|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 35337 |
FusionGeneSummary for SNX9_ZDHHC14 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SNX9_ZDHHC14 | Fusion gene ID: 35337 | Hgene | Tgene | Gene symbol | SNX9 | ZDHHC14 | Gene ID | 51429 | 79683 |
| Gene name | sorting nexin 9 | zinc finger DHHC-type containing 14 | |
| Synonyms | SDP1|SH3PX1|SH3PXD3A|WISP | NEW1CP | |
| Cytomap | 6q25.3 | 6q25.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | sorting nexin-9SH3 and PX domain-containing protein 1SH3 and PX domain-containing protein 3AWiskott-Aldrich syndrome protein (WASP) interactor protein | probable palmitoyltransferase ZDHHC14DHHC-14NEW1 domain-containing proteinzinc finger DHHC domain-containing protein 14zinc finger, DHHC domain containing 14 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q9Y5X1 | Q8IZN3 | |
| Ensembl transtripts involved in fusion gene | ENST00000392185, | ENST00000414563, ENST00000359775, ENST00000341375, | |
| Fusion gene scores | * DoF score | 5 X 7 X 5=175 | 7 X 5 X 7=245 |
| # samples | 7 | 8 | |
| ** MAII score | log2(7/175*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/245*10)=-1.61470984411521 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SNX9 [Title/Abstract] AND ZDHHC14 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SNX9 | GO:0032461 | positive regulation of protein oligomerization | 15703209 |
| Hgene | SNX9 | GO:0043547 | positive regulation of GTPase activity | 15703209 |
| Hgene | SNX9 | GO:0045860 | positive regulation of protein kinase activity | 18388313 |
| Hgene | SNX9 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis | 18353773 |
| Hgene | SNX9 | GO:0060988 | lipid tube assembly | 17948057 |
| Hgene | SNX9 | GO:0097320 | plasma membrane tubulation | 18388313 |
| Tgene | ZDHHC14 | GO:0018345 | protein palmitoylation | 23034182 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | STAD | TCGA-FP-8631-01A | SNX9 | chr6 | 158318030 | + | ZDHHC14 | chr6 | 158014020 | + |
| TCGA | RV | UCEC | TCGA-AP-A5FX-01A | SNX9 | chr6 | 158353304 | + | ZDHHC14 | chr6 | 157963617 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000392185 | ENST00000414563 | SNX9 | chr6 | 158318030 | + | ZDHHC14 | chr6 | 158014020 | + |
| In-frame | ENST00000392185 | ENST00000359775 | SNX9 | chr6 | 158318030 | + | ZDHHC14 | chr6 | 158014020 | + |
| 5CDS-3UTR | ENST00000392185 | ENST00000341375 | SNX9 | chr6 | 158318030 | + | ZDHHC14 | chr6 | 158014020 | + |
| Frame-shift | ENST00000392185 | ENST00000414563 | SNX9 | chr6 | 158353304 | + | ZDHHC14 | chr6 | 157963617 | + |
