![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 35398 |
FusionGeneSummary for SORCS2_SH3TC1 |
![]() |
Fusion gene information | Fusion gene name: SORCS2_SH3TC1 | Fusion gene ID: 35398 | Hgene | Tgene | Gene symbol | SORCS2 | SH3TC1 | Gene ID | 57537 | 54436 |
Gene name | sortilin related VPS10 domain containing receptor 2 | SH3 domain and tetratricopeptide repeats 1 | |
Synonyms | - | - | |
Cytomap | 4p16.1 | 4p16.1 | |
Type of gene | protein-coding | protein-coding | |
Description | VPS10 domain-containing receptor SorCS2VPS10 domain receptor protein | SH3 domain and tetratricopeptide repeat-containing protein 1SH3 domain and tetratricopeptide repeats-containing protein 1 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q96PQ0 | Q8TE82 | |
Ensembl transtripts involved in fusion gene | ENST00000507866, ENST00000511199, ENST00000329016, | ENST00000382521, ENST00000245105, ENST00000539824, ENST00000514274, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 2 X 2 X 2=8 |
# samples | 2 | 2 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: SORCS2 [Title/Abstract] AND SH3TC1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BLCA | TCGA-DK-A3IS-01A | SORCS2 | chr4 | 7194853 | + | SH3TC1 | chr4 | 8242425 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000507866 | ENST00000382521 | SORCS2 | chr4 | 7194853 | + | SH3TC1 | chr4 | 8242425 | + |
5CDS-intron | ENST00000507866 | ENST00000245105 | SORCS2 | chr4 | 7194853 | + | SH3TC1 | chr4 | 8242425 | + |
5CDS-intron | ENST00000507866 | ENST00000539824 | SORCS2 | chr4 | 7194853 | + | SH3TC1 | chr4 | 8242425 | + |
5CDS-intron | ENST00000507866 | ENST00000514274 | SORCS2 | chr4 | 7194853 | + | SH3TC1 | chr4 | 8242425 | + |
intron-intron | ENST00000511199 | ENST00000382521 | SORCS2 | chr4 | 7194853 | + | SH3TC1 | chr4 | 8242425 | + |
intron-intron | ENST00000511199 | ENST00000245105 | SORCS2 | chr4 | 7194853 | + | SH3TC1 | chr4 | 8242425 | + |
intron-intron | ENST00000511199 | ENST00000539824 | SORCS2 | chr4 | 7194853 | + | SH3TC1 | chr4 | 8242425 | + |
intron-intron | ENST00000511199 | ENST00000514274 | SORCS2 | chr4 | 7194853 | + | SH3TC1 | chr4 | 8242425 | + |
intron-intron | ENST00000329016 | ENST00000382521 | SORCS2 | chr4 | 7194853 | + | SH3TC1 | chr4 | 8242425 | + |
intron-intron | ENST00000329016 | ENST00000245105 | SORCS2 | chr4 | 7194853 | + | SH3TC1 | chr4 | 8242425 | + |
intron-intron | ENST00000329016 | ENST00000539824 | SORCS2 | chr4 | 7194853 | + | SH3TC1 | chr4 | 8242425 | + |
intron-intron | ENST00000329016 | ENST00000514274 | SORCS2 | chr4 | 7194853 | + | SH3TC1 | chr4 | 8242425 | + |
Top |
FusionProtFeatures for SORCS2_SH3TC1 |
![]() |
Hgene | Tgene |
SORCS2 | SH3TC1 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for SORCS2_SH3TC1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for SORCS2_SH3TC1 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SORCS2 | TRIM25 | SH3TC1 | ATF6 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for SORCS2_SH3TC1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for SORCS2_SH3TC1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SORCS2 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Tgene | SH3TC1 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |