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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 35416

FusionGeneSummary for SORL1_TECTA

check button Fusion gene summary
Fusion gene informationFusion gene name: SORL1_TECTA
Fusion gene ID: 35416
HgeneTgene
Gene symbol

SORL1

TECTA

Gene ID

6653

7007

Gene namesortilin related receptor 1tectorin alpha
SynonymsC11orf32|LR11|LRP9|SORLA|SorLA-1|gp250DFNA12|DFNA8|DFNB21
Cytomap

11q24.1

11q23.3

Type of geneprotein-codingprotein-coding
Descriptionsortilin-related receptorLDLR relative with 11 ligand-binding repeatslow-density lipoprotein receptor relative with 11 ligand-binding repeatsmosaic protein LR11sortilin-related receptor, L(DLR class) A repeats containingsorting protein-related receptalpha-tectorin
Modification date2018052720180522
UniProtAcc

Q92673

O75443

Ensembl transtripts involved in fusion geneENST00000260197, ENST00000532451, 
ENST00000525532, ENST00000532694, 
ENST00000534286, ENST00000527934, 
ENST00000392793, ENST00000264037, 
ENST00000478058, 
Fusion gene scores* DoF score13 X 10 X 7=9104 X 2 X 5=40
# samples 145
** MAII scorelog2(14/910*10)=-2.70043971814109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SORL1 [Title/Abstract] AND TECTA [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSORL1

GO:0006605

protein targeting

16407538

HgeneSORL1

GO:0006622

protein targeting to lysosome

24523320

HgeneSORL1

GO:0006892

post-Golgi vesicle-mediated transport

17855360

HgeneSORL1

GO:0014910

regulation of smooth muscle cell migration

14764453

HgeneSORL1

GO:0032091

negative regulation of protein binding

16407538

HgeneSORL1

GO:0034067

protein localization to Golgi apparatus

17855360

HgeneSORL1

GO:0045053

protein retention in Golgi apparatus

17855360

HgeneSORL1

GO:0045732

positive regulation of protein catabolic process

24523320

HgeneSORL1

GO:0051604

protein maturation

17855360

HgeneSORL1

GO:1902430

negative regulation of amyloid-beta formation

16407538|22621900

HgeneSORL1

GO:1902960

negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process

16407538


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-E9-A22G-01ASORL1chr11

121403261

+TECTAchr11

121058541

+
TCGARVOVTCGA-13-1487-01ASORL1chr11

121360819

+TECTAchr11

121058541

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000260197ENST00000392793SORL1chr11

121403261

+TECTAchr11

121058541

+
In-frameENST00000260197ENST00000264037SORL1chr11

121403261

+TECTAchr11

121058541

+
5CDS-intronENST00000260197ENST00000478058SORL1chr11

121403261

+TECTAchr11

121058541

+
3UTR-3CDSENST00000532451ENST00000392793SORL1chr11

121403261

+TECTAchr11

121058541

+
3UTR-3CDSENST00000532451ENST00000264037SORL1chr11

121403261

+TECTAchr11

121058541

+
3UTR-intronENST00000532451ENST00000478058SORL1chr11

121403261

+TECTAchr11

121058541

+
intron-3CDSENST00000525532ENST00000392793SORL1chr11

121403261

+TECTAchr11

121058541

+
intron-3CDSENST00000525532ENST00000264037SORL1chr11

121403261

+TECTAchr11

121058541

+
intron-intronENST00000525532ENST00000478058SORL1chr11

121403261

+TECTAchr11

121058541

+
intron-3CDSENST00000532694ENST00000392793SORL1chr11

121403261

+TECTAchr11

121058541

+
intron-3CDSENST00000532694ENST00000264037SORL1chr11

121403261

+TECTAchr11

121058541

+
intron-intronENST00000532694ENST00000478058SORL1chr11

121403261

+TECTAchr11

121058541

+
intron-3CDSENST00000534286ENST00000392793SORL1chr11

121403261

+TECTAchr11

121058541

+
intron-3CDSENST00000534286ENST00000264037SORL1chr11

121403261

+TECTAchr11

121058541

+
intron-intronENST00000534286ENST00000478058SORL1chr11

121403261

+TECTAchr11

121058541

+
intron-3CDSENST00000527934ENST00000392793SORL1chr11

121403261

+TECTAchr11

121058541

+
intron-3CDSENST00000527934ENST00000264037SORL1chr11

121403261

+TECTAchr11

121058541

+
intron-intronENST00000527934ENST00000478058SORL1chr11

121403261

+TECTAchr11

121058541

+
In-frameENST00000260197ENST00000392793SORL1chr11

121360819

+TECTAchr11

121058541

+
In-frameENST00000260197ENST00000264037SORL1chr11

121360819

+TECTAchr11

121058541

+
5CDS-intronENST00000260197ENST00000478058SORL1chr11

121360819

+TECTAchr11

121058541

+
3UTR-3CDSENST00000532451ENST00000392793SORL1chr11

121360819

+TECTAchr11

121058541

+
3UTR-3CDSENST00000532451ENST00000264037SORL1chr11

121360819

+TECTAchr11

121058541

+
3UTR-intronENST00000532451ENST00000478058SORL1chr11

121360819

+TECTAchr11

121058541

+
intron-3CDSENST00000525532ENST00000392793SORL1chr11

121360819

+TECTAchr11

121058541

+
intron-3CDSENST00000525532ENST00000264037SORL1chr11

121360819

+TECTAchr11

121058541

+
intron-intronENST00000525532ENST00000478058SORL1chr11

121360819

+TECTAchr11

121058541

+
intron-3CDSENST00000532694ENST00000392793SORL1chr11

121360819

+TECTAchr11

121058541

+
intron-3CDSENST00000532694ENST00000264037SORL1chr11

121360819

+TECTAchr11

121058541

+
intron-intronENST00000532694ENST00000478058SORL1chr11

121360819

+TECTAchr11

121058541

+
intron-3CDSENST00000534286ENST00000392793SORL1chr11

121360819

+TECTAchr11

121058541

+
intron-3CDSENST00000534286ENST00000264037SORL1chr11

121360819

+TECTAchr11

121058541

+
intron-intronENST00000534286ENST00000478058SORL1chr11

121360819

+TECTAchr11

121058541

+
intron-3CDSENST00000527934ENST00000392793SORL1chr11

121360819

+TECTAchr11

121058541

+
intron-3CDSENST00000527934ENST00000264037SORL1chr11

121360819

+TECTAchr11

121058541

+
intron-intronENST00000527934ENST00000478058SORL1chr11

121360819

+TECTAchr11

121058541

+

Top

FusionProtFeatures for SORL1_TECTA


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SORL1

Q92673

TECTA

O75443

Likely to be a multifunctional endocytic receptor, thatmay be implicated in the uptake of lipoproteins and of proteases.Binds LDL, the major cholesterol-carrying lipoprotein of plasma,and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cellinteraction. Involved in APP trafficking to and from the Golgiapparatus. It probably acts as a sorting receptor that protectsAPP from trafficking to late endosome and from processing intoamyloid beta, thereby reducing the burden of amyloidogenic peptideformation. Involved in the regulation of smooth muscle cellsmigration, probably through PLAUR binding and decreasedinternalization. {ECO:0000269|PubMed:14764453,ECO:0000269|PubMed:16174740}. One of the major non-collagenous components of thetectorial membrane (By similarity). The tectorial membrane is anextracellular matrix of the inner ear that covers theneuroepithelium of the cochlea and contacts the stereociliabundles of specialized sensory hair cells. Sound induces movementof these hair cells relative to the tectorial membrane, deflectsthe stereocilia and leads to fluctuations in hair-cell membranepotential, transducing sound into electrical signals.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSORL1chr11:121360819chr11:121058541ENST00000260197+54863_652522215MotifCell attachment site
HgeneSORL1chr11:121403261chr11:121058541ENST00000260197+124863_655612215MotifCell attachment site
HgeneSORL1chr11:121360819chr11:121058541ENST00000260197+548136_1472522215RepeatNote=BNR 1
HgeneSORL1chr11:121360819chr11:121058541ENST00000260197+548232_2432522215RepeatNote=BNR 2
HgeneSORL1chr11:121403261chr11:121058541ENST00000260197+1248136_1475612215RepeatNote=BNR 1
HgeneSORL1chr11:121403261chr11:121058541ENST00000260197+1248232_2435612215RepeatNote=BNR 2
HgeneSORL1chr11:121403261chr11:121058541ENST00000260197+1248441_4525612215RepeatNote=BNR 3
HgeneSORL1chr11:121403261chr11:121058541ENST00000260197+1248521_5325612215RepeatNote=BNR 4

