	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
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Fusion gene ID: 35383

FusionGeneSummary for SORBS2_AIF1

Fusion gene summary

Fusion gene information	Fusion gene name: SORBS2_AIF1
	Fusion gene ID: 35383
		Hgene	Tgene
	Gene symbol	SORBS2	AIF1
	Gene ID	8470	199
	Gene name	sorbin and SH3 domain containing 2	allograft inflammatory factor 1
	Synonyms	ARGBP2\|PRO0618	AIF-1\|IBA1\|IRT-1\|IRT1
	Cytomap	4q35.1	6p21.33
	Type of gene	protein-coding	protein-coding
	Description	sorbin and SH3 domain-containing protein 2Arg binding protein 2Arg/Abl-interacting protein 2arg-binding protein 2	allograft inflammatory factor 1interferon gamma responsive transcriptionized calcium-binding adapter molecule 1protein G1
	Modification date	20180523	20180523
	UniProtAcc	O94875	P55008
	Ensembl transtripts involved in fusion gene	ENST00000448662, ENST00000431808, ENST00000284776, ENST00000437304, ENST00000319471, ENST00000449407, ENST00000355634, ENST00000393528, ENST00000418609, ENST00000498125,	ENST00000376059, ENST00000376049, ENST00000414149, ENST00000419376, ENST00000425748, ENST00000416422, ENST00000413349, ENST00000415830, ENST00000383474, ENST00000488491, ENST00000383473, ENST00000440907, ENST00000549432, ENST00000424944,
Fusion gene scores	* DoF score	14 X 16 X 6=1344	3 X 3 X 3=27
	# samples	18	6
	** MAII score	log2(18/1344*10)=-2.90046432644909 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/27*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: SORBS2 [Title/Abstract] AND AIF1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	AIF1	GO:0030041	actin filament polymerization	16049345
Tgene	AIF1	GO:0042102	positive regulation of T cell proliferation	16049345
Tgene	AIF1	GO:0048661	positive regulation of smooth muscle cell proliferation	15117732\|22116621
Tgene	AIF1	GO:0048662	negative regulation of smooth muscle cell proliferation	9614071\|22116621
Tgene	AIF1	GO:0051017	actin filament bundle assembly	18699778
Tgene	AIF1	GO:0071672	negative regulation of smooth muscle cell chemotaxis	22116621
Tgene	AIF1	GO:0071673	positive regulation of smooth muscle cell chemotaxis	22116621
Tgene	AIF1	GO:0090026	positive regulation of monocyte chemotaxis	15117732
Tgene	AIF1	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	11557666\|15117732
Tgene	AIF1	GO:2000406	positive regulation of T cell migration	16049345

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	BRCA	TCGA-AR-A24Z-01A	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000448662	ENST00000376059	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-3CDS	ENST00000448662	ENST00000376049	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000448662	ENST00000414149	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000448662	ENST00000419376	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000448662	ENST00000425748	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000448662	ENST00000416422	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000448662	ENST00000413349	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000448662	ENST00000415830	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000448662	ENST00000383474	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000448662	ENST00000488491	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000448662	ENST00000383473	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000448662	ENST00000440907	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000448662	ENST00000549432	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000448662	ENST00000424944	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
5UTR-3CDS	ENST00000431808	ENST00000376059	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
5UTR-3CDS	ENST00000431808	ENST00000376049	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
5UTR-intron	ENST00000431808	ENST00000414149	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
5UTR-intron	ENST00000431808	ENST00000419376	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
5UTR-intron	ENST00000431808	ENST00000425748	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
5UTR-intron	ENST00000431808	ENST00000416422	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
5UTR-intron	ENST00000431808	ENST00000413349	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
5UTR-intron	ENST00000431808	ENST00000415830	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
5UTR-intron	ENST00000431808	ENST00000383474	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
5UTR-intron	ENST00000431808	ENST00000488491	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
5UTR-intron	ENST00000431808	ENST00000383473	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
5UTR-intron	ENST00000431808	ENST00000440907	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
5UTR-intron	ENST00000431808	ENST00000549432	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
5UTR-intron	ENST00000431808	ENST00000424944	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-3CDS	ENST00000284776	ENST00000376059	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-3CDS	ENST00000284776	ENST00000376049	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000284776	ENST00000414149	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000284776	ENST00000419376	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000284776	ENST00000425748	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000284776	ENST00000416422	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000284776	ENST00000413349	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000284776	ENST00000415830	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000284776	ENST00000383474	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000284776	ENST00000488491	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000284776	ENST00000383473	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000284776	ENST00000440907	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000284776	ENST00000549432	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000284776	ENST00000424944	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-3CDS	ENST00000437304	ENST00000376059	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-3CDS	ENST00000437304	ENST00000376049	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000437304	ENST00000414149	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000437304	ENST00000419376	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000437304	ENST00000425748	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000437304	ENST00000416422	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000437304	ENST00000413349	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000437304	ENST00000415830	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000437304	ENST00000383474	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000437304	ENST00000488491	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000437304	ENST00000383473	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000437304	ENST00000440907	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000437304	ENST00000549432	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000437304	ENST00000424944	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
Frame-shift	ENST00000319471	ENST00000376059	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
Frame-shift	ENST00000319471	ENST00000376049	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
5CDS-intron	ENST00000319471	ENST00000414149	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
5CDS-intron	ENST00000319471	ENST00000419376	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
5CDS-intron	ENST00000319471	ENST00000425748	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
5CDS-intron	ENST00000319471	ENST00000416422	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
5CDS-intron	ENST00000319471	ENST00000413349	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
5CDS-intron	ENST00000319471	ENST00000415830	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
5CDS-intron	ENST00000319471	ENST00000383474	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
5CDS-intron	ENST00000319471	ENST00000488491	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
5CDS-intron	ENST00000319471	ENST00000383473	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
5CDS-intron	ENST00000319471	ENST00000440907	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
5CDS-intron	ENST00000319471	ENST00000549432	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
5CDS-intron	ENST00000319471	ENST00000424944	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
Frame-shift	ENST00000449407	ENST00000376059	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
Frame-shift	ENST00000449407	ENST00000376049	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
5CDS-intron	ENST00000449407	ENST00000414149	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
5CDS-intron	ENST00000449407	ENST00000419376	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
5CDS-intron	ENST00000449407	ENST00000425748	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
5CDS-intron	ENST00000449407	ENST00000416422	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
5CDS-intron	ENST00000449407	ENST00000413349	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
5CDS-intron	ENST00000449407	ENST00000415830	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
5CDS-intron	ENST00000449407	ENST00000383474	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
5CDS-intron	ENST00000449407	ENST00000488491	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
5CDS-intron	ENST00000449407	ENST00000383473	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
5CDS-intron	ENST00000449407	ENST00000440907	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
5CDS-intron	ENST00000449407	ENST00000549432	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
5CDS-intron	ENST00000449407	ENST00000424944	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
Frame-shift	ENST00000355634	ENST00000376059	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
Frame-shift	ENST00000355634	ENST00000376049	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
5CDS-intron	ENST00000355634	ENST00000414149	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
5CDS-intron	ENST00000355634	ENST00000419376	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
5CDS-intron	ENST00000355634	ENST00000425748	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
5CDS-intron	ENST00000355634	ENST00000416422	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
5CDS-intron	ENST00000355634	ENST00000413349	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
5CDS-intron	ENST00000355634	ENST00000415830	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
5CDS-intron	ENST00000355634	ENST00000383474	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
5CDS-intron	ENST00000355634	ENST00000488491	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
5CDS-intron	ENST00000355634	ENST00000383473	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
5CDS-intron	ENST00000355634	ENST00000440907	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
5CDS-intron	ENST00000355634	ENST00000549432	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
5CDS-intron	ENST00000355634	ENST00000424944	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-3CDS	ENST00000393528	ENST00000376059	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-3CDS	ENST00000393528	ENST00000376049	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000393528	ENST00000414149	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000393528	ENST00000419376	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000393528	ENST00000425748	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000393528	ENST00000416422	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000393528	ENST00000413349	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000393528	ENST00000415830	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000393528	ENST00000383474	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000393528	ENST00000488491	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000393528	ENST00000383473	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000393528	ENST00000440907	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000393528	ENST00000549432	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000393528	ENST00000424944	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-3CDS	ENST00000418609	ENST00000376059	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-3CDS	ENST00000418609	ENST00000376049	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000418609	ENST00000414149	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000418609	ENST00000419376	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000418609	ENST00000425748	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000418609	ENST00000416422	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000418609	ENST00000413349	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000418609	ENST00000415830	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000418609	ENST00000383474	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000418609	ENST00000488491	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000418609	ENST00000383473	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000418609	ENST00000440907	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000418609	ENST00000549432	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000418609	ENST00000424944	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-3CDS	ENST00000498125	ENST00000376059	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-3CDS	ENST00000498125	ENST00000376049	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000498125	ENST00000414149	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000498125	ENST00000419376	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000498125	ENST00000425748	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000498125	ENST00000416422	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000498125	ENST00000413349	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000498125	ENST00000415830	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000498125	ENST00000383474	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000498125	ENST00000488491	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000498125	ENST00000383473	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000498125	ENST00000440907	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000498125	ENST00000549432	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+
intron-intron	ENST00000498125	ENST00000424944	SORBS2	chr4	186605908	-	AIF1	chr6	31584121	+

