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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35414

FusionGeneSummary for SORL1_SYTL2

check button Fusion gene summary
Fusion gene informationFusion gene name: SORL1_SYTL2
Fusion gene ID: 35414
HgeneTgene
Gene symbol

SORL1

SYTL2

Gene ID

6653

54843

Gene namesortilin related receptor 1synaptotagmin like 2
SynonymsC11orf32|LR11|LRP9|SORLA|SorLA-1|gp250CHR11SYT|EXO4|PPP1R151|SGA72M|SLP2|SLP2A
Cytomap

11q24.1

11q14.1

Type of geneprotein-codingprotein-coding
Descriptionsortilin-related receptorLDLR relative with 11 ligand-binding repeatslow-density lipoprotein receptor relative with 11 ligand-binding repeatsmosaic protein LR11sortilin-related receptor, L(DLR class) A repeats containingsorting protein-related receptsynaptotagmin-like protein 2breast cancer-associated antigen SGA-72Mchromosome 11 synaptotagminexophilin-4protein phosphatase 1, regulatory subunit 151
Modification date2018052720180523
UniProtAcc

Q92673

Q9HCH5

Ensembl transtripts involved in fusion geneENST00000260197, ENST00000532451, 
ENST00000525532, ENST00000532694, 
ENST00000534286, ENST00000527934, 
ENST00000389960, ENST00000316356, 
ENST00000528231, ENST00000527523, 
ENST00000524452, ENST00000359152, 
ENST00000354566, ENST00000525702, 
ENST00000525423, ENST00000529581, 
ENST00000389958, ENST00000533892, 
ENST00000528566, 
Fusion gene scores* DoF score13 X 10 X 7=9104 X 4 X 4=64
# samples 144
** MAII scorelog2(14/910*10)=-2.70043971814109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SORL1 [Title/Abstract] AND SYTL2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSORL1

GO:0006605

protein targeting

16407538

HgeneSORL1

GO:0006622

protein targeting to lysosome

24523320

HgeneSORL1

GO:0006892

post-Golgi vesicle-mediated transport

17855360

HgeneSORL1

GO:0014910

regulation of smooth muscle cell migration

14764453

HgeneSORL1

GO:0032091

negative regulation of protein binding

16407538

HgeneSORL1

GO:0034067

protein localization to Golgi apparatus

17855360

HgeneSORL1

GO:0045053

protein retention in Golgi apparatus

17855360

HgeneSORL1

GO:0045732

positive regulation of protein catabolic process

24523320

HgeneSORL1

GO:0051604

protein maturation

17855360

HgeneSORL1

GO:1902430

negative regulation of amyloid-beta formation

16407538|22621900

HgeneSORL1

GO:1902960

negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process

16407538

TgeneSYTL2

GO:0006887

exocytosis

18812475

TgeneSYTL2

GO:0006904

vesicle docking involved in exocytosis

18812475

TgeneSYTL2

GO:0010923

negative regulation of phosphatase activity

19389623


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-38-4632-01ASORL1chr11

121466481

+SYTL2chr11

85428573

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000260197ENST00000389960SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000260197ENST00000316356SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000260197ENST00000528231SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000260197ENST00000527523SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000260197ENST00000524452SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000260197ENST00000359152SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000260197ENST00000354566SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000260197ENST00000525702SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000260197ENST00000525423SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-5UTRENST00000260197ENST00000529581SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000260197ENST00000389958SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-5UTRENST00000260197ENST00000533892SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000260197ENST00000528566SORL1chr11

121466481

+SYTL2chr11

85428573

-
intron-3CDSENST00000532451ENST00000389960SORL1chr11

121466481

+SYTL2chr11

85428573

-
intron-intronENST00000532451ENST00000316356SORL1chr11

121466481

+SYTL2chr11

85428573

-
intron-intronENST00000532451ENST00000528231SORL1chr11

121466481

+SYTL2chr11

85428573

-
intron-intronENST00000532451ENST00000527523SORL1chr11

121466481

+SYTL2chr11

85428573

-
intron-intronENST00000532451ENST00000524452SORL1chr11

121466481

+SYTL2chr11

85428573

-
intron-intronENST00000532451ENST00000359152SORL1chr11

121466481

+SYTL2chr11

85428573

-
intron-intronENST00000532451ENST00000354566SORL1chr11

121466481

+SYTL2chr11

85428573

-
intron-intronENST00000532451ENST00000525702SORL1chr11

121466481

+SYTL2chr11

85428573

-
intron-intronENST00000532451ENST00000525423SORL1chr11

121466481

+SYTL2chr11

85428573

-
intron-5UTRENST00000532451ENST00000529581SORL1chr11

121466481

+SYTL2chr11

85428573

-
intron-intronENST00000532451ENST00000389958SORL1chr11

121466481

+SYTL2chr11

85428573

-
intron-5UTRENST00000532451ENST00000533892SORL1chr11

121466481

+SYTL2chr11

85428573

-
intron-intronENST00000532451ENST00000528566SORL1chr11

121466481

+SYTL2chr11

85428573

-
In-frameENST00000525532ENST00000389960SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000525532ENST00000316356SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000525532ENST00000528231SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000525532ENST00000527523SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000525532ENST00000524452SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000525532ENST00000359152SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000525532ENST00000354566SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000525532ENST00000525702SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000525532ENST00000525423SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-5UTRENST00000525532ENST00000529581SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000525532ENST00000389958SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-5UTRENST00000525532ENST00000533892SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000525532ENST00000528566SORL1chr11

121466481

+SYTL2chr11

85428573

-
In-frameENST00000532694ENST00000389960SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000532694ENST00000316356SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000532694ENST00000528231SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000532694ENST00000527523SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000532694ENST00000524452SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000532694ENST00000359152SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000532694ENST00000354566SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000532694ENST00000525702SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000532694ENST00000525423SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-5UTRENST00000532694ENST00000529581SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000532694ENST00000389958SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-5UTRENST00000532694ENST00000533892SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000532694ENST00000528566SORL1chr11

121466481

+SYTL2chr11

85428573

-
In-frameENST00000534286ENST00000389960SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000534286ENST00000316356SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000534286ENST00000528231SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000534286ENST00000527523SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000534286ENST00000524452SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000534286ENST00000359152SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000534286ENST00000354566SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000534286ENST00000525702SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000534286ENST00000525423SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-5UTRENST00000534286ENST00000529581SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000534286ENST00000389958SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-5UTRENST00000534286ENST00000533892SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000534286ENST00000528566SORL1chr11

121466481

+SYTL2chr11

85428573

-
In-frameENST00000527934ENST00000389960SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000527934ENST00000316356SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000527934ENST00000528231SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000527934ENST00000527523SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000527934ENST00000524452SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000527934ENST00000359152SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000527934ENST00000354566SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000527934ENST00000525702SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000527934ENST00000525423SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-5UTRENST00000527934ENST00000529581SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000527934ENST00000389958SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-5UTRENST00000527934ENST00000533892SORL1chr11

121466481

+SYTL2chr11

85428573

-
5CDS-intronENST00000527934ENST00000528566SORL1chr11

121466481

+SYTL2chr11

85428573

-

Top

FusionProtFeatures for SORL1_SYTL2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SORL1

Q92673

SYTL2

Q9HCH5

Likely to be a multifunctional endocytic receptor, thatmay be implicated in the uptake of lipoproteins and of proteases.Binds LDL, the major cholesterol-carrying lipoprotein of plasma,and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cellinteraction. Involved in APP trafficking to and from the Golgiapparatus. It probably acts as a sorting receptor that protectsAPP from trafficking to late endosome and from processing intoamyloid beta, thereby reducing the burden of amyloidogenic peptideformation. Involved in the regulation of smooth muscle cellsmigration, probably through PLAUR binding and decreasedinternalization. {ECO:0000269|PubMed:14764453,ECO:0000269|PubMed:16174740}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+32481026_107215062215DomainNote=EGF-like
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+32481076_111415062215DomainLDL-receptor class A 1
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+32481115_115515062215DomainLDL-receptor class A 2
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+32481156_119415062215DomainLDL-receptor class A 3
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+32481198_123615062215DomainLDL-receptor class A 4
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+32481238_127215062215DomainLDL-receptor class A 5
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+32481273_131715062215DomainLDL-receptor class A 6
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+32481323_136115062215DomainLDL-receptor class A 7
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+32481366_140515062215DomainLDL-receptor class A 8
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+32481417_145515062215DomainLDL-receptor class A 9
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+32481469_150815062215DomainLDL-receptor class A 10
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+324863_6515062215MotifCell attachment site
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+3248136_14715062215RepeatNote=BNR 1
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+3248232_24315062215RepeatNote=BNR 2
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+3248441_45215062215RepeatNote=BNR 3
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+3248521_53215062215RepeatNote=BNR 4
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+3248562_57315062215RepeatNote=BNR 5
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+3248800_84315062215RepeatNote=LDL-receptor class B 1
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+3248844_88715062215RepeatNote=LDL-receptor class B 2
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+3248888_93215062215RepeatNote=LDL-receptor class B 3
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+3248933_97015062215RepeatNote=LDL-receptor class B 4
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+3248971_101315062215RepeatNote=LDL-receptor class B 5
TgeneSYTL2chr11:121466481chr11:85428573ENST00000316356-019579_619-189936Compositional biasNote=Ser-rich
TgeneSYTL2chr11:121466481chr11:85428573ENST00000389958-09579_619-126366Compositional biasNote=Ser-rich
TgeneSYTL2chr11:121466481chr11:85428573ENST00000389960-919579_619538911Compositional biasNote=Ser-rich
TgeneSYTL2chr11:121466481chr11:85428573ENST00000524452-818579_619538911Compositional biasNote=Ser-rich
TgeneSYTL2chr11:121466481chr11:85428573ENST00000525423-012579_619-5241257Compositional biasNote=Ser-rich
TgeneSYTL2chr11:121466481chr11:85428573ENST00000525702-09579_619-230377Compositional biasNote=Ser-rich
TgeneSYTL2chr11:121466481chr11:85428573ENST00000527523-819579_619490903Compositional biasNote=Ser-rich
TgeneSYTL2chr11:121466481chr11:85428573ENST00000528231-018579_619-93935Compositional biasNote=Ser-rich
TgeneSYTL2chr11:121466481chr11:85428573ENST00000529581-112579_619-36377Compositional biasNote=Ser-rich
TgeneSYTL2chr11:121466481chr11:85428573ENST00000533892-111579_619-36337Compositional biasNote=Ser-rich
TgeneSYTL2chr11:121466481chr11:85428573ENST00000316356-0191_57-189936DomainRabBD
TgeneSYTL2chr11:121466481chr11:85428573ENST00000316356-019629_733-189936DomainC2 1
TgeneSYTL2chr11:121466481chr11:85428573ENST00000316356-019778_880-189936DomainC2 2
TgeneSYTL2chr11:121466481chr11:85428573ENST00000389958-091_57-126366DomainRabBD
TgeneSYTL2chr11:121466481chr11:85428573ENST00000389958-09629_733-126366DomainC2 1
TgeneSYTL2chr11:121466481chr11:85428573ENST00000389958-09778_880-126366DomainC2 2
TgeneSYTL2chr11:121466481chr11:85428573ENST00000389960-919629_733538911DomainC2 1
TgeneSYTL2chr11:121466481chr11:85428573ENST00000389960-919778_880538911DomainC2 2
TgeneSYTL2chr11:121466481chr11:85428573ENST00000524452-818629_733538911DomainC2 1
TgeneSYTL2chr11:121466481chr11:85428573ENST00000524452-818778_880538911DomainC2 2
TgeneSYTL2chr11:121466481chr11:85428573ENST00000525423-0121_57-5241257DomainRabBD
TgeneSYTL2chr11:121466481chr11:85428573ENST00000525423-012629_733-5241257DomainC2 1
TgeneSYTL2chr11:121466481chr11:85428573ENST00000525423-012778_880-5241257DomainC2 2
TgeneSYTL2chr11:121466481chr11:85428573ENST00000525702-091_57-230377DomainRabBD
TgeneSYTL2chr11:121466481chr11:85428573ENST00000525702-09629_733-230377DomainC2 1
TgeneSYTL2chr11:121466481chr11:85428573ENST00000525702-09778_880-230377DomainC2 2
TgeneSYTL2chr11:121466481chr11:85428573ENST00000527523-819629_733490903DomainC2 1
TgeneSYTL2chr11:121466481chr11:85428573ENST00000527523-819778_880490903DomainC2 2
TgeneSYTL2chr11:121466481chr11:85428573ENST00000528231-0181_57-93935DomainRabBD
TgeneSYTL2chr11:121466481chr11:85428573ENST00000528231-018629_733-93935DomainC2 1
TgeneSYTL2chr11:121466481chr11:85428573ENST00000528231-018778_880-93935DomainC2 2
TgeneSYTL2chr11:121466481chr11:85428573ENST00000529581-1121_57-36377DomainRabBD
TgeneSYTL2chr11:121466481chr11:85428573ENST00000529581-112629_733-36377DomainC2 1
TgeneSYTL2chr11:121466481chr11:85428573ENST00000529581-112778_880-36377DomainC2 2
TgeneSYTL2chr11:121466481chr11:85428573ENST00000533892-1111_57-36337DomainRabBD
TgeneSYTL2chr11:121466481chr11:85428573ENST00000533892-111629_733-36337DomainC2 1
TgeneSYTL2chr11:121466481chr11:85428573ENST00000533892-111778_880-36337DomainC2 2

