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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3535

FusionGeneSummary for ATRNL1_ATAD1

check button Fusion gene summary
Fusion gene informationFusion gene name: ATRNL1_ATAD1
Fusion gene ID: 3535
HgeneTgene
Gene symbol

ATRNL1

ATAD1

Gene ID

26033

84896

Gene nameattractin like 1ATPase family, AAA domain containing 1
SynonymsALP|bA338L11.1|bA454H24.1AFDC1|FNP001|THORASE
Cytomap

10q25.3

10q23.31

Type of geneprotein-codingprotein-coding
Descriptionattractin-like protein 1ATPase family AAA domain-containing protein 1
Modification date2018051920180522
UniProtAcc

Q5VV63

Q8NBU5

Ensembl transtripts involved in fusion geneENST00000355044, ENST00000423111, 
ENST00000303745, ENST00000529665, 
ENST00000527407, 		ENST00000308448, 
ENST00000328142, ENST00000400215, 
ENST00000541004, ENST00000495903, 
Fusion gene scores* DoF score1 X 1 X 1=113 X 5 X 7=455
# samples 114
** MAII scorelog2(1/1*10)=3.32192809488736log2(14/455*10)=-1.70043971814109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATRNL1 [Title/Abstract] AND ATAD1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-BH-A18K-01AATRNL1chr10

117278834

+ATAD1chr10

89574369

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000355044ENST00000308448ATRNL1chr10

117278834

+ATAD1chr10

89574369

-
5CDS-5UTRENST00000355044ENST00000328142ATRNL1chr10

117278834

+ATAD1chr10

89574369

-
5CDS-intronENST00000355044ENST00000400215ATRNL1chr10

117278834

+ATAD1chr10

89574369

-
5CDS-5UTRENST00000355044ENST00000541004ATRNL1chr10

117278834

+ATAD1chr10

89574369

-
5CDS-5UTRENST00000355044ENST00000495903ATRNL1chr10

117278834

+ATAD1chr10

89574369

-
5CDS-5UTRENST00000423111ENST00000308448ATRNL1chr10

117278834

+ATAD1chr10

89574369

-
5CDS-5UTRENST00000423111ENST00000328142ATRNL1chr10

117278834

+ATAD1chr10

89574369

-
5CDS-intronENST00000423111ENST00000400215ATRNL1chr10

117278834

+ATAD1chr10

89574369

-
5CDS-5UTRENST00000423111ENST00000541004ATRNL1chr10

117278834

+ATAD1chr10

89574369

-
5CDS-5UTRENST00000423111ENST00000495903ATRNL1chr10

117278834

+ATAD1chr10

89574369

-
5CDS-5UTRENST00000303745ENST00000308448ATRNL1chr10

117278834

+ATAD1chr10

89574369

-
5CDS-5UTRENST00000303745ENST00000328142ATRNL1chr10

117278834

+ATAD1chr10

89574369

-
5CDS-intronENST00000303745ENST00000400215ATRNL1chr10

117278834

+ATAD1chr10

89574369

-
5CDS-5UTRENST00000303745ENST00000541004ATRNL1chr10

117278834

+ATAD1chr10

89574369

-
5CDS-5UTRENST00000303745ENST00000495903ATRNL1chr10

117278834

+ATAD1chr10

89574369

-
intron-5UTRENST00000529665ENST00000308448ATRNL1chr10

117278834

+ATAD1chr10

89574369

-
intron-5UTRENST00000529665ENST00000328142ATRNL1chr10

117278834

+ATAD1chr10

89574369

-
intron-intronENST00000529665ENST00000400215ATRNL1chr10

117278834

+ATAD1chr10

89574369

-
intron-5UTRENST00000529665ENST00000541004ATRNL1chr10

117278834

+ATAD1chr10

89574369

-
intron-5UTRENST00000529665ENST00000495903ATRNL1chr10

117278834

+ATAD1chr10

89574369

-
intron-5UTRENST00000527407ENST00000308448ATRNL1chr10

117278834

+ATAD1chr10

89574369

-
intron-5UTRENST00000527407ENST00000328142ATRNL1chr10

117278834

+ATAD1chr10

89574369

-
intron-intronENST00000527407ENST00000400215ATRNL1chr10

117278834

+ATAD1chr10

89574369

-
intron-5UTRENST00000527407ENST00000541004ATRNL1chr10

117278834

+ATAD1chr10

89574369

-
intron-5UTRENST00000527407ENST00000495903ATRNL1chr10

117278834

+ATAD1chr10

89574369

-

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FusionProtFeatures for ATRNL1_ATAD1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATRNL1

Q5VV63

ATAD1

Q8NBU5

May play a role in melanocortin signaling pathways thatregulate energy homeostasis. {ECO:0000250}. ATPase that plays a critical role in regulating thesurface expression of AMPA receptors (AMPAR), thereby regulatingsynaptic plasticity and learning and memory. Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2recycling back to the plasma membrane; these activities areATPase-dependent (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ATRNL1_ATAD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ATRNL1_ATAD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ATRNL1MC4RATAD1USP19, BABAM1, ELAVL1, PEX14, EGFR, BSCL2, FAF2, GOSR1, REV3L, VAPA, COQ9, NDUFA4, OCIAD1, TPM2, MAS1, ANKS6


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ATRNL1_ATAD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ATRNL1_ATAD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource