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Fusion gene ID: 35383 |
FusionGeneSummary for SORBS2_AIF1 |
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Fusion gene information | Fusion gene name: SORBS2_AIF1 | Fusion gene ID: 35383 | Hgene | Tgene | Gene symbol | SORBS2 | AIF1 | Gene ID | 8470 | 199 |
Gene name | sorbin and SH3 domain containing 2 | allograft inflammatory factor 1 | |
Synonyms | ARGBP2|PRO0618 | AIF-1|IBA1|IRT-1|IRT1 | |
Cytomap | 4q35.1 | 6p21.33 | |
Type of gene | protein-coding | protein-coding | |
Description | sorbin and SH3 domain-containing protein 2Arg binding protein 2Arg/Abl-interacting protein 2arg-binding protein 2 | allograft inflammatory factor 1interferon gamma responsive transcriptionized calcium-binding adapter molecule 1protein G1 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | O94875 | P55008 | |
Ensembl transtripts involved in fusion gene | ENST00000448662, ENST00000431808, ENST00000284776, ENST00000437304, ENST00000319471, ENST00000449407, ENST00000355634, ENST00000393528, ENST00000418609, ENST00000498125, | ENST00000376059, ENST00000376049, ENST00000414149, ENST00000419376, ENST00000425748, ENST00000416422, ENST00000413349, ENST00000415830, ENST00000383474, ENST00000488491, ENST00000383473, ENST00000440907, ENST00000549432, ENST00000424944, | |
Fusion gene scores | * DoF score | 14 X 16 X 6=1344 | 3 X 3 X 3=27 |
# samples | 18 | 6 | |
** MAII score | log2(18/1344*10)=-2.90046432644909 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/27*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: SORBS2 [Title/Abstract] AND AIF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | AIF1 | GO:0030041 | actin filament polymerization | 16049345 |
Tgene | AIF1 | GO:0042102 | positive regulation of T cell proliferation | 16049345 |
Tgene | AIF1 | GO:0048661 | positive regulation of smooth muscle cell proliferation | 15117732|22116621 |
Tgene | AIF1 | GO:0048662 | negative regulation of smooth muscle cell proliferation | 9614071|22116621 |
Tgene | AIF1 | GO:0051017 | actin filament bundle assembly | 18699778 |
Tgene | AIF1 | GO:0071672 | negative regulation of smooth muscle cell chemotaxis | 22116621 |
Tgene | AIF1 | GO:0071673 | positive regulation of smooth muscle cell chemotaxis | 22116621 |
Tgene | AIF1 | GO:0090026 | positive regulation of monocyte chemotaxis | 15117732 |
Tgene | AIF1 | GO:1900087 | positive regulation of G1/S transition of mitotic cell cycle | 11557666|15117732 |
Tgene | AIF1 | GO:2000406 | positive regulation of T cell migration | 16049345 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-AR-A24Z-01A | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000448662 | ENST00000376059 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-3CDS | ENST00000448662 | ENST00000376049 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000448662 | ENST00000414149 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000448662 | ENST00000419376 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000448662 | ENST00000425748 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000448662 | ENST00000416422 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000448662 | ENST00000413349 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000448662 | ENST00000415830 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000448662 | ENST00000383474 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000448662 | ENST00000488491 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000448662 | ENST00000383473 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000448662 | ENST00000440907 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000448662 | ENST00000549432 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000448662 | ENST00000424944 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
5UTR-3CDS | ENST00000431808 | ENST00000376059 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
5UTR-3CDS | ENST00000431808 | ENST00000376049 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
5UTR-intron | ENST00000431808 | ENST00000414149 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
5UTR-intron | ENST00000431808 | ENST00000419376 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
5UTR-intron | ENST00000431808 | ENST00000425748 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
5UTR-intron | ENST00000431808 | ENST00000416422 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
5UTR-intron | ENST00000431808 | ENST00000413349 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
5UTR-intron | ENST00000431808 | ENST00000415830 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
5UTR-intron | ENST00000431808 | ENST00000383474 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
5UTR-intron | ENST00000431808 | ENST00000488491 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
5UTR-intron | ENST00000431808 | ENST00000383473 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
5UTR-intron | ENST00000431808 | ENST00000440907 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
5UTR-intron | ENST00000431808 | ENST00000549432 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
