGGACAACAACAAATTATTATAGATCCAAGTC AAGGATTGGTGCAACTTCAAAATCAACCACAACAGCTAGAACTGGTAACAACGCAACTTGCTGGAAACGCTTGGCAACTTGTTGCCTCCA CTCCTCCTGCTTCAAAAGAGAATAACGTTTCTCAACCAGCCTCTAGTTCGTCTAGTTCTTCCAGCAGTAATAACGGGAGTGCATCTCCTA CAAAAACTAAATCAGGTAATTCTTCCACCCCTGGTCAATTTCAAGTCATACAAGTACAAAATCCAAGTGGTAGTGTACAGTACCAAGTAA TTCCACAACTTCAGACAGTGGAAGGTCAACAAATTCAAATCAATCCAACTAGTAGTTCATCTCTACAGGATTTGCAGGGTCAAATTCAGC TCATTTCTGCAGGTAATAATCAAGCTATACTCACAGCTGCTAACAGGACAGCTTCTGGGAATATTCTTGCTCAAAACCTGGCAAATCAGA CAGTTCCGGTCCAAATTAGACCTGGTGTTTCAATACCACTGCAGTTACAGACTCTTCCTGGTACTCAGGCTCAAGTTGTAACAACCCTAC CAATTAACATTGGAGGAGTGACTCTAGCTTTGCCAGTGATAAACAACGTGGCTGCCGGAGGAGGGACTGGGCAGGTTGGCCAGCCTGCTG CTACTGCTGATAGTGGGACTTCCAATGGGAATCAATTAGTTTCCACACCCACCAACACCACTACTTCTGCCAGTACTATGCCAGAATCTC CCTCCTCCTCCACTACCTGCACAACCACTGCTTCAACGTCTTTGACAAGCAGTGACACATTAGTGAGCTCAGCAGATACTGGCCAGTATG CAAGCACATCAGCCAGTAGTTCTGAACGCACCATTGAAGAATCTCAAACACCTGCTGCTACTGAGTCTGAAGCCCAGAGCTCCAGTCAGC TTCAGCCTAATGGAATGCAGAATGCACAGGATCAATCAAATTCTCTTCAGCAGGTGCAAATTGTAGGCCAACCTATCTTACAGCAGATCC AGATCCAACAGCCTCAGCAACAGATCATTCAGGCTATTCCACCACAGTCGTTTCAACTCCAGTCAGGGCAGACGATTCAGACCATCCAGC AGCAGCCTTTACAGAATGTTCAACTTCAAGCAGTAAATCCGACTCAGGTGCTTATCAGGGCTCCAACTTTAACACCTTCAGGGCAAATCA GTTGGCAAACTGTACAGGTTCAGAATATTCAGAGTCTTTCAAATTTGCAAGTTCAGAATGCTGGGTTATCCCAACAATTAACCATCACCC CAGTGTCTTCAAGTGGTGGCACAACTCTTGCTCAGATTGCTCCTGTGGCTGTTGCTGGTGCCCCAATAACTTTGAATACTGCCCAGCTTG CATCAGTGCCTAACCTTCAGACAGTGAGCGTTGCCAACCTGGGTGCTGCAGGTGTTCAAGTGCAGGGAGTTCCCGTTACAATCACTAGTG TTGCAGACCCAGCCTCGCCTTTAAGGATGGCAAACAGTGCCCTGATCTCCGTTGGCTGCTTGGCCATATTTGTCACTGTGATCTCCCTCT TGGTGTACAAAAAACACAAGGAATACAACCCAATAGAAAATAGTCCTGGGAATGTGGTCAGAAGCAAAGGCCTGAGTGTCTTTCTCAACC GTGCAAAAGCCGTGTTCTTCCCGGGAAACCAGGAAAAGGATCCGCTACTCAAAAACCAAGAATTTAAAGGAGTTTCTTAAATTTCGACCT TGTTTCTGAAGCTCACTTTTCAGTGCCATTGATGTGAGATGTGCTGGAGTGGCTATTAACCTTTTTTTCCTAAAGATTATTGTTAAATAG ATATTGTGGTTTGGGGAAGTTGAATTTTTTATAGGTTAAATGTCATTTTAGAGATGGGGAGAGGGATTATACTGCAGGCAGCTTCAGCCA TGTTGTGAAACTGATAAAAGCAACTTAGCAAGGCTTCTTTTCATTATTTTTTATGTTTCACTTATAAAGTCTTAGGTAACTAGTAGGATA GAAACACTGTGTCCCGAGAGTAAGGAGAGAAGCTACTATTGATTAGAGCCTAACCCAGGTTAACTGCAAGAAGAGGCGGGATACTTTCAG CTTTCCATGTAACTGTATGCATAAAGCCAATGTAGTCCAGTTTCTAAGATCATGTTCCAAGCTAACTGAATCCCACTTCAATACACACTC