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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35396

FusionGeneSummary for SORBS2_TNRC6A

check button Fusion gene summary
Fusion gene informationFusion gene name: SORBS2_TNRC6A
Fusion gene ID: 35396
HgeneTgene
Gene symbol

SORBS2

TNRC6A

Gene ID

8470

27327

Gene namesorbin and SH3 domain containing 2trinucleotide repeat containing 6A
SynonymsARGBP2|PRO0618CAGH26|GW1|GW182|TNRC6
Cytomap

4q35.1

16p12.1

Type of geneprotein-codingprotein-coding
Descriptionsorbin and SH3 domain-containing protein 2Arg binding protein 2Arg/Abl-interacting protein 2arg-binding protein 2trinucleotide repeat-containing gene 6A proteinCAG repeat protein 26CTD-2540M10.1EDIEEMSY interactor proteinGW182 autoantigenglycine-tryptophan protein of 182 kDa
Modification date2018052320180519
UniProtAcc

O94875

Q8NDV7

Ensembl transtripts involved in fusion geneENST00000448662, ENST00000431808, 
ENST00000284776, ENST00000437304, 
ENST00000319471, ENST00000449407, 
ENST00000355634, ENST00000393528, 
ENST00000418609, ENST00000498125, 
ENST00000315183, ENST00000562829, 
ENST00000395799, ENST00000432286, 
Fusion gene scores* DoF score14 X 16 X 6=134411 X 11 X 3=363
# samples 1811
** MAII scorelog2(18/1344*10)=-2.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(11/363*10)=-1.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SORBS2 [Title/Abstract] AND TNRC6A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTNRC6A

GO:0035278

miRNA mediated inhibition of translation

17671087


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AK025277SORBS2chr4

186610266

-TNRC6Achr16

24828954

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000448662ENST00000315183SORBS2chr4

186610266

-TNRC6Achr16

24828954

+
intron-intronENST00000448662ENST00000562829SORBS2chr4

186610266

-TNRC6Achr16

24828954

+
intron-intronENST00000448662ENST00000395799SORBS2chr4

186610266

-TNRC6Achr16

24828954

+
intron-intronENST00000448662ENST00000432286SORBS2chr4

186610266

-TNRC6Achr16

24828954

+
intron-intronENST00000431808ENST00000315183SORBS2chr4

186610266

-TNRC6Achr16

24828954

+
intron-intronENST00000431808ENST00000562829SORBS2chr4

186610266

-TNRC6Achr16

24828954

+
intron-intronENST00000431808ENST00000395799SORBS2chr4

186610266

-TNRC6Achr16

24828954

+
intron-intronENST00000431808ENST00000432286SORBS2chr4

186610266

-TNRC6Achr16

24828954

+
intron-intronENST00000284776ENST00000315183SORBS2chr4

186610266

-TNRC6Achr16

24828954

+
intron-intronENST00000284776ENST00000562829SORBS2chr4

186610266

-TNRC6Achr16

24828954

+
intron-intronENST00000284776ENST00000395799SORBS2chr4

186610266

-TNRC6Achr16

24828954

+
intron-intronENST00000284776ENST00000432286SORBS2chr4

186610266

-TNRC6Achr16

24828954

+
intron-intronENST00000437304ENST00000315183SORBS2chr4

186610266

-TNRC6Achr16

24828954

+
intron-intronENST00000437304ENST00000562829SORBS2chr4

186610266

-TNRC6Achr16

24828954

+
intron-intronENST00000437304ENST00000395799SORBS2chr4

186610266

-TNRC6Achr16

24828954

+
intron-intronENST00000437304ENST00000432286SORBS2chr4

186610266

-TNRC6Achr16

24828954

+
intron-intronENST00000319471ENST00000315183SORBS2chr4

186610266

-TNRC6Achr16

24828954

+
intron-intronENST00000319471ENST00000562829SORBS2chr4

186610266

-TNRC6Achr16

24828954

+
intron-intronENST00000319471ENST00000395799SORBS2chr4

186610266

-TNRC6Achr16

24828954

+
intron-intronENST00000319471ENST00000432286SORBS2chr4

186610266

-TNRC6Achr16

24828954

+
intron-intronENST00000449407ENST00000315183SORBS2chr4

186610266

-TNRC6Achr16

24828954

+
intron-intronENST00000449407ENST00000562829SORBS2chr4

186610266

-TNRC6Achr16

24828954

+
intron-intronENST00000449407ENST00000395799SORBS2chr4

186610266

-TNRC6Achr16

24828954

+
intron-intronENST00000449407ENST00000432286SORBS2chr4

186610266

-TNRC6Achr16

24828954

+
intron-intronENST00000355634ENST00000315183SORBS2chr4

186610266

-TNRC6Achr16

24828954

+
intron-intronENST00000355634ENST00000562829SORBS2chr4

186610266

-TNRC6Achr16

24828954

+
intron-intronENST00000355634ENST00000395799SORBS2chr4

186610266

-TNRC6Achr16

24828954

+
intron-intronENST00000355634ENST00000432286SORBS2chr4

186610266

-TNRC6Achr16

24828954

+
intron-intronENST00000393528ENST00000315183SORBS2chr4

186610266

-TNRC6Achr16

24828954

+
intron-intronENST00000393528ENST00000562829SORBS2chr4

186610266

-TNRC6Achr16

24828954

+
intron-intronENST00000393528ENST00000395799SORBS2chr4

186610266

-TNRC6Achr16

24828954

+
intron-intronENST00000393528ENST00000432286SORBS2chr4

186610266

-TNRC6Achr16

24828954

+
intron-intronENST00000418609ENST00000315183SORBS2chr4

186610266

-TNRC6Achr16

24828954

+
intron-intronENST00000418609ENST00000562829SORBS2chr4

186610266

-TNRC6Achr16

24828954

+
intron-intronENST00000418609ENST00000395799SORBS2chr4

186610266

-TNRC6Achr16

24828954

+
intron-intronENST00000418609ENST00000432286SORBS2chr4

186610266

-TNRC6Achr16

24828954

+
intron-intronENST00000498125ENST00000315183SORBS2chr4

186610266

-TNRC6Achr16

24828954

+
intron-intronENST00000498125ENST00000562829SORBS2chr4

186610266

-TNRC6Achr16

24828954

+
intron-intronENST00000498125ENST00000395799SORBS2chr4

186610266

-TNRC6Achr16

24828954

+
intron-intronENST00000498125ENST00000432286SORBS2chr4

186610266

-TNRC6Achr16

24828954

+

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FusionProtFeatures for SORBS2_TNRC6A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SORBS2

O94875

TNRC6A

Q8NDV7


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SORBS2_TNRC6A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SORBS2_TNRC6A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SORBS2_TNRC6A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SORBS2_TNRC6A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSORBS2C0043094Weight Gain1CTD_human