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Fusion gene ID: 35366 |
FusionGeneSummary for SOGA1_RBL1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SOGA1_RBL1 | Fusion gene ID: 35366 | Hgene | Tgene | Gene symbol | SOGA1 | RBL1 | Gene ID | 140710 | 5933 |
| Gene name | suppressor of glucose, autophagy associated 1 | RB transcriptional corepressor like 1 | |
| Synonyms | C20orf117|KIAA0889|SOGA | CP107|PRB1|p107 | |
| Cytomap | 20q11.23 | 20q11.23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein SOGA1SOGA family member 1suppressor of glucose by autophagysuppressor of glucose from autophagysuppressor of glucose, autophagy-associated protein 1 | retinoblastoma-like protein 1107 kDa retinoblastoma-associated proteinretinoblastoma-like 1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O94964 | P28749 | |
| Ensembl transtripts involved in fusion gene | ENST00000237536, ENST00000279034, ENST00000456801, ENST00000357779, | ENST00000373664, ENST00000344359, ENST00000598590, | |
| Fusion gene scores | * DoF score | 5 X 4 X 5=100 | 4 X 5 X 5=100 |
| # samples | 6 | 5 | |
| ** MAII score | log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SOGA1 [Title/Abstract] AND RBL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | RBL1 | GO:0043550 | regulation of lipid kinase activity | 16286473 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-EW-A6SD-01A | SOGA1 | chr20 | 35431259 | - | RBL1 | chr20 | 35627332 | - |
| TCGA | LD | CESC | TCGA-C5-A7UH-01A | SOGA1 | chr20 | 35457457 | - | RBL1 | chr20 | 35632269 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000237536 | ENST00000373664 | SOGA1 | chr20 | 35431259 | - | RBL1 | chr20 | 35627332 | - |
| 5CDS-intron | ENST00000237536 | ENST00000344359 | SOGA1 | chr20 | 35431259 | - | RBL1 | chr20 | 35627332 | - |
| 5CDS-intron | ENST00000237536 | ENST00000598590 | SOGA1 | chr20 | 35431259 | - | RBL1 | chr20 | 35627332 | - |
| Frame-shift | ENST00000279034 | ENST00000373664 | SOGA1 | chr20 | 35431259 | - | RBL1 | chr20 | 35627332 | - |
| 5CDS-intron | ENST00000279034 | ENST00000344359 | SOGA1 | chr20 | 35431259 | - | RBL1 | chr20 | 35627332 | - |
| 5CDS-intron | ENST00000279034 | ENST00000598590 | SOGA1 | chr20 | 35431259 | - | RBL1 | chr20 | 35627332 | - |
| Frame-shift | ENST00000456801 | ENST00000373664 | SOGA1 | chr20 | 35431259 | - | RBL1 | chr20 | 35627332 | - |
| 5CDS-intron | ENST00000456801 | ENST00000344359 | SOGA1 | chr20 | 35431259 | - | RBL1 | chr20 | 35627332 | - |
| 5CDS-intron | ENST00000456801 | ENST00000598590 | SOGA1 | chr20 | 35431259 | - | RBL1 | chr20 | 35627332 | - |
| Frame-shift | ENST00000357779 | ENST00000373664 | SOGA1 | chr20 | 35431259 | - | RBL1 | chr20 | 35627332 | - |
| 5CDS-intron | ENST00000357779 | ENST00000344359 | SOGA1 | chr20 | 35431259 | - | RBL1 | chr20 | 35627332 | - |
| 5CDS-intron | ENST00000357779 | ENST00000598590 | SOGA1 | chr20 | 35431259 | - | RBL1 | chr20 | 35627332 | - |
| In-frame | ENST00000237536 | ENST00000373664 | SOGA1 | chr20 | 35457457 | - | RBL1 | chr20 | 35632269 | - |
| Frame-shift | ENST00000237536 | ENST00000344359 | SOGA1 | chr20 | 35457457 | - | RBL1 | chr20 | 35632269 | - |
| 5CDS-intron | ENST00000237536 | ENST00000598590 | SOGA1 | chr20 | 35457457 | - | RBL1 | chr20 | 35632269 | - |
| Frame-shift | ENST00000279034 | ENST00000373664 | SOGA1 | chr20 | 35457457 | - | RBL1 | chr20 | 35632269 | - |
| In-frame | ENST00000279034 | ENST00000344359 | SOGA1 | chr20 | 35457457 | - | RBL1 | chr20 | 35632269 | - |
| 5CDS-intron | ENST00000279034 | ENST00000598590 | SOGA1 | chr20 | 35457457 | - | RBL1 | chr20 | 35632269 | - |
| intron-3CDS | ENST00000456801 | ENST00000373664 | SOGA1 | chr20 | 35457457 | - | RBL1 | chr20 | 35632269 | - |
| intron-3CDS | ENST00000456801 | ENST00000344359 | SOGA1 | chr20 | 35457457 | - | RBL1 | chr20 | 35632269 | - |
| intron-intron | ENST00000456801 | ENST00000598590 | SOGA1 | chr20 | 35457457 | - | RBL1 | chr20 | 35632269 | - |
| Frame-shift | ENST00000357779 | ENST00000373664 | SOGA1 | chr20 | 35457457 | - | RBL1 | chr20 | 35632269 | - |
| In-frame | ENST00000357779 | ENST00000344359 | SOGA1 | chr20 | 35457457 | - | RBL1 | chr20 | 35632269 | - |
| 5CDS-intron | ENST00000357779 | ENST00000598590 | SOGA1 | chr20 | 35457457 | - | RBL1 | chr20 | 35632269 | - |
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FusionProtFeatures for SOGA1_RBL1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SOGA1 | RBL1 |
| Regulates autophagy by playing a role in the reductionof glucose production in an adiponectin- and insulin-dependentmanner. {ECO:0000250}. | Key regulator of entry into cell division. Directlyinvolved in heterochromatin formation by maintaining overallchromatin structure and, in particular, that of constitutiveheterochromatin by stabilizing histone methylation. Recruits andtargets histone methyltransferases KMT5B and KMT5C, leading toepigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor byrecruiting chromatin-modifying enzymes to promoters. Potentinhibitor of E2F-mediated trans-activation. Forms a complex withadenovirus E1A and with SV40 large T antigen. May bind andmodulate functionally certain cellular proteins with which T andE1A compete for pocket binding. May act as a tumor suppressor. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | RBL1 | chr20:35457457 | chr20:35632269 | ENST00000344359 | - | 19 | 21 | 385_584 | 957 | 1015 | Region | Note=Domain A |
| Tgene | RBL1 | chr20:35457457 | chr20:35632269 | ENST00000344359 | - | 19 | 21 | 385_949 | 957 | 1015 | Region | Note=Pocket%3B binds T and E1A |
| Tgene | RBL1 | chr20:35457457 | chr20:35632269 | ENST00000344359 | - | 19 | 21 | 585_780 | 957 | 1015 | Region | Note=Spacer |
| Tgene | RBL1 | chr20:35457457 | chr20:35632269 | ENST00000344359 | - | 19 | 21 | 781_949 | 957 | 1015 | Region | Note=Domain B |
| Tgene | RBL1 | chr20:35457457 | chr20:35632269 | ENST00000373664 | - | 19 | 22 | 385_584 | 957 | 1069 | Region | Note=Domain A |
| Tgene | RBL1 | chr20:35457457 | chr20:35632269 | ENST00000373664 | - | 19 | 22 | 385_949 | 957 | 1069 | Region | Note=Pocket%3B binds T and E1A |
| Tgene | RBL1 | chr20:35457457 | chr20:35632269 | ENST00000373664 | - | 19 | 22 | 585_780 | 957 | 1069 | Region | Note=Spacer |
| Tgene | RBL1 | chr20:35457457 | chr20:35632269 | ENST00000373664 | - | 19 | 22 | 781_949 | 957 | 1069 | Region | Note=Domain B |
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FusionGeneSequence for SOGA1_RBL1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SOGA1_ENST00000237536_chr20_35457457_-_RBL1_ENST00000373664_chr20_35632269_-_469aa MEAPAAEPPVRGCGPQPAPAPAPAPERKKSHRAPSPARPKDVAGWSLAKGRRGPGPGSAVACSAAFSSRPDKKGRAVAPGARGAGVRVAG VRTGVRAKGRPRSGAGPRPPPPPPSLTDSSSEVSDCASEEARLLGLELALSSDAESAAGGPAGVRTGQPAQPAPSAQQPPRPPASPDEPS VAASSVGSSRLPLSASLAFSDLTEEMLDCGPSGLVRELEELRSENDYLKDEIEELRAEMLEMRDVYMEEDVYQLQELRQQLDQASKTCRI LQYRLRKAERRSLRAAQTGQVDGELIRGLEQDVKVSKDISMRLHKELEVVEKKRARLEEENEELRQRLIETELAKQVLQTELERPREMDA PPLSPFPHIKQQPGSPRRISQQHSIYISPHKNGSGLTPRSALLYKFNGSPSKSLKDINNMIRQGEQRTKKRVIAIDSDAESPAKRVCQEN >In-frame_SOGA1_ENST00000279034_chr20_35457457_-_RBL1_ENST00000344359_chr20_35632269_-_177aa MLEMRDVYMEEDVYQLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRGLEQDVKVSKDISMRLHKELEVVEKKRARLE >In-frame_SOGA1_ENST00000357779_chr20_35457457_-_RBL1_ENST00000344359_chr20_35632269_-_177aa MLEMRDVYMEEDVYQLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRGLEQDVKVSKDISMRLHKELEVVEKKRARLE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SOGA1_ENST00000237536_chr20_35457457_-_RBL1_ENST00000373664_chr20_35632269_-_1407nt