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Fusion gene ID: 35444 |
FusionGeneSummary for SOX21-AS1_TM7SF2 |
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Fusion gene information | Fusion gene name: SOX21-AS1_TM7SF2 | Fusion gene ID: 35444 | Hgene | Tgene | Gene symbol | SOX21-AS1 | TM7SF2 | Gene ID | 100507533 | 7108 |
Gene name | SOX21 antisense divergent transcript 1 | transmembrane 7 superfamily member 2 | |
Synonyms | - | ANG1|DHCR14A|NET47 | |
Cytomap | 13q32.1 | 11q13.1 | |
Type of gene | ncRNA | protein-coding | |
Description | SOX21 antisense RNA 1 (head to head)SOX21 antisense RNA 1 (non-protein coding) | delta(14)-sterol reductaseC-14 sterol reductaseanother new gene 1 proteindelta-14-SRputative sterol reductase SR-1sterol C14-reductase | |
Modification date | 20180329 | 20180523 | |
UniProtAcc | O76062 | ||
Ensembl transtripts involved in fusion gene | ENST00000438290, | ENST00000279263, ENST00000540748, ENST00000345348, ENST00000531029, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 2=8 |
# samples | 1 | 2 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: SOX21-AS1 [Title/Abstract] AND TM7SF2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DR761293 | SOX21-AS1 | chr13 | 95365044 | + | TM7SF2 | chr11 | 64879495 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3CDS | ENST00000438290 | ENST00000279263 | SOX21-AS1 | chr13 | 95365044 | + | TM7SF2 | chr11 | 64879495 | + |
3UTR-5UTR | ENST00000438290 | ENST00000540748 | SOX21-AS1 | chr13 | 95365044 | + | TM7SF2 | chr11 | 64879495 | + |
3UTR-5UTR | ENST00000438290 | ENST00000345348 | SOX21-AS1 | chr13 | 95365044 | + | TM7SF2 | chr11 | 64879495 | + |
3UTR-intron | ENST00000438290 | ENST00000531029 | SOX21-AS1 | chr13 | 95365044 | + | TM7SF2 | chr11 | 64879495 | + |
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FusionProtFeatures for SOX21-AS1_TM7SF2 |
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Hgene | Tgene |
SOX21-AS1 | TM7SF2 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Involved in the conversion of lanosterol to cholesterol.{ECO:0000269|PubMed:11784322}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SOX21-AS1_TM7SF2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SOX21-AS1_TM7SF2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SOX21-AS1_TM7SF2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SOX21-AS1_TM7SF2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |