FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 35429

FusionGeneSummary for SOS2_POLN

check button Fusion gene summary
Fusion gene informationFusion gene name: SOS2_POLN
Fusion gene ID: 35429
HgeneTgene
Gene symbol

SOS2

POLN

Gene ID

6655

353497

Gene nameSOS Ras/Rho guanine nucleotide exchange factor 2DNA polymerase nu
SynonymsNS9|SOS-2POL4P
Cytomap

14q21.3

4p16.3

Type of geneprotein-codingprotein-coding
Descriptionson of sevenless homolog 2guanine nucleotide releasing factorDNA polymerase nuDNA polymerase NDNA polymerase POL4Ppolymerase (DNA directed) nupolymerase (DNA) nu
Modification date2018052220180523
UniProtAcc

Q07890

Q7Z5Q5

Ensembl transtripts involved in fusion geneENST00000216373, ENST00000543680, 
ENST00000555794, 
ENST00000382865, 
ENST00000511885, ENST00000515357, 
Fusion gene scores* DoF score5 X 5 X 4=10012 X 7 X 9=756
# samples 612
** MAII scorelog2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(12/756*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SOS2 [Title/Abstract] AND POLN [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePOLN

GO:0019985

translesion synthesis

20102227


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCSTCGA-NA-A5I1-01ASOS2chr14

50697915

-POLNchr4

2176478

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000216373ENST00000382865SOS2chr14

50697915

-POLNchr4

2176478

-
In-frameENST00000216373ENST00000511885SOS2chr14

50697915

-POLNchr4

2176478

-
5CDS-5UTRENST00000216373ENST00000515357SOS2chr14

50697915

-POLNchr4

2176478

-
In-frameENST00000543680ENST00000382865SOS2chr14

50697915

-POLNchr4

2176478

-
In-frameENST00000543680ENST00000511885SOS2chr14

50697915

-POLNchr4

2176478

-
5CDS-5UTRENST00000543680ENST00000515357SOS2chr14

50697915

-POLNchr4

2176478

-
intron-3CDSENST00000555794ENST00000382865SOS2chr14

50697915

-POLNchr4

2176478

-
intron-3CDSENST00000555794ENST00000511885SOS2chr14

50697915

-POLNchr4

2176478

-
intron-5UTRENST00000555794ENST00000515357SOS2chr14

50697915

-POLNchr4

2176478

-

Top

FusionProtFeatures for SOS2_POLN


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SOS2

Q07890

POLN

Q7Z5Q5

Promotes the exchange of Ras-bound GDP by GTP.{ECO:0000250|UniProtKB:Q62245}. DNA polymerase with very low fidelity that catalyzesconsiderable misincorporation by inserting dTTP opposite a Gtemplate, and dGTP opposite a T template (PubMed:16787914,PubMed:17118716). Is the least accurate of the DNA polymerase Afamily (i.e. POLG, POLN and POLQ) (PubMed:17118716). Can performaccurate translesion DNA synthesis (TLS) past a 5S-thymine glycol.Can perform efficient strand displacement past a nick or a gap andgives rise to an amount of product similar to that on non-damagedtemplate. Has no exonuclease activity (PubMed:16787914). Error-prone DNA polymerase that preferentially misincorporates dTregardless of template sequence (PubMed:25775266). May play a rolein TLS during interstrand cross-link (ICL) repair(PubMed:19908865). May be involved in TLS when genomic replicationis blocked by extremely large major groove DNA lesions. Mayfunction in the bypass of some DNA-protein and DNA-DNA cross-links. May have a role in cellular tolerance to DNA cross-linkingagents (PubMed:20102227). Involved in the repair of DNA cross-links and double-strand break (DSB) resistance. Participates inFANCD2-mediated repair. Forms a complex with HELQ helicase thatparticipates in homologous recombination (HR) repair and isessential for cellular protection against DNA cross-links(PubMed:19995904). {ECO:0000269|PubMed:16787914,ECO:0000269|PubMed:17118716, ECO:0000269|PubMed:19908865,ECO:0000269|PubMed:19995904, ECO:0000269|PubMed:20102227,ECO:0000269|PubMed:25775266}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSOS2chr14:50697915chr4:2176478ENST00000216373-1231180_1183291333Compositional biasNote=Poly-Pro
HgeneSOS2chr14:50697915chr4:2176478ENST00000216373-1231203_1208291333Compositional biasNote=Poly-Pro
HgeneSOS2chr14:50697915chr4:2176478ENST00000216373-123755_758291333Compositional biasNote=Poly-Pro
HgeneSOS2chr14:50697915chr4:2176478ENST00000216373-123198_388291333DomainDH
HgeneSOS2chr14:50697915chr4:2176478ENST00000216373-123442_546291333DomainPH
HgeneSOS2chr14:50697915chr4:2176478ENST00000216373-123595_739291333DomainN-terminal Ras-GEF
HgeneSOS2chr14:50697915chr4:2176478ENST00000216373-123778_1017291333DomainRas-GEF