| Frame-shift | ENST00000392185 | ENST00000359775 | SNX9 | chr6 | 158353304 | + | ZDHHC14 | chr6 | 157963617 | + |
| 5CDS-intron | ENST00000392185 | ENST00000341375 | SNX9 | chr6 | 158353304 | + | ZDHHC14 | chr6 | 157963617 | + |
Top |
FusionProtFeatures for SNX9_ZDHHC14 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SNX9 | ZDHHC14 |
| Involved in endocytosis and intracellular vesicletrafficking, both during interphase and at the end of mitosis.Required for efficient progress through mitosis and cytokinesis.Required for normal formation of the cleavage furrow at the end ofmitosis. Plays a role in endocytosis via clathrin-coated pits, butalso clathrin-independent, actin-dependent fluid-phaseendocytosis. Plays a role in macropinocytosis. Promotesinternalization of TNFR. Promotes degradation of EGFR after EGFsignaling. Stimulates the GTPase activity of DNM1. Promotes DNM1oligomerization. Promotes activation of the Arp2/3 complex byWASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched inphosphatidylinositol 4,5-bisphosphate and promotes membranetubulation. Has lower affinity for membranes enriched inphosphatidylinositol 3-phosphate. {ECO:0000269|PubMed:11799118,ECO:0000269|PubMed:12952949, ECO:0000269|PubMed:15703209,ECO:0000269|PubMed:17609109, ECO:0000269|PubMed:17948057,ECO:0000269|PubMed:18388313, ECO:0000269|PubMed:20427313,ECO:0000269|PubMed:21048941, ECO:0000269|PubMed:22718350}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | SNX9 | chr6:158318030 | chr6:158014020 | ENST00000392185 | + | 5 | 18 | 1_62 | 157 | 596 | Domain | SH3 |
| Tgene | >ZDHHC14 | chr6:158318030 | chr6:158014020 | ENST00000359775 | + | 1 | 9 | 165_215 | 135 | 489 | Domain | DHHC |
| Tgene | >ZDHHC14 | chr6:158318030 | chr6:158014020 | ENST00000414563 | + | 1 | 9 | 165_215 | 135 | 474 | Domain | DHHC |
| Tgene | >ZDHHC14 | chr6:158318030 | chr6:158014020 | ENST00000359775 | + | 1 | 9 | 209_229 | 135 | 489 | Transmembrane | Helical |
| Tgene | >ZDHHC14 | chr6:158318030 | chr6:158014020 | ENST00000359775 | + | 1 | 9 | 256_276 | 135 | 489 | Transmembrane | Helical |
| Tgene | >ZDHHC14 | chr6:158318030 | chr6:158014020 | ENST00000414563 | + | 1 | 9 | 209_229 | 135 | 474 | Transmembrane | Helical |
| Tgene | >ZDHHC14 | chr6:158318030 | chr6:158014020 | ENST00000414563 | + | 1 | 9 | 256_276 | 135 | 474 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >SNX9 | chr6:158318030 | chr6:158014020 | ENST00000392185 | + | 5 | 18 | 250_361 | 157 | 596 | Domain | PX |
