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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35321

FusionGeneSummary for SNX5_SLC35C2

check button Fusion gene summary
Fusion gene informationFusion gene name: SNX5_SLC35C2
Fusion gene ID: 35321
HgeneTgene
Gene symbol

SNX5

SLC35C2

Gene ID

27131

51006

Gene namesorting nexin 5solute carrier family 35 member C2
Synonyms-BA394O2.1|C20orf5|CGI-15|OVCOV1
Cytomap

20p11.23

20q13.12

Type of geneprotein-codingprotein-coding
Descriptionsorting nexin-5solute carrier family 35 member C2ovarian cancer-overexpressed gene 1 proteinsolute carrier family 35 (GDP-fucose transporter), member C2
Modification date2018052220180523
UniProtAcc

Q9Y5X3

Q9NQQ7

Ensembl transtripts involved in fusion geneENST00000483485, ENST00000377759, 
ENST00000377768, ENST00000606557, 
ENST00000606602, ENST00000481323, 
ENST00000486039, 
ENST00000493599, 
ENST00000372227, ENST00000372229, 
ENST00000372230, ENST00000243896, 
ENST00000317734, ENST00000543605, 
Fusion gene scores* DoF score3 X 3 X 2=181 X 1 X 1=1
# samples 31
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: SNX5 [Title/Abstract] AND SLC35C2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSNX5

GO:0006907

pinocytosis

18854019


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA789110SNX5chr20

17943351

-SLC35C2chr20

44993053

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000483485ENST00000493599SNX5chr20