ATGAACTCCTGATGGAACAATAACAGGCCCAAGCCTGTGGTATGATGTGCACACTTGCTAGACTCAGAAAAAATACTACTCTCATAAATG GGTGGGAGTATTTTGGTGACAACCTACTTTGCTTGGCTGAGTGAAGGAATGATATTCATATATTCATTTATTCCATGGACATTTAGTTAG TGCTTTTTATATACCAGGCATGATGCTGAGTGACACTCTTGTGTATATTTCCAAATTTTTGTACAGTCGCTGCACATATTTGAAATCATA TATTAAGACTTTCCAAAGATGAGGTCCCTGGTTTTTCATGGCAACTTGATCAGTAAGGATTTCACCTCTGTTTGTAACTAAAACCATCTA >In-frame_SP4_ENST00000222584_chr7_21469210_+_GPNMB_ENST00000381990_chr7_23313140_+_3123nt GGCTGGGCGGGGCCGGGAAGCGGCAGTGGCGGCTACGCGCGCGGGGGTGCGCGCGGGAACGACCGGGAAACACCGCGAGGGCCGGGGTGG GCCAGGCTGTGGGGACGACGGGCTGCGACGATGGCCGCAGCGGCGGGCGGCGGCGGGCCGGGGACAGCGGTAGGCGCCACGGGCTCGGGG ATTGCGGCGGCAGCCGCAGGCCTAGCTGTTTATCGACGGAAGGATGGGGGCCCGGCCACCAAGTTTTGGGAGAGCCCGGAGACGGTGTCC CAGCTGGATTCGGTGCGGGTCTGGCTGGGCAAGCACTACAAGAAGATCAGAAGAAGGAGGAGGAGGAGGAGGCGGCAGCGGCAGCGGCGA TGGCTACAGAAGGAGGGAAAACCTCTGAGCCAGAGAATAACAATAAAAAACCCAAAACCTCAGGCTCCCAGGACTCTCAGCCCTCTCCTC TGGCTTTACTGGCAGCTACTTGCAGCAAAATAGGGACTCCTGGTGAAAATCAAGCAACTGGACAACAACAAATTATTATAGATCCAAGTC AAGGATTGGTGCAACTTCAAAATCAACCACAACAGCTAGAACTGGTAACAACGCAACTTGCTGGAAACGCTTGGCAACTTGTTGCCTCCA CTCCTCCTGCTTCAAAAGAGAATAACGTTTCTCAACCAGCCTCTAGTTCGTCTAGTTCTTCCAGCAGTAATAACGGGAGTGCATCTCCTA CAAAAACTAAATCAGGTAATTCTTCCACCCCTGGTCAATTTCAAGTCATACAAGTACAAAATCCAAGTGGTAGTGTACAGTACCAAGTAA TTCCACAACTTCAGACAGTGGAAGGTCAACAAATTCAAATCAATCCAACTAGTAGTTCATCTCTACAGGATTTGCAGGGTCAAATTCAGC TCATTTCTGCAGGTAATAATCAAGCTATACTCACAGCTGCTAACAGGACAGCTTCTGGGAATATTCTTGCTCAAAACCTGGCAAATCAGA CAGTTCCGGTCCAAATTAGACCTGGTGTTTCAATACCACTGCAGTTACAGACTCTTCCTGGTACTCAGGCTCAAGTTGTAACAACCCTAC CAATTAACATTGGAGGAGTGACTCTAGCTTTGCCAGTGATAAACAACGTGGCTGCCGGAGGAGGGACTGGGCAGGTTGGCCAGCCTGCTG CTACTGCTGATAGTGGGACTTCCAATGGGAATCAATTAGTTTCCACACCCACCAACACCACTACTTCTGCCAGTACTATGCCAGAATCTC CCTCCTCCTCCACTACCTGCACAACCACTGCTTCAACGTCTTTGACAAGCAGTGACACATTAGTGAGCTCAGCAGATACTGGCCAGTATG CAAGCACATCAGCCAGTAGTTCTGAACGCACCATTGAAGAATCTCAAACACCTGCTGCTACTGAGTCTGAAGCCCAGAGCTCCAGTCAGC TTCAGCCTAATGGAATGCAGAATGCACAGGATCAATCAAATTCTCTTCAGCAGGTGCAAATTGTAGGCCAACCTATCTTACAGCAGATCC AGATCCAACAGCCTCAGCAACAGATCATTCAGGCTATTCCACCACAGTCGTTTCAACTCCAGTCAGGGCAGACGATTCAGACCATCCAGC AGCAGCCTTTACAGAATGTTCAACTTCAAGCAGTAAATCCGACTCAGGTGCTTATCAGGGCTCCAACTTTAACACCTTCAGGGCAAATCA GTTGGCAAACTGTACAGGTTCAGAATATTCAGAGTCTTTCAAATTTGCAAGTTCAGAATGCTGGGTTATCCCAACAATTAACCATCACCC CAGTGTCTTCAAGTGGTGGCACAACTCTTGCTCAGATTGCTCCTGTGGCTGTTGCTGGTGCCCCAATAACTTTGAATACTGCCCAGCTTG CATCAGTGCCTAACCTTCAGACAGTGAGCGTTGCCAACCTGGGTGCTGCAGGTGTTCAAGTGCAGGGAGTTCCCGTTACAATCACTAGTG TTGCAGACCCAGCCTCGCCTTTAAGGATGGCAAACAGTGCCCTGATCTCCGTTGGCTGCTTGGCCATATTTGTCACTGTGATCTCCCTCT TGGTGTACAAAAAACACAAGGAATACAACCCAATAGAAAATAGTCCTGGGAATGTGGTCAGAAGCAAAGGCCTGAGTGTCTTTCTCAACC GTGCAAAAGCCGTGTTCTTCCCGGGAAACCAGGAAAAGGATCCGCTACTCAAAAACCAAGAATTTAAAGGAGTTTCTTAAATTTCGACCT TGTTTCTGAAGCTCACTTTTCAGTGCCATTGATGTGAGATGTGCTGGAGTGGCTATTAACCTTTTTTTCCTAAAGATTATTGTTAAATAG ATATTGTGGTTTGGGGAAGTTGAATTTTTTATAGGTTAAATGTCATTTTAGAGATGGGGAGAGGGATTATACTGCAGGCAGCTTCAGCCA TGTTGTGAAACTGATAAAAGCAACTTAGCAAGGCTTCTTTTCATTATTTTTTATGTTTCACTTATAAAGTCTTAGGTAACTAGTAGGATA GAAACACTGTGTCCCGAGAGTAAGGAGAGAAGCTACTATTGATTAGAGCCTAACCCAGGTTAACTGCAAGAAGAGGCGGGATACTTTCAG CTTTCCATGTAACTGTATGCATAAAGCCAATGTAGTCCAGTTTCTAAGATCATGTTCCAAGCTAACTGAATCCCACTTCAATACACACTC ATGAACTCCTGATGGAACAATAACAGGCCCAAGCCTGTGGTATGATGTGCACACTTGCTAGACTCAGAAAAAATACTACTCTCATAAATG GGTGGGAGTATTTTGGTGACAACCTACTTTGCTTGGCTGAGTGAAGGAATGATATTCATATATTCATTTATTCCATGGACATTTAGTTAG TGCTTTTTATATACCAGGCATGATGCTGAGTGACACTCTTGTGTATATTTCCAAATTTTTGTACAGTCGCTGCACATATTTGAAATCATA TATTAAGACTTTCCAAAGATGAGGTCCCTGGTTTTTCATGGCAACTTGATCAGTAAGGATTTCACCTCTGTTTGTAACTAAAACCATCTA |
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FusionGenePPI for SP4_GPNMB |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SP4 | SP1, SP3, E2F1, NKX3-1, CRX, FOXP2, COL8A1, NRF1, POU2F1, ADAM15, SERF2, LMO3, CIB3, PRR20A, ATXN7L1, TRY2P, VRK3, PTPRA, HIRA | GPNMB | ITSN2, SMAD4, IL31RA, TFEB, FBXL4, LINC01139, EGFR |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SP4_GPNMB |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SP4_GPNMB |
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Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SP4 | C0005586 | Bipolar Disorder | 2 | CTD_human;PSYGENET |
Hgene | SP4 | C0036341 | Schizophrenia | 1 | CTD_human |
Tgene | GPNMB | C0009404 | Colorectal Neoplasms | 2 | CTD_human |
Tgene | GPNMB | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | GPNMB | C0162557 | Liver Failure, Acute | 1 | CTD_human |
Tgene | GPNMB | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Tgene | GPNMB | C2609414 | Acute kidney injury | 1 | CTD_human |