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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35392

FusionGeneSummary for SORBS2_PDLIM5

check button Fusion gene summary
Fusion gene informationFusion gene name: SORBS2_PDLIM5
Fusion gene ID: 35392
HgeneTgene
Gene symbol

SORBS2

PDLIM5

Gene ID

8470

10611

Gene namesorbin and SH3 domain containing 2PDZ and LIM domain 5
SynonymsARGBP2|PRO0618ENH|ENH1|L9|LIM
Cytomap

4q35.1

4q22.3

Type of geneprotein-codingprotein-coding
Descriptionsorbin and SH3 domain-containing protein 2Arg binding protein 2Arg/Abl-interacting protein 2arg-binding protein 2PDZ and LIM domain protein 5enigma homologenigma-like LIM domain proteinenigma-like PDZ and LIM domains protein
Modification date2018052320180522
UniProtAcc

O94875

Q96HC4

Ensembl transtripts involved in fusion geneENST00000448662, ENST00000431808, 
ENST00000284776, ENST00000437304, 
ENST00000319471, ENST00000449407, 
ENST00000355634, ENST00000393528, 
ENST00000418609, ENST00000498125, 
ENST00000450793, ENST00000538141, 
ENST00000380180, ENST00000318007, 
ENST00000437932, ENST00000317968, 
ENST00000542407, ENST00000508216, 
ENST00000514743, ENST00000380176, 
ENST00000359265, ENST00000512274, 
ENST00000504489, 
Fusion gene scores* DoF score14 X 16 X 6=13449 X 12 X 5=540
# samples 1812
** MAII scorelog2(18/1344*10)=-2.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(12/540*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SORBS2 [Title/Abstract] AND PDLIM5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ941394SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000448662ENST00000450793SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000448662ENST00000538141SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000448662ENST00000380180SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000448662ENST00000318007SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-3UTRENST00000448662ENST00000437932SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-3UTRENST00000448662ENST00000317968SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000448662ENST00000542407SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000448662ENST00000508216SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000448662ENST00000514743SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000448662ENST00000380176SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000448662ENST00000359265SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000448662ENST00000512274SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000448662ENST00000504489SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000431808ENST00000450793SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000431808ENST00000538141SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000431808ENST00000380180SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000431808ENST00000318007SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-3UTRENST00000431808ENST00000437932SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-3UTRENST00000431808ENST00000317968SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000431808ENST00000542407SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000431808ENST00000508216SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000431808ENST00000514743SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000431808ENST00000380176SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000431808ENST00000359265SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000431808ENST00000512274SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000431808ENST00000504489SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000284776ENST00000450793SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000284776ENST00000538141SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000284776ENST00000380180SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000284776ENST00000318007SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-3UTRENST00000284776ENST00000437932SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-3UTRENST00000284776ENST00000317968SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000284776ENST00000542407SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000284776ENST00000508216SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000284776ENST00000514743SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000284776ENST00000380176SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000284776ENST00000359265SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000284776ENST00000512274SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000284776ENST00000504489SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000437304ENST00000450793SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000437304ENST00000538141SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000437304ENST00000380180SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000437304ENST00000318007SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-3UTRENST00000437304ENST00000437932SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-3UTRENST00000437304ENST00000317968SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000437304ENST00000542407SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000437304ENST00000508216SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000437304ENST00000514743SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000437304ENST00000380176SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000437304ENST00000359265SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000437304ENST00000512274SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000437304ENST00000504489SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000319471ENST00000450793SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000319471ENST00000538141SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000319471ENST00000380180SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000319471ENST00000318007SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-3UTRENST00000319471ENST00000437932SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-3UTRENST00000319471ENST00000317968SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000319471ENST00000542407SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000319471ENST00000508216SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000319471ENST00000514743SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000319471ENST00000380176SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000319471ENST00000359265SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000319471ENST00000512274SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000319471ENST00000504489SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000449407ENST00000450793SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000449407ENST00000538141SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000449407ENST00000380180SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000449407ENST00000318007SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-3UTRENST00000449407ENST00000437932SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-3UTRENST00000449407ENST00000317968SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000449407ENST00000542407SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000449407ENST00000508216SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000449407ENST00000514743SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000449407ENST00000380176SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000449407ENST00000359265SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000449407ENST00000512274SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000449407ENST00000504489SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000355634ENST00000450793SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000355634ENST00000538141SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000355634ENST00000380180SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000355634ENST00000318007SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-3UTRENST00000355634ENST00000437932SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-3UTRENST00000355634ENST00000317968SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000355634ENST00000542407SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000355634ENST00000508216SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000355634ENST00000514743SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000355634ENST00000380176SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000355634ENST00000359265SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000355634ENST00000512274SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000355634ENST00000504489SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000393528ENST00000450793SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000393528ENST00000538141SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000393528ENST00000380180SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000393528ENST00000318007SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-3UTRENST00000393528ENST00000437932SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-3UTRENST00000393528ENST00000317968SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000393528ENST00000542407SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000393528ENST00000508216SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000393528ENST00000514743SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000393528ENST00000380176SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000393528ENST00000359265SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000393528ENST00000512274SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000393528ENST00000504489SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000418609ENST00000450793SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000418609ENST00000538141SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000418609ENST00000380180SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000418609ENST00000318007SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-3UTRENST00000418609ENST00000437932SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-3UTRENST00000418609ENST00000317968SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000418609ENST00000542407SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000418609ENST00000508216SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000418609ENST00000514743SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000418609ENST00000380176SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000418609ENST00000359265SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000418609ENST00000512274SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000418609ENST00000504489SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000498125ENST00000450793SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000498125ENST00000538141SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000498125ENST00000380180SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000498125ENST00000318007SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-3UTRENST00000498125ENST00000437932SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-3UTRENST00000498125ENST00000317968SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000498125ENST00000542407SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000498125ENST00000508216SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000498125ENST00000514743SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000498125ENST00000380176SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000498125ENST00000359265SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000498125ENST00000512274SORBS2chr4

186516508

-PDLIM5chr4

95589273

+
intron-intronENST00000498125ENST00000504489SORBS2chr4

186516508

-PDLIM5chr4

95589273

+

Top

FusionProtFeatures for SORBS2_PDLIM5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SORBS2

O94875

PDLIM5

Q96HC4

May play an important role in the heart development byscaffolding PKC to the Z-disk region. May play a role in theregulation of cardiomyocyte expansion. Overexpression promotes thedevelopment of heart hypertrophy. Contributes to the regulation ofdendritic spine morphogenesis in neurons. May restrainpostsynaptic growth of excitatory synapses (By similarity).{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for SORBS2_PDLIM5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for SORBS2_PDLIM5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for SORBS2_PDLIM5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for SORBS2_PDLIM5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSORBS2C0043094Weight Gain1CTD_human
TgenePDLIM5C0005586Bipolar Disorder5PSYGENET
TgenePDLIM5C0036341Schizophrenia4PSYGENET
TgenePDLIM5C0041696Unipolar Depression4PSYGENET
TgenePDLIM5C1269683Major Depressive Disorder4PSYGENET
TgenePDLIM5C0151744Myocardial Ischemia1CTD_human
TgenePDLIM5C0221765Chronic schizophrenia1PSYGENET