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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35359

FusionGeneSummary for SOD1_CXCL9

check button Fusion gene summary
Fusion gene informationFusion gene name: SOD1_CXCL9
Fusion gene ID: 35359
HgeneTgene
Gene symbol

SOD1

CXCL9

Gene ID

6647

4283

Gene namesuperoxide dismutase 1C-X-C motif chemokine ligand 9
SynonymsALS|ALS1|HEL-S-44|IPOA|SOD|hSod1|homodimerCMK|Humig|MIG|SCYB9|crg-10
Cytomap

21q22.11

4q21.1

Type of geneprotein-codingprotein-coding
Descriptionsuperoxide dismutase [Cu-Zn]Cu/Zn superoxide dismutaseSOD, solubleepididymis secretory protein Li 44indophenoloxidase Asuperoxide dismutase 1, solublesuperoxide dismutase, cystolicC-X-C motif chemokine 9chemokine (C-X-C motif) ligand 9gamma-interferon-induced monokinemonokine induced by gamma interferonmonokine induced by interferon-gammasmall-inducible cytokine B9
Modification date2018052720180523
UniProtAcc

P00441

Q07325

Ensembl transtripts involved in fusion geneENST00000270142, ENST00000389995, 
ENST00000470944, 		ENST00000264888, 
Fusion gene scores* DoF score3 X 3 X 1=93 X 2 X 3=18
# samples 33
** MAII scorelog2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SOD1 [Title/Abstract] AND CXCL9 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSOD1

GO:0000303

response to superoxide

16790527

HgeneSOD1

GO:0001819

positive regulation of cytokine production

15544046

HgeneSOD1

GO:0006801

superoxide metabolic process

12551919

HgeneSOD1

GO:0010033

response to organic substance

12921788

HgeneSOD1

GO:0032930

positive regulation of superoxide anion generation

18219391

HgeneSOD1

GO:0043085

positive regulation of catalytic activity

17324120

HgeneSOD1

GO:0043087

regulation of GTPase activity

18219391

HgeneSOD1

GO:0045541

negative regulation of cholesterol biosynthetic process

15473258

HgeneSOD1

GO:0045859

regulation of protein kinase activity

16254550

HgeneSOD1

GO:0050665

hydrogen peroxide biosynthetic process

15544046

HgeneSOD1

GO:0060047

heart contraction

9539776

HgeneSOD1

GO:0072593

reactive oxygen species metabolic process

24140062

TgeneCXCL9

GO:0006935

chemotaxis

12782716

TgeneCXCL9

GO:0030816

positive regulation of cAMP metabolic process

12782716

TgeneCXCL9

GO:0042127

regulation of cell proliferation

12782716

TgeneCXCL9

GO:0043950

positive regulation of cAMP-mediated signaling

12782716

TgeneCXCL9

GO:0051281

positive regulation of release of sequestered calcium ion into cytosol

12782716


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW389351SOD1chr21

33040852

+CXCL9chr4

76924037

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000270142ENST00000264888SOD1chr21

33040852

+CXCL9chr4

76924037

+
5CDS-3UTRENST00000389995ENST00000264888SOD1chr21

33040852

+CXCL9chr4

76924037

+
3UTR-3UTRENST00000470944ENST00000264888SOD1chr21

33040852

+CXCL9chr4

76924037

+

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FusionProtFeatures for SOD1_CXCL9


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SOD1

P00441

CXCL9

Q07325

Cytokine that affects the growth, movement, oractivation state of cells that participate in immune andinflammatory response. Chemotactic for activated T-cells. Binds toCXCR3.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SOD1_CXCL9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SOD1_CXCL9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SOD1_CXCL9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneSOD1P00441DB00988DopamineSuperoxide dismutase [Cu-Zn]small moleculeapproved
HgeneSOD1P00441DB01064IsoprenalineSuperoxide dismutase [Cu-Zn]small moleculeapproved|investigational
HgeneSOD1P00441DB01593ZincSuperoxide dismutase [Cu-Zn]small moleculeapproved|investigational
HgeneSOD1P00441DB00668EpinephrineSuperoxide dismutase [Cu-Zn]small moleculeapproved|vet_approved