5UTR-intron | ENST00000431808 | ENST00000424944 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-3CDS | ENST00000284776 | ENST00000376059 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-3CDS | ENST00000284776 | ENST00000376049 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000284776 | ENST00000414149 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000284776 | ENST00000419376 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000284776 | ENST00000425748 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000284776 | ENST00000416422 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000284776 | ENST00000413349 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000284776 | ENST00000415830 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000284776 | ENST00000383474 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000284776 | ENST00000488491 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000284776 | ENST00000383473 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000284776 | ENST00000440907 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000284776 | ENST00000549432 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000284776 | ENST00000424944 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-3CDS | ENST00000437304 | ENST00000376059 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-3CDS | ENST00000437304 | ENST00000376049 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000437304 | ENST00000414149 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000437304 | ENST00000419376 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000437304 | ENST00000425748 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000437304 | ENST00000416422 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000437304 | ENST00000413349 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000437304 | ENST00000415830 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000437304 | ENST00000383474 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000437304 | ENST00000488491 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000437304 | ENST00000383473 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000437304 | ENST00000440907 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000437304 | ENST00000549432 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000437304 | ENST00000424944 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
Frame-shift | ENST00000319471 | ENST00000376059 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
Frame-shift | ENST00000319471 | ENST00000376049 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
5CDS-intron | ENST00000319471 | ENST00000414149 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
5CDS-intron | ENST00000319471 | ENST00000419376 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
5CDS-intron | ENST00000319471 | ENST00000425748 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
5CDS-intron | ENST00000319471 | ENST00000416422 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
5CDS-intron | ENST00000319471 | ENST00000413349 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
5CDS-intron | ENST00000319471 | ENST00000415830 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
5CDS-intron | ENST00000319471 | ENST00000383474 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
5CDS-intron | ENST00000319471 | ENST00000488491 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
5CDS-intron | ENST00000319471 | ENST00000383473 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
5CDS-intron | ENST00000319471 | ENST00000440907 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
5CDS-intron | ENST00000319471 | ENST00000549432 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
5CDS-intron | ENST00000319471 | ENST00000424944 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
Frame-shift | ENST00000449407 | ENST00000376059 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
Frame-shift | ENST00000449407 | ENST00000376049 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
5CDS-intron | ENST00000449407 | ENST00000414149 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
5CDS-intron | ENST00000449407 | ENST00000419376 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
5CDS-intron | ENST00000449407 | ENST00000425748 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
5CDS-intron | ENST00000449407 | ENST00000416422 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
5CDS-intron | ENST00000449407 | ENST00000413349 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
5CDS-intron | ENST00000449407 | ENST00000415830 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
5CDS-intron | ENST00000449407 | ENST00000383474 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
5CDS-intron | ENST00000449407 | ENST00000488491 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
5CDS-intron | ENST00000449407 | ENST00000383473 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
5CDS-intron | ENST00000449407 | ENST00000440907 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
5CDS-intron | ENST00000449407 | ENST00000549432 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
5CDS-intron | ENST00000449407 | ENST00000424944 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
Frame-shift | ENST00000355634 | ENST00000376059 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
Frame-shift | ENST00000355634 | ENST00000376049 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
5CDS-intron | ENST00000355634 | ENST00000414149 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
5CDS-intron | ENST00000355634 | ENST00000419376 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
5CDS-intron | ENST00000355634 | ENST00000425748 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
5CDS-intron | ENST00000355634 | ENST00000416422 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
5CDS-intron | ENST00000355634 | ENST00000413349 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
5CDS-intron | ENST00000355634 | ENST00000415830 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
5CDS-intron | ENST00000355634 | ENST00000383474 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
