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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35399

FusionGeneSummary for SORCS2_SPSB1

check button Fusion gene summary
Fusion gene informationFusion gene name: SORCS2_SPSB1
Fusion gene ID: 35399
HgeneTgene
Gene symbol

SORCS2

SPSB1

Gene ID

57537

80176

Gene namesortilin related VPS10 domain containing receptor 2splA/ryanodine receptor domain and SOCS box containing 1
Synonyms-SSB-1|SSB1
Cytomap

4p16.1

1p36.22

Type of geneprotein-codingprotein-coding
DescriptionVPS10 domain-containing receptor SorCS2VPS10 domain receptor proteinSPRY domain-containing SOCS box protein 1SPRY domain-containing SOCS box protein SSB-1novel SPRY domain containing protein
Modification date2018051920180523
UniProtAcc

Q96PQ0

Q96BD6

Ensembl transtripts involved in fusion geneENST00000507866, ENST00000511199, 
ENST00000329016, 
ENST00000328089, 
ENST00000357898, ENST00000377399, 
Fusion gene scores* DoF score2 X 2 X 2=88 X 6 X 7=336
# samples 28
** MAII scorelog2(2/8*10)=1.32192809488736log2(8/336*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SORCS2 [Title/Abstract] AND SPSB1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF854699SORCS2chr4

7705143

-SPSB1chr1

9365320

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000507866ENST00000328089SORCS2chr4

7705143

-SPSB1chr1

9365320

-
intron-intronENST00000507866ENST00000357898SORCS2chr4

7705143

-SPSB1chr1

9365320

-
intron-intronENST00000507866ENST00000377399SORCS2chr4

7705143

-SPSB1chr1

9365320

-
intron-intronENST00000511199ENST00000328089SORCS2chr4

7705143

-SPSB1chr1

9365320

-
intron-intronENST00000511199ENST00000357898SORCS2chr4

7705143

-SPSB1chr1

9365320

-
intron-intronENST00000511199ENST00000377399SORCS2chr4

7705143

-SPSB1chr1

9365320

-
intron-intronENST00000329016ENST00000328089SORCS2chr4

7705143

-SPSB1chr1

9365320

-
intron-intronENST00000329016ENST00000357898SORCS2chr4

7705143

-SPSB1chr1

9365320

-
intron-intronENST00000329016ENST00000377399SORCS2chr4

7705143

-SPSB1chr1

9365320

-

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FusionProtFeatures for SORCS2_SPSB1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SORCS2

Q96PQ0

SPSB1

Q96BD6

Probable substrate recognition component of a SCF-likeECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-proteinligase complex which mediates the ubiquitination and subsequentproteasomal degradation of target proteins.{ECO:0000269|PubMed:15601820}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SORCS2_SPSB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SORCS2_SPSB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SORCS2_SPSB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SORCS2_SPSB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSORCS2C0005586Bipolar Disorder1PSYGENET