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+32481512_155115062215DomainLDL-receptor class A 11
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+32481557_164915062215DomainFibronectin type-III 1
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+32481653_174515062215DomainFibronectin type-III 2
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+32481749_184415062215DomainFibronectin type-III 3
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+32481843_192715062215DomainFibronectin type-III 4
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+32481934_202915062215DomainFibronectin type-III 5
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+32482030_211815062215DomainFibronectin type-III 6
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+32482172_217715062215MotifEndocytosis signal
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+32482159_221415062215Topological domainCytoplasmic
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+324882_213715062215Topological domainExtracellular
HgeneSORL1chr11:121466481chr11:85428573ENST00000260197+32482138_215815062215TransmembraneHelical
TgeneSYTL2chr11:121466481chr11:85428573ENST00000354566-213579_6198601273Compositional biasNote=Ser-rich
TgeneSYTL2chr11:121466481chr11:85428573ENST00000354566-2131_578601273DomainRabBD
TgeneSYTL2chr11:121466481chr11:85428573ENST00000354566-213629_7338601273DomainC2 1
TgeneSYTL2chr11:121466481chr11:85428573ENST00000354566-213778_8808601273DomainC2 2
TgeneSYTL2chr11:121466481chr11:85428573ENST00000389960-9191_57538911DomainRabBD
TgeneSYTL2chr11:121466481chr11:85428573ENST00000524452-8181_57538911DomainRabBD
TgeneSYTL2chr11:121466481chr11:85428573ENST00000527523-8191_57490903DomainRabBD


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FusionGeneSequence for SORL1_SYTL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_SORL1_ENST00000260197_chr11_121466481_+_SYTL2_ENST00000389960_chr11_85428573_-_1879aa
MATRSSRRESRLPFLFTLVALLPPGALCEVWTQRLHGGSAPLPQDRGFLVVQGDPRELRLWARGDARGASRADEKPLRRKRSAALQPEPI
KVYGQVSLNDSHNQMVVHWAGEKSNVIVALARDSLALARPKSSDVYVSYDYGKSFKKISDKLNFGLGNRSEAVIAQFYHSPADNKRYIFA
DAYAQYLWITFDFCNTLQGFSIPFRAADLLLHSKASNLLLGFDRSHPNKQLWKSDDFGQTWIMIQEHVKSFSWGIDPYDKPNTIYIERHE
PSGYSTVFRSTDFFQSRENQEVILEEVRDFQLRDKYMFATKVVHLLGSEQQSSVQLWVSFGRKPMRAAQFVTRHPINEYYIADASEDQVF
VCVSHSNNRTNLYISEAEGLKFSLSLENVLYYSPGGAGSDTLVRYFANEPFADFHRVEGLQGVYIATLINGSMNEENMRSVITFDKGGTW
EFLQAPAFTGYGEKINCELSQGCSLHLAQRLSQLLNLQLRRMPILSKESAPGLIIATGSVGKNLASKTNVYISSSAGARWREALPGPHYY
TWGDHGGIITAIAQGMETNELKYSTNEGETWKTFIFSEKPVFVYGLLTEPGEKSTVFTIFGSNKENVHSWLILQVNATDALGVPCTENDY
KLWSPSDERGNECLLGHKTVFKRRTPHATCFNGEDFDRPVVVSNCSCTREDYECDFGFKMSEDLSLEVCVPDPEFSGKSYSPPVPCPVGS
TYRRTRGYRKISGDTCSGGDVEARLEGELVPCPLAEENEFILYAVRKSIYRYDLASGATEQLPLTGLRAAVALDFDYEHNCLYWSDLALD
VIQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKP
GIYRSNMDGSAAYHLVSEDVKWPNGISVDDQWIYWTDAYLECIERITFSGQQRSVILDNLPHPYAIAVFKNEIYWDDWSQLSIFRASKYS
GSQMEILANQLTGLMDMKIFYKGKNTGSNACVPRPCSLLCLPKANNSRSCRCPEDVSSSVLPSGDLMCDCPQGYQLKNNTCVKQENTCLR
NQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMC
IRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCNGFRCPNGTCIPSSKHCDGLR
DCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDC
GDYSDEANCENPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDG
YRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCHEKPDQKPVTNECVPRISTVPTQP
DNPFSHPDKLKRMSKSVPAFLQDEVSGSVMSVYSGDFGNLEVKGNIQFAIEYVESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPD
KGKMGKKKTLVVKKTLNPVYNEILRYKIEKQILKTQKLNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEA
ENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPED

>In-frame_SORL1_ENST00000525532_chr11_121466481_+_SYTL2_ENST00000389960_chr11_85428573_-_823aa
MCDCPQGYQLKNNTCVKQENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQESGTCIPLSYKCDLEDDCGD
NSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCE
KKCNGFRCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCD
EFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGP
STCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANC
HEKPDQKPVTNECVPRISTVPTQPDNPFSHPDKLKRMSKSVPAFLQDEVSGSVMSVYSGDFGNLEVKGNIQFAIEYVESLKELHVFVAQC
KDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYKIEKQILKTQKLNLSIWHRDTFKRNSFLGEVELDLETWDW
DNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKT
RAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDWMDSTSEEVALWEKMVNSPNTWIEATL

>In-frame_SORL1_ENST00000532694_chr11_121466481_+_SYTL2_ENST00000389960_chr11_85428573_-_725aa
MHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCNGFRC
PNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQN
GVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYY
RCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCHEKPDQKP
VTNECVPRISTVPTQPDNPFSHPDKLKRMSKSVPAFLQDEVSGSVMSVYSGDFGNLEVKGNIQFAIEYVESLKELHVFVAQCKDLAAADV
KKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYKIEKQILKTQKLNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQL
RWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTN
PIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDWMDSTSEEVALWEKMVNSPNTWIEATLPLRMLLIA

>In-frame_SORL1_ENST00000534286_chr11_121466481_+_SYTL2_ENST00000389960_chr11_85428573_-_789aa
MQTSRHSFSQTTGCVCRSPLFLESSTSWPPLSLLPNLLPIIASIENNICGEHWDEWTRMLLSREMHQCRSDEYNCSSGMCIRSSWVCDGD
NDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCNGFRCPNGTCIPSSKHCDGLRDCSDGSDEQH
CEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCE
NPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDE
EACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCHEKPDQKPVTNECVPRISTVPTQPDNPFSHPDKL
KRMSKSVPAFLQDEVSGSVMSVYSGDFGNLEVKGNIQFAIEYVESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTL
VVKKTLNPVYNEILRYKIEKQILKTQKLNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLAL
QYVPEPVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTV

>In-frame_SORL1_ENST00000527934_chr11_121466481_+_SYTL2_ENST00000389960_chr11_85428573_-_494aa
MISRLAAAQSCASHWPPSADSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFE
FECHQPKTCIPNWKRCDGHQDCQDGRDEANCHEKPDQKPVTNECVPRISTVPTQPDNPFSHPDKLKRMSKSVPAFLQDEVSGSVMSVYSG
DFGNLEVKGNIQFAIEYVESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYKIEKQILKT
QKLNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKEC
LDLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYG


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_SORL1_ENST00000260197_chr11_121466481_+_SYTL2_ENST00000389960_chr11_85428573_-_5637nt
ATGGCGACACGGAGCAGCAGGAGGGAGTCGCGACTCCCGTTCCTATTCACCCTGGTCGCACTGCTGCCGCCCGGAGCTCTCTGCGAAGTC
TGGACGCAGAGGCTGCACGGCGGCAGCGCGCCCTTGCCCCAGGACCGGGGCTTCCTCGTGGTGCAGGGCGACCCGCGCGAGCTGCGGCTG
TGGGCGCGCGGGGATGCCAGGGGGGCGAGCCGCGCGGACGAGAAGCCGCTCCGGAGGAAACGGAGCGCTGCCCTGCAGCCCGAGCCCATC
AAGGTGTACGGACAGGTTAGTCTGAATGATTCCCACAATCAGATGGTGGTGCACTGGGCTGGAGAGAAAAGCAACGTGATCGTGGCCTTG
GCCCGAGATAGCCTGGCATTGGCGAGGCCCAAGAGCAGTGATGTGTACGTGTCTTACGACTATGGAAAATCATTCAAGAAAATTTCAGAC
AAGTTAAACTTTGGCTTGGGAAATAGGAGTGAAGCTGTTATCGCCCAGTTCTACCACAGCCCTGCGGACAACAAGCGGTACATCTTTGCA
GACGCTTATGCCCAGTACCTCTGGATCACGTTTGACTTCTGCAACACTCTTCAAGGCTTTTCCATCCCATTTCGGGCAGCTGATCTCCTC
CTACACAGTAAGGCCTCCAACCTTCTCTTGGGCTTTGACAGGTCCCACCCCAACAAGCAGCTGTGGAAGTCAGATGACTTTGGCCAGACC
TGGATCATGATTCAGGAACATGTCAAGTCCTTTTCTTGGGGAATTGATCCCTATGACAAACCAAATACCATCTACATTGAACGACATGAA
CCCTCTGGCTACTCCACTGTCTTCCGAAGTACAGATTTCTTCCAGTCCCGGGAAAACCAGGAAGTGATCCTTGAGGAAGTGAGAGATTTT
CAGCTTCGGGACAAGTACATGTTTGCTACAAAGGTGGTGCATCTCTTGGGCAGTGAACAGCAGTCTTCTGTCCAGCTCTGGGTCTCCTTT
GGCCGGAAGCCCATGAGAGCAGCCCAGTTTGTCACAAGACATCCTATTAATGAATATTACATCGCAGATGCCTCCGAGGACCAGGTGTTT
GTGTGTGTCAGCCACAGTAACAACCGCACCAATTTATACATCTCAGAGGCAGAGGGGCTGAAGTTCTCCCTGTCCTTGGAGAACGTGCTC
TATTACAGCCCAGGAGGGGCCGGCAGTGACACCTTGGTGAGGTATTTTGCAAATGAACCATTTGCTGACTTCCACCGAGTGGAAGGATTG
CAAGGAGTCTACATTGCTACTCTGATTAATGGTTCTATGAATGAGGAGAACATGAGATCGGTCATCACCTTTGACAAAGGGGGAACCTGG
GAGTTTCTTCAGGCTCCAGCCTTCACGGGATATGGAGAGAAAATCAATTGTGAGCTTTCCCAGGGCTGTTCCCTTCATCTGGCTCAGCGC
CTCAGTCAGCTCCTCAACCTCCAGCTCCGGAGAATGCCCATCCTGTCCAAGGAGTCGGCTCCAGGCCTCATCATCGCCACTGGCTCAGTG
GGAAAGAACTTGGCTAGCAAGACAAACGTGTACATCTCTAGCAGTGCTGGAGCCAGGTGGCGAGAGGCACTTCCTGGACCTCACTACTAC
ACATGGGGAGACCACGGCGGAATCATCACGGCTATTGCCCAGGGCATGGAAACCAACGAGCTAAAATACAGTACCAATGAAGGGGAGACC
TGGAAAACATTCATCTTCTCTGAGAAGCCAGTGTTTGTGTATGGCCTCCTCACAGAACCTGGGGAGAAGAGCACTGTCTTCACCATCTTT
GGCTCGAACAAAGAGAATGTCCACAGCTGGCTGATCCTCCAGGTCAATGCCACGGATGCCTTGGGAGTTCCCTGCACAGAGAATGACTAC
AAGCTGTGGTCACCATCTGATGAGCGGGGGAATGAGTGTTTGCTGGGACACAAGACTGTTTTCAAACGGCGGACCCCCCATGCCACATGC
TTCAATGGAGAGGACTTTGACAGGCCGGTGGTCGTGTCCAACTGCTCCTGCACCCGGGAGGACTATGAGTGTGACTTCGGTTTCAAGATG
AGTGAAGATTTGTCATTAGAGGTTTGTGTTCCAGATCCGGAATTTTCTGGAAAGTCATACTCCCCTCCTGTGCCTTGCCCTGTGGGTTCT
ACTTACAGGAGAACGAGAGGCTACCGGAAGATTTCTGGGGACACTTGTAGCGGAGGAGATGTTGAAGCGCGACTGGAAGGAGAGCTGGTC
CCCTGTCCCCTGGCAGAAGAGAACGAGTTCATTCTGTATGCTGTGAGGAAATCCATCTACCGCTATGACCTGGCCTCGGGAGCCACCGAG
CAGTTGCCTCTCACCGGGCTACGGGCAGCAGTGGCCCTGGACTTTGACTATGAGCACAACTGTTTGTATTGGTCCGACCTGGCCTTGGAC
GTCATCCAGCGCCTCTGTTTGAATGGAAGCACAGGGCAAGAGGTGATCATCAATTCTGGCCTGGAGACAGTAGAAGCTTTGGCTTTTGAA
CCCCTCAGCCAGCTGCTTTACTGGGTAGATGCAGGCTTCAAAAAGATTGAGGTAGCTAATCCAGATGGCGACTTCCGACTCACAATCGTC
AATTCCTCTGTGCTTGATCGTCCCAGGGCTCTGGTCCTCGTGCCCCAAGAGGGGGTGATGTTCTGGACAGACTGGGGAGACCTGAAGCCT
GGGATTTATCGGAGCAATATGGATGGTTCTGCTGCCTATCACCTGGTGTCTGAGGATGTGAAGTGGCCCAATGGCATCTCTGTGGACGAC
CAGTGGATTTACTGGACGGATGCCTACCTGGAGTGCATAGAGCGGATCACGTTCAGTGGCCAGCAGCGCTCTGTCATTCTGGACAACCTC
CCGCACCCCTATGCCATTGCTGTCTTTAAGAATGAAATCTACTGGGATGACTGGTCACAGCTCAGCATATTCCGAGCTTCCAAATACAGT
GGGTCCCAGATGGAGATTCTGGCAAACCAGCTCACGGGGCTCATGGACATGAAGATTTTCTACAAGGGGAAGAACACTGGAAGCAATGCC
TGTGTGCCCAGGCCATGCAGCCTGCTGTGCCTGCCCAAGGCCAACAACAGTAGAAGCTGCAGGTGTCCAGAGGATGTGTCCAGCAGTGTG
CTTCCATCAGGGGACCTGATGTGTGACTGCCCTCAGGGCTATCAGCTCAAGAACAATACCTGTGTCAAACAAGAGAACACCTGTCTTCGC
AACCAGTATCGCTGCAGCAACGGGAACTGTATCAACAGCATTTGGTGGTGTGACTTTGACAACGACTGTGGAGACATGAGCGATGAGAGA
AACTGCCCTACCACCATCTGTGACCTGGACACCCAGTTTCGTTGCCAGGAGTCTGGGACTTGTATCCCACTGTCCTATAAATGTGACCTT
GAGGATGACTGTGGAGACAACAGTGATGAAAGTCATTGTGAAATGCACCAGTGCCGGAGTGACGAGTACAACTGCAGTTCCGGCATGTGC
ATCCGCTCCTCCTGGGTATGTGACGGGGACAACGACTGCAGGGACTGGTCTGATGAAGCCAACTGTACCGCCATCTATCACACCTGTGAG
GCCTCCAACTTCCAGTGCCGAAACGGGCACTGCATCCCCCAGCGGTGGGCGTGTGACGGGGATACGGACTGCCAGGATGGTTCCGATGAG
GATCCAGTCAACTGTGAGAAGAAGTGCAATGGATTCCGCTGCCCAAACGGCACTTGCATCCCATCCAGCAAACATTGTGATGGTCTGCGT
GATTGCTCTGATGGCTCCGATGAACAGCACTGCGAGCCCCTCTGTACGCACTTCATGGACTTTGTGTGTAAGAACCGCCAGCAGTGCCTG
TTCCACTCCATGGTCTGTGACGGAATCATCCAGTGCCGCGACGGGTCCGATGAGGATGCGGCGTTTGCAGGATGCTCCCAAGATCCTGAG
TTCCACAAGGTATGTGATGAGTTCGGTTTCCAGTGTCAGAATGGAGTGTGCATCAGTTTGATTTGGAAGTGCGACGGGATGGATGATTGC
GGCGATTATTCTGATGAAGCCAACTGCGAAAACCCCACAGAAGCCCCAAACTGCTCCCGCTACTTCCAGTTTCGGTGTGAGAATGGCCAC
TGCATCCCCAACAGATGGAAATGTGACAGGGAGAACGACTGTGGGGACTGGTCTGATGAGAAGGATTGTGGAGATTCACATATTCTTCCC
TTCTCGACTCCTGGGCCCTCCACGTGTCTGCCCAATTACTACCGCTGCAGCAGTGGGACCTGCGTGATGGACACCTGGGTGTGCGACGGG
TACCGAGATTGTGCAGATGGCTCTGACGAGGAAGCCTGCCCCTTGCTTGCAAACGTCACTGCTGCCTCCACTCCCACCCAACTTGGGCGA
TGTGACCGATTTGAGTTCGAATGCCACCAACCGAAGACGTGTATTCCCAACTGGAAGCGCTGTGACGGCCACCAAGATTGCCAGGATGGC
CGGGACGAGGCCAATTGCCATGAGAAACCAGATCAGAAGCCAGTTACAAATGAATGCGTACCAAGAATTTCCACAGTGCCTACACAACCT
GATAATCCATTTTCTCACCCTGACAAACTCAAAAGGATGAGCAAGTCTGTTCCAGCATTTCTCCAAGATGAGGTGAGTGGCAGTGTGATG
AGTGTTTATAGTGGAGACTTTGGCAATCTGGAAGTTAAAGGAAATATTCAGTTTGCAATTGAATATGTGGAGTCACTGAAGGAGTTGCAT
GTTTTTGTGGCCCAGTGTAAGGACTTAGCAGCAGCGGATGTAAAAAAACAGCGTTCAGACCCATATGTAAAGGCCTATTTGCTACCAGAC
AAAGGCAAAATGGGCAAGAAGAAAACACTCGTAGTGAAGAAAACCTTGAATCCTGTGTATAACGAAATACTGCGGTATAAAATTGAAAAA
CAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGAT
TTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCA
GAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATC
TGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGG
AAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGAT
CTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACA
GGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACT

>In-frame_SORL1_ENST00000525532_chr11_121466481_+_SYTL2_ENST00000389960_chr11_85428573_-_2469nt
ATGTGTGACTGCCCTCAGGGCTATCAGCTCAAGAACAATACCTGTGTCAAACAAGAGAACACCTGTCTTCGCAACCAGTATCGCTGCAGC
AACGGGAACTGTATCAACAGCATTTGGTGGTGTGACTTTGACAACGACTGTGGAGACATGAGCGATGAGAGAAACTGCCCTACCACCATC
TGTGACCTGGACACCCAGTTTCGTTGCCAGGAGTCTGGGACTTGTATCCCACTGTCCTATAAATGTGACCTTGAGGATGACTGTGGAGAC
AACAGTGATGAAAGTCATTGTGAAATGCACCAGTGCCGGAGTGACGAGTACAACTGCAGTTCCGGCATGTGCATCCGCTCCTCCTGGGTA
TGTGACGGGGACAACGACTGCAGGGACTGGTCTGATGAAGCCAACTGTACCGCCATCTATCACACCTGTGAGGCCTCCAACTTCCAGTGC
CGAAACGGGCACTGCATCCCCCAGCGGTGGGCGTGTGACGGGGATACGGACTGCCAGGATGGTTCCGATGAGGATCCAGTCAACTGTGAG
AAGAAGTGCAATGGATTCCGCTGCCCAAACGGCACTTGCATCCCATCCAGCAAACATTGTGATGGTCTGCGTGATTGCTCTGATGGCTCC
GATGAACAGCACTGCGAGCCCCTCTGTACGCACTTCATGGACTTTGTGTGTAAGAACCGCCAGCAGTGCCTGTTCCACTCCATGGTCTGT
GACGGAATCATCCAGTGCCGCGACGGGTCCGATGAGGATGCGGCGTTTGCAGGATGCTCCCAAGATCCTGAGTTCCACAAGGTATGTGAT
GAGTTCGGTTTCCAGTGTCAGAATGGAGTGTGCATCAGTTTGATTTGGAAGTGCGACGGGATGGATGATTGCGGCGATTATTCTGATGAA
GCCAACTGCGAAAACCCCACAGAAGCCCCAAACTGCTCCCGCTACTTCCAGTTTCGGTGTGAGAATGGCCACTGCATCCCCAACAGATGG
AAATGTGACAGGGAGAACGACTGTGGGGACTGGTCTGATGAGAAGGATTGTGGAGATTCACATATTCTTCCCTTCTCGACTCCTGGGCCC
TCCACGTGTCTGCCCAATTACTACCGCTGCAGCAGTGGGACCTGCGTGATGGACACCTGGGTGTGCGACGGGTACCGAGATTGTGCAGAT
GGCTCTGACGAGGAAGCCTGCCCCTTGCTTGCAAACGTCACTGCTGCCTCCACTCCCACCCAACTTGGGCGATGTGACCGATTTGAGTTC
GAATGCCACCAACCGAAGACGTGTATTCCCAACTGGAAGCGCTGTGACGGCCACCAAGATTGCCAGGATGGCCGGGACGAGGCCAATTGC
CATGAGAAACCAGATCAGAAGCCAGTTACAAATGAATGCGTACCAAGAATTTCCACAGTGCCTACACAACCTGATAATCCATTTTCTCAC
CCTGACAAACTCAAAAGGATGAGCAAGTCTGTTCCAGCATTTCTCCAAGATGAGGTGAGTGGCAGTGTGATGAGTGTTTATAGTGGAGAC
TTTGGCAATCTGGAAGTTAAAGGAAATATTCAGTTTGCAATTGAATATGTGGAGTCACTGAAGGAGTTGCATGTTTTTGTGGCCCAGTGT
AAGGACTTAGCAGCAGCGGATGTAAAAAAACAGCGTTCAGACCCATATGTAAAGGCCTATTTGCTACCAGACAAAGGCAAAATGGGCAAG
AAGAAAACACTCGTAGTGAAGAAAACCTTGAATCCTGTGTATAACGAAATACTGCGGTATAAAATTGAAAAACAAATCTTAAAGACACAG
AAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGG
GATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATG
AAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTT
GATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACA
AGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTA
GAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACT
GAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTG

>In-frame_SORL1_ENST00000532694_chr11_121466481_+_SYTL2_ENST00000389960_chr11_85428573_-_2175nt
ATGCACCAGTGCCGGAGTGACGAGTACAACTGCAGTTCCGGCATGTGCATCCGCTCCTCCTGGGTATGTGACGGGGACAACGACTGCAGG
GACTGGTCTGATGAAGCCAACTGTACCGCCATCTATCACACCTGTGAGGCCTCCAACTTCCAGTGCCGAAACGGGCACTGCATCCCCCAG
CGGTGGGCGTGTGACGGGGATACGGACTGCCAGGATGGTTCCGATGAGGATCCAGTCAACTGTGAGAAGAAGTGCAATGGATTCCGCTGC
CCAAACGGCACTTGCATCCCATCCAGCAAACATTGTGATGGTCTGCGTGATTGCTCTGATGGCTCCGATGAACAGCACTGCGAGCCCCTC
TGTACGCACTTCATGGACTTTGTGTGTAAGAACCGCCAGCAGTGCCTGTTCCACTCCATGGTCTGTGACGGAATCATCCAGTGCCGCGAC
GGGTCCGATGAGGATGCGGCGTTTGCAGGATGCTCCCAAGATCCTGAGTTCCACAAGGTATGTGATGAGTTCGGTTTCCAGTGTCAGAAT
GGAGTGTGCATCAGTTTGATTTGGAAGTGCGACGGGATGGATGATTGCGGCGATTATTCTGATGAAGCCAACTGCGAAAACCCCACAGAA
GCCCCAAACTGCTCCCGCTACTTCCAGTTTCGGTGTGAGAATGGCCACTGCATCCCCAACAGATGGAAATGTGACAGGGAGAACGACTGT
GGGGACTGGTCTGATGAGAAGGATTGTGGAGATTCACATATTCTTCCCTTCTCGACTCCTGGGCCCTCCACGTGTCTGCCCAATTACTAC
CGCTGCAGCAGTGGGACCTGCGTGATGGACACCTGGGTGTGCGACGGGTACCGAGATTGTGCAGATGGCTCTGACGAGGAAGCCTGCCCC
TTGCTTGCAAACGTCACTGCTGCCTCCACTCCCACCCAACTTGGGCGATGTGACCGATTTGAGTTCGAATGCCACCAACCGAAGACGTGT
ATTCCCAACTGGAAGCGCTGTGACGGCCACCAAGATTGCCAGGATGGCCGGGACGAGGCCAATTGCCATGAGAAACCAGATCAGAAGCCA
GTTACAAATGAATGCGTACCAAGAATTTCCACAGTGCCTACACAACCTGATAATCCATTTTCTCACCCTGACAAACTCAAAAGGATGAGC
AAGTCTGTTCCAGCATTTCTCCAAGATGAGGTGAGTGGCAGTGTGATGAGTGTTTATAGTGGAGACTTTGGCAATCTGGAAGTTAAAGGA
AATATTCAGTTTGCAATTGAATATGTGGAGTCACTGAAGGAGTTGCATGTTTTTGTGGCCCAGTGTAAGGACTTAGCAGCAGCGGATGTA
AAAAAACAGCGTTCAGACCCATATGTAAAGGCCTATTTGCTACCAGACAAAGGCAAAATGGGCAAGAAGAAAACACTCGTAGTGAAGAAA
ACCTTGAATCCTGTGTATAACGAAATACTGCGGTATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCAT
CGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTG
AGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCA
GAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGT
CATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAAC
CCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTAC
AAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACT
TCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCC

>In-frame_SORL1_ENST00000534286_chr11_121466481_+_SYTL2_ENST00000389960_chr11_85428573_-_2367nt
ATGCAGACCTCTCGGCACTCCTTTTCTCAAACCACAGGCTGTGTCTGTAGGAGTCCTCTGTTTCTTGAAAGTTCTACTTCCTGGCCTCCT
CTATCACTGCTTCCTAACCTTCTTCCCATCATAGCAAGCATAGAAAATAATATATGTGGAGAGCACTGGGATGAATGGACAAGGATGCTG
TTGTCAAGAGAAATGCACCAGTGCCGGAGTGACGAGTACAACTGCAGTTCCGGCATGTGCATCCGCTCCTCCTGGGTATGTGACGGGGAC
AACGACTGCAGGGACTGGTCTGATGAAGCCAACTGTACCGCCATCTATCACACCTGTGAGGCCTCCAACTTCCAGTGCCGAAACGGGCAC
TGCATCCCCCAGCGGTGGGCGTGTGACGGGGATACGGACTGCCAGGATGGTTCCGATGAGGATCCAGTCAACTGTGAGAAGAAGTGCAAT
GGATTCCGCTGCCCAAACGGCACTTGCATCCCATCCAGCAAACATTGTGATGGTCTGCGTGATTGCTCTGATGGCTCCGATGAACAGCAC
TGCGAGCCCCTCTGTACGCACTTCATGGACTTTGTGTGTAAGAACCGCCAGCAGTGCCTGTTCCACTCCATGGTCTGTGACGGAATCATC
CAGTGCCGCGACGGGTCCGATGAGGATGCGGCGTTTGCAGGATGCTCCCAAGATCCTGAGTTCCACAAGGTATGTGATGAGTTCGGTTTC
CAGTGTCAGAATGGAGTGTGCATCAGTTTGATTTGGAAGTGCGACGGGATGGATGATTGCGGCGATTATTCTGATGAAGCCAACTGCGAA
AACCCCACAGAAGCCCCAAACTGCTCCCGCTACTTCCAGTTTCGGTGTGAGAATGGCCACTGCATCCCCAACAGATGGAAATGTGACAGG
GAGAACGACTGTGGGGACTGGTCTGATGAGAAGGATTGTGGAGATTCACATATTCTTCCCTTCTCGACTCCTGGGCCCTCCACGTGTCTG
CCCAATTACTACCGCTGCAGCAGTGGGACCTGCGTGATGGACACCTGGGTGTGCGACGGGTACCGAGATTGTGCAGATGGCTCTGACGAG
GAAGCCTGCCCCTTGCTTGCAAACGTCACTGCTGCCTCCACTCCCACCCAACTTGGGCGATGTGACCGATTTGAGTTCGAATGCCACCAA
CCGAAGACGTGTATTCCCAACTGGAAGCGCTGTGACGGCCACCAAGATTGCCAGGATGGCCGGGACGAGGCCAATTGCCATGAGAAACCA
GATCAGAAGCCAGTTACAAATGAATGCGTACCAAGAATTTCCACAGTGCCTACACAACCTGATAATCCATTTTCTCACCCTGACAAACTC
AAAAGGATGAGCAAGTCTGTTCCAGCATTTCTCCAAGATGAGGTGAGTGGCAGTGTGATGAGTGTTTATAGTGGAGACTTTGGCAATCTG
GAAGTTAAAGGAAATATTCAGTTTGCAATTGAATATGTGGAGTCACTGAAGGAGTTGCATGTTTTTGTGGCCCAGTGTAAGGACTTAGCA
GCAGCGGATGTAAAAAAACAGCGTTCAGACCCATATGTAAAGGCCTATTTGCTACCAGACAAAGGCAAAATGGGCAAGAAGAAAACACTC
GTAGTGAAGAAAACCTTGAATCCTGTGTATAACGAAATACTGCGGTATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTG
TCCATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAG
AATAAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTC
CAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTG
CTAAGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGG
AAAACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTC
TGGGACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGG
ATGGACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATG

>In-frame_SORL1_ENST00000527934_chr11_121466481_+_SYTL2_ENST00000389960_chr11_85428573_-_1482nt
ATGATTTCTAGATTAGCCGCTGCTCAGAGCTGTGCCAGTCACTGGCCTCCCTCAGCAGATTCACATATTCTTCCCTTCTCGACTCCTGGG
CCCTCCACGTGTCTGCCCAATTACTACCGCTGCAGCAGTGGGACCTGCGTGATGGACACCTGGGTGTGCGACGGGTACCGAGATTGTGCA
GATGGCTCTGACGAGGAAGCCTGCCCCTTGCTTGCAAACGTCACTGCTGCCTCCACTCCCACCCAACTTGGGCGATGTGACCGATTTGAG
TTCGAATGCCACCAACCGAAGACGTGTATTCCCAACTGGAAGCGCTGTGACGGCCACCAAGATTGCCAGGATGGCCGGGACGAGGCCAAT
TGCCATGAGAAACCAGATCAGAAGCCAGTTACAAATGAATGCGTACCAAGAATTTCCACAGTGCCTACACAACCTGATAATCCATTTTCT
CACCCTGACAAACTCAAAAGGATGAGCAAGTCTGTTCCAGCATTTCTCCAAGATGAGGTGAGTGGCAGTGTGATGAGTGTTTATAGTGGA
GACTTTGGCAATCTGGAAGTTAAAGGAAATATTCAGTTTGCAATTGAATATGTGGAGTCACTGAAGGAGTTGCATGTTTTTGTGGCCCAG
TGTAAGGACTTAGCAGCAGCGGATGTAAAAAAACAGCGTTCAGACCCATATGTAAAGGCCTATTTGCTACCAGACAAAGGCAAAATGGGC
AAGAAGAAAACACTCGTAGTGAAGAAAACCTTGAATCCTGTGTATAACGAAATACTGCGGTATAAAATTGAAAAACAAATCTTAAAGACA
CAGAAATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGAC
TGGGATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAA
ATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGC
CTTGATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAG
ACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGT
GTAGAGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGG
ACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACA


* Fusion transcript sequences (Full-length transcript).
>In-frame_SORL1_ENST00000260197_chr11_121466481_+_SYTL2_ENST00000389960_chr11_85428573_-_6737nt
CCCGGAGCGGCGCGGGCGGCCTGGAGCCCCGGGAGCGGCGCGCGCGGTCCCGGCCCAGCGGCTCTCCTGGCCTCGCGCTGCACATTCTCT
CCTGGCGGCGGCGCCACCTGCAGTAGCGTTCGCCCGAACATGGCGACACGGAGCAGCAGGAGGGAGTCGCGACTCCCGTTCCTATTCACC
CTGGTCGCACTGCTGCCGCCCGGAGCTCTCTGCGAAGTCTGGACGCAGAGGCTGCACGGCGGCAGCGCGCCCTTGCCCCAGGACCGGGGC
TTCCTCGTGGTGCAGGGCGACCCGCGCGAGCTGCGGCTGTGGGCGCGCGGGGATGCCAGGGGGGCGAGCCGCGCGGACGAGAAGCCGCTC
CGGAGGAAACGGAGCGCTGCCCTGCAGCCCGAGCCCATCAAGGTGTACGGACAGGTTAGTCTGAATGATTCCCACAATCAGATGGTGGTG
CACTGGGCTGGAGAGAAAAGCAACGTGATCGTGGCCTTGGCCCGAGATAGCCTGGCATTGGCGAGGCCCAAGAGCAGTGATGTGTACGTG
TCTTACGACTATGGAAAATCATTCAAGAAAATTTCAGACAAGTTAAACTTTGGCTTGGGAAATAGGAGTGAAGCTGTTATCGCCCAGTTC
TACCACAGCCCTGCGGACAACAAGCGGTACATCTTTGCAGACGCTTATGCCCAGTACCTCTGGATCACGTTTGACTTCTGCAACACTCTT
CAAGGCTTTTCCATCCCATTTCGGGCAGCTGATCTCCTCCTACACAGTAAGGCCTCCAACCTTCTCTTGGGCTTTGACAGGTCCCACCCC
AACAAGCAGCTGTGGAAGTCAGATGACTTTGGCCAGACCTGGATCATGATTCAGGAACATGTCAAGTCCTTTTCTTGGGGAATTGATCCC
TATGACAAACCAAATACCATCTACATTGAACGACATGAACCCTCTGGCTACTCCACTGTCTTCCGAAGTACAGATTTCTTCCAGTCCCGG
GAAAACCAGGAAGTGATCCTTGAGGAAGTGAGAGATTTTCAGCTTCGGGACAAGTACATGTTTGCTACAAAGGTGGTGCATCTCTTGGGC
AGTGAACAGCAGTCTTCTGTCCAGCTCTGGGTCTCCTTTGGCCGGAAGCCCATGAGAGCAGCCCAGTTTGTCACAAGACATCCTATTAAT
GAATATTACATCGCAGATGCCTCCGAGGACCAGGTGTTTGTGTGTGTCAGCCACAGTAACAACCGCACCAATTTATACATCTCAGAGGCA
GAGGGGCTGAAGTTCTCCCTGTCCTTGGAGAACGTGCTCTATTACAGCCCAGGAGGGGCCGGCAGTGACACCTTGGTGAGGTATTTTGCA
AATGAACCATTTGCTGACTTCCACCGAGTGGAAGGATTGCAAGGAGTCTACATTGCTACTCTGATTAATGGTTCTATGAATGAGGAGAAC
ATGAGATCGGTCATCACCTTTGACAAAGGGGGAACCTGGGAGTTTCTTCAGGCTCCAGCCTTCACGGGATATGGAGAGAAAATCAATTGT
GAGCTTTCCCAGGGCTGTTCCCTTCATCTGGCTCAGCGCCTCAGTCAGCTCCTCAACCTCCAGCTCCGGAGAATGCCCATCCTGTCCAAG
GAGTCGGCTCCAGGCCTCATCATCGCCACTGGCTCAGTGGGAAAGAACTTGGCTAGCAAGACAAACGTGTACATCTCTAGCAGTGCTGGA
GCCAGGTGGCGAGAGGCACTTCCTGGACCTCACTACTACACATGGGGAGACCACGGCGGAATCATCACGGCTATTGCCCAGGGCATGGAA
ACCAACGAGCTAAAATACAGTACCAATGAAGGGGAGACCTGGAAAACATTCATCTTCTCTGAGAAGCCAGTGTTTGTGTATGGCCTCCTC
ACAGAACCTGGGGAGAAGAGCACTGTCTTCACCATCTTTGGCTCGAACAAAGAGAATGTCCACAGCTGGCTGATCCTCCAGGTCAATGCC
ACGGATGCCTTGGGAGTTCCCTGCACAGAGAATGACTACAAGCTGTGGTCACCATCTGATGAGCGGGGGAATGAGTGTTTGCTGGGACAC
AAGACTGTTTTCAAACGGCGGACCCCCCATGCCACATGCTTCAATGGAGAGGACTTTGACAGGCCGGTGGTCGTGTCCAACTGCTCCTGC
ACCCGGGAGGACTATGAGTGTGACTTCGGTTTCAAGATGAGTGAAGATTTGTCATTAGAGGTTTGTGTTCCAGATCCGGAATTTTCTGGA
AAGTCATACTCCCCTCCTGTGCCTTGCCCTGTGGGTTCTACTTACAGGAGAACGAGAGGCTACCGGAAGATTTCTGGGGACACTTGTAGC
GGAGGAGATGTTGAAGCGCGACTGGAAGGAGAGCTGGTCCCCTGTCCCCTGGCAGAAGAGAACGAGTTCATTCTGTATGCTGTGAGGAAA
TCCATCTACCGCTATGACCTGGCCTCGGGAGCCACCGAGCAGTTGCCTCTCACCGGGCTACGGGCAGCAGTGGCCCTGGACTTTGACTAT
GAGCACAACTGTTTGTATTGGTCCGACCTGGCCTTGGACGTCATCCAGCGCCTCTGTTTGAATGGAAGCACAGGGCAAGAGGTGATCATC
AATTCTGGCCTGGAGACAGTAGAAGCTTTGGCTTTTGAACCCCTCAGCCAGCTGCTTTACTGGGTAGATGCAGGCTTCAAAAAGATTGAG
GTAGCTAATCCAGATGGCGACTTCCGACTCACAATCGTCAATTCCTCTGTGCTTGATCGTCCCAGGGCTCTGGTCCTCGTGCCCCAAGAG
GGGGTGATGTTCTGGACAGACTGGGGAGACCTGAAGCCTGGGATTTATCGGAGCAATATGGATGGTTCTGCTGCCTATCACCTGGTGTCT
GAGGATGTGAAGTGGCCCAATGGCATCTCTGTGGACGACCAGTGGATTTACTGGACGGATGCCTACCTGGAGTGCATAGAGCGGATCACG
TTCAGTGGCCAGCAGCGCTCTGTCATTCTGGACAACCTCCCGCACCCCTATGCCATTGCTGTCTTTAAGAATGAAATCTACTGGGATGAC
TGGTCACAGCTCAGCATATTCCGAGCTTCCAAATACAGTGGGTCCCAGATGGAGATTCTGGCAAACCAGCTCACGGGGCTCATGGACATG
AAGATTTTCTACAAGGGGAAGAACACTGGAAGCAATGCCTGTGTGCCCAGGCCATGCAGCCTGCTGTGCCTGCCCAAGGCCAACAACAGT
AGAAGCTGCAGGTGTCCAGAGGATGTGTCCAGCAGTGTGCTTCCATCAGGGGACCTGATGTGTGACTGCCCTCAGGGCTATCAGCTCAAG
AACAATACCTGTGTCAAACAAGAGAACACCTGTCTTCGCAACCAGTATCGCTGCAGCAACGGGAACTGTATCAACAGCATTTGGTGGTGT
GACTTTGACAACGACTGTGGAGACATGAGCGATGAGAGAAACTGCCCTACCACCATCTGTGACCTGGACACCCAGTTTCGTTGCCAGGAG
TCTGGGACTTGTATCCCACTGTCCTATAAATGTGACCTTGAGGATGACTGTGGAGACAACAGTGATGAAAGTCATTGTGAAATGCACCAG
TGCCGGAGTGACGAGTACAACTGCAGTTCCGGCATGTGCATCCGCTCCTCCTGGGTATGTGACGGGGACAACGACTGCAGGGACTGGTCT
GATGAAGCCAACTGTACCGCCATCTATCACACCTGTGAGGCCTCCAACTTCCAGTGCCGAAACGGGCACTGCATCCCCCAGCGGTGGGCG
TGTGACGGGGATACGGACTGCCAGGATGGTTCCGATGAGGATCCAGTCAACTGTGAGAAGAAGTGCAATGGATTCCGCTGCCCAAACGGC
ACTTGCATCCCATCCAGCAAACATTGTGATGGTCTGCGTGATTGCTCTGATGGCTCCGATGAACAGCACTGCGAGCCCCTCTGTACGCAC
TTCATGGACTTTGTGTGTAAGAACCGCCAGCAGTGCCTGTTCCACTCCATGGTCTGTGACGGAATCATCCAGTGCCGCGACGGGTCCGAT
GAGGATGCGGCGTTTGCAGGATGCTCCCAAGATCCTGAGTTCCACAAGGTATGTGATGAGTTCGGTTTCCAGTGTCAGAATGGAGTGTGC
ATCAGTTTGATTTGGAAGTGCGACGGGATGGATGATTGCGGCGATTATTCTGATGAAGCCAACTGCGAAAACCCCACAGAAGCCCCAAAC
TGCTCCCGCTACTTCCAGTTTCGGTGTGAGAATGGCCACTGCATCCCCAACAGATGGAAATGTGACAGGGAGAACGACTGTGGGGACTGG
TCTGATGAGAAGGATTGTGGAGATTCACATATTCTTCCCTTCTCGACTCCTGGGCCCTCCACGTGTCTGCCCAATTACTACCGCTGCAGC
AGTGGGACCTGCGTGATGGACACCTGGGTGTGCGACGGGTACCGAGATTGTGCAGATGGCTCTGACGAGGAAGCCTGCCCCTTGCTTGCA
AACGTCACTGCTGCCTCCACTCCCACCCAACTTGGGCGATGTGACCGATTTGAGTTCGAATGCCACCAACCGAAGACGTGTATTCCCAAC
TGGAAGCGCTGTGACGGCCACCAAGATTGCCAGGATGGCCGGGACGAGGCCAATTGCCATGAGAAACCAGATCAGAAGCCAGTTACAAAT
GAATGCGTACCAAGAATTTCCACAGTGCCTACACAACCTGATAATCCATTTTCTCACCCTGACAAACTCAAAAGGATGAGCAAGTCTGTT
CCAGCATTTCTCCAAGATGAGGTGAGTGGCAGTGTGATGAGTGTTTATAGTGGAGACTTTGGCAATCTGGAAGTTAAAGGAAATATTCAG
TTTGCAATTGAATATGTGGAGTCACTGAAGGAGTTGCATGTTTTTGTGGCCCAGTGTAAGGACTTAGCAGCAGCGGATGTAAAAAAACAG
CGTTCAGACCCATATGTAAAGGCCTATTTGCTACCAGACAAAGGCAAAATGGGCAAGAAGAAAACACTCGTAGTGAAGAAAACCTTGAAT
CCTGTGTATAACGAAATACTGCGGTATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATACA
TTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTAC
CCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGTC
CCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAAT
TCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTTC
AACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAACC
AACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGAA
GTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTCC
AAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATATC
CTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGGAT
TTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATATTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTTCA
AAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAATTC
TGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGATACTCAAAGTGGAGCAGGG
AATGGAGACAGACATCAGTGATGATAAAAAAAAAAATGGACCTTAAGAAACTATTTACTCTGTAATCTCTAATAAAATATGGAATTCCAT
ATTAGGGCAATGAGACTGAAACTACTGGTGTTTTTCTGCCTTGAGAAAACAAACAGTTAAAACAAGCCTCAAATGTATTTTAGTGCCACC
CACTGGCCATAGGTACAATTCAGTTGTTGGCTTGTTTTGACTTAATTCTAAAATAGGTCTCAAGCCTGTATTTTTATGAGTTTATTTTTT
TAAAACCCTGCATATATATGATTGTTTTTCTTATAACTTTACTATATGAAAGCAGCATAAGAGTAGTCACAAACATGTTTTGCAACAAAG
TTTTAATTAGAATGTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATGTAAAATTTTCGTATTTTGTAAAAACCCTTAGAATAAATTAT

>In-frame_SORL1_ENST00000525532_chr11_121466481_+_SYTL2_ENST00000389960_chr11_85428573_-_3678nt
AGTCTGATCTGGCTGAAGACAGGATGCAAGTCACTGGTTATACTGAGCAGAAGTTTTCAGCACAGTAGGCGCCCCAAAGCTTGCCACTTG
ACCCTTGAGAGCTTCTCGCTGTCCTTTCCGAAGCAATGCCTGTGTGCCCAGGCCATGCAGCCTGCTGTGCCTGCCCAAGGCCAACAACAG
TAGAAGCTGCAGGTGTCCAGAGGATGTGTCCAGCAGTGTGCTTCCATCAGGGGACCTGATGTGTGACTGCCCTCAGGGCTATCAGCTCAA
GAACAATACCTGTGTCAAACAAGAGAACACCTGTCTTCGCAACCAGTATCGCTGCAGCAACGGGAACTGTATCAACAGCATTTGGTGGTG
TGACTTTGACAACGACTGTGGAGACATGAGCGATGAGAGAAACTGCCCTACCACCATCTGTGACCTGGACACCCAGTTTCGTTGCCAGGA
GTCTGGGACTTGTATCCCACTGTCCTATAAATGTGACCTTGAGGATGACTGTGGAGACAACAGTGATGAAAGTCATTGTGAAATGCACCA
GTGCCGGAGTGACGAGTACAACTGCAGTTCCGGCATGTGCATCCGCTCCTCCTGGGTATGTGACGGGGACAACGACTGCAGGGACTGGTC
TGATGAAGCCAACTGTACCGCCATCTATCACACCTGTGAGGCCTCCAACTTCCAGTGCCGAAACGGGCACTGCATCCCCCAGCGGTGGGC
GTGTGACGGGGATACGGACTGCCAGGATGGTTCCGATGAGGATCCAGTCAACTGTGAGAAGAAGTGCAATGGATTCCGCTGCCCAAACGG
CACTTGCATCCCATCCAGCAAACATTGTGATGGTCTGCGTGATTGCTCTGATGGCTCCGATGAACAGCACTGCGAGCCCCTCTGTACGCA
CTTCATGGACTTTGTGTGTAAGAACCGCCAGCAGTGCCTGTTCCACTCCATGGTCTGTGACGGAATCATCCAGTGCCGCGACGGGTCCGA
TGAGGATGCGGCGTTTGCAGGATGCTCCCAAGATCCTGAGTTCCACAAGGTATGTGATGAGTTCGGTTTCCAGTGTCAGAATGGAGTGTG
CATCAGTTTGATTTGGAAGTGCGACGGGATGGATGATTGCGGCGATTATTCTGATGAAGCCAACTGCGAAAACCCCACAGAAGCCCCAAA
CTGCTCCCGCTACTTCCAGTTTCGGTGTGAGAATGGCCACTGCATCCCCAACAGATGGAAATGTGACAGGGAGAACGACTGTGGGGACTG
GTCTGATGAGAAGGATTGTGGAGATTCACATATTCTTCCCTTCTCGACTCCTGGGCCCTCCACGTGTCTGCCCAATTACTACCGCTGCAG
CAGTGGGACCTGCGTGATGGACACCTGGGTGTGCGACGGGTACCGAGATTGTGCAGATGGCTCTGACGAGGAAGCCTGCCCCTTGCTTGC
AAACGTCACTGCTGCCTCCACTCCCACCCAACTTGGGCGATGTGACCGATTTGAGTTCGAATGCCACCAACCGAAGACGTGTATTCCCAA
CTGGAAGCGCTGTGACGGCCACCAAGATTGCCAGGATGGCCGGGACGAGGCCAATTGCCATGAGAAACCAGATCAGAAGCCAGTTACAAA
TGAATGCGTACCAAGAATTTCCACAGTGCCTACACAACCTGATAATCCATTTTCTCACCCTGACAAACTCAAAAGGATGAGCAAGTCTGT
TCCAGCATTTCTCCAAGATGAGGTGAGTGGCAGTGTGATGAGTGTTTATAGTGGAGACTTTGGCAATCTGGAAGTTAAAGGAAATATTCA
GTTTGCAATTGAATATGTGGAGTCACTGAAGGAGTTGCATGTTTTTGTGGCCCAGTGTAAGGACTTAGCAGCAGCGGATGTAAAAAAACA
GCGTTCAGACCCATATGTAAAGGCCTATTTGCTACCAGACAAAGGCAAAATGGGCAAGAAGAAAACACTCGTAGTGAAGAAAACCTTGAA
TCCTGTGTATAACGAAATACTGCGGTATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATCGGGATAC
ATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGAGATGGTA
CCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAGAGCCAGT
CCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTCATCTAAA
TTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACCCTATCTT
CAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACAAATTAAC
CAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTTCAGAGGA
AGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCAAGATTTC
CAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGACAAATAT
CCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGATTACAAGGCCCAAGGGA
TTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATATTTGAACAAGCTAGGAAAATTGAATTTCTGCTGCTGCTTC
AAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATGTGTTTCACACCACAATT
CTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGATACTCAAAGTGGAGCAGG
GAATGGAGACAGACATCAGTGATGATAAAAAAAAAAATGGACCTTAAGAAACTATTTACTCTGTAATCTCTAATAAAATATGGAATTCCA
TATTAGGGCAATGAGACTGAAACTACTGGTGTTTTTCTGCCTTGAGAAAACAAACAGTTAAAACAAGCCTCAAATGTATTTTAGTGCCAC
CCACTGGCCATAGGTACAATTCAGTTGTTGGCTTGTTTTGACTTAATTCTAAAATAGGTCTCAAGCCTGTATTTTTATGAGTTTATTTTT
TTAAAACCCTGCATATATATGATTGTTTTTCTTATAACTTTACTATATGAAAGCAGCATAAGAGTAGTCACAAACATGTTTTGCAACAAA
GTTTTAATTAGAATGTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATGTAAAATTTTCGTATTTTGTAAAAACCCTTAGAATAAATTA

>In-frame_SORL1_ENST00000532694_chr11_121466481_+_SYTL2_ENST00000389960_chr11_85428573_-_3527nt
ACAGAAAGTCCCGAGTTATGTTTCCTCCGTTTTGGGAGCTCAGCACTGATTTTACTCTCTCTGACTGAGCATCTCACGGTGATCAGCTCA
TGCAGACCTCTCGGCACTCCTTTTCTCAAACCACAGGCTGTGTCTGTAGGAGTCCTCTGTTTCTTGAAAGTTCTACTTCCTGGCCTCCTC
TATCACTGCTTCCTAACCTTCTTCCCATCATAGCAAGCATAGAAAATAATATATGTGGAGAGCACTGGGATGAATGGACAAGGATGCTGT
TGTCAAGAGGCAAGCAGCTCTAAGGGTCTGAGGGTCTCAGAATCTCAGCCCACCTGTAACCCATTTGCAGCACACTGACTGGAAGCTGTT
AAATGACCTTTTGTCCCTGAAATGCACCAGTGCCGGAGTGACGAGTACAACTGCAGTTCCGGCATGTGCATCCGCTCCTCCTGGGTATGT
GACGGGGACAACGACTGCAGGGACTGGTCTGATGAAGCCAACTGTACCGCCATCTATCACACCTGTGAGGCCTCCAACTTCCAGTGCCGA
AACGGGCACTGCATCCCCCAGCGGTGGGCGTGTGACGGGGATACGGACTGCCAGGATGGTTCCGATGAGGATCCAGTCAACTGTGAGAAG
AAGTGCAATGGATTCCGCTGCCCAAACGGCACTTGCATCCCATCCAGCAAACATTGTGATGGTCTGCGTGATTGCTCTGATGGCTCCGAT
GAACAGCACTGCGAGCCCCTCTGTACGCACTTCATGGACTTTGTGTGTAAGAACCGCCAGCAGTGCCTGTTCCACTCCATGGTCTGTGAC
GGAATCATCCAGTGCCGCGACGGGTCCGATGAGGATGCGGCGTTTGCAGGATGCTCCCAAGATCCTGAGTTCCACAAGGTATGTGATGAG
TTCGGTTTCCAGTGTCAGAATGGAGTGTGCATCAGTTTGATTTGGAAGTGCGACGGGATGGATGATTGCGGCGATTATTCTGATGAAGCC
AACTGCGAAAACCCCACAGAAGCCCCAAACTGCTCCCGCTACTTCCAGTTTCGGTGTGAGAATGGCCACTGCATCCCCAACAGATGGAAA
TGTGACAGGGAGAACGACTGTGGGGACTGGTCTGATGAGAAGGATTGTGGAGATTCACATATTCTTCCCTTCTCGACTCCTGGGCCCTCC
ACGTGTCTGCCCAATTACTACCGCTGCAGCAGTGGGACCTGCGTGATGGACACCTGGGTGTGCGACGGGTACCGAGATTGTGCAGATGGC
TCTGACGAGGAAGCCTGCCCCTTGCTTGCAAACGTCACTGCTGCCTCCACTCCCACCCAACTTGGGCGATGTGACCGATTTGAGTTCGAA
TGCCACCAACCGAAGACGTGTATTCCCAACTGGAAGCGCTGTGACGGCCACCAAGATTGCCAGGATGGCCGGGACGAGGCCAATTGCCAT
GAGAAACCAGATCAGAAGCCAGTTACAAATGAATGCGTACCAAGAATTTCCACAGTGCCTACACAACCTGATAATCCATTTTCTCACCCT
GACAAACTCAAAAGGATGAGCAAGTCTGTTCCAGCATTTCTCCAAGATGAGGTGAGTGGCAGTGTGATGAGTGTTTATAGTGGAGACTTT
GGCAATCTGGAAGTTAAAGGAAATATTCAGTTTGCAATTGAATATGTGGAGTCACTGAAGGAGTTGCATGTTTTTGTGGCCCAGTGTAAG
GACTTAGCAGCAGCGGATGTAAAAAAACAGCGTTCAGACCCATATGTAAAGGCCTATTTGCTACCAGACAAAGGCAAAATGGGCAAGAAG
AAAACACTCGTAGTGAAGAAAACCTTGAATCCTGTGTATAACGAAATACTGCGGTATAAAATTGAAAAACAAATCTTAAAGACACAGAAA
TTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGAT
AACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAA
CTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGAT
CTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGA
GCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAG
CTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAA
GTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCT
CTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGAT
CTTGAAAATCTGAGTAGGTGGACAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGCAT
GTGCTTCTTTGATTACAAGGCCCAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATATTTGAACAAGC
TAGGAAAATTGAATTTCTGCTGCTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAATGTTCTTG
TTTGCCATCATGTGTTTCACACCACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAAAG
TCGCAGAAAGATACTCAAAGTGGAGCAGGGAATGGAGACAGACATCAGTGATGATAAAAAAAAAAATGGACCTTAAGAAACTATTTACTC
TGTAATCTCTAATAAAATATGGAATTCCATATTAGGGCAATGAGACTGAAACTACTGGTGTTTTTCTGCCTTGAGAAAACAAACAGTTAA
AACAAGCCTCAAATGTATTTTAGTGCCACCCACTGGCCATAGGTACAATTCAGTTGTTGGCTTGTTTTGACTTAATTCTAAAATAGGTCT
CAAGCCTGTATTTTTATGAGTTTATTTTTTTAAAACCCTGCATATATATGATTGTTTTTCTTATAACTTTACTATATGAAAGCAGCATAA
GAGTAGTCACAAACATGTTTTGCAACAAAGTTTTAATTAGAATGTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATGTAAAATTTTCG
TATTTTGTAAAAACCCTTAGAATAAATTATCATTTGATTTAAATTGTATTAGAAAATTAGCGTGACTTCTCATTTTAAATAAAATATTTT

