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Fusion gene ID: 35400 |
FusionGeneSummary for SORCS3_REC8 |
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Fusion gene information | Fusion gene name: SORCS3_REC8 | Fusion gene ID: 35400 | Hgene | Tgene | Gene symbol | SORCS3 | REC8 | Gene ID | 22986 | 9985 |
Gene name | sortilin related VPS10 domain containing receptor 3 | REC8 meiotic recombination protein | |
Synonyms | SORCS | HR21spB|REC8L1|Rec8p | |
Cytomap | 10q25.1 | 14q12 | |
Type of gene | protein-coding | protein-coding | |
Description | VPS10 domain-containing receptor SorCS3VPS10 domain receptor protein SORCS 3 (SORCS3) | meiotic recombination protein REC8 homologREC8 homologREC8-like 1cohesin Rec8pcohesion rec8phuman homolog of rad21, S. pombekleisin-alphameiotic recombination and sister chromatid cohesion phosphoprotein of the rad21p familymeiotic recombination p | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | Q9UPU3 | O95072 | |
Ensembl transtripts involved in fusion gene | ENST00000369701, ENST00000369699, | ENST00000311457, ENST00000559919, ENST00000559939, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 1 X 1 X 1=1 |
# samples | 1 | 1 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: SORCS3 [Title/Abstract] AND REC8 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | T07523 | SORCS3 | chr10 | 106961058 | + | REC8 | chr14 | 24649463 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000369701 | ENST00000311457 | SORCS3 | chr10 | 106961058 | + | REC8 | chr14 | 24649463 | - |
intron-intron | ENST00000369701 | ENST00000559919 | SORCS3 | chr10 | 106961058 | + | REC8 | chr14 | 24649463 | - |
intron-intron | ENST00000369701 | ENST00000559939 | SORCS3 | chr10 | 106961058 | + | REC8 | chr14 | 24649463 | - |
intron-intron | ENST00000369699 | ENST00000311457 | SORCS3 | chr10 | 106961058 | + | REC8 | chr14 | 24649463 | - |
intron-intron | ENST00000369699 | ENST00000559919 | SORCS3 | chr10 | 106961058 | + | REC8 | chr14 | 24649463 | - |
intron-intron | ENST00000369699 | ENST00000559939 | SORCS3 | chr10 | 106961058 | + | REC8 | chr14 | 24649463 | - |
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FusionProtFeatures for SORCS3_REC8 |
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Hgene | Tgene |
SORCS3 | REC8 |
Required during meiosis for separation of sisterchromatids and homologous chromosomes. Proteolytic cleavage ofREC8 on chromosome arms by separin during anaphase I allows forhomologous chromosome separation in meiosis I and cleavage of REC8on centromeres during anaphase II allows for sister chromatidseparation in meiosis II (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SORCS3_REC8 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SORCS3_REC8 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SORCS3_REC8 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SORCS3_REC8 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | REC8 | C0025202 | melanoma | 1 | CTD_human |
Tgene | REC8 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |