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Fusion gene ID: 35399 |
FusionGeneSummary for SORCS2_SPSB1 |
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Fusion gene information | Fusion gene name: SORCS2_SPSB1 | Fusion gene ID: 35399 | Hgene | Tgene | Gene symbol | SORCS2 | SPSB1 | Gene ID | 57537 | 80176 |
Gene name | sortilin related VPS10 domain containing receptor 2 | splA/ryanodine receptor domain and SOCS box containing 1 | |
Synonyms | - | SSB-1|SSB1 | |
Cytomap | 4p16.1 | 1p36.22 | |
Type of gene | protein-coding | protein-coding | |
Description | VPS10 domain-containing receptor SorCS2VPS10 domain receptor protein | SPRY domain-containing SOCS box protein 1SPRY domain-containing SOCS box protein SSB-1novel SPRY domain containing protein | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q96PQ0 | Q96BD6 | |
Ensembl transtripts involved in fusion gene | ENST00000507866, ENST00000511199, ENST00000329016, | ENST00000328089, ENST00000357898, ENST00000377399, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 8 X 6 X 7=336 |
# samples | 2 | 8 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(8/336*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SORCS2 [Title/Abstract] AND SPSB1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF854699 | SORCS2 | chr4 | 7705143 | - | SPSB1 | chr1 | 9365320 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000507866 | ENST00000328089 | SORCS2 | chr4 | 7705143 | - | SPSB1 | chr1 | 9365320 | - |
intron-intron | ENST00000507866 | ENST00000357898 | SORCS2 | chr4 | 7705143 | - | SPSB1 | chr1 | 9365320 | - |
intron-intron | ENST00000507866 | ENST00000377399 | SORCS2 | chr4 | 7705143 | - | SPSB1 | chr1 | 9365320 | - |
intron-intron | ENST00000511199 | ENST00000328089 | SORCS2 | chr4 | 7705143 | - | SPSB1 | chr1 | 9365320 | - |
intron-intron | ENST00000511199 | ENST00000357898 | SORCS2 | chr4 | 7705143 | - | SPSB1 | chr1 | 9365320 | - |
intron-intron | ENST00000511199 | ENST00000377399 | SORCS2 | chr4 | 7705143 | - | SPSB1 | chr1 | 9365320 | - |
intron-intron | ENST00000329016 | ENST00000328089 | SORCS2 | chr4 | 7705143 | - | SPSB1 | chr1 | 9365320 | - |
intron-intron | ENST00000329016 | ENST00000357898 | SORCS2 | chr4 | 7705143 | - | SPSB1 | chr1 | 9365320 | - |
intron-intron | ENST00000329016 | ENST00000377399 | SORCS2 | chr4 | 7705143 | - | SPSB1 | chr1 | 9365320 | - |
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FusionProtFeatures for SORCS2_SPSB1 |
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Hgene | Tgene |
SORCS2 | SPSB1 |
Probable substrate recognition component of a SCF-likeECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-proteinligase complex which mediates the ubiquitination and subsequentproteasomal degradation of target proteins.{ECO:0000269|PubMed:15601820}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SORCS2_SPSB1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SORCS2_SPSB1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SORCS2_SPSB1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SORCS2_SPSB1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SORCS2 | C0005586 | Bipolar Disorder | 1 | PSYGENET |