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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35477

FusionGeneSummary for SP100_SUCLG1

check button Fusion gene summary
Fusion gene informationFusion gene name: SP100_SUCLG1
Fusion gene ID: 35477
HgeneTgene
Gene symbol

SP100

SUCLG1

Gene ID

6672

8802

Gene nameSP100 nuclear antigensuccinate-CoA ligase alpha subunit
Synonymslysp100bGALPHA|MTDPS9|SUCLA1
Cytomap

2q37.1

2p11.2

Type of geneprotein-codingprotein-coding
Descriptionnuclear autoantigen Sp-100SP100-HMG nuclear autoantigennuclear dot-associated Sp100 proteinspeckled 100 kDasuccinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrialSCS-alphasuccinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrialsuccinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrialsuccinyl-CoA synthetase subunit alpha
Modification date2018052220180523
UniProtAcc

P23497

P53597

Ensembl transtripts involved in fusion geneENST00000264052, ENST00000409112, 
ENST00000340126, ENST00000427101, 
ENST00000409824, ENST00000409341, 
ENST00000341950, ENST00000409897, 
ENST00000393868, ENST00000491123, 
Fusion gene scores* DoF score4 X 4 X 2=322 X 2 X 1=4
# samples 43
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/4*10)=2.90689059560852
Context

PubMed: SP100 [Title/Abstract] AND SUCLG1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSP100

GO:0000122

negative regulation of transcription by RNA polymerase II

15247905

HgeneSP100

GO:0006978

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

14647468

HgeneSP100

GO:0034340

response to type I interferon

9230084|15247905

HgeneSP100

GO:0034341

response to interferon-gamma

9230084

HgeneSP100

GO:0043392

negative regulation of DNA binding

15247905

HgeneSP100

GO:0043433

negative regulation of DNA binding transcription factor activity

15247905

HgeneSP100

GO:0045185

maintenance of protein location

12470659


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BP319935SP100chr2

231307732

+SUCLG1chr2

84650733

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000264052ENST00000393868SP100chr2

231307732

+SUCLG1chr2

84650733

-
5CDS-5UTRENST00000264052ENST00000491123SP100chr2

231307732

+SUCLG1chr2

84650733

-
5CDS-3UTRENST00000409112ENST00000393868SP100chr2

231307732

+SUCLG1chr2

84650733

-
5CDS-5UTRENST00000409112ENST00000491123SP100chr2

231307732

+SUCLG1chr2

84650733

-
5CDS-3UTRENST00000340126ENST00000393868SP100chr2

231307732

+SUCLG1chr2

84650733

-
5CDS-5UTRENST00000340126ENST00000491123SP100chr2

231307732

+SUCLG1chr2

84650733

-
5CDS-3UTRENST00000427101ENST00000393868SP100chr2

231307732

+SUCLG1chr2

84650733

-
5CDS-5UTRENST00000427101ENST00000491123SP100chr2

231307732

+SUCLG1chr2

84650733

-
5CDS-3UTRENST00000409824ENST00000393868SP100chr2

231307732

+SUCLG1chr2

84650733

-
5CDS-5UTRENST00000409824ENST00000491123SP100chr2

231307732

+SUCLG1chr2

84650733

-
5CDS-3UTRENST00000409341ENST00000393868SP100chr2

231307732

+SUCLG1chr2

84650733

-
5CDS-5UTRENST00000409341ENST00000491123SP100chr2

231307732

+SUCLG1chr2

84650733

-
5CDS-3UTRENST00000341950ENST00000393868SP100chr2

231307732

+SUCLG1chr2

84650733

-
5CDS-5UTRENST00000341950ENST00000491123SP100chr2

231307732

+SUCLG1chr2

84650733

-
5CDS-3UTRENST00000409897ENST00000393868SP100chr2

231307732

+SUCLG1chr2

84650733

-
5CDS-5UTRENST00000409897ENST00000491123SP100chr2

231307732

+SUCLG1chr2

84650733

-

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FusionProtFeatures for SP100_SUCLG1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SP100

P23497

SUCLG1

P53597

Succinyl-CoA synthetase functions in the citric acidcycle (TCA), coupling the hydrolysis of succinyl-CoA to thesynthesis of either ATP or GTP and thus represents the only stepof substrate-level phosphorylation in the TCA. The alpha subunitof the enzyme binds the substrates coenzyme A and phosphate, whilesuccinate binding and specificity for either ATP or GTP isprovided by different beta subunits. {ECO:0000255|HAMAP-Rule:MF_03222}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SP100_SUCLG1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SP100_SUCLG1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SP100_SUCLG1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SP100_SUCLG1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSUCLG1C3151476MITOCHONDRIAL DNA DEPLETION SYNDROME 9 (ENCEPHALOMYOPATHIC TYPE WITH METHYLMALONIC ACIDURIA)3CTD_human;ORPHANET;UNIPROT
TgeneSUCLG1C0038356Stomach Neoplasms1CTD_human