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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35383

FusionGeneSummary for SORBS2_AIF1

check button Fusion gene summary
Fusion gene informationFusion gene name: SORBS2_AIF1
Fusion gene ID: 35383
HgeneTgene
Gene symbol

SORBS2

AIF1

Gene ID

8470

199

Gene namesorbin and SH3 domain containing 2allograft inflammatory factor 1
SynonymsARGBP2|PRO0618AIF-1|IBA1|IRT-1|IRT1
Cytomap

4q35.1

6p21.33

Type of geneprotein-codingprotein-coding
Descriptionsorbin and SH3 domain-containing protein 2Arg binding protein 2Arg/Abl-interacting protein 2arg-binding protein 2allograft inflammatory factor 1interferon gamma responsive transcriptionized calcium-binding adapter molecule 1protein G1
Modification date2018052320180523
UniProtAcc

O94875

P55008

Ensembl transtripts involved in fusion geneENST00000448662, ENST00000431808, 
ENST00000284776, ENST00000437304, 
ENST00000319471, ENST00000449407, 
ENST00000355634, ENST00000393528, 
ENST00000418609, ENST00000498125, 
ENST00000376059, ENST00000376049, 
ENST00000414149, ENST00000419376, 
ENST00000425748, ENST00000416422, 
ENST00000413349, ENST00000415830, 
ENST00000383474, ENST00000488491, 
ENST00000383473, ENST00000440907, 
ENST00000549432, ENST00000424944, 
Fusion gene scores* DoF score14 X 16 X 6=13443 X 3 X 3=27
# samples 186
** MAII scorelog2(18/1344*10)=-2.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/27*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SORBS2 [Title/Abstract] AND AIF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneAIF1

GO:0030041

actin filament polymerization

16049345

TgeneAIF1

GO:0042102

positive regulation of T cell proliferation

16049345

TgeneAIF1

GO:0048661

positive regulation of smooth muscle cell proliferation

15117732|22116621

TgeneAIF1

GO:0048662

negative regulation of smooth muscle cell proliferation

9614071|22116621

TgeneAIF1

GO:0051017

actin filament bundle assembly

18699778

TgeneAIF1

GO:0071672

negative regulation of smooth muscle cell chemotaxis

22116621

TgeneAIF1

GO:0071673

positive regulation of smooth muscle cell chemotaxis

22116621

TgeneAIF1

GO:0090026

positive regulation of monocyte chemotaxis

15117732

TgeneAIF1

GO:1900087

positive regulation of G1/S transition of mitotic cell cycle

11557666|15117732

TgeneAIF1

GO:2000406

positive regulation of T cell migration

16049345


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AR-A24Z-01ASORBS2chr4

186605908

-AIF1chr6

31584121

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000448662ENST00000376059SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-3CDSENST00000448662ENST00000376049SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000448662ENST00000414149SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000448662ENST00000419376SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000448662ENST00000425748SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000448662ENST00000416422SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000448662ENST00000413349SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000448662ENST00000415830SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000448662ENST00000383474SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000448662ENST00000488491SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000448662ENST00000383473SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000448662ENST00000440907SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000448662ENST00000549432SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000448662ENST00000424944SORBS2chr4