Top

FusionGeneSequence for SOS2_POLN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_SOS2_ENST00000216373_chr14_50697915_-_POLN_ENST00000382865_chr4_2176478_-_514aa
MQQAPQPYEFFSEENSPKWRGLLVSALRKDYGLWQLFRTLELPLIPILAVMESHAIQVNKEEMEKTSALLGARLKELEQEAHFVAGERFL
ITSNNQLREILFGKLKLHLLSQRNSLPRTGLQKYPSTSEAVLNALRDLHPLPKIILEYRQVHKIKSTFVDGLLACMKKGSISSTWNQTGT
VTGRLSAKHPNIQGISKHPIQITTPKNFKGKEDKILTISPRAMFVSSKGHTFLAADFSQIELRILTHLSGDPELLKLFQESERDDVFSTL
TSQWKDVPVEQVTHADREQTKKVVYAVVYGAGKERLAACLGVPIQEAAQFLESFLQKYKKIKDFARAAIAQCHQTGCVVSIMGRRRPLPR
IHAHDQQLRAQAERQAVNFVVQGSAADLCKLAMIHVFTAVAASHTLTARLVAQIHDELLFEVEDPQIPECAALVRRTMESLEQVQALELQ

>In-frame_SOS2_ENST00000216373_chr14_50697915_-_POLN_ENST00000511885_chr4_2176478_-_514aa
MQQAPQPYEFFSEENSPKWRGLLVSALRKDYGLWQLFRTLELPLIPILAVMESHAIQVNKEEMEKTSALLGARLKELEQEAHFVAGERFL
ITSNNQLREILFGKLKLHLLSQRNSLPRTGLQKYPSTSEAVLNALRDLHPLPKIILEYRQVHKIKSTFVDGLLACMKKGSISSTWNQTGT
VTGRLSAKHPNIQGISKHPIQITTPKNFKGKEDKILTISPRAMFVSSKGHTFLAADFSQIELRILTHLSGDPELLKLFQESERDDVFSTL
TSQWKDVPVEQVTHADREQTKKVVYAVVYGAGKERLAACLGVPIQEAAQFLESFLQKYKKIKDFARAAIAQCHQTGCVVSIMGRRRPLPR
IHAHDQQLRAQAERQAVNFVVQGSAADLCKLAMIHVFTAVAASHTLTARLVAQIHDELLFEVEDPQIPECAALVRRTMESLEQVQALELQ

>In-frame_SOS2_ENST00000543680_chr14_50697915_-_POLN_ENST00000382865_chr4_2176478_-_514aa
MQQAPQPYEFFSEENSPKWRGLLVSALRKDYGLWQLFRTLELPLIPILAVMESHAIQVNKEEMEKTSALLGARLKELEQEAHFVAGERFL
ITSNNQLREILFGKLKLHLLSQRNSLPRTGLQKYPSTSEAVLNALRDLHPLPKIILEYRQVHKIKSTFVDGLLACMKKGSISSTWNQTGT
VTGRLSAKHPNIQGISKHPIQITTPKNFKGKEDKILTISPRAMFVSSKGHTFLAADFSQIELRILTHLSGDPELLKLFQESERDDVFSTL
TSQWKDVPVEQVTHADREQTKKVVYAVVYGAGKERLAACLGVPIQEAAQFLESFLQKYKKIKDFARAAIAQCHQTGCVVSIMGRRRPLPR
IHAHDQQLRAQAERQAVNFVVQGSAADLCKLAMIHVFTAVAASHTLTARLVAQIHDELLFEVEDPQIPECAALVRRTMESLEQVQALELQ

>In-frame_SOS2_ENST00000543680_chr14_50697915_-_POLN_ENST00000511885_chr4_2176478_-_514aa
MQQAPQPYEFFSEENSPKWRGLLVSALRKDYGLWQLFRTLELPLIPILAVMESHAIQVNKEEMEKTSALLGARLKELEQEAHFVAGERFL
ITSNNQLREILFGKLKLHLLSQRNSLPRTGLQKYPSTSEAVLNALRDLHPLPKIILEYRQVHKIKSTFVDGLLACMKKGSISSTWNQTGT
VTGRLSAKHPNIQGISKHPIQITTPKNFKGKEDKILTISPRAMFVSSKGHTFLAADFSQIELRILTHLSGDPELLKLFQESERDDVFSTL
TSQWKDVPVEQVTHADREQTKKVVYAVVYGAGKERLAACLGVPIQEAAQFLESFLQKYKKIKDFARAAIAQCHQTGCVVSIMGRRRPLPR
IHAHDQQLRAQAERQAVNFVVQGSAADLCKLAMIHVFTAVAASHTLTARLVAQIHDELLFEVEDPQIPECAALVRRTMESLEQVQALELQ


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_SOS2_ENST00000216373_chr14_50697915_-_POLN_ENST00000382865_chr4_2176478_-_1542nt
ATGCAGCAGGCGCCGCAGCCTTACGAGTTCTTCAGCGAGGAGAACAGTCCGAAATGGCGGGGACTGTTGGTCTCGGCCCTGCGGAAGGAT
TATGGTTTATGGCAACTATTTCGTACTTTGGAGCTTCCTCTGATACCAATTTTGGCAGTGATGGAAAGCCATGCCATTCAGGTGAACAAA
GAGGAGATGGAGAAGACGTCAGCACTTCTTGGGGCTCGTCTCAAGGAATTGGAGCAAGAAGCTCATTTTGTTGCAGGAGAACGGTTTCTT
ATAACGAGCAATAACCAGCTTCGAGAGATCCTCTTTGGCAAGTTAAAGCTGCACCTGCTGAGTCAAAGGAACAGTCTCCCCAGAACGGGG
TTGCAGAAATACCCGTCTACATCAGAAGCAGTGTTAAATGCTCTGCGAGACCTTCATCCATTACCCAAGATAATTTTGGAATACAGGCAG
GTTCACAAGATCAAGTCAACCTTTGTAGATGGATTACTAGCTTGCATGAAAAAGGGCTCCATTTCCTCTACATGGAATCAGACTGGAACT
GTGACTGGAAGACTTTCAGCCAAGCATCCTAATATCCAAGGTATCTCCAAGCACCCAATTCAGATTACTACACCTAAGAATTTTAAAGGT
AAAGAAGACAAGATTCTCACGATCTCCCCGAGGGCCATGTTTGTTTCATCCAAAGGCCACACCTTTCTAGCAGCAGACTTTTCACAGATT
GAATTGCGCATTCTTACACATTTATCTGGAGATCCGGAACTTCTGAAGTTATTCCAGGAATCTGAAAGAGATGATGTATTTTCTACTCTG
ACTTCACAGTGGAAGGATGTGCCCGTGGAACAGGTGACACACGCAGACAGAGAGCAAACCAAGAAGGTGGTGTACGCGGTGGTCTATGGA
GCAGGGAAGGAGCGGCTGGCTGCTTGCCTTGGAGTTCCTATTCAGGAAGCTGCCCAGTTTTTGGAGAGTTTTTTGCAGAAGTACAAGAAA
ATCAAGGACTTCGCCCGAGCAGCTATTGCCCAGTGTCACCAGACAGGCTGTGTGGTGTCCATCATGGGCAGAAGGAGACCCCTGCCAAGG
ATTCACGCTCATGACCAGCAACTCCGGGCACAAGCAGAGCGACAGGCAGTGAACTTCGTGGTGCAAGGCTCCGCTGCTGACCTCTGCAAG
CTGGCCATGATCCATGTCTTCACTGCAGTGGCTGCTTCCCACACCTTGACGGCCAGGCTGGTGGCCCAGATCCATGATGAGCTGCTGTTT
GAAGTGGAAGATCCGCAGATCCCGGAGTGTGCAGCTCTCGTCAGGAGGACCATGGAGTCCTTGGAACAGGTGCAGGCATTGGAGCTGCAG
CTTCAGGTACCCCTCAAGGTGAGCCTGAGTGCCGGCCGCTCATGGGGACACCTGGTGCCACTGCAGGAGGCCTGGGGCCCTCCGCCAGGC
CCATGTCGCACTGAGTCTCCCAGCAACAGCCTGGCTGCCCCTGGGTCCCCTGCCAGCACCCAGCCCCCACCCCTGCATTTTTCGCCTTCA

>In-frame_SOS2_ENST00000216373_chr14_50697915_-_POLN_ENST00000511885_chr4_2176478_-_1542nt
ATGCAGCAGGCGCCGCAGCCTTACGAGTTCTTCAGCGAGGAGAACAGTCCGAAATGGCGGGGACTGTTGGTCTCGGCCCTGCGGAAGGAT
TATGGTTTATGGCAACTATTTCGTACTTTGGAGCTTCCTCTGATACCAATTTTGGCAGTGATGGAAAGCCATGCCATTCAGGTGAACAAA
GAGGAGATGGAGAAGACGTCAGCACTTCTTGGGGCTCGTCTCAAGGAATTGGAGCAAGAAGCTCATTTTGTTGCAGGAGAACGGTTTCTT
ATAACGAGCAATAACCAGCTTCGAGAGATCCTCTTTGGCAAGTTAAAGCTGCACCTGCTGAGTCAAAGGAACAGTCTCCCCAGAACGGGG
TTGCAGAAATACCCGTCTACATCAGAAGCAGTGTTAAATGCTCTGCGAGACCTTCATCCATTACCCAAGATAATTTTGGAATACAGGCAG
GTTCACAAGATCAAGTCAACCTTTGTAGATGGATTACTAGCTTGCATGAAAAAGGGCTCCATTTCCTCTACATGGAATCAGACTGGAACT
GTGACTGGAAGACTTTCAGCCAAGCATCCTAATATCCAAGGTATCTCCAAGCACCCAATTCAGATTACTACACCTAAGAATTTTAAAGGT
AAAGAAGACAAGATTCTCACGATCTCCCCGAGGGCCATGTTTGTTTCATCCAAAGGCCACACCTTTCTAGCAGCAGACTTTTCACAGATT
GAATTGCGCATTCTTACACATTTATCTGGAGATCCGGAACTTCTGAAGTTATTCCAGGAATCTGAAAGAGATGATGTATTTTCTACTCTG
ACTTCACAGTGGAAGGATGTGCCCGTGGAACAGGTGACACACGCAGACAGAGAGCAAACCAAGAAGGTGGTGTACGCGGTGGTCTATGGA
GCAGGGAAGGAGCGGCTGGCTGCTTGCCTTGGAGTTCCTATTCAGGAAGCTGCCCAGTTTTTGGAGAGTTTTTTGCAGAAGTACAAGAAA
ATCAAGGACTTCGCCCGAGCAGCTATTGCCCAGTGTCACCAGACAGGCTGTGTGGTGTCCATCATGGGCAGAAGGAGACCCCTGCCAAGG
ATTCACGCTCATGACCAGCAACTCCGGGCACAAGCAGAGCGACAGGCAGTGAACTTCGTGGTGCAAGGCTCCGCTGCTGACCTCTGCAAG
CTGGCCATGATCCATGTCTTCACTGCAGTGGCTGCTTCCCACACCTTGACGGCCAGGCTGGTGGCCCAGATCCATGATGAGCTGCTGTTT
GAAGTGGAAGATCCGCAGATCCCGGAGTGTGCAGCTCTCGTCAGGAGGACCATGGAGTCCTTGGAACAGGTGCAGGCATTGGAGCTGCAG
CTTCAGGTACCCCTCAAGGTGAGCCTGAGTGCCGGCCGCTCATGGGGACACCTGGTGCCACTGCAGGAGGCCTGGGGCCCTCCGCCAGGC
CCATGTCGCACTGAGTCTCCCAGCAACAGCCTGGCTGCCCCTGGGTCCCCTGCCAGCACCCAGCCCCCACCCCTGCATTTTTCGCCTTCA

>In-frame_SOS2_ENST00000543680_chr14_50697915_-_POLN_ENST00000382865_chr4_2176478_-_1542nt
ATGCAGCAGGCGCCGCAGCCTTACGAGTTCTTCAGCGAGGAGAACAGTCCGAAATGGCGGGGACTGTTGGTCTCGGCCCTGCGGAAGGAT
TATGGTTTATGGCAACTATTTCGTACTTTGGAGCTTCCTCTGATACCAATTTTGGCAGTGATGGAAAGCCATGCCATTCAGGTGAACAAA
GAGGAGATGGAGAAGACGTCAGCACTTCTTGGGGCTCGTCTCAAGGAATTGGAGCAAGAAGCTCATTTTGTTGCAGGAGAACGGTTTCTT
ATAACGAGCAATAACCAGCTTCGAGAGATCCTCTTTGGCAAGTTAAAGCTGCACCTGCTGAGTCAAAGGAACAGTCTCCCCAGAACGGGG
TTGCAGAAATACCCGTCTACATCAGAAGCAGTGTTAAATGCTCTGCGAGACCTTCATCCATTACCCAAGATAATTTTGGAATACAGGCAG
GTTCACAAGATCAAGTCAACCTTTGTAGATGGATTACTAGCTTGCATGAAAAAGGGCTCCATTTCCTCTACATGGAATCAGACTGGAACT
GTGACTGGAAGACTTTCAGCCAAGCATCCTAATATCCAAGGTATCTCCAAGCACCCAATTCAGATTACTACACCTAAGAATTTTAAAGGT
AAAGAAGACAAGATTCTCACGATCTCCCCGAGGGCCATGTTTGTTTCATCCAAAGGCCACACCTTTCTAGCAGCAGACTTTTCACAGATT
GAATTGCGCATTCTTACACATTTATCTGGAGATCCGGAACTTCTGAAGTTATTCCAGGAATCTGAAAGAGATGATGTATTTTCTACTCTG
ACTTCACAGTGGAAGGATGTGCCCGTGGAACAGGTGACACACGCAGACAGAGAGCAAACCAAGAAGGTGGTGTACGCGGTGGTCTATGGA
GCAGGGAAGGAGCGGCTGGCTGCTTGCCTTGGAGTTCCTATTCAGGAAGCTGCCCAGTTTTTGGAGAGTTTTTTGCAGAAGTACAAGAAA
ATCAAGGACTTCGCCCGAGCAGCTATTGCCCAGTGTCACCAGACAGGCTGTGTGGTGTCCATCATGGGCAGAAGGAGACCCCTGCCAAGG
ATTCACGCTCATGACCAGCAACTCCGGGCACAAGCAGAGCGACAGGCAGTGAACTTCGTGGTGCAAGGCTCCGCTGCTGACCTCTGCAAG
CTGGCCATGATCCATGTCTTCACTGCAGTGGCTGCTTCCCACACCTTGACGGCCAGGCTGGTGGCCCAGATCCATGATGAGCTGCTGTTT
GAAGTGGAAGATCCGCAGATCCCGGAGTGTGCAGCTCTCGTCAGGAGGACCATGGAGTCCTTGGAACAGGTGCAGGCATTGGAGCTGCAG
CTTCAGGTACCCCTCAAGGTGAGCCTGAGTGCCGGCCGCTCATGGGGACACCTGGTGCCACTGCAGGAGGCCTGGGGCCCTCCGCCAGGC
CCATGTCGCACTGAGTCTCCCAGCAACAGCCTGGCTGCCCCTGGGTCCCCTGCCAGCACCCAGCCCCCACCCCTGCATTTTTCGCCTTCA