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSORL1chr11:121360819chr11:121058541ENST00000260197+5481026_10722522215DomainNote=EGF-like
HgeneSORL1chr11:121360819chr11:121058541ENST00000260197+5481076_11142522215DomainLDL-receptor class A 1
HgeneSORL1chr11:121360819chr11:121058541ENST00000260197+5481115_11552522215DomainLDL-receptor class A 2
HgeneSORL1chr11:121360819chr11:121058541ENST00000260197+5481156_11942522215DomainLDL-receptor class A 3
HgeneSORL1chr11:121360819chr11:121058541ENST00000260197+5481198_12362522215DomainLDL-receptor class A 4
HgeneSORL1chr11:121360819chr11:121058541ENST00000260197+5481238_12722522215DomainLDL-receptor class A 5
HgeneSORL1chr11:121360819chr11:121058541ENST00000260197+5481273_13172522215DomainLDL-receptor class A 6
HgeneSORL1chr11:121360819chr11:121058541ENST00000260197+5481323_13612522215DomainLDL-receptor class A 7
HgeneSORL1chr11:121360819chr11:121058541ENST00000260197+5481366_14052522215DomainLDL-receptor class A 8
HgeneSORL1chr11:121360819chr11:121058541ENST00000260197+5481417_14552522215DomainLDL-receptor class A 9
HgeneSORL1chr11:121360819chr11:121058541ENST00000260197+5481469_15082522215DomainLDL-receptor class A 10
HgeneSORL1chr11:121360819chr11:121058541ENST00000260197+5481512_15512522215DomainLDL-receptor class A 11
HgeneSORL1chr11:121360819chr11:121058541ENST00000260197+5481557_16492522215DomainFibronectin type-III 1
HgeneSORL1chr11:121360819chr11:121058541ENST00000260197+5481653_17452522215DomainFibronectin type-III 2
HgeneSORL1chr11:121360819chr11:121058541ENST00000260197+5481749_18442522215DomainFibronectin type-III 3
HgeneSORL1chr11:121360819chr11:121058541ENST00000260197+5481843_19272522215DomainFibronectin type-III 4
HgeneSORL1chr11:121360819chr11:121058541ENST00000260197+5481934_20292522215DomainFibronectin type-III 5
HgeneSORL1chr11:121360819chr11:121058541ENST00000260197+5482030_21182522215DomainFibronectin type-III 6
HgeneSORL1chr11:121403261chr11:121058541ENST00000260197+12481026_10725612215DomainNote=EGF-like
HgeneSORL1chr11:121403261chr11:121058541ENST00000260197+12481076_11145612215DomainLDL-receptor class A 1
HgeneSORL1chr11:121403261chr11:121058541ENST00000260197+12481115_11555612215DomainLDL-receptor class A 2
HgeneSORL1chr11:121403261chr11:121058541ENST00000260197+12481156_11945612215DomainLDL-receptor class A 3
HgeneSORL1chr11:121403261chr11:121058541ENST00000260197+12481198_12365612215DomainLDL-receptor class A 4
HgeneSORL1chr11:121403261chr11:121058541ENST00000260197+12481238_12725612215DomainLDL-receptor class A 5
HgeneSORL1chr11:121403261chr11:121058541ENST00000260197+12481273_13175612215DomainLDL-receptor class A 6
HgeneSORL1chr11:121403261chr11:121058541ENST00000260197+12481323_13615612215DomainLDL-receptor class A 7
HgeneSORL1chr11:121403261chr11:121058541ENST00000260197+12481366_14055612215DomainLDL-receptor class A 8
HgeneSORL1chr11:121403261chr11:121058541ENST00000260197+12481417_14555612215DomainLDL-receptor class A 9
HgeneSORL1chr11:121403261chr11:121058541ENST00000260197+12481469_15085612215DomainLDL-receptor class A 10
HgeneSORL1chr11:121403261chr11:121058541ENST00000260197+12481512_15515612215DomainLDL-receptor class A 11
HgeneSORL1chr11:121403261chr11:121058541ENST00000260197+12481557_16495612215DomainFibronectin type-III 1
HgeneSORL1chr11:121403261chr11:121058541ENST00000260197+12481653_17455612215DomainFibronectin type-III 2
HgeneSORL1chr11:121403261chr11:121058541ENST00000260197+12481749_18445612215DomainFibronectin type-III 3
HgeneSORL1chr11:121403261chr11:121058541ENST00000260197+12481843_19275612215DomainFibronectin type-III 4
HgeneSORL1chr11:121403261chr11:121058541ENST00000260197+12481934_20295612215DomainFibronectin type-III 5
HgeneSORL1chr11:121403261chr11:121058541ENST00000260197+12482030_21185612215DomainFibronectin type-III 6
HgeneSORL1chr11:121360819chr11:121058541ENST00000260197+5482172_21772522215MotifEndocytosis signal
HgeneSORL1chr11:121403261chr11:121058541ENST00000260197+12482172_21775612215MotifEndocytosis signal
HgeneSORL1chr11:121360819chr11:121058541ENST00000260197+548441_4522522215RepeatNote=BNR 3
HgeneSORL1chr11:121360819chr11:121058541ENST00000260197+548521_5322522215RepeatNote=BNR 4
HgeneSORL1chr11:121360819chr11:121058541ENST00000260197+548562_5732522215RepeatNote=BNR 5
HgeneSORL1chr11:121360819chr11:121058541ENST00000260197+548800_8432522215RepeatNote=LDL-receptor class B 1
HgeneSORL1chr11:121360819chr11:121058541ENST00000260197+548844_8872522215RepeatNote=LDL-receptor class B 2
HgeneSORL1chr11:121360819chr11:121058541ENST00000260197+548888_9322522215RepeatNote=LDL-receptor class B 3
HgeneSORL1chr11:121360819chr11:121058541ENST00000260197+548933_9702522215RepeatNote=LDL-receptor class B 4
HgeneSORL1chr11:121360819chr11:121058541ENST00000260197+548971_10132522215RepeatNote=LDL-receptor class B 5
HgeneSORL1chr11:121403261chr11:121058541ENST00000260197+1248562_5735612215RepeatNote=BNR 5
HgeneSORL1chr11:121403261chr11:121058541ENST00000260197+1248800_8435612215RepeatNote=LDL-receptor class B 1
HgeneSORL1chr11:121403261chr11:121058541ENST00000260197+1248844_8875612215RepeatNote=LDL-receptor class B 2
HgeneSORL1chr11:121403261chr11:121058541ENST00000260197+1248888_9325612215RepeatNote=LDL-receptor class B 3
HgeneSORL1chr11:121403261chr11:121058541ENST00000260197+1248933_9705612215RepeatNote=LDL-receptor class B 4
HgeneSORL1chr11:121403261chr11:121058541ENST00000260197+1248971_10135612215RepeatNote=LDL-receptor class B 5
HgeneSORL1chr11:121360819chr11:121058541ENST00000260197+5482159_22142522215Topological domainCytoplasmic
HgeneSORL1chr11:121360819chr11:121058541ENST00000260197+54882_21372522215Topological domainExtracellular
HgeneSORL1chr11:121403261chr11:121058541ENST00000260197+12482159_22145612215Topological domainCytoplasmic
HgeneSORL1chr11:121403261chr11:121058541ENST00000260197+124882_21375612215Topological domainExtracellular
HgeneSORL1chr11:121360819chr11:121058541ENST00000260197+5482138_21582522215TransmembraneHelical
HgeneSORL1chr11:121403261chr11:121058541ENST00000260197+12482138_21585612215TransmembraneHelical
TgeneTECTAchr11:121360819chr11:121058541ENST00000264037+18231099_131719992156DomainVWFD 3
TgeneTECTAchr11:121360819chr11:121058541ENST00000264037+18231372_142519992156DomainNote=TIL 3
TgeneTECTAchr11:121360819chr11:121058541ENST00000264037+18231486_169419992156DomainVWFD 4
TgeneTECTAchr11:121360819chr11:121058541ENST00000264037+18231805_205919992156DomainZP
TgeneTECTAchr11:121360819chr11:121058541ENST00000264037+1823260_31419992156DomainNote=VWFC
TgeneTECTAchr11:121360819chr11:121058541ENST00000264037+1823321_54019992156DomainVWFD 1
TgeneTECTAchr11:121360819chr11:121058541ENST00000264037+1823597_65019992156DomainNote=TIL 1
TgeneTECTAchr11:121360819chr11:121058541ENST00000264037+1823712_92919992156DomainVWFD 2
TgeneTECTAchr11:121360819chr11:121058541ENST00000264037+1823984_103619992156DomainNote=TIL 2
TgeneTECTAchr11:121360819chr11:121058541ENST00000264037+182398_25219992156DomainNIDO
TgeneTECTAchr11:121360819chr11:121058541ENST00000392793+19241099_131719992156DomainVWFD 3
TgeneTECTAchr11:121360819chr11:121058541ENST00000392793+19241372_142519992156DomainNote=TIL 3
TgeneTECTAchr11:121360819chr11:121058541ENST00000392793+19241486_169419992156DomainVWFD 4
TgeneTECTAchr11:121360819chr11:121058541ENST00000392793+19241805_205919992156DomainZP
TgeneTECTAchr11:121360819chr11:121058541ENST00000392793+1924260_31419992156DomainNote=VWFC
TgeneTECTAchr11:121360819chr11:121058541ENST00000392793+1924321_54019992156DomainVWFD 1
TgeneTECTAchr11:121360819chr11:121058541ENST00000392793+1924597_65019992156DomainNote=TIL 1
TgeneTECTAchr11:121360819chr11:121058541ENST00000392793+1924712_92919992156DomainVWFD 2
TgeneTECTAchr11:121360819chr11:121058541ENST00000392793+1924984_103619992156DomainNote=TIL 2
TgeneTECTAchr11:121360819chr11:121058541ENST00000392793+192498_25219992156DomainNIDO
TgeneTECTAchr11:121403261chr11:121058541ENST00000264037+18231099_131719992156DomainVWFD 3
TgeneTECTAchr11:121403261chr11:121058541ENST00000264037+18231372_142519992156DomainNote=TIL 3
TgeneTECTAchr11:121403261chr11:121058541ENST00000264037+18231486_169419992156DomainVWFD 4
TgeneTECTAchr11:121403261chr11:121058541ENST00000264037+18231805_205919992156DomainZP
TgeneTECTAchr11:121403261chr11:121058541ENST00000264037+1823260_31419992156DomainNote=VWFC
TgeneTECTAchr11:121403261chr11:121058541ENST00000264037+1823321_54019992156DomainVWFD 1
TgeneTECTAchr11:121403261chr11:121058541ENST00000264037+1823597_65019992156DomainNote=TIL 1
TgeneTECTAchr11:121403261chr11:121058541ENST00000264037+1823712_92919992156DomainVWFD 2
TgeneTECTAchr11:121403261chr11:121058541ENST00000264037+1823984_103619992156DomainNote=TIL 2
TgeneTECTAchr11:121403261chr11:121058541ENST00000264037+182398_25219992156DomainNIDO
TgeneTECTAchr11:121403261chr11:121058541ENST00000392793+19241099_131719992156DomainVWFD 3
TgeneTECTAchr11:121403261chr11:121058541ENST00000392793+19241372_142519992156DomainNote=TIL 3
TgeneTECTAchr11:121403261chr11:121058541ENST00000392793+19241486_169419992156DomainVWFD 4
TgeneTECTAchr11:121403261chr11:121058541ENST00000392793+19241805_205919992156DomainZP
TgeneTECTAchr11:121403261chr11:121058541ENST00000392793+1924260_31419992156DomainNote=VWFC
TgeneTECTAchr11:121403261chr11:121058541ENST00000392793+1924321_54019992156DomainVWFD 1
TgeneTECTAchr11:121403261chr11:121058541ENST00000392793+1924597_65019992156DomainNote=TIL 1
TgeneTECTAchr11:121403261chr11:121058541ENST00000392793+1924712_92919992156DomainVWFD 2
TgeneTECTAchr11:121403261chr11:121058541ENST00000392793+1924984_103619992156DomainNote=TIL 2
TgeneTECTAchr11:121403261chr11:121058541ENST00000392793+192498_25219992156DomainNIDO


