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Fusion gene ID: 35388 |
FusionGeneSummary for SORBS2_FAM53B |
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Fusion gene information | Fusion gene name: SORBS2_FAM53B | Fusion gene ID: 35388 | Hgene | Tgene | Gene symbol | SORBS2 | FAM53B | Gene ID | 8470 | 9679 |
Gene name | sorbin and SH3 domain containing 2 | family with sequence similarity 53 member B | |
Synonyms | ARGBP2|PRO0618 | KIAA0140|bA12J10.2|smp | |
Cytomap | 4q35.1 | 10q26.13 | |
Type of gene | protein-coding | protein-coding | |
Description | sorbin and SH3 domain-containing protein 2Arg binding protein 2Arg/Abl-interacting protein 2arg-binding protein 2 | protein FAM53Bprotein simpletsimplet homolog | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | O94875 | Q14153 | |
Ensembl transtripts involved in fusion gene | ENST00000448662, ENST00000431808, ENST00000284776, ENST00000437304, ENST00000319471, ENST00000449407, ENST00000355634, ENST00000393528, ENST00000418609, ENST00000498125, | ENST00000337318, ENST00000392754, ENST00000280780, | |
Fusion gene scores | * DoF score | 14 X 16 X 6=1344 | 4 X 5 X 3=60 |
# samples | 18 | 5 | |
** MAII score | log2(18/1344*10)=-2.90046432644909 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SORBS2 [Title/Abstract] AND FAM53B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LIHC | TCGA-BC-A216-01A | SORBS2 | chr4 | 186732818 | - | FAM53B | chr10 | 126384781 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000448662 | ENST00000337318 | SORBS2 | chr4 | 186732818 | - | FAM53B | chr10 | 126384781 | - |
intron-3CDS | ENST00000448662 | ENST00000392754 | SORBS2 | chr4 | 186732818 | - | FAM53B | chr10 | 126384781 | - |
intron-3CDS | ENST00000448662 | ENST00000280780 | SORBS2 | chr4 | 186732818 | - | FAM53B | chr10 | 126384781 | - |
intron-3CDS | ENST00000431808 | ENST00000337318 | SORBS2 | chr4 | 186732818 | - | FAM53B | chr10 | 126384781 | - |
intron-3CDS | ENST00000431808 | ENST00000392754 | SORBS2 | chr4 | 186732818 | - | FAM53B | chr10 | 126384781 | - |
intron-3CDS | ENST00000431808 | ENST00000280780 | SORBS2 | chr4 | 186732818 | - | FAM53B | chr10 | 126384781 | - |
intron-3CDS | ENST00000284776 | ENST00000337318 | SORBS2 | chr4 | 186732818 | - | FAM53B | chr10 | 126384781 | - |
intron-3CDS | ENST00000284776 | ENST00000392754 | SORBS2 | chr4 | 186732818 | - | FAM53B | chr10 | 126384781 | - |
intron-3CDS | ENST00000284776 | ENST00000280780 | SORBS2 | chr4 | 186732818 | - | FAM53B | chr10 | 126384781 | - |
intron-3CDS | ENST00000437304 | ENST00000337318 | SORBS2 | chr4 | 186732818 | - | FAM53B | chr10 | 126384781 | - |
intron-3CDS | ENST00000437304 | ENST00000392754 | SORBS2 | chr4 | 186732818 | - | FAM53B | chr10 | 126384781 | - |
intron-3CDS | ENST00000437304 | ENST00000280780 | SORBS2 | chr4 | 186732818 | - | FAM53B | chr10 | 126384781 | - |
intron-3CDS | ENST00000319471 | ENST00000337318 | SORBS2 | chr4 | 186732818 | - | FAM53B | chr10 | 126384781 | - |