>In-frame_SOS2_ENST00000543680_chr14_50697915_-_POLN_ENST00000511885_chr4_2176478_-_1542nt
ATGCAGCAGGCGCCGCAGCCTTACGAGTTCTTCAGCGAGGAGAACAGTCCGAAATGGCGGGGACTGTTGGTCTCGGCCCTGCGGAAGGAT
TATGGTTTATGGCAACTATTTCGTACTTTGGAGCTTCCTCTGATACCAATTTTGGCAGTGATGGAAAGCCATGCCATTCAGGTGAACAAA
GAGGAGATGGAGAAGACGTCAGCACTTCTTGGGGCTCGTCTCAAGGAATTGGAGCAAGAAGCTCATTTTGTTGCAGGAGAACGGTTTCTT
ATAACGAGCAATAACCAGCTTCGAGAGATCCTCTTTGGCAAGTTAAAGCTGCACCTGCTGAGTCAAAGGAACAGTCTCCCCAGAACGGGG
TTGCAGAAATACCCGTCTACATCAGAAGCAGTGTTAAATGCTCTGCGAGACCTTCATCCATTACCCAAGATAATTTTGGAATACAGGCAG
GTTCACAAGATCAAGTCAACCTTTGTAGATGGATTACTAGCTTGCATGAAAAAGGGCTCCATTTCCTCTACATGGAATCAGACTGGAACT
GTGACTGGAAGACTTTCAGCCAAGCATCCTAATATCCAAGGTATCTCCAAGCACCCAATTCAGATTACTACACCTAAGAATTTTAAAGGT
AAAGAAGACAAGATTCTCACGATCTCCCCGAGGGCCATGTTTGTTTCATCCAAAGGCCACACCTTTCTAGCAGCAGACTTTTCACAGATT
GAATTGCGCATTCTTACACATTTATCTGGAGATCCGGAACTTCTGAAGTTATTCCAGGAATCTGAAAGAGATGATGTATTTTCTACTCTG
ACTTCACAGTGGAAGGATGTGCCCGTGGAACAGGTGACACACGCAGACAGAGAGCAAACCAAGAAGGTGGTGTACGCGGTGGTCTATGGA
GCAGGGAAGGAGCGGCTGGCTGCTTGCCTTGGAGTTCCTATTCAGGAAGCTGCCCAGTTTTTGGAGAGTTTTTTGCAGAAGTACAAGAAA
ATCAAGGACTTCGCCCGAGCAGCTATTGCCCAGTGTCACCAGACAGGCTGTGTGGTGTCCATCATGGGCAGAAGGAGACCCCTGCCAAGG
ATTCACGCTCATGACCAGCAACTCCGGGCACAAGCAGAGCGACAGGCAGTGAACTTCGTGGTGCAAGGCTCCGCTGCTGACCTCTGCAAG
CTGGCCATGATCCATGTCTTCACTGCAGTGGCTGCTTCCCACACCTTGACGGCCAGGCTGGTGGCCCAGATCCATGATGAGCTGCTGTTT
GAAGTGGAAGATCCGCAGATCCCGGAGTGTGCAGCTCTCGTCAGGAGGACCATGGAGTCCTTGGAACAGGTGCAGGCATTGGAGCTGCAG
CTTCAGGTACCCCTCAAGGTGAGCCTGAGTGCCGGCCGCTCATGGGGACACCTGGTGCCACTGCAGGAGGCCTGGGGCCCTCCGCCAGGC
CCATGTCGCACTGAGTCTCCCAGCAACAGCCTGGCTGCCCCTGGGTCCCCTGCCAGCACCCAGCCCCCACCCCTGCATTTTTCGCCTTCA


* Fusion transcript sequences (Full-length transcript).
>In-frame_SOS2_ENST00000216373_chr14_50697915_-_POLN_ENST00000382865_chr4_2176478_-_2013nt
GGGAAAGGAGGTCGCCGCCCGGGGTCGCCCGGGCTTGCGGGTCGCCGCGCTTCCTCTGCGGGCGCTGCGGGAGGCGAGGGCCGCCTCGGC
GGAGGAAGCCGACCCCGGGGTCTCCGCCAGCCCGCCGGCGCCGCCTCCGAGCCGCCTCGGCCGTAGCCTCGGCCCGGGCGGGAGGCGGCG
GCCGCCGGCGAGGCGAGGCGGCCCGCGCCCTGCCTGTCAGGCCACCGGCCCGGCCCGCGGGCTGCCCCCGATGCGGAGGCGCTGTCGCCG
GGGCCATGCAGCAGGCGCCGCAGCCTTACGAGTTCTTCAGCGAGGAGAACAGTCCGAAATGGCGGGGACTGTTGGTCTCGGCCCTGCGGA
AGGATTATGGTTTATGGCAACTATTTCGTACTTTGGAGCTTCCTCTGATACCAATTTTGGCAGTGATGGAAAGCCATGCCATTCAGGTGA
ACAAAGAGGAGATGGAGAAGACGTCAGCACTTCTTGGGGCTCGTCTCAAGGAATTGGAGCAAGAAGCTCATTTTGTTGCAGGAGAACGGT
TTCTTATAACGAGCAATAACCAGCTTCGAGAGATCCTCTTTGGCAAGTTAAAGCTGCACCTGCTGAGTCAAAGGAACAGTCTCCCCAGAA
CGGGGTTGCAGAAATACCCGTCTACATCAGAAGCAGTGTTAAATGCTCTGCGAGACCTTCATCCATTACCCAAGATAATTTTGGAATACA
GGCAGGTTCACAAGATCAAGTCAACCTTTGTAGATGGATTACTAGCTTGCATGAAAAAGGGCTCCATTTCCTCTACATGGAATCAGACTG
GAACTGTGACTGGAAGACTTTCAGCCAAGCATCCTAATATCCAAGGTATCTCCAAGCACCCAATTCAGATTACTACACCTAAGAATTTTA
AAGGTAAAGAAGACAAGATTCTCACGATCTCCCCGAGGGCCATGTTTGTTTCATCCAAAGGCCACACCTTTCTAGCAGCAGACTTTTCAC
AGATTGAATTGCGCATTCTTACACATTTATCTGGAGATCCGGAACTTCTGAAGTTATTCCAGGAATCTGAAAGAGATGATGTATTTTCTA
CTCTGACTTCACAGTGGAAGGATGTGCCCGTGGAACAGGTGACACACGCAGACAGAGAGCAAACCAAGAAGGTGGTGTACGCGGTGGTCT
ATGGAGCAGGGAAGGAGCGGCTGGCTGCTTGCCTTGGAGTTCCTATTCAGGAAGCTGCCCAGTTTTTGGAGAGTTTTTTGCAGAAGTACA
AGAAAATCAAGGACTTCGCCCGAGCAGCTATTGCCCAGTGTCACCAGACAGGCTGTGTGGTGTCCATCATGGGCAGAAGGAGACCCCTGC
CAAGGATTCACGCTCATGACCAGCAACTCCGGGCACAAGCAGAGCGACAGGCAGTGAACTTCGTGGTGCAAGGCTCCGCTGCTGACCTCT
GCAAGCTGGCCATGATCCATGTCTTCACTGCAGTGGCTGCTTCCCACACCTTGACGGCCAGGCTGGTGGCCCAGATCCATGATGAGCTGC
TGTTTGAAGTGGAAGATCCGCAGATCCCGGAGTGTGCAGCTCTCGTCAGGAGGACCATGGAGTCCTTGGAACAGGTGCAGGCATTGGAGC
TGCAGCTTCAGGTACCCCTCAAGGTGAGCCTGAGTGCCGGCCGCTCATGGGGACACCTGGTGCCACTGCAGGAGGCCTGGGGCCCTCCGC
CAGGCCCATGTCGCACTGAGTCTCCCAGCAACAGCCTGGCTGCCCCTGGGTCCCCTGCCAGCACCCAGCCCCCACCCCTGCATTTTTCGC
CTTCATTTTGTCTGTAGCCCCAGGCAACAGTGGGAGGAGAGAACTGGTTTCCAGCAGTCCATTGTGTGGCCTTCCCCAAGGTCACCAGCT
CTGTACGCCCCAGGACGCATTAACCCTTTGGGGCTGGGGTGGCCCGCCATCCCCTGGAGTAAATGCCTGTGCAAAGCCCTCCTCATCCTT

>In-frame_SOS2_ENST00000216373_chr14_50697915_-_POLN_ENST00000511885_chr4_2176478_-_2013nt
GGGAAAGGAGGTCGCCGCCCGGGGTCGCCCGGGCTTGCGGGTCGCCGCGCTTCCTCTGCGGGCGCTGCGGGAGGCGAGGGCCGCCTCGGC
GGAGGAAGCCGACCCCGGGGTCTCCGCCAGCCCGCCGGCGCCGCCTCCGAGCCGCCTCGGCCGTAGCCTCGGCCCGGGCGGGAGGCGGCG
GCCGCCGGCGAGGCGAGGCGGCCCGCGCCCTGCCTGTCAGGCCACCGGCCCGGCCCGCGGGCTGCCCCCGATGCGGAGGCGCTGTCGCCG
GGGCCATGCAGCAGGCGCCGCAGCCTTACGAGTTCTTCAGCGAGGAGAACAGTCCGAAATGGCGGGGACTGTTGGTCTCGGCCCTGCGGA
AGGATTATGGTTTATGGCAACTATTTCGTACTTTGGAGCTTCCTCTGATACCAATTTTGGCAGTGATGGAAAGCCATGCCATTCAGGTGA
ACAAAGAGGAGATGGAGAAGACGTCAGCACTTCTTGGGGCTCGTCTCAAGGAATTGGAGCAAGAAGCTCATTTTGTTGCAGGAGAACGGT
TTCTTATAACGAGCAATAACCAGCTTCGAGAGATCCTCTTTGGCAAGTTAAAGCTGCACCTGCTGAGTCAAAGGAACAGTCTCCCCAGAA
CGGGGTTGCAGAAATACCCGTCTACATCAGAAGCAGTGTTAAATGCTCTGCGAGACCTTCATCCATTACCCAAGATAATTTTGGAATACA
GGCAGGTTCACAAGATCAAGTCAACCTTTGTAGATGGATTACTAGCTTGCATGAAAAAGGGCTCCATTTCCTCTACATGGAATCAGACTG
GAACTGTGACTGGAAGACTTTCAGCCAAGCATCCTAATATCCAAGGTATCTCCAAGCACCCAATTCAGATTACTACACCTAAGAATTTTA
AAGGTAAAGAAGACAAGATTCTCACGATCTCCCCGAGGGCCATGTTTGTTTCATCCAAAGGCCACACCTTTCTAGCAGCAGACTTTTCAC
AGATTGAATTGCGCATTCTTACACATTTATCTGGAGATCCGGAACTTCTGAAGTTATTCCAGGAATCTGAAAGAGATGATGTATTTTCTA
CTCTGACTTCACAGTGGAAGGATGTGCCCGTGGAACAGGTGACACACGCAGACAGAGAGCAAACCAAGAAGGTGGTGTACGCGGTGGTCT
ATGGAGCAGGGAAGGAGCGGCTGGCTGCTTGCCTTGGAGTTCCTATTCAGGAAGCTGCCCAGTTTTTGGAGAGTTTTTTGCAGAAGTACA
AGAAAATCAAGGACTTCGCCCGAGCAGCTATTGCCCAGTGTCACCAGACAGGCTGTGTGGTGTCCATCATGGGCAGAAGGAGACCCCTGC
CAAGGATTCACGCTCATGACCAGCAACTCCGGGCACAAGCAGAGCGACAGGCAGTGAACTTCGTGGTGCAAGGCTCCGCTGCTGACCTCT
GCAAGCTGGCCATGATCCATGTCTTCACTGCAGTGGCTGCTTCCCACACCTTGACGGCCAGGCTGGTGGCCCAGATCCATGATGAGCTGC
TGTTTGAAGTGGAAGATCCGCAGATCCCGGAGTGTGCAGCTCTCGTCAGGAGGACCATGGAGTCCTTGGAACAGGTGCAGGCATTGGAGC
TGCAGCTTCAGGTACCCCTCAAGGTGAGCCTGAGTGCCGGCCGCTCATGGGGACACCTGGTGCCACTGCAGGAGGCCTGGGGCCCTCCGC
CAGGCCCATGTCGCACTGAGTCTCCCAGCAACAGCCTGGCTGCCCCTGGGTCCCCTGCCAGCACCCAGCCCCCACCCCTGCATTTTTCGC
CTTCATTTTGTCTGTAGCCCCAGGCAACAGTGGGAGGAGAGAACTGGTTTCCAGCAGTCCATTGTGTGGCCTTCCCCAAGGTCACCAGCT
CTGTACGCCCCAGGACGCATTAACCCTTTGGGGCTGGGGTGGCCCGCCATCCCCTGGAGTAAATGCCTGTGCAAAGCCCTCCTCATCCTT