17943351

-SLC35C2chr20

44993053

-
intron-intronENST00000483485ENST00000372227SNX5chr20

17943351

-SLC35C2chr20

44993053

-
intron-intronENST00000483485ENST00000372229SNX5chr20

17943351

-SLC35C2chr20

44993053

-
intron-intronENST00000483485ENST00000372230SNX5chr20

17943351

-SLC35C2chr20

44993053

-
intron-intronENST00000483485ENST00000243896SNX5chr20

17943351

-SLC35C2chr20

44993053

-
intron-intronENST00000483485ENST00000317734SNX5chr20

17943351

-SLC35C2chr20

44993053

-
intron-intronENST00000483485ENST00000543605SNX5chr20

17943351

-SLC35C2chr20

44993053

-
intron-intronENST00000377759ENST00000493599SNX5chr20

17943351

-SLC35C2chr20

44993053

-
intron-intronENST00000377759ENST00000372227SNX5chr20

17943351

-SLC35C2chr20

44993053

-
intron-intronENST00000377759ENST00000372229SNX5chr20

17943351

-SLC35C2chr20

44993053

-
intron-intronENST00000377759ENST00000372230SNX5chr20

17943351

-SLC35C2chr20

44993053

-
intron-intronENST00000377759ENST00000243896SNX5chr20

17943351

-SLC35C2chr20

44993053

-
intron-intronENST00000377759ENST00000317734SNX5chr20

17943351

-SLC35C2chr20

44993053

-
intron-intronENST00000377759ENST00000543605SNX5chr20

17943351

-SLC35C2chr20

44993053

-
intron-intronENST00000377768ENST00000493599SNX5chr20

17943351

-SLC35C2chr20

44993053

-
intron-intronENST00000377768ENST00000372227SNX5chr20

17943351

-SLC35C2chr20

44993053

-
intron-intronENST00000377768ENST00000372229SNX5chr20

17943351

-SLC35C2chr20

44993053

-
intron-intronENST00000377768ENST00000372230SNX5chr20

17943351

-SLC35C2chr20

44993053

-
intron-intronENST00000377768ENST00000243896SNX5chr20

17943351

-SLC35C2chr20

44993053

-
intron-intronENST00000377768ENST00000317734SNX5chr20

17943351

-SLC35C2chr20

44993053

-
intron-intronENST00000377768ENST00000543605SNX5chr20

17943351

-SLC35C2chr20

44993053

-
intron-intronENST00000606557ENST00000493599SNX5chr20

17943351

-SLC35C2chr20

44993053

-
intron-intronENST00000606557ENST00000372227SNX5chr20

17943351

-SLC35C2chr20

44993053

-
intron-intronENST00000606557ENST00000372229SNX5chr20

17943351

-SLC35C2chr20

44993053

-
intron-intronENST00000606557ENST00000372230SNX5chr20

17943351

-SLC35C2chr20

44993053

-
intron-intronENST00000606557ENST00000243896SNX5chr20

17943351

-SLC35C2chr20

44993053

-
intron-intronENST00000606557ENST00000317734SNX5chr20

17943351

-SLC35C2chr20

44993053

-
intron-intronENST00000606557ENST00000543605SNX5chr20

17943351

-SLC35C2chr20

44993053

-
intron-intronENST00000606602ENST00000493599SNX5chr20

17943351

-SLC35C2chr20

44993053

-
intron-intronENST00000606602ENST00000372227SNX5chr20

17943351

-SLC35C2chr20

44993053

-
intron-intronENST00000606602ENST00000372229SNX5chr20

17943351

-SLC35C2chr20

44993053

-
intron-intronENST00000606602ENST00000372230SNX5chr20

17943351

-SLC35C2chr20

44993053

-
intron-intronENST00000606602ENST00000243896SNX5chr20

17943351

-SLC35C2chr20

44993053

-
intron-intronENST00000606602ENST00000317734SNX5chr20

17943351

-SLC35C2chr20

44993053

-
intron-intronENST00000606602ENST00000543605SNX5chr20

17943351

-SLC35C2chr20

44993053

-
intron-intronENST00000481323ENST00000493599SNX5chr20

17943351

-SLC35C2chr20

44993053

-
intron-intronENST00000481323ENST00000372227SNX5chr20

17943351

-SLC35C2chr20

44993053

-
intron-intronENST00000481323ENST00000372229SNX5chr20

17943351

-SLC35C2chr20

44993053

-
intron-intronENST00000481323ENST00000372230SNX5chr20

17943351

-SLC35C2chr20

44993053

-
intron-intronENST00000481323ENST00000243896SNX5chr20

17943351

-SLC35C2chr20

44993053

-
intron-intronENST00000481323ENST00000317734SNX5chr20

17943351

-SLC35C2chr20

44993053

-
intron-intronENST00000481323ENST00000543605SNX5chr20

17943351

-SLC35C2chr20

44993053

-
intron-intronENST00000486039ENST00000493599SNX5chr20

17943351

-SLC35C2chr20

44993053

-
intron-intronENST00000486039ENST00000372227SNX5chr20

17943351

-SLC35C2chr20

44993053

-
intron-intronENST00000486039ENST00000372229SNX5chr20

17943351

-SLC35C2chr20

44993053

-
intron-intronENST00000486039ENST00000372230SNX5chr20

17943351

-SLC35C2chr20

44993053

-
intron-intronENST00000486039ENST00000243896SNX5chr20

17943351

-SLC35C2chr20

44993053

-
intron-intronENST00000486039ENST00000317734SNX5chr20

17943351

-SLC35C2chr20

44993053

-
intron-intronENST00000486039ENST00000543605SNX5chr20

17943351

-SLC35C2chr20

44993053

-

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FusionProtFeatures for SNX5_SLC35C2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SNX5

Q9Y5X3

SLC35C2

Q9NQQ7

Involved in several stages of intracellular trafficking.Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,4-bisphosphate(PtdIns(3,4)P2) (PubMed:15561769). Acts in part as component ofthe retromer membrane-deforming SNX-BAR subcomplex. The SNX-BARretromer mediates retrograde transport of cargo proteins fromendosomes to the trans-Golgi network (TGN) and is involved inendosome-to-plasma membrane transport for cargo protein recycling.The SNX-BAR subcomplex functions to deform the donor membrane intoa tubular profile called endosome-to-TGN transport carrier (ETC)(Probable). Does not have in vitro vesicle-to-membrane remodelingactivity (PubMed:23085988). Involved in retrograde transport oflysosomal enzyme receptor IGF2R (PubMed:17148574,PubMed:18596235). May function as link between endosomal transportvesicles and dynactin (Probable). Plays a role in theinternalization of EGFR after EGF stimulation (Probable). Involvedin EGFR endosomal sorting and degradation; the function involvesPIP5K1C isoform 3 and is retromer-independent (PubMed:23602387).Together with PIP5K1C isoform 3 facilitates HGS interaction withubiquitinated EGFR, which initiates EGFR sorting to intraluminalvesicles (ILVs) of the multivesicular body for subsequentlysosomal degradation (Probable). Involved in E-cadherin sortingand degradation; inhibits PIP5K1C isoform 3-mediated E-cadherindegradation (PubMed:24610942). Plays a role in macropinocytosis(PubMed:18854019, PubMed:21048941). {ECO:0000269|PubMed:18854019,ECO:0000269|PubMed:21048941, ECO:0000269|PubMed:24610942,ECO:0000303|PubMed:15561769, ECO:0000303|PubMed:19619496,ECO:0000303|PubMed:23085988}. May play an important role in the cellular response totissue hypoxia. May be either a GDP-fucose transporter thatcompetes with SLC35C1 for GDP-fucose, or a factor that otherwiseenhances the fucosylation of Notch and is required for optimalNotch signaling in mammalian cells. {ECO:0000269|PubMed:20837470}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SNX5_SLC35C2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SNX5_SLC35C2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SNX5_SLC35C2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SNX5_SLC35C2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSNX5C0038356Stomach Neoplasms1CTD_human