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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35490

FusionGeneSummary for SP1_TUBB

check button Fusion gene summary
Fusion gene informationFusion gene name: SP1_TUBB
Fusion gene ID: 35490
HgeneTgene
Gene symbol

SP1

TUBB

Gene ID

199699

203068

Gene nameDAN domain BMP antagonist family member 5tubulin beta class I
SynonymsCER2|CERL2|CKTSF1B3|COCO|CRL2|DANTE|GREM3|SP1CDCBM6|CSCSC1|M40|OK/SW-cl.56|TUBB1|TUBB5
Cytomap

19p13.13

6p21.33

Type of geneprotein-codingprotein-coding
DescriptionDAN domain family member 5DAN domain family member 5, BMP antagonistDAN domain family, member 5cerberus 2cerberus-like 2cerberus-like protein 2cerl-2cysteine knot superfamily 1, BMP antagonist 3gremlin-3tubulin beta chainbeta Ib tubulintubulin beta-1 chaintubulin beta-5 chaintubulin, beta polypeptide
Modification date2018052320180523
UniProtAcc

P08047

P07437

Ensembl transtripts involved in fusion geneENST00000327443, ENST00000426431, 
ENST00000327892, ENST00000435534, 
ENST00000330914, ENST00000396389, 
ENST00000396384, ENST00000421473, 
ENST00000549614, ENST00000413547, 
ENST00000419551, ENST00000454620, 
ENST00000422674, ENST00000548023, 
ENST00000435546, ENST00000420400, 
ENST00000453350, ENST00000419792, 
ENST00000547690, ENST00000436335, 
ENST00000425136, ENST00000444441, 
ENST00000422650, ENST00000547695, 
ENST00000454454, ENST00000412136, 
ENST00000446385, ENST00000383564, 
ENST00000551208, ENST00000400531, 
ENST00000400534, ENST00000400530, 
ENST00000436628, ENST00000549902, 
ENST00000437490, ENST00000426754, 
ENST00000425102, ENST00000432462, 
ENST00000549654, ENST00000427480, 
ENST00000424734, ENST00000420618, 
Fusion gene scores* DoF score9 X 7 X 4=2524 X 4 X 2=32
# samples 94
** MAII scorelog2(9/252*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SP1 [Title/Abstract] AND TUBB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTUBB

GO:0009987

cellular process

19567321


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF902308SP1chr12

53777114

-TUBBchr6

2025181

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000327443ENST00000327892SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000327443ENST00000435534SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000327443ENST00000330914SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000327443ENST00000396389SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000327443ENST00000396384SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000327443ENST00000421473SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000327443ENST00000549614SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000327443ENST00000413547SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000327443ENST00000419551SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000327443ENST00000454620SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000327443ENST00000422674SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000327443ENST00000548023SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000327443ENST00000435546SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000327443ENST00000420400SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000327443ENST00000453350SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000327443ENST00000419792SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000327443ENST00000547690SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000327443ENST00000436335SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000327443ENST00000425136SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000327443ENST00000444441SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000327443ENST00000422650SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000327443ENST00000547695SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000327443ENST00000454454SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000327443ENST00000412136SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000327443ENST00000446385SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000327443ENST00000383564SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000327443ENST00000551208SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000327443ENST00000400531SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000327443ENST00000400534SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000327443ENST00000400530SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000327443ENST00000436628SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000327443ENST00000549902SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000327443ENST00000437490SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000327443ENST00000426754SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000327443ENST00000425102SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-3UTRENST00000327443ENST00000432462SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000327443ENST00000549654SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-3UTRENST00000327443ENST00000427480SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-3UTRENST00000327443ENST00000424734SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-3UTRENST00000327443ENST00000420618SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000426431ENST00000327892SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000426431ENST00000435534SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000426431ENST00000330914SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000426431ENST00000396389SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000426431ENST00000396384SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000426431ENST00000421473SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000426431ENST00000549614SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000426431ENST00000413547SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000426431ENST00000419551SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000426431ENST00000454620SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000426431ENST00000422674SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000426431ENST00000548023SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000426431ENST00000435546SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000426431ENST00000420400SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000426431ENST00000453350SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000426431ENST00000419792SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000426431ENST00000547690SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000426431ENST00000436335SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000426431ENST00000425136SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000426431ENST00000444441SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000426431ENST00000422650SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000426431ENST00000547695SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000426431ENST00000454454SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000426431ENST00000412136SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000426431ENST00000446385SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000426431ENST00000383564SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000426431ENST00000551208SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000426431ENST00000400531SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000426431ENST00000400534SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000426431ENST00000400530SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000426431ENST00000436628SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000426431ENST00000549902SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000426431ENST00000437490SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000426431ENST00000426754SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000426431ENST00000425102SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-3UTRENST00000426431ENST00000432462SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-intronENST00000426431ENST00000549654SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-3UTRENST00000426431ENST00000427480SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-3UTRENST00000426431ENST00000424734SP1chr12

53777114

-TUBBchr6

2025181

+
5CDS-3UTRENST00000426431ENST00000420618SP1chr12

53777114

-TUBBchr6

2025181

+

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FusionProtFeatures for SP1_TUBB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SP1

P08047

TUBB

P07437

Transcription factor that can activate or represstranscription in response to physiological and pathologicalstimuli. Binds with high affinity to GC-rich motifs and regulatesthe expression of a large number of genes involved in a variety ofprocesses such as cell growth, apoptosis, differentiation andimmune responses. Highly regulated by post-translationalmodifications (phosphorylations, sumoylation, proteolyticcleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellularresponse to DNA damage. Implicated in chromatin remodeling. Playsan essential role in the regulation of FE65 gene expression. Incomplex with ATF7IP, maintains telomerase activity in cancer cellsby inducing TERT and TERC gene expression. Isoform 3 is a strongeractivator of transcription than isoform 1. Positively regulatesthe transcription of the core clock component ARNTL/BMAL1(PubMed:10391891, PubMed:11371615, PubMed:11904305,PubMed:14593115, PubMed:16377629, PubMed:16478997,PubMed:16943418, PubMed:17049555, PubMed:18171990,PubMed:18199680, PubMed:18239466, PubMed:18513490,PubMed:18619531, PubMed:19193796, PubMed:20091743,PubMed:21798247). Plays a role in the recruitment of SMARCA4/BRG1on the c-FOS promoter. Plays a role in protecting cells againstoxidative stress following brain injury by regulating theexpression of RNF112 (By similarity).{ECO:0000250|UniProtKB:O89090, ECO:0000250|UniProtKB:Q01714,ECO:0000269|PubMed:10391891, ECO:0000269|PubMed:11371615,ECO:0000269|PubMed:11904305, ECO:0000269|PubMed:14593115,ECO:0000269|PubMed:16377629, ECO:0000269|PubMed:16478997,ECO:0000269|PubMed:16943418, ECO:0000269|PubMed:17049555,ECO:0000269|PubMed:18171990, ECO:0000269|PubMed:18199680,ECO:0000269|PubMed:18239466, ECO:0000269|PubMed:18513490,ECO:0000269|PubMed:18619531, ECO:0000269|PubMed:19193796,ECO:0000269|PubMed:20091743, ECO:0000269|PubMed:21798247}. Tubulin is the major constituent of microtubules. Itbinds two moles of GTP, one at an exchangeable site on the betachain and one at a non-exchangeable site on the alpha chain.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SP1_TUBB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SP1_TUBB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for SP1_TUBB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneTUBBP07437DB00570VinblastineTubulin beta chainsmall moleculeapproved
TgeneTUBBP07437DB01179PodofiloxTubulin beta chainsmall moleculeapproved
TgeneTUBBP07437DB01394ColchicineTubulin beta chainsmall moleculeapproved
TgeneTUBBP07437DB00361VinorelbineTubulin beta chainsmall moleculeapproved|investigational
TgeneTUBBP07437DB00541VincristineTubulin beta chainsmall moleculeapproved|investigational
TgeneTUBBP07437DB11638ArtenimolTubulin beta chainsmall moleculeapproved|investigational

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RelatedDiseases for SP1_TUBB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSP1C0036341Schizophrenia3PSYGENET
HgeneSP1C0007621Neoplastic Cell Transformation1CTD_human
HgeneSP1C0020456Hyperglycemia1CTD_human
HgeneSP1C0027626Neoplasm Invasiveness1CTD_human
HgeneSP1C0027627Neoplasm Metastasis1CTD_human
HgeneSP1C0033975Psychotic Disorders1PSYGENET
HgeneSP1C0037286Skin Neoplasms1CTD_human
HgeneSP1C0221765Chronic schizophrenia1PSYGENET
HgeneSP1C0349204Nonorganic psychosis1PSYGENET
TgeneTUBBC0473586Michelin tire baby syndrome1ORPHANET;UNIPROT
TgeneTUBBC4014283CORTICAL DYSPLASIA, COMPLEX, WITH OTHER BRAIN MALFORMATIONS 61UNIPROT