>In-frame_SOS2_ENST00000543680_chr14_50697915_-_POLN_ENST00000382865_chr4_2176478_-_1764nt
GATGCGGAGGCGCTGTCGCCGGGGCCATGCAGCAGGCGCCGCAGCCTTACGAGTTCTTCAGCGAGGAGAACAGTCCGAAATGGCGGGGAC
TGTTGGTCTCGGCCCTGCGGAAGGATTATGGTTTATGGCAACTATTTCGTACTTTGGAGCTTCCTCTGATACCAATTTTGGCAGTGATGG
AAAGCCATGCCATTCAGGTGAACAAAGAGGAGATGGAGAAGACGTCAGCACTTCTTGGGGCTCGTCTCAAGGAATTGGAGCAAGAAGCTC
ATTTTGTTGCAGGAGAACGGTTTCTTATAACGAGCAATAACCAGCTTCGAGAGATCCTCTTTGGCAAGTTAAAGCTGCACCTGCTGAGTC
AAAGGAACAGTCTCCCCAGAACGGGGTTGCAGAAATACCCGTCTACATCAGAAGCAGTGTTAAATGCTCTGCGAGACCTTCATCCATTAC
CCAAGATAATTTTGGAATACAGGCAGGTTCACAAGATCAAGTCAACCTTTGTAGATGGATTACTAGCTTGCATGAAAAAGGGCTCCATTT
CCTCTACATGGAATCAGACTGGAACTGTGACTGGAAGACTTTCAGCCAAGCATCCTAATATCCAAGGTATCTCCAAGCACCCAATTCAGA
TTACTACACCTAAGAATTTTAAAGGTAAAGAAGACAAGATTCTCACGATCTCCCCGAGGGCCATGTTTGTTTCATCCAAAGGCCACACCT
TTCTAGCAGCAGACTTTTCACAGATTGAATTGCGCATTCTTACACATTTATCTGGAGATCCGGAACTTCTGAAGTTATTCCAGGAATCTG
AAAGAGATGATGTATTTTCTACTCTGACTTCACAGTGGAAGGATGTGCCCGTGGAACAGGTGACACACGCAGACAGAGAGCAAACCAAGA
AGGTGGTGTACGCGGTGGTCTATGGAGCAGGGAAGGAGCGGCTGGCTGCTTGCCTTGGAGTTCCTATTCAGGAAGCTGCCCAGTTTTTGG
AGAGTTTTTTGCAGAAGTACAAGAAAATCAAGGACTTCGCCCGAGCAGCTATTGCCCAGTGTCACCAGACAGGCTGTGTGGTGTCCATCA
TGGGCAGAAGGAGACCCCTGCCAAGGATTCACGCTCATGACCAGCAACTCCGGGCACAAGCAGAGCGACAGGCAGTGAACTTCGTGGTGC
AAGGCTCCGCTGCTGACCTCTGCAAGCTGGCCATGATCCATGTCTTCACTGCAGTGGCTGCTTCCCACACCTTGACGGCCAGGCTGGTGG
CCCAGATCCATGATGAGCTGCTGTTTGAAGTGGAAGATCCGCAGATCCCGGAGTGTGCAGCTCTCGTCAGGAGGACCATGGAGTCCTTGG
AACAGGTGCAGGCATTGGAGCTGCAGCTTCAGGTACCCCTCAAGGTGAGCCTGAGTGCCGGCCGCTCATGGGGACACCTGGTGCCACTGC
AGGAGGCCTGGGGCCCTCCGCCAGGCCCATGTCGCACTGAGTCTCCCAGCAACAGCCTGGCTGCCCCTGGGTCCCCTGCCAGCACCCAGC
CCCCACCCCTGCATTTTTCGCCTTCATTTTGTCTGTAGCCCCAGGCAACAGTGGGAGGAGAGAACTGGTTTCCAGCAGTCCATTGTGTGG
CCTTCCCCAAGGTCACCAGCTCTGTACGCCCCAGGACGCATTAACCCTTTGGGGCTGGGGTGGCCCGCCATCCCCTGGAGTAAATGCCTG