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FusionGeneSequence for SORL1_TECTA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_SORL1_ENST00000260197_chr11_121403261_+_TECTA_ENST00000392793_chr11_121058541_+_718aa
MATRSSRRESRLPFLFTLVALLPPGALCEVWTQRLHGGSAPLPQDRGFLVVQGDPRELRLWARGDARGASRADEKPLRRKRSAALQPEPI
KVYGQVSLNDSHNQMVVHWAGEKSNVIVALARDSLALARPKSSDVYVSYDYGKSFKKISDKLNFGLGNRSEAVIAQFYHSPADNKRYIFA
DAYAQYLWITFDFCNTLQGFSIPFRAADLLLHSKASNLLLGFDRSHPNKQLWKSDDFGQTWIMIQEHVKSFSWGIDPYDKPNTIYIERHE
PSGYSTVFRSTDFFQSRENQEVILEEVRDFQLRDKYMFATKVVHLLGSEQQSSVQLWVSFGRKPMRAAQFVTRHPINEYYIADASEDQVF
VCVSHSNNRTNLYISEAEGLKFSLSLENVLYYSPGGAGSDTLVRYFANEPFADFHRVEGLQGVYIATLINGSMNEENMRSVITFDKGGTW
EFLQAPAFTGYGEKINCELSQGCSLHLAQRLSQLLNLQLRRMPILSKESAPGLIIATGSVGKNLASKTNVYISSSAGARWREALPGPHYY
TWGDHGGIITAIAQGMETNELKCQNLKDNTIGIEENAVSLTCRFHVTVFKFIGDYDEVHLHCAVSLCDSEKYSCKITCPHNSRIATDYTK