ATGGAGGCGCCGGCGGCCGAGCCCCCGGTCCGGGGCTGCGGTCCCCAGCCCGCGCCTGCACCCGCGCCTGCCCCGGAGAGGAAAAAGAGC CACCGCGCGCCGTCGCCGGCCCGGCCCAAAGACGTGGCCGGCTGGTCGCTGGCTAAGGGCCGCCGCGGCCCAGGCCCGGGCTCAGCAGTC GCCTGCAGCGCCGCGTTCTCCTCACGGCCGGACAAGAAGGGGCGCGCAGTGGCTCCCGGGGCGCGCGGTGCGGGTGTGCGGGTGGCCGGG GTCCGCACCGGGGTCCGTGCCAAGGGCCGTCCGCGCTCGGGTGCGGGGCCGCGACCGCCACCGCCGCCCCCCAGCCTCACGGATAGCAGC TCGGAGGTGTCGGACTGCGCGTCGGAGGAGGCGCGCCTGCTGGGCCTGGAGCTGGCGCTGAGCAGCGACGCCGAGTCCGCGGCCGGGGGC CCGGCGGGGGTCCGTACGGGGCAGCCGGCCCAGCCCGCGCCCTCCGCGCAGCAGCCCCCGCGGCCGCCCGCCTCCCCGGACGAGCCGTCG GTGGCCGCGTCGTCGGTGGGCAGCAGCCGCTTGCCGCTCAGCGCCTCGCTTGCCTTCTCCGACCTCACCGAGGAGATGCTGGACTGCGGG CCCAGCGGCTTGGTGCGGGAGCTGGAGGAGCTGCGCTCGGAGAACGACTATCTCAAGGACGAGATTGAGGAGCTGCGGGCCGAGATGCTG GAGATGCGGGACGTCTATATGGAGGAGGACGTGTATCAGCTGCAGGAGCTGCGACAGCAGCTGGACCAGGCCAGCAAGACCTGCCGCATC CTGCAGTACCGGCTGCGCAAAGCCGAGCGCCGCAGTCTCCGTGCCGCCCAGACCGGCCAGGTGGACGGCGAGCTTATCCGTGGTCTGGAG CAGGATGTCAAGGTCTCTAAGGACATCTCCATGCGGCTGCATAAGGAGCTCGAGGTGGTGGAGAAGAAACGGGCGCGGCTGGAGGAGGAG AACGAAGAGCTTCGTCAGCGGCTCATCGAGACTGAGCTGGCTAAGCAGGTGCTGCAGACGGAGCTGGAGCGACCGAGAGAGATGGATGCT CCACCACTCTCTCCTTTTCCACATATTAAACAACAGCCAGGCTCACCACGCCGCATTTCCCAGCAGCACTCCATTTATATTTCCCCGCAC AAGAATGGGTCAGGCCTTACACCAAGAAGCGCTCTGCTGTACAAGTTCAATGGCAGCCCTTCTAAGAGTTTGAAAGATATCAACAACATG ATAAGGCAAGGTGAGCAGAGAACCAAGAAGCGAGTAATAGCCATCGATAGTGATGCAGAATCCCCTGCCAAACGCGTCTGTCAAGAAAAT >In-frame_SOGA1_ENST00000279034_chr20_35457457_-_RBL1_ENST00000344359_chr20_35632269_-_531nt ATGCTGGAGATGCGGGACGTCTATATGGAGGAGGACGTGTATCAGCTGCAGGAGCTGCGACAGCAGCTGGACCAGGCCAGCAAGACCTGC CGCATCCTGCAGTACCGGCTGCGCAAAGCCGAGCGCCGCAGTCTCCGTGCCGCCCAGACCGGCCAGGTGGACGGCGAGCTTATCCGTGGT CTGGAGCAGGATGTCAAGGTCTCTAAGGACATCTCCATGCGGCTGCATAAGGAGCTCGAGGTGGTGGAGAAGAAACGGGCGCGGCTGGAG GAGGAGAACGAAGAGCTTCGTCAGCGGCTCATCGAGACTGAGCTGGCTAAGCAGGTGCTGCAGACGGAGCTGGAGCGACCGAGAGAGATG GATGCTCCACCACTCTCTCCTTTTCCACATATTAAACAACAGCCAGGCTCACCACGCCGCATTTCCCAGCAGCACTCCATTTATATTTCC >In-frame_SOGA1_ENST00000357779_chr20_35457457_-_RBL1_ENST00000344359_chr20_35632269_-_531nt ATGCTGGAGATGCGGGACGTCTATATGGAGGAGGACGTGTATCAGCTGCAGGAGCTGCGACAGCAGCTGGACCAGGCCAGCAAGACCTGC CGCATCCTGCAGTACCGGCTGCGCAAAGCCGAGCGCCGCAGTCTCCGTGCCGCCCAGACCGGCCAGGTGGACGGCGAGCTTATCCGTGGT CTGGAGCAGGATGTCAAGGTCTCTAAGGACATCTCCATGCGGCTGCATAAGGAGCTCGAGGTGGTGGAGAAGAAACGGGCGCGGCTGGAG GAGGAGAACGAAGAGCTTCGTCAGCGGCTCATCGAGACTGAGCTGGCTAAGCAGGTGCTGCAGACGGAGCTGGAGCGACCGAGAGAGATG