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Fusion gene ID: 35387 |
FusionGeneSummary for SORBS2_ELK4 |
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Fusion gene information | Fusion gene name: SORBS2_ELK4 | Fusion gene ID: 35387 | Hgene | Tgene | Gene symbol | SORBS2 | ELK4 | Gene ID | 8470 | 2005 |
Gene name | sorbin and SH3 domain containing 2 | ELK4, ETS transcription factor | |
Synonyms | ARGBP2|PRO0618 | SAP1 | |
Cytomap | 4q35.1 | 1q32.1 | |
Type of gene | protein-coding | protein-coding | |
Description | sorbin and SH3 domain-containing protein 2Arg binding protein 2Arg/Abl-interacting protein 2arg-binding protein 2 | ETS domain-containing protein Elk-4ELK4, ETS-domain protein (SRF accessory protein 1)SAP-1serum response factor accessory protein 1 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | O94875 | P28324 | |
Ensembl transtripts involved in fusion gene | ENST00000448662, ENST00000431808, ENST00000284776, ENST00000437304, ENST00000319471, ENST00000449407, ENST00000355634, ENST00000393528, ENST00000418609, ENST00000498125, | ENST00000357992, ENST00000289703, ENST00000468523, | |
Fusion gene scores | * DoF score | 14 X 16 X 6=1344 | 4 X 4 X 2=32 |
# samples | 18 | 4 | |
** MAII score | log2(18/1344*10)=-2.90046432644909 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: SORBS2 [Title/Abstract] AND ELK4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ELK4 | GO:0070932 | histone H3 deacetylation | 22722849 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | PRAD | TCGA-J4-8198-01A | SORBS2 | chr4 | 186732818 | - | ELK4 | chr1 | 205567777 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000448662 | ENST00000357992 | SORBS2 | chr4 | 186732818 | - | ELK4 | chr1 | 205567777 | - |
intron-intron | ENST00000448662 | ENST00000289703 | SORBS2 | chr4 | 186732818 | - | ELK4 | chr1 | 205567777 | - |
intron-intron | ENST00000448662 | ENST00000468523 | SORBS2 | chr4 | 186732818 | - | ELK4 | chr1 | 205567777 | - |
intron-intron | ENST00000431808 | ENST00000357992 | SORBS2 | chr4 | 186732818 | - | ELK4 | chr1 | 205567777 | - |
intron-intron | ENST00000431808 | ENST00000289703 | SORBS2 | chr4 | 186732818 | - | ELK4 | chr1 | 205567777 | - |
intron-intron | ENST00000431808 | ENST00000468523 | SORBS2 | chr4 | 186732818 | - | ELK4 | chr1 | 205567777 | - |
intron-intron | ENST00000284776 | ENST00000357992 | SORBS2 | chr4 | 186732818 | - | ELK4 | chr1 | 205567777 | - |
intron-intron | ENST00000284776 | ENST00000289703 | SORBS2 | chr4 | 186732818 | - | ELK4 | chr1 | 205567777 | - |
intron-intron | ENST00000284776 | ENST00000468523 | SORBS2 | chr4 | 186732818 | - | ELK4 | chr1 | 205567777 | - |
intron-intron | ENST00000437304 | ENST00000357992 | SORBS2 | chr4 | 186732818 | - | ELK4 | chr1 | 205567777 | - |
intron-intron | ENST00000437304 | ENST00000289703 | SORBS2 | chr4 | 186732818 | - | ELK4 | chr1 | 205567777 | - |
intron-intron | ENST00000437304 | ENST00000468523 | SORBS2 | chr4 | 186732818 | - | ELK4 | chr1 | 205567777 | - |
intron-intron | ENST00000319471 | ENST00000357992 | SORBS2 | chr4 | 186732818 | - | ELK4 | chr1 | 205567777 | - |
intron-intron | ENST00000319471 | ENST00000289703 | SORBS2 | chr4 | 186732818 | - | ELK4 | chr1 | 205567777 | - |
intron-intron | ENST00000319471 | ENST00000468523 | SORBS2 | chr4 | 186732818 | - | ELK4 | chr1 | 205567777 | - |
5UTR-intron | ENST00000449407 | ENST00000357992 | SORBS2 | chr4 | 186732818 | - | ELK4 | chr1 | 205567777 | - |
5UTR-intron | ENST00000449407 | ENST00000289703 | SORBS2 | chr4 | 186732818 | - | ELK4 | chr1 | 205567777 | - |
5UTR-intron | ENST00000449407 | ENST00000468523 | SORBS2 | chr4 | 186732818 | - | ELK4 | chr1 | 205567777 | - |
intron-intron | ENST00000355634 | ENST00000357992 | SORBS2 | chr4 | 186732818 | - | ELK4 | chr1 | 205567777 | - |
intron-intron | ENST00000355634 | ENST00000289703 | SORBS2 | chr4 | 186732818 | - | ELK4 | chr1 | 205567777 | - |
intron-intron | ENST00000355634 | ENST00000468523 | SORBS2 | chr4 | 186732818 | - | ELK4 | chr1 | 205567777 | - |
5UTR-intron | ENST00000393528 | ENST00000357992 | SORBS2 | chr4 | 186732818 | - | ELK4 | chr1 | 205567777 | - |
5UTR-intron | ENST00000393528 | ENST00000289703 | SORBS2 | chr4 | 186732818 | - | ELK4 | chr1 | 205567777 | - |
5UTR-intron | ENST00000393528 | ENST00000468523 | SORBS2 | chr4 | 186732818 | - | ELK4 | chr1 | 205567777 | - |
intron-intron | ENST00000418609 | ENST00000357992 | SORBS2 | chr4 | 186732818 | - | ELK4 | chr1 | 205567777 | - |
intron-intron | ENST00000418609 | ENST00000289703 | SORBS2 | chr4 | 186732818 | - | ELK4 | chr1 | 205567777 | - |
intron-intron | ENST00000418609 | ENST00000468523 | SORBS2 | chr4 | 186732818 | - | ELK4 | chr1 | 205567777 | - |
intron-intron | ENST00000498125 | ENST00000357992 | SORBS2 | chr4 | 186732818 | - | ELK4 | chr1 | 205567777 | - |
intron-intron | ENST00000498125 | ENST00000289703 | SORBS2 | chr4 | 186732818 | - | ELK4 | chr1 | 205567777 | - |
intron-intron | ENST00000498125 | ENST00000468523 | SORBS2 | chr4 | 186732818 | - | ELK4 | chr1 | 205567777 | - |
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FusionProtFeatures for SORBS2_ELK4 |
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Hgene | Tgene |
SORBS2 | ELK4 |
Involved in both transcriptional activation andrepression. Interaction with SIRT7 leads to recruitment andstabilization of SIRT7 at promoters, followed by deacetylation ofhistone H3 at 'Lys-18' (H3K18Ac) and subsequent transcriptionrepression. Forms a ternary complex with the serum response factor(SRF). Requires DNA-bound SRF for ternary complex formation andmakes extensive DNA contacts to the 5'side of SRF, but does notbind DNA autonomously. {ECO:0000269|PubMed:22722849}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SORBS2_ELK4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SORBS2_ELK4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SORBS2 | YWHAE, SFN, CBL, PTK2B, FLOT1, RPL9, DLGAP4, DLGAP1, VCL, MLLT4, ABL2, ABL1, EGFR, NR1H2, SEMA6A, PALLD, ACTN1, ADAM15, WASF1, PTPN12, BAG3, AKT2, MDM2, YWHAZ, YWHAB, WAS, NCK2, SORBS2, EFS, VPS37C, SH2D4A, ATPAF2, SUZ12, CAPZA2, CLTC, DBN1, FLNA, MYH9, MYO1C, PPP1CB, IQGAP1, SYNPO, MAPRE1, LIMA1, ANLN, MYO18A, FAT1 | ELK4 | BRCA1, SRF, ELAVL1, MAPK8, MAPK3, BLM, MUS81, MAPK1, TRIM25, SIRT7 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SORBS2_ELK4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SORBS2_ELK4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SORBS2 | C0043094 | Weight Gain | 1 | CTD_human |