>In-frame_SORL1_ENST00000260197_chr11_121403261_+_TECTA_ENST00000264037_chr11_121058541_+_718aa
MATRSSRRESRLPFLFTLVALLPPGALCEVWTQRLHGGSAPLPQDRGFLVVQGDPRELRLWARGDARGASRADEKPLRRKRSAALQPEPI
KVYGQVSLNDSHNQMVVHWAGEKSNVIVALARDSLALARPKSSDVYVSYDYGKSFKKISDKLNFGLGNRSEAVIAQFYHSPADNKRYIFA
DAYAQYLWITFDFCNTLQGFSIPFRAADLLLHSKASNLLLGFDRSHPNKQLWKSDDFGQTWIMIQEHVKSFSWGIDPYDKPNTIYIERHE
PSGYSTVFRSTDFFQSRENQEVILEEVRDFQLRDKYMFATKVVHLLGSEQQSSVQLWVSFGRKPMRAAQFVTRHPINEYYIADASEDQVF
VCVSHSNNRTNLYISEAEGLKFSLSLENVLYYSPGGAGSDTLVRYFANEPFADFHRVEGLQGVYIATLINGSMNEENMRSVITFDKGGTW
EFLQAPAFTGYGEKINCELSQGCSLHLAQRLSQLLNLQLRRMPILSKESAPGLIIATGSVGKNLASKTNVYISSSAGARWREALPGPHYY
TWGDHGGIITAIAQGMETNELKCQNLKDNTIGIEENAVSLTCRFHVTVFKFIGDYDEVHLHCAVSLCDSEKYSCKITCPHNSRIATDYTK

>In-frame_SORL1_ENST00000260197_chr11_121360819_+_TECTA_ENST00000392793_chr11_121058541_+_409aa
MATRSSRRESRLPFLFTLVALLPPGALCEVWTQRLHGGSAPLPQDRGFLVVQGDPRELRLWARGDARGASRADEKPLRRKRSAALQPEPI
KVYGQVSLNDSHNQMVVHWAGEKSNVIVALARDSLALARPKSSDVYVSYDYGKSFKKISDKLNFGLGNRSEAVIAQFYHSPADNKRYIFA
DAYAQYLWITFDFCNTLQGFSIPFRAADLLLHSKASNLLLGFDRSHPNKQLWKSDDFGQTWIMIQEHVKSFSWCQNLKDNTIGIEENAVS
LTCRFHVTVFKFIGDYDEVHLHCAVSLCDSEKYSCKITCPHNSRIATDYTKEPKEQIISVGPIRRKRLDWCEDNGGCEQICTSRVDGPLC

>In-frame_SORL1_ENST00000260197_chr11_121360819_+_TECTA_ENST00000264037_chr11_121058541_+_409aa
MATRSSRRESRLPFLFTLVALLPPGALCEVWTQRLHGGSAPLPQDRGFLVVQGDPRELRLWARGDARGASRADEKPLRRKRSAALQPEPI
KVYGQVSLNDSHNQMVVHWAGEKSNVIVALARDSLALARPKSSDVYVSYDYGKSFKKISDKLNFGLGNRSEAVIAQFYHSPADNKRYIFA
DAYAQYLWITFDFCNTLQGFSIPFRAADLLLHSKASNLLLGFDRSHPNKQLWKSDDFGQTWIMIQEHVKSFSWCQNLKDNTIGIEENAVS
LTCRFHVTVFKFIGDYDEVHLHCAVSLCDSEKYSCKITCPHNSRIATDYTKEPKEQIISVGPIRRKRLDWCEDNGGCEQICTSRVDGPLC


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_SORL1_ENST00000260197_chr11_121403261_+_TECTA_ENST00000392793_chr11_121058541_+_2154nt
ATGGCGACACGGAGCAGCAGGAGGGAGTCGCGACTCCCGTTCCTATTCACCCTGGTCGCACTGCTGCCGCCCGGAGCTCTCTGCGAAGTC
TGGACGCAGAGGCTGCACGGCGGCAGCGCGCCCTTGCCCCAGGACCGGGGCTTCCTCGTGGTGCAGGGCGACCCGCGCGAGCTGCGGCTG
TGGGCGCGCGGGGATGCCAGGGGGGCGAGCCGCGCGGACGAGAAGCCGCTCCGGAGGAAACGGAGCGCTGCCCTGCAGCCCGAGCCCATC
AAGGTGTACGGACAGGTTAGTCTGAATGATTCCCACAATCAGATGGTGGTGCACTGGGCTGGAGAGAAAAGCAACGTGATCGTGGCCTTG
GCCCGAGATAGCCTGGCATTGGCGAGGCCCAAGAGCAGTGATGTGTACGTGTCTTACGACTATGGAAAATCATTCAAGAAAATTTCAGAC
AAGTTAAACTTTGGCTTGGGAAATAGGAGTGAAGCTGTTATCGCCCAGTTCTACCACAGCCCTGCGGACAACAAGCGGTACATCTTTGCA
GACGCTTATGCCCAGTACCTCTGGATCACGTTTGACTTCTGCAACACTCTTCAAGGCTTTTCCATCCCATTTCGGGCAGCTGATCTCCTC
CTACACAGTAAGGCCTCCAACCTTCTCTTGGGCTTTGACAGGTCCCACCCCAACAAGCAGCTGTGGAAGTCAGATGACTTTGGCCAGACC
TGGATCATGATTCAGGAACATGTCAAGTCCTTTTCTTGGGGAATTGATCCCTATGACAAACCAAATACCATCTACATTGAACGACATGAA
CCCTCTGGCTACTCCACTGTCTTCCGAAGTACAGATTTCTTCCAGTCCCGGGAAAACCAGGAAGTGATCCTTGAGGAAGTGAGAGATTTT
CAGCTTCGGGACAAGTACATGTTTGCTACAAAGGTGGTGCATCTCTTGGGCAGTGAACAGCAGTCTTCTGTCCAGCTCTGGGTCTCCTTT
GGCCGGAAGCCCATGAGAGCAGCCCAGTTTGTCACAAGACATCCTATTAATGAATATTACATCGCAGATGCCTCCGAGGACCAGGTGTTT
GTGTGTGTCAGCCACAGTAACAACCGCACCAATTTATACATCTCAGAGGCAGAGGGGCTGAAGTTCTCCCTGTCCTTGGAGAACGTGCTC
TATTACAGCCCAGGAGGGGCCGGCAGTGACACCTTGGTGAGGTATTTTGCAAATGAACCATTTGCTGACTTCCACCGAGTGGAAGGATTG
CAAGGAGTCTACATTGCTACTCTGATTAATGGTTCTATGAATGAGGAGAACATGAGATCGGTCATCACCTTTGACAAAGGGGGAACCTGG
GAGTTTCTTCAGGCTCCAGCCTTCACGGGATATGGAGAGAAAATCAATTGTGAGCTTTCCCAGGGCTGTTCCCTTCATCTGGCTCAGCGC
CTCAGTCAGCTCCTCAACCTCCAGCTCCGGAGAATGCCCATCCTGTCCAAGGAGTCGGCTCCAGGCCTCATCATCGCCACTGGCTCAGTG
GGAAAGAACTTGGCTAGCAAGACAAACGTGTACATCTCTAGCAGTGCTGGAGCCAGGTGGCGAGAGGCACTTCCTGGACCTCACTACTAC
ACATGGGGAGACCACGGCGGAATCATCACGGCTATTGCCCAGGGCATGGAAACCAACGAGCTAAAGTGTCAGAACCTCAAAGATAACACC
ATTGGCATCGAGGAGAATGCAGTCTCCCTGACCTGTCGCTTTCACGTCACCGTCTTTAAATTCATAGGGGATTACGACGAAGTTCACCTT
CACTGTGCAGTGTCACTCTGCGACTCAGAAAAGTACTCCTGTAAAATCACTTGCCCACACAATTCCAGGATTGCCACAGATTACACAAAA
GAGCCCAAAGAACAGATCATTTCAGTGGGACCTATTAGGAGAAAAAGGCTGGACTGGTGTGAGGACAATGGAGGGTGTGAGCAGATTTGC
ACGAGCCGGGTGGATGGGCCTCTCTGCAGCTGTGTAACAGGAACCCTGCAGGAGGACGGCAAGAGCTGCAGAGCCTCTAATTCTTCAATG

>In-frame_SORL1_ENST00000260197_chr11_121403261_+_TECTA_ENST00000264037_chr11_121058541_+_2154nt
ATGGCGACACGGAGCAGCAGGAGGGAGTCGCGACTCCCGTTCCTATTCACCCTGGTCGCACTGCTGCCGCCCGGAGCTCTCTGCGAAGTC
TGGACGCAGAGGCTGCACGGCGGCAGCGCGCCCTTGCCCCAGGACCGGGGCTTCCTCGTGGTGCAGGGCGACCCGCGCGAGCTGCGGCTG
TGGGCGCGCGGGGATGCCAGGGGGGCGAGCCGCGCGGACGAGAAGCCGCTCCGGAGGAAACGGAGCGCTGCCCTGCAGCCCGAGCCCATC
AAGGTGTACGGACAGGTTAGTCTGAATGATTCCCACAATCAGATGGTGGTGCACTGGGCTGGAGAGAAAAGCAACGTGATCGTGGCCTTG
GCCCGAGATAGCCTGGCATTGGCGAGGCCCAAGAGCAGTGATGTGTACGTGTCTTACGACTATGGAAAATCATTCAAGAAAATTTCAGAC
AAGTTAAACTTTGGCTTGGGAAATAGGAGTGAAGCTGTTATCGCCCAGTTCTACCACAGCCCTGCGGACAACAAGCGGTACATCTTTGCA
GACGCTTATGCCCAGTACCTCTGGATCACGTTTGACTTCTGCAACACTCTTCAAGGCTTTTCCATCCCATTTCGGGCAGCTGATCTCCTC
CTACACAGTAAGGCCTCCAACCTTCTCTTGGGCTTTGACAGGTCCCACCCCAACAAGCAGCTGTGGAAGTCAGATGACTTTGGCCAGACC
TGGATCATGATTCAGGAACATGTCAAGTCCTTTTCTTGGGGAATTGATCCCTATGACAAACCAAATACCATCTACATTGAACGACATGAA
CCCTCTGGCTACTCCACTGTCTTCCGAAGTACAGATTTCTTCCAGTCCCGGGAAAACCAGGAAGTGATCCTTGAGGAAGTGAGAGATTTT
CAGCTTCGGGACAAGTACATGTTTGCTACAAAGGTGGTGCATCTCTTGGGCAGTGAACAGCAGTCTTCTGTCCAGCTCTGGGTCTCCTTT
GGCCGGAAGCCCATGAGAGCAGCCCAGTTTGTCACAAGACATCCTATTAATGAATATTACATCGCAGATGCCTCCGAGGACCAGGTGTTT
GTGTGTGTCAGCCACAGTAACAACCGCACCAATTTATACATCTCAGAGGCAGAGGGGCTGAAGTTCTCCCTGTCCTTGGAGAACGTGCTC
TATTACAGCCCAGGAGGGGCCGGCAGTGACACCTTGGTGAGGTATTTTGCAAATGAACCATTTGCTGACTTCCACCGAGTGGAAGGATTG
CAAGGAGTCTACATTGCTACTCTGATTAATGGTTCTATGAATGAGGAGAACATGAGATCGGTCATCACCTTTGACAAAGGGGGAACCTGG
GAGTTTCTTCAGGCTCCAGCCTTCACGGGATATGGAGAGAAAATCAATTGTGAGCTTTCCCAGGGCTGTTCCCTTCATCTGGCTCAGCGC
CTCAGTCAGCTCCTCAACCTCCAGCTCCGGAGAATGCCCATCCTGTCCAAGGAGTCGGCTCCAGGCCTCATCATCGCCACTGGCTCAGTG
GGAAAGAACTTGGCTAGCAAGACAAACGTGTACATCTCTAGCAGTGCTGGAGCCAGGTGGCGAGAGGCACTTCCTGGACCTCACTACTAC
ACATGGGGAGACCACGGCGGAATCATCACGGCTATTGCCCAGGGCATGGAAACCAACGAGCTAAAGTGTCAGAACCTCAAAGATAACACC
ATTGGCATCGAGGAGAATGCAGTCTCCCTGACCTGTCGCTTTCACGTCACCGTCTTTAAATTCATAGGGGATTACGACGAAGTTCACCTT
CACTGTGCAGTGTCACTCTGCGACTCAGAAAAGTACTCCTGTAAAATCACTTGCCCACACAATTCCAGGATTGCCACAGATTACACAAAA
GAGCCCAAAGAACAGATCATTTCAGTGGGACCTATTAGGAGAAAAAGGCTGGACTGGTGTGAGGACAATGGAGGGTGTGAGCAGATTTGC
ACGAGCCGGGTGGATGGGCCTCTCTGCAGCTGTGTAACAGGAACCCTGCAGGAGGACGGCAAGAGCTGCAGAGCCTCTAATTCTTCAATG

>In-frame_SORL1_ENST00000260197_chr11_121360819_+_TECTA_ENST00000392793_chr11_121058541_+_1227nt
ATGGCGACACGGAGCAGCAGGAGGGAGTCGCGACTCCCGTTCCTATTCACCCTGGTCGCACTGCTGCCGCCCGGAGCTCTCTGCGAAGTC
TGGACGCAGAGGCTGCACGGCGGCAGCGCGCCCTTGCCCCAGGACCGGGGCTTCCTCGTGGTGCAGGGCGACCCGCGCGAGCTGCGGCTG
TGGGCGCGCGGGGATGCCAGGGGGGCGAGCCGCGCGGACGAGAAGCCGCTCCGGAGGAAACGGAGCGCTGCCCTGCAGCCCGAGCCCATC
AAGGTGTACGGACAGGTTAGTCTGAATGATTCCCACAATCAGATGGTGGTGCACTGGGCTGGAGAGAAAAGCAACGTGATCGTGGCCTTG
GCCCGAGATAGCCTGGCATTGGCGAGGCCCAAGAGCAGTGATGTGTACGTGTCTTACGACTATGGAAAATCATTCAAGAAAATTTCAGAC
AAGTTAAACTTTGGCTTGGGAAATAGGAGTGAAGCTGTTATCGCCCAGTTCTACCACAGCCCTGCGGACAACAAGCGGTACATCTTTGCA
GACGCTTATGCCCAGTACCTCTGGATCACGTTTGACTTCTGCAACACTCTTCAAGGCTTTTCCATCCCATTTCGGGCAGCTGATCTCCTC
CTACACAGTAAGGCCTCCAACCTTCTCTTGGGCTTTGACAGGTCCCACCCCAACAAGCAGCTGTGGAAGTCAGATGACTTTGGCCAGACC
TGGATCATGATTCAGGAACATGTCAAGTCCTTTTCTTGGTGTCAGAACCTCAAAGATAACACCATTGGCATCGAGGAGAATGCAGTCTCC
CTGACCTGTCGCTTTCACGTCACCGTCTTTAAATTCATAGGGGATTACGACGAAGTTCACCTTCACTGTGCAGTGTCACTCTGCGACTCA
GAAAAGTACTCCTGTAAAATCACTTGCCCACACAATTCCAGGATTGCCACAGATTACACAAAAGAGCCCAAAGAACAGATCATTTCAGTG
GGACCTATTAGGAGAAAAAGGCTGGACTGGTGTGAGGACAATGGAGGGTGTGAGCAGATTTGCACGAGCCGGGTGGATGGGCCTCTCTGC
AGCTGTGTAACAGGAACCCTGCAGGAGGACGGCAAGAGCTGCAGAGCCTCTAATTCTTCAATGGAACTTCAAGTCTGGACGCTTCTTCTC