GATGCTCCACCACTCTCTCCTTTTCCACATATTAAACAACAGCCAGGCTCACCACGCCGCATTTCCCAGCAGCACTCCATTTATATTTCC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SOGA1_ENST00000237536_chr20_35457457_-_RBL1_ENST00000373664_chr20_35632269_-_4159nt CGGGCCGCAGCCGGACTCGGAGCCCGAGGGAGCGATCGGCGTGCGGGCGGCGGGGGCCCGGGCGCGCTCCGGGGGCGCGGCGAGGCCGAG GGGGCGGGCGCCGGGCGGAGCCGCAGCCGGAGCCGGGGCGCCTGGAGGCGGTCGGGCCGCACTCTCCGAGCCCAGAGCAGCGGAGAGACC GCGCGGCGGGGCTTGGGACGGGGACGCGGTGTCGGGGCCGAGGTGGGCCGAGAGCAGCCGCAGCCCCAGCGGCCGGAGCCGCGCCGGGTC CCTCCCCAGGGACGTCGAGGCCGGGCGGGCCTGGGCCATGCGCGCAGCTCGCTGAGGCCGAGGGAGGCCGCGATGGAGGCGCCGGCGGCC GAGCCCCCGGTCCGGGGCTGCGGTCCCCAGCCCGCGCCTGCACCCGCGCCTGCCCCGGAGAGGAAAAAGAGCCACCGCGCGCCGTCGCCG GCCCGGCCCAAAGACGTGGCCGGCTGGTCGCTGGCTAAGGGCCGCCGCGGCCCAGGCCCGGGCTCAGCAGTCGCCTGCAGCGCCGCGTTC TCCTCACGGCCGGACAAGAAGGGGCGCGCAGTGGCTCCCGGGGCGCGCGGTGCGGGTGTGCGGGTGGCCGGGGTCCGCACCGGGGTCCGT GCCAAGGGCCGTCCGCGCTCGGGTGCGGGGCCGCGACCGCCACCGCCGCCCCCCAGCCTCACGGATAGCAGCTCGGAGGTGTCGGACTGC GCGTCGGAGGAGGCGCGCCTGCTGGGCCTGGAGCTGGCGCTGAGCAGCGACGCCGAGTCCGCGGCCGGGGGCCCGGCGGGGGTCCGTACG GGGCAGCCGGCCCAGCCCGCGCCCTCCGCGCAGCAGCCCCCGCGGCCGCCCGCCTCCCCGGACGAGCCGTCGGTGGCCGCGTCGTCGGTG GGCAGCAGCCGCTTGCCGCTCAGCGCCTCGCTTGCCTTCTCCGACCTCACCGAGGAGATGCTGGACTGCGGGCCCAGCGGCTTGGTGCGG GAGCTGGAGGAGCTGCGCTCGGAGAACGACTATCTCAAGGACGAGATTGAGGAGCTGCGGGCCGAGATGCTGGAGATGCGGGACGTCTAT ATGGAGGAGGACGTGTATCAGCTGCAGGAGCTGCGACAGCAGCTGGACCAGGCCAGCAAGACCTGCCGCATCCTGCAGTACCGGCTGCGC AAAGCCGAGCGCCGCAGTCTCCGTGCCGCCCAGACCGGCCAGGTGGACGGCGAGCTTATCCGTGGTCTGGAGCAGGATGTCAAGGTCTCT AAGGACATCTCCATGCGGCTGCATAAGGAGCTCGAGGTGGTGGAGAAGAAACGGGCGCGGCTGGAGGAGGAGAACGAAGAGCTTCGTCAG CGGCTCATCGAGACTGAGCTGGCTAAGCAGGTGCTGCAGACGGAGCTGGAGCGACCGAGAGAGATGGATGCTCCACCACTCTCTCCTTTT CCACATATTAAACAACAGCCAGGCTCACCACGCCGCATTTCCCAGCAGCACTCCATTTATATTTCCCCGCACAAGAATGGGTCAGGCCTT ACACCAAGAAGCGCTCTGCTGTACAAGTTCAATGGCAGCCCTTCTAAGAGTTTGAAAGATATCAACAACATGATAAGGCAAGGTGAGCAG AGAACCAAGAAGCGAGTAATAGCCATCGATAGTGATGCAGAATCCCCTGCCAAACGCGTCTGTCAAGAAAATGATGACGTTTTACTGAAA CGACTACAGGATGTTGTCAGTGAAAGAGCAAATCATTAATGTTGTTCTTGTTTCTATGATAAAAGCACTTTCAGATTGTTCTGCAGAAAG TTGGAGCTCTGTCCTTCAAACCTTTTAGCCCTATAGATGATAAATATCACTGGGTTATAAGAAAAAATTGCACAAAAATTATGTGCTTTT TAAAATATTTATCCAAAATGTAGTTGACAGAGATGTATTTTGAGTTGGATTGGAAAGGAATATTTTAAGTGCCTTTTAAAAATACTAATA GTCCGGCCAGGCGCTGTGGCTCACGCCTGTAATCCCAGGACTTTGGGAGGCCAAGGCGGGCAGATCACCGGAGGTCAGGAGTTCGAGACC AGCCTGACCAACATGGAGAAACCCCATCTCTACTAAAAATACAAAATTAGCCGGGTGTGGTGGCGCATGCCTGTAATCCCAGCTACTTGG GAGGCTGAGGCAGAATTGCTTGAACCCAGGAAGCGGAGGTTGTGGTGAGCCAAGGTTGCGCCACTGCACTCCAGCCTGGGCAACAAGAGT