>In-frame_SOS2_ENST00000543680_chr14_50697915_-_POLN_ENST00000511885_chr4_2176478_-_1764nt
GATGCGGAGGCGCTGTCGCCGGGGCCATGCAGCAGGCGCCGCAGCCTTACGAGTTCTTCAGCGAGGAGAACAGTCCGAAATGGCGGGGAC
TGTTGGTCTCGGCCCTGCGGAAGGATTATGGTTTATGGCAACTATTTCGTACTTTGGAGCTTCCTCTGATACCAATTTTGGCAGTGATGG
AAAGCCATGCCATTCAGGTGAACAAAGAGGAGATGGAGAAGACGTCAGCACTTCTTGGGGCTCGTCTCAAGGAATTGGAGCAAGAAGCTC
ATTTTGTTGCAGGAGAACGGTTTCTTATAACGAGCAATAACCAGCTTCGAGAGATCCTCTTTGGCAAGTTAAAGCTGCACCTGCTGAGTC
AAAGGAACAGTCTCCCCAGAACGGGGTTGCAGAAATACCCGTCTACATCAGAAGCAGTGTTAAATGCTCTGCGAGACCTTCATCCATTAC
CCAAGATAATTTTGGAATACAGGCAGGTTCACAAGATCAAGTCAACCTTTGTAGATGGATTACTAGCTTGCATGAAAAAGGGCTCCATTT
CCTCTACATGGAATCAGACTGGAACTGTGACTGGAAGACTTTCAGCCAAGCATCCTAATATCCAAGGTATCTCCAAGCACCCAATTCAGA
TTACTACACCTAAGAATTTTAAAGGTAAAGAAGACAAGATTCTCACGATCTCCCCGAGGGCCATGTTTGTTTCATCCAAAGGCCACACCT
TTCTAGCAGCAGACTTTTCACAGATTGAATTGCGCATTCTTACACATTTATCTGGAGATCCGGAACTTCTGAAGTTATTCCAGGAATCTG
AAAGAGATGATGTATTTTCTACTCTGACTTCACAGTGGAAGGATGTGCCCGTGGAACAGGTGACACACGCAGACAGAGAGCAAACCAAGA
AGGTGGTGTACGCGGTGGTCTATGGAGCAGGGAAGGAGCGGCTGGCTGCTTGCCTTGGAGTTCCTATTCAGGAAGCTGCCCAGTTTTTGG
AGAGTTTTTTGCAGAAGTACAAGAAAATCAAGGACTTCGCCCGAGCAGCTATTGCCCAGTGTCACCAGACAGGCTGTGTGGTGTCCATCA
TGGGCAGAAGGAGACCCCTGCCAAGGATTCACGCTCATGACCAGCAACTCCGGGCACAAGCAGAGCGACAGGCAGTGAACTTCGTGGTGC
AAGGCTCCGCTGCTGACCTCTGCAAGCTGGCCATGATCCATGTCTTCACTGCAGTGGCTGCTTCCCACACCTTGACGGCCAGGCTGGTGG
CCCAGATCCATGATGAGCTGCTGTTTGAAGTGGAAGATCCGCAGATCCCGGAGTGTGCAGCTCTCGTCAGGAGGACCATGGAGTCCTTGG
AACAGGTGCAGGCATTGGAGCTGCAGCTTCAGGTACCCCTCAAGGTGAGCCTGAGTGCCGGCCGCTCATGGGGACACCTGGTGCCACTGC
AGGAGGCCTGGGGCCCTCCGCCAGGCCCATGTCGCACTGAGTCTCCCAGCAACAGCCTGGCTGCCCCTGGGTCCCCTGCCAGCACCCAGC
CCCCACCCCTGCATTTTTCGCCTTCATTTTGTCTGTAGCCCCAGGCAACAGTGGGAGGAGAGAACTGGTTTCCAGCAGTCCATTGTGTGG
CCTTCCCCAAGGTCACCAGCTCTGTACGCCCCAGGACGCATTAACCCTTTGGGGCTGGGGTGGCCCGCCATCCCCTGGAGTAAATGCCTG


Top

FusionGenePPI for SOS2_POLN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SOS2GRAP2, SHC1, EGFR, PLCG1, GRB2, ESR1, ITSN2, LRRK1, CRK, BIN1, NTRK1POLNATR, FANCD2, POLDIP2, FANCA, FANCG, PCNA, FANCI, RAD51, HELQ, RAD18, BRCA1, BARD1, PALB2, BRCA2, BRIP1, RBBP8


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for SOS2_POLN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for SOS2_POLN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSOS2C4225282NOONAN SYNDROME 91UNIPROT