>In-frame_SORL1_ENST00000260197_chr11_121360819_+_TECTA_ENST00000264037_chr11_121058541_+_1227nt
ATGGCGACACGGAGCAGCAGGAGGGAGTCGCGACTCCCGTTCCTATTCACCCTGGTCGCACTGCTGCCGCCCGGAGCTCTCTGCGAAGTC
TGGACGCAGAGGCTGCACGGCGGCAGCGCGCCCTTGCCCCAGGACCGGGGCTTCCTCGTGGTGCAGGGCGACCCGCGCGAGCTGCGGCTG
TGGGCGCGCGGGGATGCCAGGGGGGCGAGCCGCGCGGACGAGAAGCCGCTCCGGAGGAAACGGAGCGCTGCCCTGCAGCCCGAGCCCATC
AAGGTGTACGGACAGGTTAGTCTGAATGATTCCCACAATCAGATGGTGGTGCACTGGGCTGGAGAGAAAAGCAACGTGATCGTGGCCTTG
GCCCGAGATAGCCTGGCATTGGCGAGGCCCAAGAGCAGTGATGTGTACGTGTCTTACGACTATGGAAAATCATTCAAGAAAATTTCAGAC
AAGTTAAACTTTGGCTTGGGAAATAGGAGTGAAGCTGTTATCGCCCAGTTCTACCACAGCCCTGCGGACAACAAGCGGTACATCTTTGCA
GACGCTTATGCCCAGTACCTCTGGATCACGTTTGACTTCTGCAACACTCTTCAAGGCTTTTCCATCCCATTTCGGGCAGCTGATCTCCTC
CTACACAGTAAGGCCTCCAACCTTCTCTTGGGCTTTGACAGGTCCCACCCCAACAAGCAGCTGTGGAAGTCAGATGACTTTGGCCAGACC
TGGATCATGATTCAGGAACATGTCAAGTCCTTTTCTTGGTGTCAGAACCTCAAAGATAACACCATTGGCATCGAGGAGAATGCAGTCTCC
CTGACCTGTCGCTTTCACGTCACCGTCTTTAAATTCATAGGGGATTACGACGAAGTTCACCTTCACTGTGCAGTGTCACTCTGCGACTCA
GAAAAGTACTCCTGTAAAATCACTTGCCCACACAATTCCAGGATTGCCACAGATTACACAAAAGAGCCCAAAGAACAGATCATTTCAGTG
GGACCTATTAGGAGAAAAAGGCTGGACTGGTGTGAGGACAATGGAGGGTGTGAGCAGATTTGCACGAGCCGGGTGGATGGGCCTCTCTGC
AGCTGTGTAACAGGAACCCTGCAGGAGGACGGCAAGAGCTGCAGAGCCTCTAATTCTTCAATGGAACTTCAAGTCTGGACGCTTCTTCTC


* Fusion transcript sequences (Full-length transcript).
>In-frame_SORL1_ENST00000260197_chr11_121403261_+_TECTA_ENST00000392793_chr11_121058541_+_2970nt
CCCGGAGCGGCGCGGGCGGCCTGGAGCCCCGGGAGCGGCGCGCGCGGTCCCGGCCCAGCGGCTCTCCTGGCCTCGCGCTGCACATTCTCT
CCTGGCGGCGGCGCCACCTGCAGTAGCGTTCGCCCGAACATGGCGACACGGAGCAGCAGGAGGGAGTCGCGACTCCCGTTCCTATTCACC
CTGGTCGCACTGCTGCCGCCCGGAGCTCTCTGCGAAGTCTGGACGCAGAGGCTGCACGGCGGCAGCGCGCCCTTGCCCCAGGACCGGGGC
TTCCTCGTGGTGCAGGGCGACCCGCGCGAGCTGCGGCTGTGGGCGCGCGGGGATGCCAGGGGGGCGAGCCGCGCGGACGAGAAGCCGCTC
CGGAGGAAACGGAGCGCTGCCCTGCAGCCCGAGCCCATCAAGGTGTACGGACAGGTTAGTCTGAATGATTCCCACAATCAGATGGTGGTG
CACTGGGCTGGAGAGAAAAGCAACGTGATCGTGGCCTTGGCCCGAGATAGCCTGGCATTGGCGAGGCCCAAGAGCAGTGATGTGTACGTG
TCTTACGACTATGGAAAATCATTCAAGAAAATTTCAGACAAGTTAAACTTTGGCTTGGGAAATAGGAGTGAAGCTGTTATCGCCCAGTTC
TACCACAGCCCTGCGGACAACAAGCGGTACATCTTTGCAGACGCTTATGCCCAGTACCTCTGGATCACGTTTGACTTCTGCAACACTCTT
CAAGGCTTTTCCATCCCATTTCGGGCAGCTGATCTCCTCCTACACAGTAAGGCCTCCAACCTTCTCTTGGGCTTTGACAGGTCCCACCCC
AACAAGCAGCTGTGGAAGTCAGATGACTTTGGCCAGACCTGGATCATGATTCAGGAACATGTCAAGTCCTTTTCTTGGGGAATTGATCCC
TATGACAAACCAAATACCATCTACATTGAACGACATGAACCCTCTGGCTACTCCACTGTCTTCCGAAGTACAGATTTCTTCCAGTCCCGG
GAAAACCAGGAAGTGATCCTTGAGGAAGTGAGAGATTTTCAGCTTCGGGACAAGTACATGTTTGCTACAAAGGTGGTGCATCTCTTGGGC
AGTGAACAGCAGTCTTCTGTCCAGCTCTGGGTCTCCTTTGGCCGGAAGCCCATGAGAGCAGCCCAGTTTGTCACAAGACATCCTATTAAT
GAATATTACATCGCAGATGCCTCCGAGGACCAGGTGTTTGTGTGTGTCAGCCACAGTAACAACCGCACCAATTTATACATCTCAGAGGCA
GAGGGGCTGAAGTTCTCCCTGTCCTTGGAGAACGTGCTCTATTACAGCCCAGGAGGGGCCGGCAGTGACACCTTGGTGAGGTATTTTGCA
AATGAACCATTTGCTGACTTCCACCGAGTGGAAGGATTGCAAGGAGTCTACATTGCTACTCTGATTAATGGTTCTATGAATGAGGAGAAC
ATGAGATCGGTCATCACCTTTGACAAAGGGGGAACCTGGGAGTTTCTTCAGGCTCCAGCCTTCACGGGATATGGAGAGAAAATCAATTGT
GAGCTTTCCCAGGGCTGTTCCCTTCATCTGGCTCAGCGCCTCAGTCAGCTCCTCAACCTCCAGCTCCGGAGAATGCCCATCCTGTCCAAG
GAGTCGGCTCCAGGCCTCATCATCGCCACTGGCTCAGTGGGAAAGAACTTGGCTAGCAAGACAAACGTGTACATCTCTAGCAGTGCTGGA
GCCAGGTGGCGAGAGGCACTTCCTGGACCTCACTACTACACATGGGGAGACCACGGCGGAATCATCACGGCTATTGCCCAGGGCATGGAA
ACCAACGAGCTAAAGTGTCAGAACCTCAAAGATAACACCATTGGCATCGAGGAGAATGCAGTCTCCCTGACCTGTCGCTTTCACGTCACC
GTCTTTAAATTCATAGGGGATTACGACGAAGTTCACCTTCACTGTGCAGTGTCACTCTGCGACTCAGAAAAGTACTCCTGTAAAATCACT
TGCCCACACAATTCCAGGATTGCCACAGATTACACAAAAGAGCCCAAAGAACAGATCATTTCAGTGGGACCTATTAGGAGAAAAAGGCTG
GACTGGTGTGAGGACAATGGAGGGTGTGAGCAGATTTGCACGAGCCGGGTGGATGGGCCTCTCTGCAGCTGTGTAACAGGAACCCTGCAG
GAGGACGGCAAGAGCTGCAGAGCCTCTAATTCTTCAATGGAACTTCAAGTCTGGACGCTTCTTCTCATCATGATCCAGATTTCATTATGG
CATTTTGTCTATAAATCAGGCACGACCTCATAATTAACTCAAGGTTGCTATATAAAGTACTGTAATTTACTTACTTCAACACCCTGTAGG
ATAAAAAGTGTGTGCCCTTAAGTCAAAACCTATTTGAAAGTGTCCAGCATCTCAAAATGATGCCACCTGCCTCCAATGGTCCAAGGTCCA
GAAACCAGCGACCATCCAAGCTCCTCTTTCAGAGTATGAAACGGGGCTTCTACAAGCCAGTTATGGAAAGTATCTCTCTTGTGTAAAATT
CCCAAACAGTTGTCACTAGAGACTTTGGTTCACATGAAAAACCAGTAAAGGAAAAAAATTCTGGTTAGAGAAATCTGACTGGAAATCTGA
CCAGAGAAATCTGTCAAGCCAGTGCTATTTCTGGATCACAGTTTTTTACAGAGAGAGGGCCTGTTGGAACGATTTTGAAGTGATGACTGG
AAGGTTTGACTCCCTCTAAGGAATCTTGCTGGTGTTTGGAAGTGTCCGATCTACGTTATGCACGTGTTCTGTCTATGAGGCGCTTCTCCA
CCCACTGTGTCCTTCAACCTTGCCATGGCAGCTTTGGCCACTGGGGATATTGTTGACCTGGGGAACCCCACCCACTCTCCTACCCCCTCG
AACCCAATCCCTTCTCTTTTTACAAATCAACCAAATACTTTTTAATGTGTTTTATCCTTAAATAAACTTTGTGTTCAAGTATTCTCATTA