| Hgene | >SNX9 | chr6:158318030 | chr6:158014020 | ENST00000392185 | + | 5 | 18 | 392_595 | 157 | 596 | Domain | Note=BAR |
| Hgene | >SNX9 | chr6:158318030 | chr6:158014020 | ENST00000392185 | + | 5 | 18 | 201_213 | 157 | 596 | Region | Note=Critical for tubulation activity |
| Tgene | ZDHHC14 | chr6:158318030 | chr6:158014020 | ENST00000359775 | + | 1 | 9 | 61_81 | 135 | 489 | Transmembrane | Helical |
| Tgene | ZDHHC14 | chr6:158318030 | chr6:158014020 | ENST00000359775 | + | 1 | 9 | 90_110 | 135 | 489 | Transmembrane | Helical |
| Tgene | ZDHHC14 | chr6:158318030 | chr6:158014020 | ENST00000414563 | + | 1 | 9 | 61_81 | 135 | 474 | Transmembrane | Helical |
| Tgene | ZDHHC14 | chr6:158318030 | chr6:158014020 | ENST00000414563 | + | 1 | 9 | 90_110 | 135 | 474 | Transmembrane | Helical |
Top |
FusionGeneSequence for SNX9_ZDHHC14 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SNX9_ENST00000392185_chr6_158318030_+_ZDHHC14_ENST00000414563_chr6_158014020_+_496aa MATKARVMYDFAAEPGNNELTVNEGEIITITNPDVGGGWLEGRNIKGERGLVPTDYVEILPSDGKDQFSCGNSVADQAFLDSLSASTAQA SSSAASNNHQVGSGNDPWSAWSASKSGNWESSEGWGAQPEGAGAQRNTNTPNNWDTAFGHPQAYQGPDIANGTSSGGYRPPPRTKEVIIN GQTVKLKYCFTCKIFRPPRASHCSLCDNCVERFDHHCPWVGNCVGKRNYRFFYMFILSLSFLTVFIFAFVITHVILRSQQTGFLNALKDS PASVLEAVVCFFSVWSIVGLSGFHTYLISSNQTTNEDIKGSWSNKRGKENYNPYSYGNIFTNCCVALCGPISPSLIDRRGYIQPDTPQPA APSNGITMYGATQSQSDMAAATPLLQSEPSLTSDELHLPGKPGLGTPCASLTLGPPTPPASMPNLAEATLADVMPRKDEHMGHQFLTPDE >In-frame_SNX9_ENST00000392185_chr6_158318030_+_ZDHHC14_ENST00000359775_chr6_158014020_+_511aa MATKARVMYDFAAEPGNNELTVNEGEIITITNPDVGGGWLEGRNIKGERGLVPTDYVEILPSDGKDQFSCGNSVADQAFLDSLSASTAQA SSSAASNNHQVGSGNDPWSAWSASKSGNWESSEGWGAQPEGAGAQRNTNTPNNWDTAFGHPQAYQGPDIANGTSSGGYRPPPRTKEVIIN GQTVKLKYCFTCKIFRPPRASHCSLCDNCVERFDHHCPWVGNCVGKRNYRFFYMFILSLSFLTVFIFAFVITHVILRSQQTGFLNALKDS PASVLEAVVCFFSVWSIVGLSGFHTYLISSNQTTNEDIKGSWSNKRGKENYNPYSYGNIFTNCCVALCGPISPSLIDRRGYIQPDTPQPA APSNGITMYGATQSQSDMCDQDQCIQSTKFVLQAAATPLLQSEPSLTSDELHLPGKPGLGTPCASLTLGPPTPPASMPNLAEATLADVMP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SNX9_ENST00000392185_chr6_158318030_+_ZDHHC14_ENST00000414563_chr6_158014020_+_1488nt ATGGCCACCAAGGCTCGGGTTATGTATGATTTTGCTGCTGAACCTGGAAATAATGAACTGACGGTTAATGAAGGAGAAATCATCACAATC ACAAATCCGGATGTAGGTGGAGGATGGCTGGAAGGAAGAAACATCAAAGGAGAACGAGGGCTGGTTCCCACAGACTACGTTGAAATTTTA CCCAGTGATGGAAAAGATCAATTTTCTTGTGGAAATTCAGTGGCTGACCAAGCCTTCCTTGATTCTCTCTCAGCCAGCACAGCTCAGGCC AGTTCGTCGGCTGCCAGCAACAATCACCAGGTTGGCAGTGGCAATGACCCCTGGTCAGCCTGGAGTGCCTCCAAATCTGGGAACTGGGAA AGCTCAGAAGGCTGGGGGGCCCAGCCAGAGGGGGCTGGAGCCCAAAGAAACACAAACACTCCCAACAACTGGGACACTGCCTTCGGCCAC CCCCAGGCCTACCAAGGACCAGATATCGCAAACGGCACCAGTTCAGGGGGGTACCGCCCGCCTCCCAGAACCAAAGAAGTCATCATCAAT GGCCAGACCGTGAAACTTAAATACTGTTTCACCTGCAAGATTTTCCGGCCCCCTCGCGCCTCCCATTGCAGCCTTTGTGATAACTGCGTA GAACGGTTTGATCACCACTGTCCCTGGGTAGGCAACTGTGTGGGGAAAAGAAACTACAGATTTTTTTATATGTTTATTTTATCTCTGTCT TTTCTGACAGTCTTTATATTTGCATTCGTTATCACCCACGTCATTCTTCGTTCACAGCAAACAGGATTCCTAAATGCCCTTAAGGACAGT CCTGCAAGCGTCCTGGAGGCTGTGGTGTGCTTCTTCTCTGTCTGGTCCATCGTTGGCCTCTCAGGATTCCACACCTACTTGATCAGCTCC AACCAGACAACAAATGAGGACATTAAAGGATCCTGGTCAAATAAAAGAGGTAAAGAAAATTACAATCCCTACAGCTACGGAAATATCTTT ACCAACTGCTGTGTTGCCCTGTGTGGGCCCATCTCACCAAGCCTGATCGACAGAAGAGGGTACATCCAGCCCGACACGCCGCAGCCAGCA GCACCCTCCAATGGCATCACCATGTACGGGGCCACGCAGTCACAGAGTGACATGGCTGCAGCCACGCCCCTGCTGCAGAGCGAGCCCAGC CTCACCAGCGACGAGCTGCACCTGCCCGGGAAGCCTGGCCTGGGCACGCCCTGCGCCAGCCTCACACTGGGCCCGCCCACACCGCCCGCC TCCATGCCCAACCTCGCCGAGGCCACGCTCGCGGACGTGATGCCCCGGAAAGATGAGCACATGGGCCACCAGTTCCTGACGCCCGATGAG GCGCCCTCGCCCCCCAGGCTACTGGCGGCGGGCAGCCCCCTGGCGCACAGCCGCACCATGCACGTGCTGGGCCTGGCCAGCCAGGACTCC >In-frame_SNX9_ENST00000392185_chr6_158318030_+_ZDHHC14_ENST00000359775_chr6_158014020_+_1533nt ATGGCCACCAAGGCTCGGGTTATGTATGATTTTGCTGCTGAACCTGGAAATAATGAACTGACGGTTAATGAAGGAGAAATCATCACAATC ACAAATCCGGATGTAGGTGGAGGATGGCTGGAAGGAAGAAACATCAAAGGAGAACGAGGGCTGGTTCCCACAGACTACGTTGAAATTTTA CCCAGTGATGGAAAAGATCAATTTTCTTGTGGAAATTCAGTGGCTGACCAAGCCTTCCTTGATTCTCTCTCAGCCAGCACAGCTCAGGCC AGTTCGTCGGCTGCCAGCAACAATCACCAGGTTGGCAGTGGCAATGACCCCTGGTCAGCCTGGAGTGCCTCCAAATCTGGGAACTGGGAA AGCTCAGAAGGCTGGGGGGCCCAGCCAGAGGGGGCTGGAGCCCAAAGAAACACAAACACTCCCAACAACTGGGACACTGCCTTCGGCCAC CCCCAGGCCTACCAAGGACCAGATATCGCAAACGGCACCAGTTCAGGGGGGTACCGCCCGCCTCCCAGAACCAAAGAAGTCATCATCAAT GGCCAGACCGTGAAACTTAAATACTGTTTCACCTGCAAGATTTTCCGGCCCCCTCGCGCCTCCCATTGCAGCCTTTGTGATAACTGCGTA GAACGGTTTGATCACCACTGTCCCTGGGTAGGCAACTGTGTGGGGAAAAGAAACTACAGATTTTTTTATATGTTTATTTTATCTCTGTCT TTTCTGACAGTCTTTATATTTGCATTCGTTATCACCCACGTCATTCTTCGTTCACAGCAAACAGGATTCCTAAATGCCCTTAAGGACAGT CCTGCAAGCGTCCTGGAGGCTGTGGTGTGCTTCTTCTCTGTCTGGTCCATCGTTGGCCTCTCAGGATTCCACACCTACTTGATCAGCTCC AACCAGACAACAAATGAGGACATTAAAGGATCCTGGTCAAATAAAAGAGGTAAAGAAAATTACAATCCCTACAGCTACGGAAATATCTTT ACCAACTGCTGTGTTGCCCTGTGTGGGCCCATCTCACCAAGCCTGATCGACAGAAGAGGGTACATCCAGCCCGACACGCCGCAGCCAGCA GCACCCTCCAATGGCATCACCATGTACGGGGCCACGCAGTCACAGAGTGACATGTGCGACCAAGACCAGTGCATTCAGAGCACCAAATTC GTTTTGCAGGCTGCAGCCACGCCCCTGCTGCAGAGCGAGCCCAGCCTCACCAGCGACGAGCTGCACCTGCCCGGGAAGCCTGGCCTGGGC ACGCCCTGCGCCAGCCTCACACTGGGCCCGCCCACACCGCCCGCCTCCATGCCCAACCTCGCCGAGGCCACGCTCGCGGACGTGATGCCC CGGAAAGATGAGCACATGGGCCACCAGTTCCTGACGCCCGATGAGGCGCCCTCGCCCCCCAGGCTACTGGCGGCGGGCAGCCCCCTGGCG