FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 35402

FusionGeneSummary for SORD_RAB27A

check button Fusion gene summary
Fusion gene informationFusion gene name: SORD_RAB27A
Fusion gene ID: 35402
HgeneTgene
Gene symbol

SORD

RAB27A

Gene ID

6652

5873

Gene namesorbitol dehydrogenaseRAB27A, member RAS oncogene family
SynonymsHEL-S-95n|SORD1GS2|HsT18676|RAB27|RAM
Cytomap

15q21.1

15q21.3

Type of geneprotein-codingprotein-coding
Descriptionsorbitol dehydrogenaseL-iditol 2-dehydrogenaseepididymis secretory sperm binding protein Li 95nras-related protein Rab-27AGTP-binding protein Rammutant Ras-related protein Rab-27Arab-27
Modification date2018052220180527
UniProtAcc

Q00796

P51159

Ensembl transtripts involved in fusion geneENST00000267814, ENST00000558580, 
ENST00000559562, 		ENST00000336787, 
ENST00000396307, ENST00000564609, 
ENST00000569493, ENST00000561545, 
Fusion gene scores* DoF score3 X 1 X 3=98 X 7 X 5=280
# samples 38
** MAII scorelog2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(8/280*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SORD [Title/Abstract] AND RAB27A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSORD

GO:0006062

sorbitol catabolic process

3365415|6870831|8487505|12962626

HgeneSORD

GO:0046370

fructose biosynthetic process

3365415|6870831|8487505

HgeneSORD

GO:0051160

L-xylitol catabolic process

8487505

HgeneSORD

GO:0051164

L-xylitol metabolic process

3365415

TgeneRAB27A

GO:0006887

exocytosis

18812475


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDKICHTCGA-KL-8341-01ASORDchr15

45315547

+RAB27Achr15

55497903

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000267814ENST00000336787SORDchr15

45315547

+RAB27Achr15

55497903

-
Frame-shiftENST00000267814ENST00000396307SORDchr15

45315547

+RAB27Achr15

55497903

-
Frame-shiftENST00000267814ENST00000564609SORDchr15

45315547

+RAB27Achr15

55497903

-
In-frameENST00000267814ENST00000569493SORDchr15

45315547

+RAB27Achr15

55497903

-
5CDS-intronENST00000267814ENST00000561545SORDchr15

45315547

+RAB27Achr15

55497903

-
intron-3CDSENST00000558580ENST00000336787SORDchr15

45315547

+RAB27Achr15

55497903

-
intron-3CDSENST00000558580ENST00000396307SORDchr15

45315547

+RAB27Achr15

55497903

-
intron-3CDSENST00000558580ENST00000564609SORDchr15

45315547

+RAB27Achr15

55497903

-
intron-3CDSENST00000558580ENST00000569493SORDchr15

45315547

+RAB27Achr15

55497903

-
intron-intronENST00000558580ENST00000561545SORDchr15

45315547

+RAB27Achr15

55497903

-
intron-3CDSENST00000559562ENST00000336787SORDchr15

45315547

+RAB27Achr15

55497903

-
intron-3CDSENST00000559562ENST00000396307SORDchr15

45315547

+RAB27Achr15

55497903

-
intron-3CDSENST00000559562ENST00000564609SORDchr15

45315547

+RAB27Achr15

55497903

-
intron-3CDSENST00000559562ENST00000569493SORDchr15

45315547

+RAB27Achr15

55497903

-
intron-intronENST00000559562ENST00000561545SORDchr15

45315547

+RAB27Achr15

55497903

-

Top

FusionProtFeatures for SORD_RAB27A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SORD