5CDS-intron | ENST00000355634 | ENST00000488491 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
5CDS-intron | ENST00000355634 | ENST00000383473 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
5CDS-intron | ENST00000355634 | ENST00000440907 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
5CDS-intron | ENST00000355634 | ENST00000549432 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
5CDS-intron | ENST00000355634 | ENST00000424944 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-3CDS | ENST00000393528 | ENST00000376059 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-3CDS | ENST00000393528 | ENST00000376049 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000393528 | ENST00000414149 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000393528 | ENST00000419376 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000393528 | ENST00000425748 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000393528 | ENST00000416422 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000393528 | ENST00000413349 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000393528 | ENST00000415830 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000393528 | ENST00000383474 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000393528 | ENST00000488491 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000393528 | ENST00000383473 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000393528 | ENST00000440907 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000393528 | ENST00000549432 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000393528 | ENST00000424944 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-3CDS | ENST00000418609 | ENST00000376059 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-3CDS | ENST00000418609 | ENST00000376049 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000418609 | ENST00000414149 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000418609 | ENST00000419376 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000418609 | ENST00000425748 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000418609 | ENST00000416422 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000418609 | ENST00000413349 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000418609 | ENST00000415830 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000418609 | ENST00000383474 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000418609 | ENST00000488491 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000418609 | ENST00000383473 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000418609 | ENST00000440907 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000418609 | ENST00000549432 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000418609 | ENST00000424944 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-3CDS | ENST00000498125 | ENST00000376059 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-3CDS | ENST00000498125 | ENST00000376049 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000498125 | ENST00000414149 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000498125 | ENST00000419376 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000498125 | ENST00000425748 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000498125 | ENST00000416422 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000498125 | ENST00000413349 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000498125 | ENST00000415830 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000498125 | ENST00000383474 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000498125 | ENST00000488491 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000498125 | ENST00000383473 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000498125 | ENST00000440907 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000498125 | ENST00000549432 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
intron-intron | ENST00000498125 | ENST00000424944 | SORBS2 | chr4 | 186605908 | - | AIF1 | chr6 | 31584121 | + |
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FusionProtFeatures for SORBS2_AIF1 |
![]() |
Hgene | Tgene |
SORBS2 | AIF1 |
Actin-binding protein that enhances membrane rufflingand RAC activation. Enhances the actin-bundling activity of LCP1.Binds calcium. Plays a role in RAC signaling and in phagocytosis.May play a role in macrophage activation and function. Promotesthe proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role invascular inflammation. {ECO:0000269|PubMed:15117732,ECO:0000269|PubMed:16049345, ECO:0000269|PubMed:18699778}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SORBS2_AIF1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SORBS2_AIF1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SORBS2 | YWHAE, SFN, CBL, PTK2B, FLOT1, RPL9, DLGAP4, DLGAP1, VCL, MLLT4, ABL2, ABL1, EGFR, NR1H2, SEMA6A, PALLD, ACTN1, ADAM15, WASF1, PTPN12, BAG3, AKT2, MDM2, YWHAZ, YWHAB, WAS, NCK2, SORBS2, EFS, VPS37C, SH2D4A, ATPAF2, SUZ12, CAPZA2, CLTC, DBN1, FLNA, MYH9, MYO1C, PPP1CB, IQGAP1, SYNPO, MAPRE1, LIMA1, ANLN, MYO18A, FAT1 | AIF1 | HSFY1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SORBS2_AIF1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SORBS2_AIF1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SORBS2 | C0043094 | Weight Gain | 1 | CTD_human |
Tgene | AIF1 | C0020429 | Hyperalgesia | 1 | CTD_human |
Tgene | AIF1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | AIF1 | C0030567 | Parkinson Disease | 1 | CTD_human |
Tgene | AIF1 | C0040997 | Trigeminal Neuralgia | 1 | CTD_human |
Tgene | AIF1 | C0752347 | Lewy Body Disease | 1 | CTD_human |