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FusionProtFeatures for SORBS2_AIF1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
SORBS2 O94875	AIF1 P55008
	Actin-binding protein that enhances membrane rufflingand RAC activation. Enhances the actin-bundling activity of LCP1.Binds calcium. Plays a role in RAC signaling and in phagocytosis.May play a role in macrophage activation and function. Promotesthe proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role invascular inflammation. {ECO:0000269\|PubMed:15117732,ECO:0000269\|PubMed:16049345, ECO:0000269\|PubMed:18699778}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for SORBS2_AIF1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SORBS2_AIF1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
SORBS2	YWHAE, SFN, CBL, PTK2B, FLOT1, RPL9, DLGAP4, DLGAP1, VCL, MLLT4, ABL2, ABL1, EGFR, NR1H2, SEMA6A, PALLD, ACTN1, ADAM15, WASF1, PTPN12, BAG3, AKT2, MDM2, YWHAZ, YWHAB, WAS, NCK2, SORBS2, EFS, VPS37C, SH2D4A, ATPAF2, SUZ12, CAPZA2, CLTC, DBN1, FLNA, MYH9, MYO1C, PPP1CB, IQGAP1, SYNPO, MAPRE1, LIMA1, ANLN, MYO18A, FAT1	AIF1	HSFY1

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for SORBS2_AIF1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for SORBS2_AIF1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	SORBS2	C0043094	Weight Gain	1	CTD_human
Tgene	AIF1	C0020429	Hyperalgesia	1	CTD_human
Tgene	AIF1	C0023893	Liver Cirrhosis, Experimental	1	CTD_human
Tgene	AIF1	C0030567	Parkinson Disease	1	CTD_human
Tgene	AIF1	C0040997	Trigeminal Neuralgia	1	CTD_human
Tgene	AIF1	C0752347	Lewy Body Disease	1	CTD_human

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Fusion gene ID: 35383

FusionGeneSummary for SORBS2_AIF1

FusionProtFeatures for SORBS2_AIF1

FusionGeneSequence for SORBS2_AIF1

FusionGenePPI for SORBS2_AIF1

RelatedDrugs for SORBS2_AIF1

RelatedDiseases for SORBS2_AIF1