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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35393

FusionGeneSummary for SORBS2_PHLPP2

check button Fusion gene summary
Fusion gene informationFusion gene name: SORBS2_PHLPP2
Fusion gene ID: 35393
HgeneTgene
Gene symbol

SORBS2

PHLPP2

Gene ID

8470

23035

Gene namesorbin and SH3 domain containing 2PH domain and leucine rich repeat protein phosphatase 2
SynonymsARGBP2|PRO0618PHLPPL|PPM3B
Cytomap

4q35.1

16q22.2

Type of geneprotein-codingprotein-coding
Descriptionsorbin and SH3 domain-containing protein 2Arg binding protein 2Arg/Abl-interacting protein 2arg-binding protein 2PH domain leucine-rich repeat-containing protein phosphatase 2protein phosphatase, Mg2+/Mn2+ dependent 3B
Modification date2018052320180523
UniProtAcc

O94875

Q6ZVD8

Ensembl transtripts involved in fusion geneENST00000448662, ENST00000431808, 
ENST00000284776, ENST00000437304, 
ENST00000319471, ENST00000449407, 
ENST00000355634, ENST00000393528, 
ENST00000418609, ENST00000498125, 
ENST00000540628, ENST00000360429, 
ENST00000568954, ENST00000393524, 
ENST00000356272, ENST00000567016, 
Fusion gene scores* DoF score14 X 16 X 6=13444 X 3 X 1=12
# samples 185
** MAII scorelog2(18/1344*10)=-2.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/12*10)=2.05889368905357
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SORBS2 [Title/Abstract] AND PHLPP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF921368SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000448662ENST00000540628SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000448662ENST00000360429SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000448662ENST00000568954SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000448662ENST00000393524SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000448662ENST00000356272SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000448662ENST00000567016SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000431808ENST00000540628SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000431808ENST00000360429SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000431808ENST00000568954SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000431808ENST00000393524SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000431808ENST00000356272SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000431808ENST00000567016SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000284776ENST00000540628SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000284776ENST00000360429SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000284776ENST00000568954SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000284776ENST00000393524SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000284776ENST00000356272SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000284776ENST00000567016SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000437304ENST00000540628SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000437304ENST00000360429SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000437304ENST00000568954SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000437304ENST00000393524SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000437304ENST00000356272SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000437304ENST00000567016SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000319471ENST00000540628SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000319471ENST00000360429SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000319471ENST00000568954SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000319471ENST00000393524SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000319471ENST00000356272SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000319471ENST00000567016SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000449407ENST00000540628SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000449407ENST00000360429SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000449407ENST00000568954SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000449407ENST00000393524SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000449407ENST00000356272SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000449407ENST00000567016SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000355634ENST00000540628SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000355634ENST00000360429SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000355634ENST00000568954SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000355634ENST00000393524SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000355634ENST00000356272SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000355634ENST00000567016SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000393528ENST00000540628SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000393528ENST00000360429SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000393528ENST00000568954SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000393528ENST00000393524SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000393528ENST00000356272SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000393528ENST00000567016SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000418609ENST00000540628SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000418609ENST00000360429SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000418609ENST00000568954SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000418609ENST00000393524SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000418609ENST00000356272SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000418609ENST00000567016SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000498125ENST00000540628SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000498125ENST00000360429SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000498125ENST00000568954SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000498125ENST00000393524SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000498125ENST00000356272SORBS2chr4

186614778

-PHLPP2chr16

71748346

+
intron-intronENST00000498125ENST00000567016SORBS2chr4

186614778

-PHLPP2chr16

71748346

+

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FusionProtFeatures for SORBS2_PHLPP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SORBS2

O94875

PHLPP2

Q6ZVD8

Protein phosphatase involved in regulation of Akt andPKC signaling. Mediates dephosphorylation in the C-terminal domainhydrophobic motif of members of the AGC Ser/Thr protein kinasefamily; specifically acts on 'Ser-473' of AKT1, 'Ser-660' of PRKCBisoform beta-II and 'Ser-657' of PRKCA. Akt regulates the balancebetween cell survival and apoptosis through a cascade thatprimarily alters the function of transcription factors thatregulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and decreases cell proliferation.Also controls the phosphorylation of AKT3. Dephosphorylates STK4on 'Thr-387' leading to STK4 activation and apoptosis(PubMed:20513427). Dephosphorylates RPS6KB1 and is involved inregulation of cap-dependent translation (PubMed:21986499).Inhibits cancer cell proliferation and may act as a tumorsuppressor. Dephosphorylation of PRKCA and PRKCB leads to theirdestabilization and degradation. Dephosphorylates RAF1 inhibitingits kinase activity (PubMed:24530606).{ECO:0000269|PubMed:17386267, ECO:0000269|PubMed:18162466,ECO:0000269|PubMed:19079341, ECO:0000269|PubMed:20513427,ECO:0000269|PubMed:21986499, ECO:0000269|PubMed:24530606}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SORBS2_PHLPP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SORBS2_PHLPP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SORBS2_PHLPP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SORBS2_PHLPP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSORBS2C0043094Weight Gain1CTD_human