186605908

-AIF1chr6

31584121

+
5UTR-3CDSENST00000431808ENST00000376059SORBS2chr4

186605908

-AIF1chr6

31584121

+
5UTR-3CDSENST00000431808ENST00000376049SORBS2chr4

186605908

-AIF1chr6

31584121

+
5UTR-intronENST00000431808ENST00000414149SORBS2chr4

186605908

-AIF1chr6

31584121

+
5UTR-intronENST00000431808ENST00000419376SORBS2chr4

186605908

-AIF1chr6

31584121

+
5UTR-intronENST00000431808ENST00000425748SORBS2chr4

186605908

-AIF1chr6

31584121

+
5UTR-intronENST00000431808ENST00000416422SORBS2chr4

186605908

-AIF1chr6

31584121

+
5UTR-intronENST00000431808ENST00000413349SORBS2chr4

186605908

-AIF1chr6

31584121

+
5UTR-intronENST00000431808ENST00000415830SORBS2chr4

186605908

-AIF1chr6

31584121

+
5UTR-intronENST00000431808ENST00000383474SORBS2chr4

186605908

-AIF1chr6

31584121

+
5UTR-intronENST00000431808ENST00000488491SORBS2chr4

186605908

-AIF1chr6

31584121

+
5UTR-intronENST00000431808ENST00000383473SORBS2chr4

186605908

-AIF1chr6

31584121

+
5UTR-intronENST00000431808ENST00000440907SORBS2chr4

186605908

-AIF1chr6

31584121

+
5UTR-intronENST00000431808ENST00000549432SORBS2chr4

186605908

-AIF1chr6

31584121

+
5UTR-intronENST00000431808ENST00000424944SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-3CDSENST00000284776ENST00000376059SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-3CDSENST00000284776ENST00000376049SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000284776ENST00000414149SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000284776ENST00000419376SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000284776ENST00000425748SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000284776ENST00000416422SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000284776ENST00000413349SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000284776ENST00000415830SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000284776ENST00000383474SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000284776ENST00000488491SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000284776ENST00000383473SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000284776ENST00000440907SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000284776ENST00000549432SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000284776ENST00000424944SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-3CDSENST00000437304ENST00000376059SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-3CDSENST00000437304ENST00000376049SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000437304ENST00000414149SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000437304ENST00000419376SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000437304ENST00000425748SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000437304ENST00000416422SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000437304ENST00000413349SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000437304ENST00000415830SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000437304ENST00000383474SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000437304ENST00000488491SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000437304ENST00000383473SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000437304ENST00000440907SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000437304ENST00000549432SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000437304ENST00000424944SORBS2chr4

186605908

-AIF1chr6

31584121

+
Frame-shiftENST00000319471ENST00000376059SORBS2chr4

186605908

-AIF1chr6

31584121

+
Frame-shiftENST00000319471ENST00000376049SORBS2chr4

186605908

-AIF1chr6

31584121

+
5CDS-intronENST00000319471ENST00000414149SORBS2chr4

186605908

-AIF1chr6

31584121

+
5CDS-intronENST00000319471ENST00000419376SORBS2chr4

186605908

-AIF1chr6

31584121

+
5CDS-intronENST00000319471ENST00000425748SORBS2chr4

186605908

-AIF1chr6

31584121

+
5CDS-intronENST00000319471ENST00000416422SORBS2chr4

186605908

-AIF1chr6

31584121

+
5CDS-intronENST00000319471ENST00000413349SORBS2chr4

186605908

-AIF1chr6

31584121

+
5CDS-intronENST00000319471ENST00000415830SORBS2chr4

186605908

-AIF1chr6

31584121

+
5CDS-intronENST00000319471ENST00000383474SORBS2chr4

186605908

-AIF1chr6

31584121

+
5CDS-intronENST00000319471ENST00000488491SORBS2chr4

186605908

-AIF1chr6

31584121

+
5CDS-intronENST00000319471ENST00000383473SORBS2chr4

186605908

-AIF1chr6

31584121

+
5CDS-intronENST00000319471ENST00000440907SORBS2chr4

186605908

-AIF1chr6

31584121

+
5CDS-intronENST00000319471ENST00000549432SORBS2chr4

186605908

-AIF1chr6

31584121

+
5CDS-intronENST00000319471ENST00000424944SORBS2chr4

186605908

-AIF1chr6

31584121

+
Frame-shiftENST00000449407ENST00000376059SORBS2chr4

186605908

-AIF1chr6

31584121

+
Frame-shiftENST00000449407ENST00000376049SORBS2chr4

186605908

-AIF1chr6

31584121

+
5CDS-intronENST00000449407ENST00000414149SORBS2chr4

186605908

-AIF1chr6

31584121

+
5CDS-intronENST00000449407ENST00000419376SORBS2chr4

186605908

-AIF1chr6

31584121

+
5CDS-intronENST00000449407ENST00000425748SORBS2chr4

186605908

-AIF1chr6

31584121

+
5CDS-intronENST00000449407ENST00000416422SORBS2chr4

186605908

-AIF1chr6

31584121

+
5CDS-intronENST00000449407ENST00000413349SORBS2chr4

186605908

-AIF1chr6

31584121

+
5CDS-intronENST00000449407ENST00000415830SORBS2chr4

186605908

-AIF1chr6

31584121

+
5CDS-intronENST00000449407ENST00000383474SORBS2chr4

186605908

-AIF1chr6

31584121

+
5CDS-intronENST00000449407ENST00000488491SORBS2chr4

186605908

-AIF1chr6

31584121

+
5CDS-intronENST00000449407ENST00000383473SORBS2chr4

186605908

-AIF1chr6

31584121

+
5CDS-intronENST00000449407ENST00000440907SORBS2chr4

186605908

-AIF1chr6

31584121

+
5CDS-intronENST00000449407ENST00000549432SORBS2chr4

186605908

-AIF1chr6

31584121

+
5CDS-intronENST00000449407ENST00000424944SORBS2chr4

186605908

-AIF1chr6

31584121

+
Frame-shiftENST00000355634ENST00000376059SORBS2chr4

186605908

-AIF1chr6

31584121

+
Frame-shiftENST00000355634ENST00000376049SORBS2chr4

186605908

-AIF1chr6

31584121

+
5CDS-intronENST00000355634ENST00000414149SORBS2chr4

186605908

-AIF1chr6

31584121

+
5CDS-intronENST00000355634ENST00000419376SORBS2chr4

186605908

-AIF1chr6

31584121

+
5CDS-intronENST00000355634ENST00000425748SORBS2chr4

186605908

-AIF1chr6

31584121

+
5CDS-intronENST00000355634ENST00000416422SORBS2chr4

186605908

-AIF1chr6

31584121

+
5CDS-intronENST00000355634ENST00000413349SORBS2chr4

186605908

-AIF1chr6

31584121

+
5CDS-intronENST00000355634ENST00000415830SORBS2chr4

186605908

-AIF1chr6

31584121

+
5CDS-intronENST00000355634ENST00000383474SORBS2chr4

186605908

-AIF1chr6

31584121

+
5CDS-intronENST00000355634ENST00000488491SORBS2chr4

186605908

-AIF1chr6

31584121

+
5CDS-intronENST00000355634ENST00000383473SORBS2chr4

186605908

-AIF1chr6

31584121

+
5CDS-intronENST00000355634ENST00000440907SORBS2chr4

186605908

-AIF1chr6

31584121

+
5CDS-intronENST00000355634ENST00000549432SORBS2chr4

186605908

-AIF1chr6

31584121

+
5CDS-intronENST00000355634ENST00000424944SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-3CDSENST00000393528ENST00000376059SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-3CDSENST00000393528ENST00000376049SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000393528ENST00000414149SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000393528ENST00000419376SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000393528ENST00000425748SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000393528ENST00000416422SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000393528ENST00000413349SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000393528ENST00000415830SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000393528ENST00000383474SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000393528ENST00000488491SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000393528ENST00000383473SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000393528ENST00000440907SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000393528ENST00000549432SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000393528ENST00000424944SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-3CDSENST00000418609ENST00000376059SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-3CDSENST00000418609ENST00000376049SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000418609ENST00000414149SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000418609ENST00000419376SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000418609ENST00000425748SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000418609ENST00000416422SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000418609ENST00000413349SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000418609ENST00000415830SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000418609ENST00000383474SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000418609ENST00000488491SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000418609ENST00000383473SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000418609ENST00000440907SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000418609ENST00000549432SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000418609ENST00000424944SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-3CDSENST00000498125ENST00000376059SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-3CDSENST00000498125ENST00000376049SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000498125ENST00000414149SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000498125ENST00000419376SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000498125ENST00000425748SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000498125ENST00000416422SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000498125ENST00000413349SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000498125ENST00000415830SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000498125ENST00000383474SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000498125ENST00000488491SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000498125ENST00000383473SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000498125ENST00000440907SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000498125ENST00000549432SORBS2chr4

186605908

-AIF1chr6

31584121

+
intron-intronENST00000498125ENST00000424944SORBS2chr4

186605908

-AIF1chr6

31584121

+

Top

FusionProtFeatures for SORBS2_AIF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SORBS2

O94875

AIF1

P55008

Actin-binding protein that enhances membrane rufflingand RAC activation. Enhances the actin-bundling activity of LCP1.Binds calcium. Plays a role in RAC signaling and in phagocytosis.May play a role in macrophage activation and function. Promotesthe proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role invascular inflammation. {ECO:0000269|PubMed:15117732,ECO:0000269|PubMed:16049345, ECO:0000269|PubMed:18699778}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for SORBS2_AIF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SORBS2_AIF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SORBS2YWHAE, SFN, CBL, PTK2B, FLOT1, RPL9, DLGAP4, DLGAP1, VCL, MLLT4, ABL2, ABL1, EGFR, NR1H2, SEMA6A, PALLD, ACTN1, ADAM15, WASF1, PTPN12, BAG3, AKT2, MDM2, YWHAZ, YWHAB, WAS, NCK2, SORBS2, EFS, VPS37C, SH2D4A, ATPAF2, SUZ12, CAPZA2, CLTC, DBN1, FLNA, MYH9, MYO1C, PPP1CB, IQGAP1, SYNPO, MAPRE1, LIMA1, ANLN, MYO18A, FAT1AIF1HSFY1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SORBS2_AIF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SORBS2_AIF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSORBS2C0043094Weight Gain1CTD_human
TgeneAIF1C0020429Hyperalgesia1CTD_human
TgeneAIF1C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneAIF1C0030567Parkinson Disease1CTD_human
TgeneAIF1C0040997Trigeminal Neuralgia1CTD_human
TgeneAIF1C0752347Lewy Body Disease1CTD_human