CACAGCCGCACCATGCACGTGCTGGGCCTGGCCAGCCAGGACTCCCTGCATGAGGACTCTGTGCGCGGCCTGGTGAAGCTCAGCTCCGTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SNX9_ENST00000392185_chr6_158318030_+_ZDHHC14_ENST00000414563_chr6_158014020_+_2482nt AGCGGCTGGGCCTGAGCGTCGAGACTCGGGGCCGAGGCGGAGGAGCGGCCGCCGCGCCGGGGCCCAGCCGGAGCCGCCGCCCTCGCCCTT GCCTTTGCCTGCGCGGCTCAGAATCACCATCCGCGGCGCGGGAGACGAGCCGGCCGTCCCGGGCCGGGGGACCCGCCCGCCATGGCCACC AAGGCTCGGGTTATGTATGATTTTGCTGCTGAACCTGGAAATAATGAACTGACGGTTAATGAAGGAGAAATCATCACAATCACAAATCCG GATGTAGGTGGAGGATGGCTGGAAGGAAGAAACATCAAAGGAGAACGAGGGCTGGTTCCCACAGACTACGTTGAAATTTTACCCAGTGAT GGAAAAGATCAATTTTCTTGTGGAAATTCAGTGGCTGACCAAGCCTTCCTTGATTCTCTCTCAGCCAGCACAGCTCAGGCCAGTTCGTCG GCTGCCAGCAACAATCACCAGGTTGGCAGTGGCAATGACCCCTGGTCAGCCTGGAGTGCCTCCAAATCTGGGAACTGGGAAAGCTCAGAA GGCTGGGGGGCCCAGCCAGAGGGGGCTGGAGCCCAAAGAAACACAAACACTCCCAACAACTGGGACACTGCCTTCGGCCACCCCCAGGCC TACCAAGGACCAGATATCGCAAACGGCACCAGTTCAGGGGGGTACCGCCCGCCTCCCAGAACCAAAGAAGTCATCATCAATGGCCAGACC GTGAAACTTAAATACTGTTTCACCTGCAAGATTTTCCGGCCCCCTCGCGCCTCCCATTGCAGCCTTTGTGATAACTGCGTAGAACGGTTT GATCACCACTGTCCCTGGGTAGGCAACTGTGTGGGGAAAAGAAACTACAGATTTTTTTATATGTTTATTTTATCTCTGTCTTTTCTGACA GTCTTTATATTTGCATTCGTTATCACCCACGTCATTCTTCGTTCACAGCAAACAGGATTCCTAAATGCCCTTAAGGACAGTCCTGCAAGC GTCCTGGAGGCTGTGGTGTGCTTCTTCTCTGTCTGGTCCATCGTTGGCCTCTCAGGATTCCACACCTACTTGATCAGCTCCAACCAGACA ACAAATGAGGACATTAAAGGATCCTGGTCAAATAAAAGAGGTAAAGAAAATTACAATCCCTACAGCTACGGAAATATCTTTACCAACTGC TGTGTTGCCCTGTGTGGGCCCATCTCACCAAGCCTGATCGACAGAAGAGGGTACATCCAGCCCGACACGCCGCAGCCAGCAGCACCCTCC AATGGCATCACCATGTACGGGGCCACGCAGTCACAGAGTGACATGGCTGCAGCCACGCCCCTGCTGCAGAGCGAGCCCAGCCTCACCAGC GACGAGCTGCACCTGCCCGGGAAGCCTGGCCTGGGCACGCCCTGCGCCAGCCTCACACTGGGCCCGCCCACACCGCCCGCCTCCATGCCC AACCTCGCCGAGGCCACGCTCGCGGACGTGATGCCCCGGAAAGATGAGCACATGGGCCACCAGTTCCTGACGCCCGATGAGGCGCCCTCG CCCCCCAGGCTACTGGCGGCGGGCAGCCCCCTGGCGCACAGCCGCACCATGCACGTGCTGGGCCTGGCCAGCCAGGACTCCCTGCATGAG GACTCTGTGCGCGGCCTGGTGAAGCTCAGCTCCGTGTGACCCACATGGCCCCAGGCCGGGGGACACCAGAGGCTCCTCCATGGGCAGCAG GAGTGAGCGGAGGGGTGTGTCCCACAGCGACTTTCCCAGCCAATGCCACGGTGGAGATGACAGCCCCAGGTCTGGGGTACAGAGACCACT TAGGATGGCACAGGGTGGCTGGCCCCGGATGCTGAGAGCTTGGTTTCATTTGAATTTTCTTCCCCAACCTGAGTGCTTTGACAACAATGG AAATAGAGAAGTGGCTGCTTTCTTTTGGTGACCCTCCAGGGGTGGAATCGGAGTGTGTCTGCCCGCCCTTGTGACAGACACACGGAAGGC TTCTGACGCTTGTGGCCAGACTGCAATTGCACTTATGTGTTATGCTACTAATATTTGAAACAGACCTGCCATTCCATTTGTTAATTAAAA AAAAAAAAAATCCTAAAGGGAAAAAACCGACCAGGTGTGGATCTGCATGCCACGCTGCCGTCTGTGTTACAGTGGTGTTGCTATTTCCAA GGAAGTGCTGCTTTCTTTTTCTTTTTTTAATTTTGTGAATTTTCAAGTGCTGTTTTGTTGGAAGACAGTGCAACGAACTGAGACTAATGG