Q00796

RAB27A

P51159

Converts sorbitol to fructose. Part of the polyolpathway that plays an important role in sperm physiology. May playa role in the sperm motility by providing an energetic source forsperm. {ECO:0000250|UniProtKB:Q64442,ECO:0000269|PubMed:16278369}. Plays a role in cytotoxic granule exocytosis inlymphocytes. Required for both granule maturation and granuledocking and priming at the immunologic synapse.{ECO:0000269|PubMed:18812475}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRAB27Achr15:45315547chr15:55497903ENST00000336787-57163_165155222Nucleotide bindingGTP
TgeneRAB27Achr15:45315547chr15:55497903ENST00000396307-46163_165155222Nucleotide bindingGTP
TgeneRAB27Achr15:45315547chr15:55497903ENST00000564609-57163_165155222Nucleotide bindingGTP
TgeneRAB27Achr15:45315547chr15:55497903ENST00000569493-57163_165155222Nucleotide bindingGTP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRAB27Achr15:45315547chr15:55497903ENST00000336787-5738_46155222MotifEffector region
TgeneRAB27Achr15:45315547chr15:55497903ENST00000396307-4638_46155222MotifEffector region
TgeneRAB27Achr15:45315547chr15:55497903ENST00000564609-5738_46155222MotifEffector region
TgeneRAB27Achr15:45315547chr15:55497903ENST00000569493-5738_46155222MotifEffector region
TgeneRAB27Achr15:45315547chr15:55497903ENST00000336787-57133_136155222Nucleotide bindingGTP
TgeneRAB27Achr15:45315547chr15:55497903ENST00000336787-5716_24155222Nucleotide bindingGTP
TgeneRAB27Achr15:45315547chr15:55497903ENST00000336787-5774_78155222Nucleotide bindingGTP
TgeneRAB27Achr15:45315547chr15:55497903ENST00000396307-46133_136155222Nucleotide bindingGTP
TgeneRAB27Achr15:45315547chr15:55497903ENST00000396307-4616_24155222Nucleotide bindingGTP
TgeneRAB27Achr15:45315547chr15:55497903ENST00000396307-4674_78155222Nucleotide bindingGTP
TgeneRAB27Achr15:45315547chr15:55497903ENST00000564609-57133_136155222Nucleotide bindingGTP
TgeneRAB27Achr15:45315547chr15:55497903ENST00000564609-5716_24155222Nucleotide bindingGTP
TgeneRAB27Achr15:45315547chr15:55497903ENST00000564609-5774_78155222Nucleotide bindingGTP
TgeneRAB27Achr15:45315547chr15:55497903ENST00000569493-57133_136155222Nucleotide bindingGTP
TgeneRAB27Achr15:45315547chr15:55497903ENST00000569493-5716_24155222Nucleotide bindingGTP
TgeneRAB27Achr15:45315547chr15:55497903ENST00000569493-5774_78155222Nucleotide bindingGTP


Top

FusionGeneSequence for SORD_RAB27A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_SORD_ENST00000267814_chr15_45315547_+_RAB27A_ENST00000336787_chr15_55497903_-_88aa

>In-frame_SORD_ENST00000267814_chr15_45315547_+_RAB27A_ENST00000569493_chr15_55497903_-_88aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_SORD_ENST00000267814_chr15_45315547_+_RAB27A_ENST00000336787_chr15_55497903_-_265nt
ATGGCGGCGGCGGCCAAGCCCAACAACCTTTCCCTGGTGGTGCACGGACCGGGGGACTTGCGCCTGAATCCCCTACTTTGAAACTAGTGC
TGCCAATGGGACAAACATAAGCCAAGCAATTGAGATGCTTCTGGACCTGATAATGAAGCGAATGGAACGGTGTGTGGACAAGTCCTGGAT

>In-frame_SORD_ENST00000267814_chr15_45315547_+_RAB27A_ENST00000569493_chr15_55497903_-_265nt
ATGGCGGCGGCGGCCAAGCCCAACAACCTTTCCCTGGTGGTGCACGGACCGGGGGACTTGCGCCTGAATCCCCTACTTTGAAACTAGTGC
TGCCAATGGGACAAACATAAGCCAAGCAATTGAGATGCTTCTGGACCTGATAATGAAGCGAATGGAACGGTGTGTGGACAAGTCCTGGAT