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RelatedDiseases for SOD1_CXCL9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSOD1C1862939AMYOTROPHIC LATERAL SCLEROSIS 151CTD_human;UNIPROT
HgeneSOD1C0002736Amyotrophic Lateral Sclerosis24CTD_human;HPO;ORPHANET
HgeneSOD1C0007787Transient Ischemic Attack4CTD_human
HgeneSOD1C0035126Reperfusion Injury4CTD_human
HgeneSOD1C0011581Depressive disorder3CTD_human;HPO;PSYGENET
HgeneSOD1C0027746Nerve Degeneration3CTD_human;HPO
HgeneSOD1C0030567Parkinson Disease3CTD_human
HgeneSOD1C0007621Neoplastic Cell Transformation2CTD_human
HgeneSOD1C0011570Mental Depression2PSYGENET
HgeneSOD1C0020538Hypertensive disease2CTD_human
HgeneSOD1C0035304Retinal Degeneration2CTD_human
HgeneSOD1C0003493Aortic Diseases1CTD_human
HgeneSOD1C0004045Asphyxia Neonatorum1CTD_human
HgeneSOD1C0004096Asthma1CTD_human
HgeneSOD1C0004153Atherosclerosis1CTD_human
HgeneSOD1C0005586Bipolar Disorder1PSYGENET
HgeneSOD1C0007786Brain Ischemia1CTD_human
HgeneSOD1C0011616Contact Dermatitis1CTD_human
HgeneSOD1C0011849Diabetes Mellitus1CTD_human
HgeneSOD1C0011853Diabetes Mellitus, Experimental1CTD_human
HgeneSOD1C0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
HgeneSOD1C0011884Diabetic Retinopathy1CTD_human
HgeneSOD1C0013080Down Syndrome1CTD_human
HgeneSOD1C0015696Fatty Liver, Alcoholic1CTD_human
HgeneSOD1C0015934Fetal Growth Retardation1CTD_human
HgeneSOD1C0017638Glioma1CTD_human
HgeneSOD1C0018801Heart failure1CTD_human
HgeneSOD1C0019054Hemolysis (disorder)1CTD_human
HgeneSOD1C0019189Hepatitis, Chronic1CTD_human
HgeneSOD1C0020550Hyperthyroidism1CTD_human
HgeneSOD1C0020649Hypotension1CTD_human
HgeneSOD1C0020672Hypothermia, natural1CTD_human
HgeneSOD1C0021368Inflammation1CTD_human
HgeneSOD1C0022116Ischemia1CTD_human
HgeneSOD1C0022650Kidney Calculi1CTD_human
HgeneSOD1C0023895Liver diseases1CTD_human
HgeneSOD1C0024796Marfan Syndrome1CTD_human
HgeneSOD1C0025312Meningomyelocele1CTD_human
HgeneSOD1C0026846Muscular Atrophy1CTD_human
HgeneSOD1C0027051Myocardial Infarction1CTD_human
HgeneSOD1C0027540Necrosis1CTD_human
HgeneSOD1C0027720Nephrosis1CTD_human
HgeneSOD1C0027765nervous system disorder1CTD_human
HgeneSOD1C0028754Obesity1CTD_human
HgeneSOD1C0033626Protein Deficiency1CTD_human
HgeneSOD1C0033687Proteinuria1CTD_human
HgeneSOD1C0036330Schistosomiasis mansoni1CTD_human
HgeneSOD1C0036341Schizophrenia1PSYGENET
HgeneSOD1C0036457Scrapie1CTD_human
HgeneSOD1C0038454Cerebrovascular accident1CTD_human
HgeneSOD1C0041408Turner Syndrome1CTD_human
HgeneSOD1C0085084Motor Neuron Disease1CTD_human
HgeneSOD1C0162316Iron deficiency anemia1CTD_human
HgeneSOD1C0162671MELAS Syndrome1CTD_human
HgeneSOD1C0162674Chronic progressive external ophthalmoplegia1CTD_human
HgeneSOD1C0751830Gait Disorders, Neurologic1CTD_human
HgeneSOD1C0919267ovarian neoplasm1CTD_human
HgeneSOD1C1262477Weight decreased1CTD_human
HgeneSOD1C1384666hearing impairment1CTD_human
HgeneSOD1C1456865Ureteral Calculi1CTD_human
HgeneSOD1C4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneCXCL9C0002171Alopecia Areata1CTD_human
TgeneCXCL9C0020517Hypersensitivity1CTD_human
TgeneCXCL9C0023892Biliary cirrhosis1CTD_human
TgeneCXCL9C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneCXCL9C0023904Liver Neoplasms, Experimental1CTD_human
TgeneCXCL9C0027643Neoplasm Recurrence, Local1CTD_human
TgeneCXCL9C0032285Pneumonia1CTD_human
TgeneCXCL9C0282488Interstitial Cystitis1CTD_human
TgeneCXCL9C0345967Malignant mesothelioma1CTD_human
TgeneCXCL9C1458155Mammary Neoplasms1CTD_human