>In-frame_SORL1_ENST00000534286_chr11_121466481_+_SYTL2_ENST00000389960_chr11_85428573_-_3349nt
GTGATCAGCTCATGCAGACCTCTCGGCACTCCTTTTCTCAAACCACAGGCTGTGTCTGTAGGAGTCCTCTGTTTCTTGAAAGTTCTACTT
CCTGGCCTCCTCTATCACTGCTTCCTAACCTTCTTCCCATCATAGCAAGCATAGAAAATAATATATGTGGAGAGCACTGGGATGAATGGA
CAAGGATGCTGTTGTCAAGAGAAATGCACCAGTGCCGGAGTGACGAGTACAACTGCAGTTCCGGCATGTGCATCCGCTCCTCCTGGGTAT
GTGACGGGGACAACGACTGCAGGGACTGGTCTGATGAAGCCAACTGTACCGCCATCTATCACACCTGTGAGGCCTCCAACTTCCAGTGCC
GAAACGGGCACTGCATCCCCCAGCGGTGGGCGTGTGACGGGGATACGGACTGCCAGGATGGTTCCGATGAGGATCCAGTCAACTGTGAGA
AGAAGTGCAATGGATTCCGCTGCCCAAACGGCACTTGCATCCCATCCAGCAAACATTGTGATGGTCTGCGTGATTGCTCTGATGGCTCCG
ATGAACAGCACTGCGAGCCCCTCTGTACGCACTTCATGGACTTTGTGTGTAAGAACCGCCAGCAGTGCCTGTTCCACTCCATGGTCTGTG
ACGGAATCATCCAGTGCCGCGACGGGTCCGATGAGGATGCGGCGTTTGCAGGATGCTCCCAAGATCCTGAGTTCCACAAGGTATGTGATG
AGTTCGGTTTCCAGTGTCAGAATGGAGTGTGCATCAGTTTGATTTGGAAGTGCGACGGGATGGATGATTGCGGCGATTATTCTGATGAAG
CCAACTGCGAAAACCCCACAGAAGCCCCAAACTGCTCCCGCTACTTCCAGTTTCGGTGTGAGAATGGCCACTGCATCCCCAACAGATGGA
AATGTGACAGGGAGAACGACTGTGGGGACTGGTCTGATGAGAAGGATTGTGGAGATTCACATATTCTTCCCTTCTCGACTCCTGGGCCCT
CCACGTGTCTGCCCAATTACTACCGCTGCAGCAGTGGGACCTGCGTGATGGACACCTGGGTGTGCGACGGGTACCGAGATTGTGCAGATG
GCTCTGACGAGGAAGCCTGCCCCTTGCTTGCAAACGTCACTGCTGCCTCCACTCCCACCCAACTTGGGCGATGTGACCGATTTGAGTTCG
AATGCCACCAACCGAAGACGTGTATTCCCAACTGGAAGCGCTGTGACGGCCACCAAGATTGCCAGGATGGCCGGGACGAGGCCAATTGCC
ATGAGAAACCAGATCAGAAGCCAGTTACAAATGAATGCGTACCAAGAATTTCCACAGTGCCTACACAACCTGATAATCCATTTTCTCACC
CTGACAAACTCAAAAGGATGAGCAAGTCTGTTCCAGCATTTCTCCAAGATGAGGTGAGTGGCAGTGTGATGAGTGTTTATAGTGGAGACT
TTGGCAATCTGGAAGTTAAAGGAAATATTCAGTTTGCAATTGAATATGTGGAGTCACTGAAGGAGTTGCATGTTTTTGTGGCCCAGTGTA
AGGACTTAGCAGCAGCGGATGTAAAAAAACAGCGTTCAGACCCATATGTAAAGGCCTATTTGCTACCAGACAAAGGCAAAATGGGCAAGA
AGAAAACACTCGTAGTGAAGAAAACCTTGAATCCTGTGTATAACGAAATACTGCGGTATAAAATTGAAAAACAAATCTTAAAGACACAGA
AATTGAACCTGTCCATTTGGCATCGGGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGG
ATAACAAACAGAATAAACAATTGAGATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGA
AACTAGCTCTCCAGTATGTCCCAGAGCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTG
ATCTACCACTGCTAAGGGGAAGTCATCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAA
GAGCTGTAGGGAAAACCACCAACCCTATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAG
AGCTTACTGTCTGGGACCATTACAAATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTG
AAGTGGACTGGATGGACTCTACTTCAGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGC
CTCTCAGAATGCTTTTGATTGCCAAGATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTG
ATCTTGAAAATCTGAGTAGGTGGACAAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGC
ATGTGCTTCTTTGATTACAAGGCCCAAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATATTTGAACAA
GCTAGGAAAATTGAATTTCTGCTGCTGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAATGTTCT
TGTTTGCCATCATGTGTTTCACACCACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAA
AGTCGCAGAAAGATACTCAAAGTGGAGCAGGGAATGGAGACAGACATCAGTGATGATAAAAAAAAAAATGGACCTTAAGAAACTATTTAC
TCTGTAATCTCTAATAAAATATGGAATTCCATATTAGGGCAATGAGACTGAAACTACTGGTGTTTTTCTGCCTTGAGAAAACAAACAGTT
AAAACAAGCCTCAAATGTATTTTAGTGCCACCCACTGGCCATAGGTACAATTCAGTTGTTGGCTTGTTTTGACTTAATTCTAAAATAGGT
CTCAAGCCTGTATTTTTATGAGTTTATTTTTTTAAAACCCTGCATATATATGATTGTTTTTCTTATAACTTTACTATATGAAAGCAGCAT
AAGAGTAGTCACAAACATGTTTTGCAACAAAGTTTTAATTAGAATGTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATGTAAAATTTT
CGTATTTTGTAAAAACCCTTAGAATAAATTATCATTTGATTTAAATTGTATTAGAAAATTAGCGTGACTTCTCATTTTAAATAAAATATT

>In-frame_SORL1_ENST00000527934_chr11_121466481_+_SYTL2_ENST00000389960_chr11_85428573_-_2874nt
AAAGTATGGTTTGCAACCAGTAGCATCTGCATCTCCTTGGAACTTGTTAGAAATGTAGAATCTCTGACCTCACCCCAGACCTACAGAGTC
AGAATCTGCATGCTAATAAGCCCCCAGGTCCTGTGTGCTCCACAATGCATTTGAGGAGCACTCATGTGGAATGCAGACTTGCCCCTTTCC
TTTCTGGCATTCTCATCTCTGAACCAGGTCGTGGAGTAGTTGCGGTTGAATTAACTAGAACACAATGCTTTGCCTCAGTAGGAATTCTCT
TAGCCACCCTGTGCCTCCTCAGCCACCTGTTTCTTTCACCAGCCCCTGCAAAAGCAAACTTATCTGAATATTAACCGAAATCAAATATAG
TAAGGGAAATCTACTCCCCAAAAGGGAAAAGAATATTGCCTCTTCTGACAACCCATTATACATGATTTCTAGATTAGCCGCTGCTCAGAG
CTGTGCCAGTCACTGGCCTCCCTCAGCAGATTCACATATTCTTCCCTTCTCGACTCCTGGGCCCTCCACGTGTCTGCCCAATTACTACCG
CTGCAGCAGTGGGACCTGCGTGATGGACACCTGGGTGTGCGACGGGTACCGAGATTGTGCAGATGGCTCTGACGAGGAAGCCTGCCCCTT
GCTTGCAAACGTCACTGCTGCCTCCACTCCCACCCAACTTGGGCGATGTGACCGATTTGAGTTCGAATGCCACCAACCGAAGACGTGTAT
TCCCAACTGGAAGCGCTGTGACGGCCACCAAGATTGCCAGGATGGCCGGGACGAGGCCAATTGCCATGAGAAACCAGATCAGAAGCCAGT
TACAAATGAATGCGTACCAAGAATTTCCACAGTGCCTACACAACCTGATAATCCATTTTCTCACCCTGACAAACTCAAAAGGATGAGCAA
GTCTGTTCCAGCATTTCTCCAAGATGAGGTGAGTGGCAGTGTGATGAGTGTTTATAGTGGAGACTTTGGCAATCTGGAAGTTAAAGGAAA
TATTCAGTTTGCAATTGAATATGTGGAGTCACTGAAGGAGTTGCATGTTTTTGTGGCCCAGTGTAAGGACTTAGCAGCAGCGGATGTAAA
AAAACAGCGTTCAGACCCATATGTAAAGGCCTATTTGCTACCAGACAAAGGCAAAATGGGCAAGAAGAAAACACTCGTAGTGAAGAAAAC
CTTGAATCCTGTGTATAACGAAATACTGCGGTATAAAATTGAAAAACAAATCTTAAAGACACAGAAATTGAACCTGTCCATTTGGCATCG
GGATACATTTAAGCGCAATAGTTTCCTAGGGGAGGTGGAACTTGATTTGGAAACATGGGACTGGGATAACAAACAGAATAAACAATTGAG
ATGGTACCCTCTGAAGCGGAAGACAGCACCAGTTGCCCTTGAAGCAGAAAACAGAGGTGAAATGAAACTAGCTCTCCAGTATGTCCCAGA
GCCAGTCCCTGGTAAAAAGCTTCCTACAACTGGAGAAGTGCACATCTGGGTGAAGGAATGCCTTGATCTACCACTGCTAAGGGGAAGTCA
TCTAAATTCTTTTGTTAAATGTACCATCCTTCCAGATACAAGTAGGAAAAGTCGCCAGAAGACAAGAGCTGTAGGGAAAACCACCAACCC
TATCTTCAACCACACTATGGTGTATGATGGGTTCAGGCCTGAAGATCTGATGGAAGCCTGTGTAGAGCTTACTGTCTGGGACCATTACAA
ATTAACCAACCAATTTTTGGGAGGTCTTCGTATTGGCTTTGGAACAGGTAAAAGTTATGGGACTGAAGTGGACTGGATGGACTCTACTTC
AGAGGAAGTTGCTCTCTGGGAGAAGATGGTAAACTCCCCCAATACTTGGATTGAAGCAACACTGCCTCTCAGAATGCTTTTGATTGCCAA
GATTTCCAAATGAGCCCAAATTCCACTGGCTCCTCCACTGAAAACTACTAAACCGGTGGAATCTGATCTTGAAAATCTGAGTAGGTGGAC
AAATATCCTCACTTTCTATCTATTGCACCTAAGGAATACTACACAGCATGTAAAAGTCAATCTGCATGTGCTTCTTTGATTACAAGGCCC
AAGGGATTTAAATATAACAAAATGTGTAATTTGTGACTCTAATATTAAATAAGATATTTGAACAAGCTAGGAAAATTGAATTTCTGCTGC
TGCTTCAAAGAAAAAGCTGCCCCAGAGCATTAAACATGGGGTATTGTTAAGAAGCAAAATGTTCTTGTTTGCCATCATGTGTTTCACACC
ACAATTCTGTGCCACAGTTAAGAGGGTCTGGTACCCTTGCAGGACCTTTGTAGGTTGTGGGAAAAAGTCGCAGAAAGATACTCAAAGTGG
AGCAGGGAATGGAGACAGACATCAGTGATGATAAAAAAAAAAATGGACCTTAAGAAACTATTTACTCTGTAATCTCTAATAAAATATGGA
ATTCCATATTAGGGCAATGAGACTGAAACTACTGGTGTTTTTCTGCCTTGAGAAAACAAACAGTTAAAACAAGCCTCAAATGTATTTTAG
TGCCACCCACTGGCCATAGGTACAATTCAGTTGTTGGCTTGTTTTGACTTAATTCTAAAATAGGTCTCAAGCCTGTATTTTTATGAGTTT
ATTTTTTTAAAACCCTGCATATATATGATTGTTTTTCTTATAACTTTACTATATGAAAGCAGCATAAGAGTAGTCACAAACATGTTTTGC
AACAAAGTTTTAATTAGAATGTAAGTTGCTCAGTTATACTGTTCTTCTTATGTATGTAAAATTTTCGTATTTTGTAAAAACCCTTAGAAT


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FusionGenePPI for SORL1_SYTL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SORL1LRPAP1, GGA1, GGA2, PPP1CA, CUL1, COPS5, COPS6, FBXO6, CFTR, DYRK3, POP1, AURKA, APP, PACS1, FAM76B, HLA-DPA1, RSPO1, LGALS8, FGL1, LGALS9, DLD, FOSL2, WISP3, SP6, ZFP41, FOXI2, ZNF354C, TYW3, ZNF563, ZNF224, ZNF408, ZNF331, EGFL6, ZNF169, FAM19A3, OS9, ZBBX, ZNF517, ZNF264, PSG1, SREBF1, MDK, SCGB1D1, ZNF816, FAM19A4, SOST, CDHR5, ZNF549, GCNT3, CEP97SYTL2RAB27A, RAB27B, HNRNPA1, RPAP1, PPP1CA, FBXO25, MTERF1, NCOA1, KRAS


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SORL1_SYTL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SORL1_SYTL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSORL1C0008370Cholestasis1CTD_human
HgeneSORL1C0027626Neoplasm Invasiveness1CTD_human
HgeneSORL1C4277682Chemical and Drug Induced Liver Injury1CTD_human