intron-3CDS | ENST00000319471 | ENST00000392754 | SORBS2 | chr4 | 186732818 | - | FAM53B | chr10 | 126384781 | - |
intron-3CDS | ENST00000319471 | ENST00000280780 | SORBS2 | chr4 | 186732818 | - | FAM53B | chr10 | 126384781 | - |
5UTR-3CDS | ENST00000449407 | ENST00000337318 | SORBS2 | chr4 | 186732818 | - | FAM53B | chr10 | 126384781 | - |
5UTR-3CDS | ENST00000449407 | ENST00000392754 | SORBS2 | chr4 | 186732818 | - | FAM53B | chr10 | 126384781 | - |
5UTR-3CDS | ENST00000449407 | ENST00000280780 | SORBS2 | chr4 | 186732818 | - | FAM53B | chr10 | 126384781 | - |
intron-3CDS | ENST00000355634 | ENST00000337318 | SORBS2 | chr4 | 186732818 | - | FAM53B | chr10 | 126384781 | - |
intron-3CDS | ENST00000355634 | ENST00000392754 | SORBS2 | chr4 | 186732818 | - | FAM53B | chr10 | 126384781 | - |
intron-3CDS | ENST00000355634 | ENST00000280780 | SORBS2 | chr4 | 186732818 | - | FAM53B | chr10 | 126384781 | - |
5UTR-3CDS | ENST00000393528 | ENST00000337318 | SORBS2 | chr4 | 186732818 | - | FAM53B | chr10 | 126384781 | - |
5UTR-3CDS | ENST00000393528 | ENST00000392754 | SORBS2 | chr4 | 186732818 | - | FAM53B | chr10 | 126384781 | - |
5UTR-3CDS | ENST00000393528 | ENST00000280780 | SORBS2 | chr4 | 186732818 | - | FAM53B | chr10 | 126384781 | - |
intron-3CDS | ENST00000418609 | ENST00000337318 | SORBS2 | chr4 | 186732818 | - | FAM53B | chr10 | 126384781 | - |
intron-3CDS | ENST00000418609 | ENST00000392754 | SORBS2 | chr4 | 186732818 | - | FAM53B | chr10 | 126384781 | - |
intron-3CDS | ENST00000418609 | ENST00000280780 | SORBS2 | chr4 | 186732818 | - | FAM53B | chr10 | 126384781 | - |
intron-3CDS | ENST00000498125 | ENST00000337318 | SORBS2 | chr4 | 186732818 | - | FAM53B | chr10 | 126384781 | - |
intron-3CDS | ENST00000498125 | ENST00000392754 | SORBS2 | chr4 | 186732818 | - | FAM53B | chr10 | 126384781 | - |
intron-3CDS | ENST00000498125 | ENST00000280780 | SORBS2 | chr4 | 186732818 | - | FAM53B | chr10 | 126384781 | - |
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FusionProtFeatures for SORBS2_FAM53B |
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Hgene | Tgene |
SORBS2 | FAM53B |
Acts as a regulator of Wnt signaling pathway byregulating beta-catenin (CTNNB1) nuclear localization.{ECO:0000269|PubMed:25183871}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SORBS2_FAM53B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SORBS2_FAM53B |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SORBS2 | YWHAE, SFN, CBL, PTK2B, FLOT1, RPL9, DLGAP4, DLGAP1, VCL, MLLT4, ABL2, ABL1, EGFR, NR1H2, SEMA6A, PALLD, ACTN1, ADAM15, WASF1, PTPN12, BAG3, AKT2, MDM2, YWHAZ, YWHAB, WAS, NCK2, SORBS2, EFS, VPS37C, SH2D4A, ATPAF2, SUZ12, CAPZA2, CLTC, DBN1, FLNA, MYH9, MYO1C, PPP1CB, IQGAP1, SYNPO, MAPRE1, LIMA1, ANLN, MYO18A, FAT1 | FAM53B | XPO1, CBY1, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SORBS2_FAM53B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SORBS2_FAM53B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SORBS2 | C0043094 | Weight Gain | 1 | CTD_human |
Tgene | FAM53B | C0600427 | Cocaine Dependence | 1 | PSYGENET |