>In-frame_SORL1_ENST00000260197_chr11_121403261_+_TECTA_ENST00000264037_chr11_121058541_+_2283nt
CCCGGAGCGGCGCGGGCGGCCTGGAGCCCCGGGAGCGGCGCGCGCGGTCCCGGCCCAGCGGCTCTCCTGGCCTCGCGCTGCACATTCTCT
CCTGGCGGCGGCGCCACCTGCAGTAGCGTTCGCCCGAACATGGCGACACGGAGCAGCAGGAGGGAGTCGCGACTCCCGTTCCTATTCACC
CTGGTCGCACTGCTGCCGCCCGGAGCTCTCTGCGAAGTCTGGACGCAGAGGCTGCACGGCGGCAGCGCGCCCTTGCCCCAGGACCGGGGC
TTCCTCGTGGTGCAGGGCGACCCGCGCGAGCTGCGGCTGTGGGCGCGCGGGGATGCCAGGGGGGCGAGCCGCGCGGACGAGAAGCCGCTC
CGGAGGAAACGGAGCGCTGCCCTGCAGCCCGAGCCCATCAAGGTGTACGGACAGGTTAGTCTGAATGATTCCCACAATCAGATGGTGGTG
CACTGGGCTGGAGAGAAAAGCAACGTGATCGTGGCCTTGGCCCGAGATAGCCTGGCATTGGCGAGGCCCAAGAGCAGTGATGTGTACGTG
TCTTACGACTATGGAAAATCATTCAAGAAAATTTCAGACAAGTTAAACTTTGGCTTGGGAAATAGGAGTGAAGCTGTTATCGCCCAGTTC
TACCACAGCCCTGCGGACAACAAGCGGTACATCTTTGCAGACGCTTATGCCCAGTACCTCTGGATCACGTTTGACTTCTGCAACACTCTT
CAAGGCTTTTCCATCCCATTTCGGGCAGCTGATCTCCTCCTACACAGTAAGGCCTCCAACCTTCTCTTGGGCTTTGACAGGTCCCACCCC
AACAAGCAGCTGTGGAAGTCAGATGACTTTGGCCAGACCTGGATCATGATTCAGGAACATGTCAAGTCCTTTTCTTGGGGAATTGATCCC
TATGACAAACCAAATACCATCTACATTGAACGACATGAACCCTCTGGCTACTCCACTGTCTTCCGAAGTACAGATTTCTTCCAGTCCCGG
GAAAACCAGGAAGTGATCCTTGAGGAAGTGAGAGATTTTCAGCTTCGGGACAAGTACATGTTTGCTACAAAGGTGGTGCATCTCTTGGGC
AGTGAACAGCAGTCTTCTGTCCAGCTCTGGGTCTCCTTTGGCCGGAAGCCCATGAGAGCAGCCCAGTTTGTCACAAGACATCCTATTAAT
GAATATTACATCGCAGATGCCTCCGAGGACCAGGTGTTTGTGTGTGTCAGCCACAGTAACAACCGCACCAATTTATACATCTCAGAGGCA
GAGGGGCTGAAGTTCTCCCTGTCCTTGGAGAACGTGCTCTATTACAGCCCAGGAGGGGCCGGCAGTGACACCTTGGTGAGGTATTTTGCA
AATGAACCATTTGCTGACTTCCACCGAGTGGAAGGATTGCAAGGAGTCTACATTGCTACTCTGATTAATGGTTCTATGAATGAGGAGAAC
ATGAGATCGGTCATCACCTTTGACAAAGGGGGAACCTGGGAGTTTCTTCAGGCTCCAGCCTTCACGGGATATGGAGAGAAAATCAATTGT
GAGCTTTCCCAGGGCTGTTCCCTTCATCTGGCTCAGCGCCTCAGTCAGCTCCTCAACCTCCAGCTCCGGAGAATGCCCATCCTGTCCAAG
GAGTCGGCTCCAGGCCTCATCATCGCCACTGGCTCAGTGGGAAAGAACTTGGCTAGCAAGACAAACGTGTACATCTCTAGCAGTGCTGGA
GCCAGGTGGCGAGAGGCACTTCCTGGACCTCACTACTACACATGGGGAGACCACGGCGGAATCATCACGGCTATTGCCCAGGGCATGGAA
ACCAACGAGCTAAAGTGTCAGAACCTCAAAGATAACACCATTGGCATCGAGGAGAATGCAGTCTCCCTGACCTGTCGCTTTCACGTCACC
GTCTTTAAATTCATAGGGGATTACGACGAAGTTCACCTTCACTGTGCAGTGTCACTCTGCGACTCAGAAAAGTACTCCTGTAAAATCACT
TGCCCACACAATTCCAGGATTGCCACAGATTACACAAAAGAGCCCAAAGAACAGATCATTTCAGTGGGACCTATTAGGAGAAAAAGGCTG
GACTGGTGTGAGGACAATGGAGGGTGTGAGCAGATTTGCACGAGCCGGGTGGATGGGCCTCTCTGCAGCTGTGTAACAGGAACCCTGCAG
GAGGACGGCAAGAGCTGCAGAGCCTCTAATTCTTCAATGGAACTTCAAGTCTGGACGCTTCTTCTCATCATGATCCAGATTTCATTATGG