ACAGTGTCATCACTCAGCTTACTGGGCTGAGGCGTCTGTGGAGAGGTGGCACCGGGGCTGCAGAGGGCGGCTGGGGTTCCGTCGTGTCGG GTGTCACTTCACCTTCTGTTTGGCCGCTCGATGAGGTCTCGTGTTGAGATATTGTGTGCCACAACCCCCACAGTCTTCACCTCCGTGTGT >In-frame_SNX9_ENST00000392185_chr6_158318030_+_ZDHHC14_ENST00000359775_chr6_158014020_+_6728nt AGCGGCTGGGCCTGAGCGTCGAGACTCGGGGCCGAGGCGGAGGAGCGGCCGCCGCGCCGGGGCCCAGCCGGAGCCGCCGCCCTCGCCCTT GCCTTTGCCTGCGCGGCTCAGAATCACCATCCGCGGCGCGGGAGACGAGCCGGCCGTCCCGGGCCGGGGGACCCGCCCGCCATGGCCACC AAGGCTCGGGTTATGTATGATTTTGCTGCTGAACCTGGAAATAATGAACTGACGGTTAATGAAGGAGAAATCATCACAATCACAAATCCG GATGTAGGTGGAGGATGGCTGGAAGGAAGAAACATCAAAGGAGAACGAGGGCTGGTTCCCACAGACTACGTTGAAATTTTACCCAGTGAT GGAAAAGATCAATTTTCTTGTGGAAATTCAGTGGCTGACCAAGCCTTCCTTGATTCTCTCTCAGCCAGCACAGCTCAGGCCAGTTCGTCG GCTGCCAGCAACAATCACCAGGTTGGCAGTGGCAATGACCCCTGGTCAGCCTGGAGTGCCTCCAAATCTGGGAACTGGGAAAGCTCAGAA GGCTGGGGGGCCCAGCCAGAGGGGGCTGGAGCCCAAAGAAACACAAACACTCCCAACAACTGGGACACTGCCTTCGGCCACCCCCAGGCC TACCAAGGACCAGATATCGCAAACGGCACCAGTTCAGGGGGGTACCGCCCGCCTCCCAGAACCAAAGAAGTCATCATCAATGGCCAGACC GTGAAACTTAAATACTGTTTCACCTGCAAGATTTTCCGGCCCCCTCGCGCCTCCCATTGCAGCCTTTGTGATAACTGCGTAGAACGGTTT GATCACCACTGTCCCTGGGTAGGCAACTGTGTGGGGAAAAGAAACTACAGATTTTTTTATATGTTTATTTTATCTCTGTCTTTTCTGACA GTCTTTATATTTGCATTCGTTATCACCCACGTCATTCTTCGTTCACAGCAAACAGGATTCCTAAATGCCCTTAAGGACAGTCCTGCAAGC GTCCTGGAGGCTGTGGTGTGCTTCTTCTCTGTCTGGTCCATCGTTGGCCTCTCAGGATTCCACACCTACTTGATCAGCTCCAACCAGACA ACAAATGAGGACATTAAAGGATCCTGGTCAAATAAAAGAGGTAAAGAAAATTACAATCCCTACAGCTACGGAAATATCTTTACCAACTGC TGTGTTGCCCTGTGTGGGCCCATCTCACCAAGCCTGATCGACAGAAGAGGGTACATCCAGCCCGACACGCCGCAGCCAGCAGCACCCTCC AATGGCATCACCATGTACGGGGCCACGCAGTCACAGAGTGACATGTGCGACCAAGACCAGTGCATTCAGAGCACCAAATTCGTTTTGCAG GCTGCAGCCACGCCCCTGCTGCAGAGCGAGCCCAGCCTCACCAGCGACGAGCTGCACCTGCCCGGGAAGCCTGGCCTGGGCACGCCCTGC GCCAGCCTCACACTGGGCCCGCCCACACCGCCCGCCTCCATGCCCAACCTCGCCGAGGCCACGCTCGCGGACGTGATGCCCCGGAAAGAT GAGCACATGGGCCACCAGTTCCTGACGCCCGATGAGGCGCCCTCGCCCCCCAGGCTACTGGCGGCGGGCAGCCCCCTGGCGCACAGCCGC ACCATGCACGTGCTGGGCCTGGCCAGCCAGGACTCCCTGCATGAGGACTCTGTGCGCGGCCTGGTGAAGCTCAGCTCCGTGTGACCCACA TGGCCCCAGGCCGGGGGACACCAGAGGCTCCTCCATGGGCAGCAGGAGTGAGCGGAGGGGTGTGTCCCACAGCGACTTTCCCAGCCAATG CCACGGTGGAGATGACAGCCCCAGGTCTGGGGTACAGAGACCACTTAGGATGGCACAGGGTGGCTGGCCCCGGATGCTGAGAGCTTGGTT TCATTTGAATTTTCTTCCCCAACCTGAGTGCTTTGACAACAATGGAAATAGAGAAGTGGCTGCTTTCTTTTGGTGACCCTCCAGGGGTGG AATCGGAGTGTGTCTGCCCGCCCTTGTGACAGACACACGGAAGGCTTCTGACGCTTGTGGCCAGACTGCAATTGCACTTATGTGTTATGC TACTAATATTTGAAACAGACCTGCCATTCCATTTGTTAATTAAAAAAAAAAAAAATCCTAAAGGGAAAAAACCGACCAGGTGTGGATCTG CATGCCACGCTGCCGTCTGTGTTACAGTGGTGTTGCTATTTCCAAGGAAGTGCTGCTTTCTTTTTCTTTTTTTAATTTTGTGAATTTTCA AGTGCTGTTTTGTTGGAAGACAGTGCAACGAACTGAGACTAATGGACAGTGTCATCACTCAGCTTACTGGGCTGAGGCGTCTGTGGAGAG GTGGCACCGGGGCTGCAGAGGGCGGCTGGGGTTCCGTCGTGTCGGGTGTCACTTCACCTTCTGTTTGGCCGCTCGATGAGGTCTCGTGTT GAGATATTGTGTGCCACAACCCCCACAGTCTTCACCTCCGTGTGTGATGAAACTTCCCGTGGACAGCCAATAAAATGACGTCCTCTGTTA TTTTGGATCTGCGTACGGTTATCCTTAATAGCATAAATGAAAACAAAGTCATCCAGATGGGGAGAGTTTTTCTTGAAATGTCCCTAGCGA GGAATGGTCCCCAGACAACCAAAAGTCAAATCTTTGAACTGGGAGATATTTATAGAATAATTTCTTAGATAAGAGGCAAGTTTTCCATCA TTTATTTTCTTTAATTATCTCTTTTTGACACCATCTTAGTGGAATTTGCTCTACGTTTGCAGTTTGCCGTGCAACAGTTGATCGGAAGTA GGGAGAGGGGAGGGGACGCTCAGGGAGAAGGTTCTGTCGGGCGTCTTCTGGGCTTCCTTCTGTGTTAACGTGTCACTCAATCCCAGAAGT GCAACTTGAGGTCCTAGTAAAGGTATCAGAAAATGAGGAGGAGAAATCGGCTTACAGTCTAAGCTGAGATCATGTAGGTCATCATCCTTC CTAGACACTGATCAGAATGAAATTAAGAAAATGACCACTTTGTTCACTTTCATTGGTCACCTAGAAGGGAACGAACTGGCTCTGGACTTA GGGAGTGTGTCACTATGGGGGCAGCCACAGGGGACACAGCAACTCCTCTCCTGGCTTCTTTCCAGACCATAAATCTAACAGCTAAAGCTA CTCAAGTTCAAAGCCATGGCCTTGCTCCTTATAACCATATGAAAGACAAGACACATTGACCAATGATACAAGTAACCCAAGTGATTTGCA TTTATGGAAAAAGGCTATTACTCCTGAGAAAGAGTTGCCATTTTATATAAAAGAAAAGAAGATAGGAAAAAGAAAAGCACACAAGTTTTA TTTGGAATGAAGGCAATTCACAGGTCACAAAATAATTCATGCTGAAAGGGCCTGCAGAGTTCTTGCACTGTGATGTCTTCGAGCCATCTT TATTGTCATGCTGCATGCACGTATAGAAAATGGAATAGGTCCATTCTATGTAGCCATTTTTGATTTTCTGAACCACCTAACTACTTGTAC CCACCTGCAATGTGTAATTCATGGGGCAGTGCCCTCCTTACACAACCGCACACGCTCACAGGCACCAACTCACAGGGATTCTCCTTGTCC ACGCTACCTGTGAGCCCAAAGTGACAGCCCCACAAAGGAGCTTCCACAACTTCCCAAACCGTCTCTGCTCCTTGCTTTCTTCCACCTGCT CCCCAGAGGCCCCAGGAAGGAGTTGGCCCTGATGAGAACGGTGCTCCATGGGTGACCGCGAATCCGGCTTAGCCCTCACTCCGGTCCCAC GTGTGGCCCAGTCCATTCTCAGCTCATTCCCCTGGAAAGCAAGATCATGGTCTTCAGAGGCCTCCCGCTTCTAACATTTCCTAACTCAGT GGTTGCCACTCTCCTGTGACCAGCCCTTCTTCCCACCTCACTGTGAAAAATTCCCAGAAGCCAGGATCACGACTCACTTGTCTTCACATA ATGGATATTTACTTAATATTTATTATCAATTTCCCCACCTCCAACCCTGTCCCTGGCACACACTTGGCATCATTTATCCAATAGGGGACT GGGAATTTTGGTGAAGTGAATCAAGGCTATTCAGGGTCAAGAGAGAGATTAACTTGAATGGGCCAATTTGCTAGATAATTAATGTCTTAA AAACCAAAACCAGAGAGAAGCCCACAGCCCTGTCCTCTGTGGCTTGAAAAAGAAACCCAGCATCAGAGGAATGAGCGATGATGCCCCCTG GGGCGCCCACTTCTGTTTGTCAGGAGGGATGGTCGGAGGGGCAGCTCACCTGGCGAGGTGATGGCTCTGCATTTCCCACGAACATATATG TGACATGTACATAAATATAAATACTTATGTTTATAAATGTTGAATGGTTCCTTCTAGCTGTGGCTGAGTAGACGTTGGTGTTTCTAACTT CTTTCAGTGTGTTAGAGATTGATTACATGCTAGCTATAAAAAGTAAAATAAATATTTTACCATGCTATTAAAGCTTGGACCATTATCAAA CACACACAAACACACACTCATTCTGCTGTTTAAAAATTCATCTGCGTTCGTTCTCCCAGGAGTGCTCCAGGGAACCACAGGCTTCCCGGC ACTTGAAGGCTGAACTGAGCGTGAGTGCCCTGGTCCCCAGGAAGCAGGCGGATGCTGCAGGAAGGTGGCAGACAGCCTGCATCCAGGAGG GCCCCAGGAAGTGGGGATGCTGCAGGAAGGCGGCACAAAGCCTGCATCCGGGAGGGCCCCAGGAAGCAGGGGGATGCTGCAGGAAGGTGG CAGACAGACTGCATCCAGGAGGGCACAGTGACCTGTCACTCCGTTCTGCAGAAATTGGCCCAGCAGTTGCGTTATGCCCAACCAAAAGAT GCTCGTTCCAGCTTTCAAATGTGATGATTTCAGCCTGTGAGGACAATGCCATGTCCCCACCCTAAGCCAGCAAAATGCGAAATCTCTGTT CTGGCCCAGAATGGCACAAGGGAGGAGTCTTTGCAGAGTTCCACGCCACCCCCCAGCTTACTGCGGCCTTCACCGGCTCTGTCTAGGATT GCCAGCTGTGGTTCCAAGTGAGGAGCAAACCCATTTTATGAGCCATGTTCCTGCGGAGACCTGATGGGCCAGGCCTTCTGTGGCTTTGAA AACCCCTAAGCTCTTCACCTCCTGGGCCTAGGCCTTCTTGTCTGACTCAACAGCAAGAAAAATGAACTTGCCAAAATTGGCAGTAGGTGT CCTTGACACAGGGGCTTCTGATGGCATCGCCCAGAAAATGCTGGAACCAGAACTGGTCAGAGACTTTGAAGGGCACAGCCTGGCGGGCTA CTCCCCAAGGGTCTCAGGTCTCTGCCCACCTGACTACCCTGCAGCAAACGCTTCTCTGTAACCTGACTTCTCCCTTCAGACCTCAGCCTA CAACCATCCTCTTCATGCCAGGAACCAACTGCTTCTCAGCCTCGGCTTAGGGTCTTAAGTTCACCAGAAGGGATCGGGGTTTGCGTTGAT ATTATAAGGAATCTTCCCAGAAGGAGCTGCCCTTCATCCATCCACAAGAATACATTGAGTTCATTTAGTTCTTGACCAGGTAAGAAAAGA ATAAAGGAGAACAAATATTAAATACTCTTTTCTAATTGATGCCTTACTACTGTTTTGAAGCTGAGCCGAAATCAAATTGATGTTTACATT TTCTATCAAGTACACATGAGCTGTGGGAGTCTAGCATATTCTTGTCCAAAAGAGAGAGACTTTCAAATGAATTCCTATTCCTCTTGGTCC CCTCCACCTATTTTGGAGGTCTGCATGTGGAGTTGTATGCTATTTTCCAAGGTACCTCATTTAAAAAAAAAAAAAAAAAAAAACTGCCTC TCATTTGTTCCCTTAAAACGTCTCTCTCTCTCATAAAACTAAGTTATCATTGAAATATTAAACGATCTGAAGCGTCTTTTTTTTTTTCAA ATAAATGTCAAAGATGGTAATAGTTTGTAAATCAGTAAATCCTCTGTCCATCTGCCCATTGTCCATGGTCCTGATAATAGAGCCAAGATG GATTTTCACATGTAAGGTGTTAGTCCATTAATCCAGCCATTAAAAGTAGTTGGGAGATTGAAGATTAGATGGTTTCTGGAGCAACCGAAT TTGCAGCTGCCACAAAACTAGATAAATAGCCACAACTGGAGTTATTTTTTGATCTCATAAACCCCAGGAATTACACACAGAATGGATTGA AAAGCAGACAAGCATCTTGTGCTATTGCAGAGACTTTTCTACCCAGGAAGTGTTGAATTTTTAAAAGAAACTTGATATTGGTGATAAAGG TATGAATGAACAACTCTCTTACTTGCCCTCGATGTTTCAAGATGCCTGGTGAAACCGAGAGGCCACATGGCATGTCCAAGGAGACATGCT TTCTGGGTTCTATATGAATAGAGATGGTTTTAGCCTGCAATTAAAAAAAAAAAAAAAAACGGTTGAAGCCTTGCTAACTTTTTCCCAGAG CATTCTGGGTTGATATTTCACAGTCAAACGTTTTGGCATGGAAAAAAAAAAAAGCATTTTAAACTCTTAGTGAATTCAAAGCTCTAAATC CAAACAATGGTGAACACATGTACATAACATTTCATGTTTTCAGAGATACGTATGCTTATTTAAGTGCCTTTCATGTTTTAATCAATGTTT |
Top |
FusionGenePPI for SNX9_ZDHHC14 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SNX9 | ADAM15, MPP6, DNM2, CLTC, ADAM9, ITCH, SIRT7, KHDRBS1, SNX33, CUL3, COPS5, TNK2, FASLG, SNX9, MED28, CFTR, DNM1, WASL, OBSL1, EGFR, DPPA4, AURKA, NTRK1, FBF1, NPHP1, HDAC1, GTSE1, NAF1, FOXG1, FOXK2, MCM2, CDH1, SYNJ1, DNM3, AP2A1, FCHSD1, MLYCD, AP2M1, AP2A2, AP1B1, HNRNPK, AP2B1, CPNE5, RNGTT, OCRL, BRCA1, TES | ZDHHC14 | ELAVL1, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for SNX9_ZDHHC14 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for SNX9_ZDHHC14 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|