* Fusion transcript sequences (Full-length transcript).
>In-frame_SORD_ENST00000267814_chr15_45315547_+_RAB27A_ENST00000336787_chr15_55497903_-_2348nt
CTCCACGCTAGCGCCGCCCAGGCTGGCACAAAGGAGGAAGCCTAGTCCCGCCCCTGCGTGCGGCGCTTCTCCCAGGCCCCACCTTCCATC
CAGTGCCCTGGACCCTCGGCTGGGTAGCGCCACCAGAGCGACCAAACGTCCCGCGCCTTCCAGGCCGCACTCCAGAGCCAAAAGAGCTCC
ATGGCGGCGGCGGCCAAGCCCAACAACCTTTCCCTGGTGGTGCACGGACCGGGGGACTTGCGCCTGAATCCCCTACTTTGAAACTAGTGC
TGCCAATGGGACAAACATAAGCCAAGCAATTGAGATGCTTCTGGACCTGATAATGAAGCGAATGGAACGGTGTGTGGACAAGTCCTGGAT
TCCTGAAGGAGTGGTGCGATCAAATGGTCATGCCTCTACGGATCAGTTAAGTGAAGAAAAGGAGAAAGGGGCATGTGGCTGTTGAGAAGT
CAAGTAAGCGACATAGTAGTTCAGGTGGCCCATGCCTGGGATCTTCTCTATGATTGATACATGGCACAGTGAGAGATTAATGGGCATTGT
GTACAAATTGCTTCTCACCATCCCCATTAGACCTACGAATAAAGCATCCGGTTCTAAAATTAATTTGTTGCAGCTTTGTAAATATTTCTT
TAAGATTCAGCCTGAGAGTTAGGAGAAATATTTCAGAGCCAAAAGTGCCTTATACAACCTTAGCCTATTATAGTAAATCATTCAAGGATT
CAGAATTTTGCAGTCACAGAAGAGTGTATTTATTATGTAGAATGAATGAGGGTACTGTCACCTGCCTTAATGTAGGTAGGCCCAGAGTCT
TACATTTAAGATCTTACATGCAGTTATAAAACCGCCACAGTCTTCAATCCAGATTTGAAGACTCATGCCATAGGTGACATTCTAAAATAC
CATTAAAGCCACTTAAATGTTAAATAAGAATATACATGCACATCAGCTCAATGTCTTTGAGTATTAATTTTATGTAAGCATTCTATTTAA
CATGAATATAGGACAAATCATGGCTATATCTATAGACCTTGGATAAACTGGATTGACCAATTATACACTCACGGTGACTTTTTTATTGGT
GGGAAGGGGATTGGGGTGGGGCAGGCTGGCTTAATGTAATATGAGCAACCAAAGTGGGACTTCTGTCTCCCCGCTATATTCCCATTGCTC
TGAATGGTTGATTGAAGGGTCAGGGAACTAGATTTTATGGCTTTAGTTCACTGTGATTGTACATTTATACTTGGCCTATGTGCTGGCCGC
ACCTGAACATAGCTGGTGCTTATGCCGAGTTATTTGCGATGAGTAAATATTTAGTTTCTTTTTCTTCATATTTATAATGTTGATCTGGCA
TCCTCAGGCTGCAGCTTTATTAGCTTATAACTTACTCATCTCTATCTTTACCAGCAGGCTCTGTATTGTTGATATTTGCAACTTGTTTTG
CTTTTCCATTGGTGGAATTGAAATAATTAGTTTTTAATTACATAAGATGCCTGTTTGCTATTTGGTGGAAGATAGATGTTCATATTGAAG
CAGTCACATTTGTACTGTAGTTCAATAAAAGAAAAATGAAGTATTCTGTAGCCTATATTTTTCATAGAGCTCATGAGCATTTACTGTACT
TGCTGGGTCTTGCCAAGATCATTTATTCCGCTGCATTGCCAAAGTGTCTTCATACCAAATTAAAGGTGGTTTTAATATATGTTTCATGGA
AGTTGTTTATAAAATTCAAAGGTATTTCATTTAGGTGAAAAGTCTTATTTATTAAAGTGGTTTGAATAAAGTAGATCAAAACTTCCAGAG
ATCTTAATGGCTATATAGGAAGAAATATCACTCACCATAATTTAAATAAAGAATAAAAATACTTGTATTTTGTGGTGGCAAATGTTTGGT
AGAACTGTAATTAGAAAAATACAAGTATATTTGCGTGATGGTTACACTAGAAGCCCAGACTTTACGACTACACAATATATTCATGTATCT
AAACTGTACTTGTACCCCCTAAATTTATTTTTAAAAAAGGAAAAATAAAAGTATCATGAAAAAACCTATTTTTTTTTCCACTGTCCTTCC
ACTACTCCCATAACAAACTTATCCATGGTTGGTAAAATTTTACATATTTCTATCCTTGAAATGAAGGCTTCTTTTAAATTCCAAAGAAGT
CATGGAGGCCTGTGCATTTGAATTGTATATGCTAGTGAGGAAAAGATTTAGACATTTCAAGAGCAGGGTTGGCCAGGCGCGGTGGCTCAC
ACCTGTAATCCCAGCACTTTGGGAGGCCGAGGAGGGCGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACAGTGAAACCCCA

>In-frame_SORD_ENST00000267814_chr15_45315547_+_RAB27A_ENST00000569493_chr15_55497903_-_599nt
CTCCACGCTAGCGCCGCCCAGGCTGGCACAAAGGAGGAAGCCTAGTCCCGCCCCTGCGTGCGGCGCTTCTCCCAGGCCCCACCTTCCATC
CAGTGCCCTGGACCCTCGGCTGGGTAGCGCCACCAGAGCGACCAAACGTCCCGCGCCTTCCAGGCCGCACTCCAGAGCCAAAAGAGCTCC
ATGGCGGCGGCGGCCAAGCCCAACAACCTTTCCCTGGTGGTGCACGGACCGGGGGACTTGCGCCTGAATCCCCTACTTTGAAACTAGTGC
TGCCAATGGGACAAACATAAGCCAAGCAATTGAGATGCTTCTGGACCTGATAATGAAGCGAATGGAACGGTGTGTGGACAAGTCCTGGAT
TCCTGAAGGAGTGGTGCGATCAAATGGTCATGCCTCTACGGATCAGTTAAGTGAAGAAAAGGAGAAAGGGGCATGTGGCTGTTGAGAAGT
CAAGTAAGCGACATAGTAGTTCAGGTGGCCCATGCCTGGGATCTTCTCTATGATTGATACATGGCACAGTGAGAGATTAATGGGCATTGT


Top

FusionGenePPI for SORD_RAB27A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SORDSORD, SHBG, PFDN4, NUDCD2, RANGAP1, GCLM, RAD23A, TIPRL, LOC440434, C16orf13, TPM1, ETFA, PIEZO1, AKR1B1, FLAD1, RELA, BCCIP, DDX39A, FDPS, GDA, NME1, PGD, PLS3, ACOT7, C12orf10, CHORDC1, LDHA, NAGK, SMS, TCEA1, THOP1, TALDO1, PRR11, CAT, FAHD1, FAHD2A, GPI, NIT2, PGM1, ABAT, ALDH7A1, BROX, CRYAB, FAH, LDHAL6A, LDHAL6B, LDHB, SOD1, DAK, TPI1, NTRK1, MYH9, PDLIM7, ANLN, CFAP97, SPATA1RAB27ASYTL4, MLPH, UNC13D, RPH3AL, SYTL1, SYTL5, MYRIP, SYTL2, SYTL3, EEF1A1, ZBTB16, C14orf1, COPS6, RBM48, GDF9, KIAA1377, LRIF1, MYO5A, EXPH5, APP, FBXO6, ADRB2, UNC13B, RPH3A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for SORD_RAB27A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for SORD_RAB27A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSORDC0027055Myocardial Reperfusion Injury1CTD_human
HgeneSORDC0520459Necrotizing Enterocolitis1CTD_human
HgeneSORDC4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneRAB27AC1868679GRISCELLI SYNDROME, TYPE 21CTD_human;ORPHANET;UNIPROT