AAAACTCCATCTCAAAAAATATATATATATATATAAATAGGGAATTTTTTTTAATGTTTGCTCCTTGAGTTTTCAAGATGAAATAAGGAG AAACCCCATAACTTTTTAGCTCTCTTTTAAAAATAAATGTCTCCTTCTGTGTTCTGTAATATGAGGATAAATAATCTACTTTTGATAGCA TGCTTTGAGATATTTGTATTCTTAATTTAATATTGAAGGAAGGGGTTGGTTCCCATAGTACCTGGCCAGAGGGTTATATACCATCCTGTC TCTGGCCCACTGTGGTAATTCCACATCCAGGTACCACCGCCATTCAGAGTTGTCTCACCCCTTCTCGTGCCTTTTCTCTCCTTGAGCTTT ATAAACAGATTTGTACCTGAGCCCCAGTGCTACACTCATCCTTGCTTTCCAGCCCTAAGCCATCTCAGCCTGATGTCACAACCCAATAAA TGGGGCACTTTCTTCTTTTGTAAACTATTATCATTTTGGTTTCTGTGACATTAACTTAATTATATATGATCGTATTAACTCATGTAGTTC TCAAAATAGGCAGCTGCTTCTGAAGCCAGTAAAATAAAATTCAGTTAGTTATTAAAAACTAAATTCCTATTAGTAAGGTAACACCATGAT TATGTGTGATATACTGTTTTTGAGATCATAGTTATCAGTCATTCTCAATATCTAATTGAGTCCCTAAGAATATTTTAAACCTTTTAAAAA TCACATAAATATCATCTCATGCCTCATAATTCTAATATATTTAATACATCAGTAAAATAGCTGCTTATTACTTCCCACACTTTGTTCTCA GTATTGTTAGTGCATCATGAGTTTCCTGCTAGTGTTTGACCACTGGGTACTCCTGAAGATGTTTTTTAGTACTAGGGATGCTTTTCAGTA TTAGGGATGCTTTTTTCAGTACTAGGGATGTACTAGGGAGTACTGAGTACTCCTGAAGATGTTTTTCAGTACTAGGGATGCTTTTTTCAG TGTTAGGGATGCTTTTCAGTACTAGGGATGCTTTTTTCAGTGCTAGGGATGCTTTTCAGTACTAGGGATGCTTTCCAAAATATCACCTCT TTAACGTTTACTTTTTCTAGTGTGTGTCTGGAATCCAAAGGACATGAATAAGCCACTCATAATTAATTTTGAGAAGTTTTATCAAATGTT TATGTTTCTAACTGCAAACCTTAATTTTGGAAAGGCACAATGTTTAACTCACCTATGTTTAACCATGGCTAATTTAAAATAGTCTAAGAT TTGGCCGTCACTAATTAGTATTCTCAAGAATTTCATTTTTCAATTTTAAGAAGAAAAGGGATTTTGGTCACATTTTGCTTGTAAATGAAA ATTACATCCTCATTCTTTGTGTAGTATCTACACATTGTTATAAGCCAAAAAACAAAGTCTGTCTGGAATCTTTGTACATATTTGTATGTT GCTATAATTGTTATTTTTATCTTCATTATTGTGCAAAATATAAATGAGCATTTGTACATTGACTGTATAAGAAACCATGGGCCAGGTCCT GTGGCTCATGCCTATAATCCCAACACTTTGGGAGGCTGAGGCAGGAGGATTGCTTCAGTCCAGGAGTTCAAGACTAACCTGGGCAACATA GCCCTCATCTCTACAAAAAATAAAAAAATTAGTTGGGTGTGATGGCATGTGCCTGTAGTCCCAGCTACTCAGGAGACTGACATGAGAGGA TCACTTGAGACTGGGAGATTCTGAGGCTGCAGTGAGCTGTGATTGCACCACTACACTCCATCCTAGGTGAGAGGGCAAGACCCTTTCTCA GAAAAGGAAAAAAAGAAATTCTGGACATGTTTTTATCAGTTTTCAGGACTTGGTATCAATGTACATAGAATGGCTAATAAAAATTGGAAT >In-frame_SOGA1_ENST00000279034_chr20_35457457_-_RBL1_ENST00000344359_chr20_35632269_-_977nt GATGTGTTTTCTGCCTTTCTGGACTACTTTGCCTCTAAGATGCAGAAACTGAGTACAAGGGAAAGGACTCCAAATCCCCAGTATGTCCCC TGCAGGAGCAGAGTTGAAGGAGGTCCCACCAGGTCTGGTGGGTGGCCCTGCTCAGGCTTACCTCCCCCTTGTAGGGGTCACTGGGAACTG TCAACTGCGAAGGACTGTGATCTCCAGTCTGGTATGGTCTGCTCTGGGGTCCAAGTGAGGAAAGCATAAATCGGGCAACTCTCTCCCAGT GAGAAGATAGAAGGAGCTTCTACAGAGAAGGACGAGATTGAGGAGCTGCGGGCCGAGATGCTGGAGATGCGGGACGTCTATATGGAGGAG GACGTGTATCAGCTGCAGGAGCTGCGACAGCAGCTGGACCAGGCCAGCAAGACCTGCCGCATCCTGCAGTACCGGCTGCGCAAAGCCGAG