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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35394

FusionGeneSummary for SORBS2_PLAGL1

check button Fusion gene summary
Fusion gene informationFusion gene name: SORBS2_PLAGL1
Fusion gene ID: 35394
HgeneTgene
Gene symbol

SORBS2

PLAGL1

Gene ID

8470

5325

Gene namesorbin and SH3 domain containing 2PLAG1 like zinc finger 1
SynonymsARGBP2|PRO0618LOT1|ZAC|ZAC1
Cytomap

4q35.1

6q24.2

Type of geneprotein-codingprotein-coding
Descriptionsorbin and SH3 domain-containing protein 2Arg binding protein 2Arg/Abl-interacting protein 2arg-binding protein 2zinc finger protein PLAGL1PLAG-like 1lost on transformation 1pleiomorphic adenoma gene-like 1tumor suppressor ZAC
Modification date2018052320180523
UniProtAcc

O94875

Q9UM63

Ensembl transtripts involved in fusion geneENST00000448662, ENST00000431808, 
ENST00000284776, ENST00000437304, 
ENST00000319471, ENST00000449407, 
ENST00000355634, ENST00000393528, 
ENST00000418609, ENST00000498125, 
ENST00000429150, ENST00000416623, 
ENST00000392309, ENST00000392307, 
ENST00000437412, ENST00000444202, 
ENST00000493898, ENST00000360537, 
ENST00000354765, ENST00000367572, 
ENST00000367571, 
Fusion gene scores* DoF score14 X 16 X 6=13446 X 4 X 4=96
# samples 186
** MAII scorelog2(18/1344*10)=-2.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SORBS2 [Title/Abstract] AND PLAGL1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePLAGL1

GO:0045944

positive regulation of transcription by RNA polymerase II

9671765|15888726


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA013158SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000448662ENST00000429150SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
intron-5UTRENST00000448662ENST00000416623SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
intron-5UTRENST00000448662ENST00000392309SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
intron-5UTRENST00000448662ENST00000392307SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
intron-5UTRENST00000448662ENST00000437412SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
intron-5UTRENST00000448662ENST00000444202SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
intron-intronENST00000448662ENST00000493898SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
intron-5UTRENST00000448662ENST00000360537SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
intron-5UTRENST00000448662ENST00000354765SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
intron-5UTRENST00000448662ENST00000367572SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
intron-5UTRENST00000448662ENST00000367571SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000431808ENST00000429150SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000431808ENST00000416623SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000431808ENST00000392309SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000431808ENST00000392307SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000431808ENST00000437412SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000431808ENST00000444202SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-intronENST00000431808ENST00000493898SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000431808ENST00000360537SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000431808ENST00000354765SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000431808ENST00000367572SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000431808ENST00000367571SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000284776ENST00000429150SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000284776ENST00000416623SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000284776ENST00000392309SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000284776ENST00000392307SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000284776ENST00000437412SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000284776ENST00000444202SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-intronENST00000284776ENST00000493898SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000284776ENST00000360537SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000284776ENST00000354765SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000284776ENST00000367572SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000284776ENST00000367571SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000437304ENST00000429150SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000437304ENST00000416623SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000437304ENST00000392309SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000437304ENST00000392307SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000437304ENST00000437412SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000437304ENST00000444202SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-intronENST00000437304ENST00000493898SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000437304ENST00000360537SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000437304ENST00000354765SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000437304ENST00000367572SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000437304ENST00000367571SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000319471ENST00000429150SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000319471ENST00000416623SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000319471ENST00000392309SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000319471ENST00000392307SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000319471ENST00000437412SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000319471ENST00000444202SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-intronENST00000319471ENST00000493898SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000319471ENST00000360537SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000319471ENST00000354765SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000319471ENST00000367572SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000319471ENST00000367571SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000449407ENST00000429150SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000449407ENST00000416623SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000449407ENST00000392309SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000449407ENST00000392307SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000449407ENST00000437412SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000449407ENST00000444202SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-intronENST00000449407ENST00000493898SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000449407ENST00000360537SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000449407ENST00000354765SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000449407ENST00000367572SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000449407ENST00000367571SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000355634ENST00000429150SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000355634ENST00000416623SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000355634ENST00000392309SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000355634ENST00000392307SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000355634ENST00000437412SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000355634ENST00000444202SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-intronENST00000355634ENST00000493898SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000355634ENST00000360537SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000355634ENST00000354765SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000355634ENST00000367572SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000355634ENST00000367571SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000393528ENST00000429150SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000393528ENST00000416623SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000393528ENST00000392309SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000393528ENST00000392307SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000393528ENST00000437412SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000393528ENST00000444202SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-intronENST00000393528ENST00000493898SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000393528ENST00000360537SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000393528ENST00000354765SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000393528ENST00000367572SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
5UTR-5UTRENST00000393528ENST00000367571SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
intron-5UTRENST00000418609ENST00000429150SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
intron-5UTRENST00000418609ENST00000416623SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
intron-5UTRENST00000418609ENST00000392309SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
intron-5UTRENST00000418609ENST00000392307SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
intron-5UTRENST00000418609ENST00000437412SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
intron-5UTRENST00000418609ENST00000444202SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
intron-intronENST00000418609ENST00000493898SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
intron-5UTRENST00000418609ENST00000360537SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
intron-5UTRENST00000418609ENST00000354765SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
intron-5UTRENST00000418609ENST00000367572SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
intron-5UTRENST00000418609ENST00000367571SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
intron-5UTRENST00000498125ENST00000429150SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
intron-5UTRENST00000498125ENST00000416623SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
intron-5UTRENST00000498125ENST00000392309SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
intron-5UTRENST00000498125ENST00000392307SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
intron-5UTRENST00000498125ENST00000437412SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
intron-5UTRENST00000498125ENST00000444202SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
intron-intronENST00000498125ENST00000493898SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
intron-5UTRENST00000498125ENST00000360537SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
intron-5UTRENST00000498125ENST00000354765SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
intron-5UTRENST00000498125ENST00000367572SORBS2chr4

186696379

-PLAGL1chr6

144281681

-
intron-5UTRENST00000498125ENST00000367571SORBS2chr4

186696379

-PLAGL1chr6

144281681

-

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FusionProtFeatures for SORBS2_PLAGL1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SORBS2

O94875

PLAGL1

Q9UM63


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SORBS2_PLAGL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for SORBS2_PLAGL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SORBS2YWHAE, SFN, CBL, PTK2B, FLOT1, RPL9, DLGAP4, DLGAP1, VCL, MLLT4, ABL2, ABL1, EGFR, NR1H2, SEMA6A, PALLD, ACTN1, ADAM15, WASF1, PTPN12, BAG3, AKT2, MDM2, YWHAZ, YWHAB, WAS, NCK2, SORBS2, EFS, VPS37C, SH2D4A, ATPAF2, SUZ12, CAPZA2, CLTC, DBN1, FLNA, MYH9, MYO1C, PPP1CB, IQGAP1, SYNPO, MAPRE1, LIMA1, ANLN, MYO18A, FAT1PLAGL1TP53, DAXX, PML, EP300, CREBBP, HDAC1, UBE2I, PIAS2, SMAD3, TP73, KAT2B, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SORBS2_PLAGL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SORBS2_PLAGL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSORBS2C0043094Weight Gain1CTD_human
TgenePLAGL1C0038356Stomach Neoplasms1CTD_human