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Fusion gene ID: 35477 |
FusionGeneSummary for SP100_SUCLG1 |
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Fusion gene information | Fusion gene name: SP100_SUCLG1 | Fusion gene ID: 35477 | Hgene | Tgene | Gene symbol | SP100 | SUCLG1 | Gene ID | 6672 | 8802 |
Gene name | SP100 nuclear antigen | succinate-CoA ligase alpha subunit | |
Synonyms | lysp100b | GALPHA|MTDPS9|SUCLA1 | |
Cytomap | 2q37.1 | 2p11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | nuclear autoantigen Sp-100SP100-HMG nuclear autoantigennuclear dot-associated Sp100 proteinspeckled 100 kDa | succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrialSCS-alphasuccinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrialsuccinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrialsuccinyl-CoA synthetase subunit alpha | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | P23497 | P53597 | |
Ensembl transtripts involved in fusion gene | ENST00000264052, ENST00000409112, ENST00000340126, ENST00000427101, ENST00000409824, ENST00000409341, ENST00000341950, ENST00000409897, | ENST00000393868, ENST00000491123, | |
Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 2 X 2 X 1=4 |
# samples | 4 | 3 | |
** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/4*10)=2.90689059560852 | |
Context | PubMed: SP100 [Title/Abstract] AND SUCLG1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | SP100 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 15247905 |
Hgene | SP100 | GO:0006978 | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator | 14647468 |
Hgene | SP100 | GO:0034340 | response to type I interferon | 9230084|15247905 |
Hgene | SP100 | GO:0034341 | response to interferon-gamma | 9230084 |
Hgene | SP100 | GO:0043392 | negative regulation of DNA binding | 15247905 |
Hgene | SP100 | GO:0043433 | negative regulation of DNA binding transcription factor activity | 15247905 |
Hgene | SP100 | GO:0045185 | maintenance of protein location | 12470659 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BP319935 | SP100 | chr2 | 231307732 | + | SUCLG1 | chr2 | 84650733 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-3UTR | ENST00000264052 | ENST00000393868 | SP100 | chr2 | 231307732 | + | SUCLG1 | chr2 | 84650733 | - |
5CDS-5UTR | ENST00000264052 | ENST00000491123 | SP100 | chr2 | 231307732 | + | SUCLG1 | chr2 | 84650733 | - |
5CDS-3UTR | ENST00000409112 | ENST00000393868 | SP100 | chr2 | 231307732 | + | SUCLG1 | chr2 | 84650733 | - |
5CDS-5UTR | ENST00000409112 | ENST00000491123 | SP100 | chr2 | 231307732 | + | SUCLG1 | chr2 | 84650733 | - |
5CDS-3UTR | ENST00000340126 | ENST00000393868 | SP100 | chr2 | 231307732 | + | SUCLG1 | chr2 | 84650733 | - |
5CDS-5UTR | ENST00000340126 | ENST00000491123 | SP100 | chr2 | 231307732 | + | SUCLG1 | chr2 | 84650733 | - |
5CDS-3UTR | ENST00000427101 | ENST00000393868 | SP100 | chr2 | 231307732 | + | SUCLG1 | chr2 | 84650733 | - |
5CDS-5UTR | ENST00000427101 | ENST00000491123 | SP100 | chr2 | 231307732 | + | SUCLG1 | chr2 | 84650733 | - |
5CDS-3UTR | ENST00000409824 | ENST00000393868 | SP100 | chr2 | 231307732 | + | SUCLG1 | chr2 | 84650733 | - |
5CDS-5UTR | ENST00000409824 | ENST00000491123 | SP100 | chr2 | 231307732 | + | SUCLG1 | chr2 | 84650733 | - |
5CDS-3UTR | ENST00000409341 | ENST00000393868 | SP100 | chr2 | 231307732 | + | SUCLG1 | chr2 | 84650733 | - |
5CDS-5UTR | ENST00000409341 | ENST00000491123 | SP100 | chr2 | 231307732 | + | SUCLG1 | chr2 | 84650733 | - |
5CDS-3UTR | ENST00000341950 | ENST00000393868 | SP100 | chr2 | 231307732 | + | SUCLG1 | chr2 | 84650733 | - |
5CDS-5UTR | ENST00000341950 | ENST00000491123 | SP100 | chr2 | 231307732 | + | SUCLG1 | chr2 | 84650733 | - |
5CDS-3UTR | ENST00000409897 | ENST00000393868 | SP100 | chr2 | 231307732 | + | SUCLG1 | chr2 | 84650733 | - |
5CDS-5UTR | ENST00000409897 | ENST00000491123 | SP100 | chr2 | 231307732 | + | SUCLG1 | chr2 | 84650733 | - |
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FusionProtFeatures for SP100_SUCLG1 |
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Hgene | Tgene |
SP100 | SUCLG1 |
Succinyl-CoA synthetase functions in the citric acidcycle (TCA), coupling the hydrolysis of succinyl-CoA to thesynthesis of either ATP or GTP and thus represents the only stepof substrate-level phosphorylation in the TCA. The alpha subunitof the enzyme binds the substrates coenzyme A and phosphate, whilesuccinate binding and specificity for either ATP or GTP isprovided by different beta subunits. {ECO:0000255|HAMAP-Rule:MF_03222}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SP100_SUCLG1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SP100_SUCLG1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SP100_SUCLG1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SP100_SUCLG1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | SUCLG1 | C3151476 | MITOCHONDRIAL DNA DEPLETION SYNDROME 9 (ENCEPHALOMYOPATHIC TYPE WITH METHYLMALONIC ACIDURIA) | 3 | CTD_human;ORPHANET;UNIPROT |
Tgene | SUCLG1 | C0038356 | Stomach Neoplasms | 1 | CTD_human |