CGCCGCAGTCTCCGTGCCGCCCAGACCGGCCAGGTGGACGGCGAGCTTATCCGTGGTCTGGAGCAGGATGTCAAGGTCTCTAAGGACATC TCCATGCGGCTGCATAAGGAGCTCGAGGTGGTGGAGAAGAAACGGGCGCGGCTGGAGGAGGAGAACGAAGAGCTTCGTCAGCGGCTCATC GAGACTGAGCTGGCTAAGCAGGTGCTGCAGACGGAGCTGGAGCGACCGAGAGAGATGGATGCTCCACCACTCTCTCCTTTTCCACATATT AAACAACAGCCAGGCTCACCACGCCGCATTTCCCAGCAGCACTCCATTTATATTTCCCCGCACAAGAATGGGTCAGGCCTTACACCAAGA AGCGCTCTGCTGTACAAGTTCAATGGCAGCCCTTCTAAGGTAAGGTGAATAGGCTAAAAGTTGGATTTCAGATTAACAGTCAGTAACTGT >In-frame_SOGA1_ENST00000357779_chr20_35457457_-_RBL1_ENST00000344359_chr20_35632269_-_977nt GATGTGTTTTCTGCCTTTCTGGACTACTTTGCCTCTAAGATGCAGAAACTGAGTACAAGGGAAAGGACTCCAAATCCCCAGTATGTCCCC TGCAGGAGCAGAGTTGAAGGAGGTCCCACCAGGTCTGGTGGGTGGCCCTGCTCAGGCTTACCTCCCCCTTGTAGGGGTCACTGGGAACTG TCAACTGCGAAGGACTGTGATCTCCAGTCTGGTATGGTCTGCTCTGGGGTCCAAGTGAGGAAAGCATAAATCGGGCAACTCTCTCCCAGT GAGAAGATAGAAGGAGCTTCTACAGAGAAGGACGAGATTGAGGAGCTGCGGGCCGAGATGCTGGAGATGCGGGACGTCTATATGGAGGAG GACGTGTATCAGCTGCAGGAGCTGCGACAGCAGCTGGACCAGGCCAGCAAGACCTGCCGCATCCTGCAGTACCGGCTGCGCAAAGCCGAG CGCCGCAGTCTCCGTGCCGCCCAGACCGGCCAGGTGGACGGCGAGCTTATCCGTGGTCTGGAGCAGGATGTCAAGGTCTCTAAGGACATC TCCATGCGGCTGCATAAGGAGCTCGAGGTGGTGGAGAAGAAACGGGCGCGGCTGGAGGAGGAGAACGAAGAGCTTCGTCAGCGGCTCATC GAGACTGAGCTGGCTAAGCAGGTGCTGCAGACGGAGCTGGAGCGACCGAGAGAGATGGATGCTCCACCACTCTCTCCTTTTCCACATATT AAACAACAGCCAGGCTCACCACGCCGCATTTCCCAGCAGCACTCCATTTATATTTCCCCGCACAAGAATGGGTCAGGCCTTACACCAAGA AGCGCTCTGCTGTACAAGTTCAATGGCAGCCCTTCTAAGGTAAGGTGAATAGGCTAAAAGTTGGATTTCAGATTAACAGTCAGTAACTGT |
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FusionGenePPI for SOGA1_RBL1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SOGA1 | PLEKHA5, MARK4, SIRT7, CCDC8, ZNF219, TSNAX, NTRK1, ANKRA2, RFXANK, HERC2, MARK2, PPP2R1A, DYNLL1, RNF41, NOP56, SAMHD1, LDHD, ZNF785, ZNF169, LZTS2, ZNF263, TRIM25 | RBL1 | RBBP8, BEGAIN, BRCA1, MYBL2, CDKN1C, SUV39H1, HDAC1, HDAC2, HDAC3, ARID4A, CCNE1, CDK2, E2F5, KDM5A, AATF, SMAD3, SMAD4, E2F4, SNW1, MCM7, CCNA2, E2F1, PPP2R3A, CREG1, CCNA1, TFDP1, TFDP2, RBBP9, TAF1, BRF1, PHB, USP4, MYC, EMD, RBL2, IRF3, MAPK6, E2F3, LIN37, LIN9, LIN54, SMARCA4, TOP1, E2F2, RINT1, ID2, DGKZ, CDK4, CDK6, SP1, GOLGA2, SNRPD3, AOX1, EPHA2, FN1, NR4A1, LAMB2, NUCB1, PLSCR1, MAGEA11, AR, DYRK1A, DYRK1B, TXNDC11, CTBP1, C3orf62, NTRK1, FOXK1, FOXO3, TSC22D2, KIAA0430, HELZ |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SOGA1_RBL1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SOGA1_RBL1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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