>In-frame_SORL1_ENST00000260197_chr11_121360819_+_TECTA_ENST00000392793_chr11_121058541_+_2043nt
CCCGGAGCGGCGCGGGCGGCCTGGAGCCCCGGGAGCGGCGCGCGCGGTCCCGGCCCAGCGGCTCTCCTGGCCTCGCGCTGCACATTCTCT
CCTGGCGGCGGCGCCACCTGCAGTAGCGTTCGCCCGAACATGGCGACACGGAGCAGCAGGAGGGAGTCGCGACTCCCGTTCCTATTCACC
CTGGTCGCACTGCTGCCGCCCGGAGCTCTCTGCGAAGTCTGGACGCAGAGGCTGCACGGCGGCAGCGCGCCCTTGCCCCAGGACCGGGGC
TTCCTCGTGGTGCAGGGCGACCCGCGCGAGCTGCGGCTGTGGGCGCGCGGGGATGCCAGGGGGGCGAGCCGCGCGGACGAGAAGCCGCTC
CGGAGGAAACGGAGCGCTGCCCTGCAGCCCGAGCCCATCAAGGTGTACGGACAGGTTAGTCTGAATGATTCCCACAATCAGATGGTGGTG
CACTGGGCTGGAGAGAAAAGCAACGTGATCGTGGCCTTGGCCCGAGATAGCCTGGCATTGGCGAGGCCCAAGAGCAGTGATGTGTACGTG
TCTTACGACTATGGAAAATCATTCAAGAAAATTTCAGACAAGTTAAACTTTGGCTTGGGAAATAGGAGTGAAGCTGTTATCGCCCAGTTC
TACCACAGCCCTGCGGACAACAAGCGGTACATCTTTGCAGACGCTTATGCCCAGTACCTCTGGATCACGTTTGACTTCTGCAACACTCTT
CAAGGCTTTTCCATCCCATTTCGGGCAGCTGATCTCCTCCTACACAGTAAGGCCTCCAACCTTCTCTTGGGCTTTGACAGGTCCCACCCC
AACAAGCAGCTGTGGAAGTCAGATGACTTTGGCCAGACCTGGATCATGATTCAGGAACATGTCAAGTCCTTTTCTTGGTGTCAGAACCTC
AAAGATAACACCATTGGCATCGAGGAGAATGCAGTCTCCCTGACCTGTCGCTTTCACGTCACCGTCTTTAAATTCATAGGGGATTACGAC
GAAGTTCACCTTCACTGTGCAGTGTCACTCTGCGACTCAGAAAAGTACTCCTGTAAAATCACTTGCCCACACAATTCCAGGATTGCCACA
GATTACACAAAAGAGCCCAAAGAACAGATCATTTCAGTGGGACCTATTAGGAGAAAAAGGCTGGACTGGTGTGAGGACAATGGAGGGTGT
GAGCAGATTTGCACGAGCCGGGTGGATGGGCCTCTCTGCAGCTGTGTAACAGGAACCCTGCAGGAGGACGGCAAGAGCTGCAGAGCCTCT
AATTCTTCAATGGAACTTCAAGTCTGGACGCTTCTTCTCATCATGATCCAGATTTCATTATGGCATTTTGTCTATAAATCAGGCACGACC
TCATAATTAACTCAAGGTTGCTATATAAAGTACTGTAATTTACTTACTTCAACACCCTGTAGGATAAAAAGTGTGTGCCCTTAAGTCAAA
ACCTATTTGAAAGTGTCCAGCATCTCAAAATGATGCCACCTGCCTCCAATGGTCCAAGGTCCAGAAACCAGCGACCATCCAAGCTCCTCT
TTCAGAGTATGAAACGGGGCTTCTACAAGCCAGTTATGGAAAGTATCTCTCTTGTGTAAAATTCCCAAACAGTTGTCACTAGAGACTTTG
GTTCACATGAAAAACCAGTAAAGGAAAAAAATTCTGGTTAGAGAAATCTGACTGGAAATCTGACCAGAGAAATCTGTCAAGCCAGTGCTA
TTTCTGGATCACAGTTTTTTACAGAGAGAGGGCCTGTTGGAACGATTTTGAAGTGATGACTGGAAGGTTTGACTCCCTCTAAGGAATCTT
GCTGGTGTTTGGAAGTGTCCGATCTACGTTATGCACGTGTTCTGTCTATGAGGCGCTTCTCCACCCACTGTGTCCTTCAACCTTGCCATG
GCAGCTTTGGCCACTGGGGATATTGTTGACCTGGGGAACCCCACCCACTCTCCTACCCCCTCGAACCCAATCCCTTCTCTTTTTACAAAT

>In-frame_SORL1_ENST00000260197_chr11_121360819_+_TECTA_ENST00000264037_chr11_121058541_+_1356nt
CCCGGAGCGGCGCGGGCGGCCTGGAGCCCCGGGAGCGGCGCGCGCGGTCCCGGCCCAGCGGCTCTCCTGGCCTCGCGCTGCACATTCTCT
CCTGGCGGCGGCGCCACCTGCAGTAGCGTTCGCCCGAACATGGCGACACGGAGCAGCAGGAGGGAGTCGCGACTCCCGTTCCTATTCACC
CTGGTCGCACTGCTGCCGCCCGGAGCTCTCTGCGAAGTCTGGACGCAGAGGCTGCACGGCGGCAGCGCGCCCTTGCCCCAGGACCGGGGC
TTCCTCGTGGTGCAGGGCGACCCGCGCGAGCTGCGGCTGTGGGCGCGCGGGGATGCCAGGGGGGCGAGCCGCGCGGACGAGAAGCCGCTC
CGGAGGAAACGGAGCGCTGCCCTGCAGCCCGAGCCCATCAAGGTGTACGGACAGGTTAGTCTGAATGATTCCCACAATCAGATGGTGGTG
CACTGGGCTGGAGAGAAAAGCAACGTGATCGTGGCCTTGGCCCGAGATAGCCTGGCATTGGCGAGGCCCAAGAGCAGTGATGTGTACGTG
TCTTACGACTATGGAAAATCATTCAAGAAAATTTCAGACAAGTTAAACTTTGGCTTGGGAAATAGGAGTGAAGCTGTTATCGCCCAGTTC
TACCACAGCCCTGCGGACAACAAGCGGTACATCTTTGCAGACGCTTATGCCCAGTACCTCTGGATCACGTTTGACTTCTGCAACACTCTT
CAAGGCTTTTCCATCCCATTTCGGGCAGCTGATCTCCTCCTACACAGTAAGGCCTCCAACCTTCTCTTGGGCTTTGACAGGTCCCACCCC
AACAAGCAGCTGTGGAAGTCAGATGACTTTGGCCAGACCTGGATCATGATTCAGGAACATGTCAAGTCCTTTTCTTGGTGTCAGAACCTC
AAAGATAACACCATTGGCATCGAGGAGAATGCAGTCTCCCTGACCTGTCGCTTTCACGTCACCGTCTTTAAATTCATAGGGGATTACGAC
GAAGTTCACCTTCACTGTGCAGTGTCACTCTGCGACTCAGAAAAGTACTCCTGTAAAATCACTTGCCCACACAATTCCAGGATTGCCACA
GATTACACAAAAGAGCCCAAAGAACAGATCATTTCAGTGGGACCTATTAGGAGAAAAAGGCTGGACTGGTGTGAGGACAATGGAGGGTGT
GAGCAGATTTGCACGAGCCGGGTGGATGGGCCTCTCTGCAGCTGTGTAACAGGAACCCTGCAGGAGGACGGCAAGAGCTGCAGAGCCTCT
AATTCTTCAATGGAACTTCAAGTCTGGACGCTTCTTCTCATCATGATCCAGATTTCATTATGGCATTTTGTCTATAAATCAGGCACGACC


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FusionGenePPI for SORL1_TECTA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SORL1LRPAP1, GGA1, GGA2, PPP1CA, CUL1, COPS5, COPS6, FBXO6, CFTR, DYRK3, POP1, AURKA, APP, PACS1, FAM76B, HLA-DPA1, RSPO1, LGALS8, FGL1, LGALS9, DLD, FOSL2, WISP3, SP6, ZFP41, FOXI2, ZNF354C, TYW3, ZNF563, ZNF224, ZNF408, ZNF331, EGFL6, ZNF169, FAM19A3, OS9, ZBBX, ZNF517, ZNF264, PSG1, SREBF1, MDK, SCGB1D1, ZNF816, FAM19A4, SOST, CDHR5, ZNF549, GCNT3, CEP97TECTA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SORL1_TECTA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SORL1_TECTA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSORL1C0008370Cholestasis1CTD_human
HgeneSORL1C0027626Neoplasm Invasiveness1CTD_human
HgeneSORL1C4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneTECTAC1832187Deafness, Autosomal Dominant 128CTD_human;UNIPROT