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Fusion gene ID: 3530 |
FusionGeneSummary for ATPAF1_PLIN3 |
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Fusion gene information | Fusion gene name: ATPAF1_PLIN3 | Fusion gene ID: 3530 | Hgene | Tgene | Gene symbol | ATPAF1 | PLIN3 | Gene ID | 64756 | 10226 |
Gene name | ATP synthase mitochondrial F1 complex assembly factor 1 | perilipin 3 | |
Synonyms | ATP11|ATP11p | M6PRBP1|PP17|TIP47 | |
Cytomap | 1p33 | 19p13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | ATP synthase mitochondrial F1 complex assembly factor 1homolog of yeast ATP11 | perilipin-347 kDa MPR-binding proteincargo selection protein TIP47mannose-6-phosphate receptor-binding protein 1placental protein 17tail-interacting protein, 47 kDtesticular tissue protein Li 114 | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | Q5TC12 | O60664 | |
Ensembl transtripts involved in fusion gene | ENST00000576409, ENST00000574428, ENST00000371937, ENST00000542495, ENST00000329231, ENST00000532925, ENST00000525633, | ENST00000221957, ENST00000592528, ENST00000585479, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 3 X 3 X 1=9 |
# samples | 2 | 6 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(6/9*10)=2.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ATPAF1 [Title/Abstract] AND PLIN3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CN418162 | ATPAF1 | chr1 | 47119503 | - | PLIN3 | chr19 | 4847827 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000576409 | ENST00000221957 | ATPAF1 | chr1 | 47119503 | - | PLIN3 | chr19 | 4847827 | - |
intron-3CDS | ENST00000576409 | ENST00000592528 | ATPAF1 | chr1 | 47119503 | - | PLIN3 | chr19 | 4847827 | - |
intron-3CDS | ENST00000576409 | ENST00000585479 | ATPAF1 | chr1 | 47119503 | - | PLIN3 | chr19 | 4847827 | - |
intron-3CDS | ENST00000574428 | ENST00000221957 | ATPAF1 | chr1 | 47119503 | - | PLIN3 | chr19 | 4847827 | - |
intron-3CDS | ENST00000574428 | ENST00000592528 | ATPAF1 | chr1 | 47119503 | - | PLIN3 | chr19 | 4847827 | - |
intron-3CDS | ENST00000574428 | ENST00000585479 | ATPAF1 | chr1 | 47119503 | - | PLIN3 | chr19 | 4847827 | - |
intron-3CDS | ENST00000371937 | ENST00000221957 | ATPAF1 | chr1 | 47119503 | - | PLIN3 | chr19 | 4847827 | - |
intron-3CDS | ENST00000371937 | ENST00000592528 | ATPAF1 | chr1 | 47119503 | - | PLIN3 | chr19 | 4847827 | - |
intron-3CDS | ENST00000371937 | ENST00000585479 | ATPAF1 | chr1 | 47119503 | - | PLIN3 | chr19 | 4847827 | - |
intron-3CDS | ENST00000542495 | ENST00000221957 | ATPAF1 | chr1 | 47119503 | - | PLIN3 | chr19 | 4847827 | - |
intron-3CDS | ENST00000542495 | ENST00000592528 | ATPAF1 | chr1 | 47119503 | - | PLIN3 | chr19 | 4847827 | - |
intron-3CDS | ENST00000542495 | ENST00000585479 | ATPAF1 | chr1 | 47119503 | - | PLIN3 | chr19 | 4847827 | - |
intron-3CDS | ENST00000329231 | ENST00000221957 | ATPAF1 | chr1 | 47119503 | - | PLIN3 | chr19 | 4847827 | - |
intron-3CDS | ENST00000329231 | ENST00000592528 | ATPAF1 | chr1 | 47119503 | - | PLIN3 | chr19 | 4847827 | - |
intron-3CDS | ENST00000329231 | ENST00000585479 | ATPAF1 | chr1 | 47119503 | - | PLIN3 | chr19 | 4847827 | - |
intron-3CDS | ENST00000532925 | ENST00000221957 | ATPAF1 | chr1 | 47119503 | - | PLIN3 | chr19 | 4847827 | - |
intron-3CDS | ENST00000532925 | ENST00000592528 | ATPAF1 | chr1 | 47119503 | - | PLIN3 | chr19 | 4847827 | - |
intron-3CDS | ENST00000532925 | ENST00000585479 | ATPAF1 | chr1 | 47119503 | - | PLIN3 | chr19 | 4847827 | - |
intron-3CDS | ENST00000525633 | ENST00000221957 | ATPAF1 | chr1 | 47119503 | - | PLIN3 | chr19 | 4847827 | - |
intron-3CDS | ENST00000525633 | ENST00000592528 | ATPAF1 | chr1 | 47119503 | - | PLIN3 | chr19 | 4847827 | - |
intron-3CDS | ENST00000525633 | ENST00000585479 | ATPAF1 | chr1 | 47119503 | - | PLIN3 | chr19 | 4847827 | - |
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FusionProtFeatures for ATPAF1_PLIN3 |
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Hgene | Tgene |
ATPAF1 | PLIN3 |
May play an essential role for the assembly of themitochondrial F1-F0 complex. {ECO:0000250}. | Required for the transport of mannose 6-phosphatereceptors (MPR) from endosomes to the trans-Golgi network.{ECO:0000269|PubMed:9590177}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ATPAF1_PLIN3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ATPAF1_PLIN3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ATPAF1_PLIN3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | PLIN3 | O60664 | DB01271 | Idursulfase | Perilipin-3 | biotech | approved |
Tgene | PLIN3 | O60664 | DB01279 | Galsulfase | Perilipin-3 | biotech | approved|investigational |
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RelatedDiseases for ATPAF1_PLIN3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ATPAF1 | C0028754 | Obesity | 1 | CTD_human |
Tgene | PLIN3 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |