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Fusion gene ID: 35280 |
FusionGeneSummary for SNX27_CDKN3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SNX27_CDKN3 | Fusion gene ID: 35280 | Hgene | Tgene | Gene symbol | SNX27 | CDKN3 | Gene ID | 81609 | 1033 |
| Gene name | sorting nexin family member 27 | cyclin dependent kinase inhibitor 3 | |
| Synonyms | MRT1|MY014 | CDI1|CIP2|KAP|KAP1 | |
| Cytomap | 1q21.3 | 14q22.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | sorting nexin-27methamphetamine-responsive transcript 1 | cyclin-dependent kinase inhibitor 3CDK2-associated dual specificity phosphataseCdk-associated protein phosphatasecyclin-dependent kinase inhibitorcyclin-dependent kinase interacting protein 2cyclin-dependent kinase interactor 1kinase-associated phos | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q96L92 | Q16667 | |
| Ensembl transtripts involved in fusion gene | ENST00000458013, ENST00000368843, ENST00000368838, ENST00000482791, | ENST00000335183, ENST00000543789, ENST00000442975, ENST00000458126, ENST00000556102, ENST00000541304, ENST00000556305, ENST00000395577, | |
| Fusion gene scores | * DoF score | 11 X 6 X 9=594 | 4 X 4 X 4=64 |
| # samples | 11 | 4 | |
| ** MAII score | log2(11/594*10)=-2.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SNX27 [Title/Abstract] AND CDKN3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CDKN3 | GO:0007050 | cell cycle arrest | 8242750 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-61-1918-01A | SNX27 | chr1 | 151584988 | + | CDKN3 | chr14 | 54882617 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000458013 | ENST00000335183 | SNX27 | chr1 | 151584988 | + | CDKN3 | chr14 | 54882617 | + |
| 5CDS-intron | ENST00000458013 | ENST00000543789 | SNX27 | chr1 | 151584988 | + | CDKN3 | chr14 | 54882617 | + |
| 5CDS-intron | ENST00000458013 | ENST00000442975 | SNX27 | chr1 | 151584988 | + | CDKN3 | chr14 | 54882617 | + |
| 5CDS-intron | ENST00000458013 | ENST00000458126 | SNX27 | chr1 | 151584988 | + | CDKN3 | chr14 | 54882617 | + |
| 5CDS-intron | ENST00000458013 | ENST00000556102 | SNX27 | chr1 | 151584988 | + | CDKN3 | chr14 | 54882617 | + |
| 5CDS-intron | ENST00000458013 | ENST00000541304 | SNX27 | chr1 | 151584988 | + | CDKN3 | chr14 | 54882617 | + |
| 5CDS-3UTR | ENST00000458013 | ENST00000556305 | SNX27 | chr1 | 151584988 | + | CDKN3 | chr14 | 54882617 | + |
| 5CDS-3UTR | ENST00000458013 | ENST00000395577 | SNX27 | chr1 | 151584988 | + | CDKN3 | chr14 | 54882617 | + |
| In-frame | ENST00000368843 | ENST00000335183 | SNX27 | chr1 | 151584988 | + | CDKN3 | chr14 | 54882617 | + |
| 5CDS-intron | ENST00000368843 | ENST00000543789 | SNX27 | chr1 | 151584988 | + | CDKN3 | chr14 | 54882617 | + |
| 5CDS-intron | ENST00000368843 | ENST00000442975 | SNX27 | chr1 | 151584988 | + | CDKN3 | chr14 | 54882617 | + |
| 5CDS-intron | ENST00000368843 | ENST00000458126 | SNX27 | chr1 | 151584988 | + | CDKN3 | chr14 | 54882617 | + |
| 5CDS-intron | ENST00000368843 | ENST00000556102 | SNX27 | chr1 | 151584988 | + | CDKN3 | chr14 | 54882617 | + |
| 5CDS-intron | ENST00000368843 | ENST00000541304 | SNX27 | chr1 | 151584988 | + | CDKN3 | chr14 | 54882617 | + |
| 5CDS-3UTR | ENST00000368843 | ENST00000556305 | SNX27 | chr1 | 151584988 | + | CDKN3 | chr14 | 54882617 | + |
| 5CDS-3UTR | ENST00000368843 | ENST00000395577 | SNX27 | chr1 | 151584988 | + | CDKN3 | chr14 | 54882617 | + |
| intron-3CDS | ENST00000368838 | ENST00000335183 | SNX27 | chr1 | 151584988 | + | CDKN3 | chr14 | 54882617 | + |
| intron-intron | ENST00000368838 | ENST00000543789 | SNX27 | chr1 | 151584988 | + | CDKN3 | chr14 | 54882617 | + |
| intron-intron | ENST00000368838 | ENST00000442975 | SNX27 | chr1 | 151584988 | + | CDKN3 | chr14 | 54882617 | + |
| intron-intron | ENST00000368838 | ENST00000458126 | SNX27 | chr1 | 151584988 | + | CDKN3 | chr14 | 54882617 | + |
| intron-intron | ENST00000368838 | ENST00000556102 | SNX27 | chr1 | 151584988 | + | CDKN3 | chr14 | 54882617 | + |
| intron-intron | ENST00000368838 | ENST00000541304 | SNX27 | chr1 | 151584988 | + | CDKN3 | chr14 | 54882617 | + |
| intron-3UTR | ENST00000368838 | ENST00000556305 | SNX27 | chr1 | 151584988 | + | CDKN3 | chr14 | 54882617 | + |
| intron-3UTR | ENST00000368838 | ENST00000395577 | SNX27 | chr1 | 151584988 | + | CDKN3 | chr14 | 54882617 | + |
| intron-3CDS | ENST00000482791 | ENST00000335183 | SNX27 | chr1 | 151584988 | + | CDKN3 | chr14 | 54882617 | + |
| intron-intron | ENST00000482791 | ENST00000543789 | SNX27 | chr1 | 151584988 | + | CDKN3 | chr14 | 54882617 | + |
| intron-intron | ENST00000482791 | ENST00000442975 | SNX27 | chr1 | 151584988 | + | CDKN3 | chr14 | 54882617 | + |
| intron-intron | ENST00000482791 | ENST00000458126 | SNX27 | chr1 | 151584988 | + | CDKN3 | chr14 | 54882617 | + |
| intron-intron | ENST00000482791 | ENST00000556102 | SNX27 | chr1 | 151584988 | + | CDKN3 | chr14 | 54882617 | + |
| intron-intron | ENST00000482791 | ENST00000541304 | SNX27 | chr1 | 151584988 | + | CDKN3 | chr14 | 54882617 | + |
| intron-3UTR | ENST00000482791 | ENST00000556305 | SNX27 | chr1 | 151584988 | + | CDKN3 | chr14 | 54882617 | + |
| intron-3UTR | ENST00000482791 | ENST00000395577 | SNX27 | chr1 | 151584988 | + | CDKN3 | chr14 | 54882617 | + |
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FusionProtFeatures for SNX27_CDKN3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SNX27 | CDKN3 |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >SNX27 | chr1:151584988 | chr14:54882617 | ENST00000368838 | + | 1 | 11 | 161_269 | 0 | 436 | Domain | PX |
| Hgene | >SNX27 | chr1:151584988 | chr14:54882617 | ENST00000368838 | + | 1 | 11 | 43_136 | 0 | 436 | Domain | PDZ |
| Hgene | >SNX27 | chr1:151584988 | chr14:54882617 | ENST00000368843 | + | 1 | 12 | 161_269 | 103 | 529 | Domain | PX |
| Hgene | >SNX27 | chr1:151584988 | chr14:54882617 | ENST00000368843 | + | 1 | 12 | 43_136 | 103 | 529 | Domain | PDZ |
| Hgene | >SNX27 | chr1:151584988 | chr14:54882617 | ENST00000458013 | + | 1 | 12 | 161_269 | 103 | 542 | Domain | PX |
| Hgene | >SNX27 | chr1:151584988 | chr14:54882617 | ENST00000458013 | + | 1 | 12 | 43_136 | 103 | 542 | Domain | PDZ |
| Hgene | >SNX27 | chr1:151584988 | chr14:54882617 | ENST00000368838 | + | 1 | 11 | 273_362 | 0 | 436 | Region | Note=FERM-like region F1 |
| Hgene | >SNX27 | chr1:151584988 | chr14:54882617 | ENST00000368838 | + | 1 | 11 | 373_421 | 0 | 436 | Region | Note=FERM-like region F2 |
| Hgene | >SNX27 | chr1:151584988 | chr14:54882617 | ENST00000368838 | + | 1 | 11 | 425_525 | 0 | 436 | Region | Note=FERM-like region F3 |
| Hgene | >SNX27 | chr1:151584988 | chr14:54882617 | ENST00000368843 | + | 1 | 12 | 273_362 | 103 | 529 | Region | Note=FERM-like region F1 |
| Hgene | >SNX27 | chr1:151584988 | chr14:54882617 | ENST00000368843 | + | 1 | 12 | 373_421 | 103 | 529 | Region | Note=FERM-like region F2 |
| Hgene | >SNX27 | chr1:151584988 | chr14:54882617 | ENST00000368843 | + | 1 | 12 | 425_525 | 103 | 529 | Region | Note=FERM-like region F3 |
| Hgene | >SNX27 | chr1:151584988 | chr14:54882617 | ENST00000458013 | + | 1 | 12 | 273_362 | 103 | 542 | Region | Note=FERM-like region F1 |
| Hgene | >SNX27 | chr1:151584988 | chr14:54882617 | ENST00000458013 | + | 1 | 12 | 373_421 | 103 | 542 | Region | Note=FERM-like region F2 |
| Hgene | >SNX27 | chr1:151584988 | chr14:54882617 | ENST00000458013 | + | 1 | 12 | 425_525 | 103 | 542 | Region | Note=FERM-like region F3 |
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FusionGeneSequence for SNX27_CDKN3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SNX27_ENST00000458013_chr1_151584988_+_CDKN3_ENST00000335183_chr14_54882617_+_178aa MADEDGEGIHPSAPHRNGGGGGGGGSGLHCAGNGGGGGGGPRVVRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAA >In-frame_SNX27_ENST00000368843_chr1_151584988_+_CDKN3_ENST00000335183_chr14_54882617_+_178aa MADEDGEGIHPSAPHRNGGGGGGGGSGLHCAGNGGGGGGGPRVVRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SNX27_ENST00000458013_chr1_151584988_+_CDKN3_ENST00000335183_chr14_54882617_+_534nt ATGGCGGACGAGGACGGGGAAGGGATTCATCCCTCAGCCCCTCACAGGAACGGAGGTGGCGGCGGCGGCGGGGGGTCTGGGCTCCACTGC GCCGGGAACGGCGGCGGGGGAGGCGGCGGCCCGCGGGTCGTGCGCATCGTCAAGTCCGAGTCCGGCTACGGCTTCAACGTGCGGGGCCAA GTGAGCGAGGGCGGGCAACTGCGGAGCATCAACGGGGAGCTGTACGCGCCGCTGCAGCATGTGAGCGCCGTGCTGCCCGGGGGGGCGGCC GATCGGGCCGGGGTGCGCAAGGGGGACCGCATCCTGGAGGTCTGCTATGGAGGACTTGGGAGATCTTGTCTTGTAGCTGCTTGTCTCCTA CTATACCTGTCTGACACAATATCACCAGAGCAAGCCATAGACAGCCTGCGAGACCTAAGAGGATCCGGGGCAATACAGACCATCAAGCAA >In-frame_SNX27_ENST00000368843_chr1_151584988_+_CDKN3_ENST00000335183_chr14_54882617_+_534nt ATGGCGGACGAGGACGGGGAAGGGATTCATCCCTCAGCCCCTCACAGGAACGGAGGTGGCGGCGGCGGCGGGGGGTCTGGGCTCCACTGC GCCGGGAACGGCGGCGGGGGAGGCGGCGGCCCGCGGGTCGTGCGCATCGTCAAGTCCGAGTCCGGCTACGGCTTCAACGTGCGGGGCCAA GTGAGCGAGGGCGGGCAACTGCGGAGCATCAACGGGGAGCTGTACGCGCCGCTGCAGCATGTGAGCGCCGTGCTGCCCGGGGGGGCGGCC GATCGGGCCGGGGTGCGCAAGGGGGACCGCATCCTGGAGGTCTGCTATGGAGGACTTGGGAGATCTTGTCTTGTAGCTGCTTGTCTCCTA CTATACCTGTCTGACACAATATCACCAGAGCAAGCCATAGACAGCCTGCGAGACCTAAGAGGATCCGGGGCAATACAGACCATCAAGCAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SNX27_ENST00000458013_chr1_151584988_+_CDKN3_ENST00000335183_chr14_54882617_+_794nt TCCCGCGGCCGGCGGATCGGGCGCGCGCGTCGGGGGTCGTCCGGCTGCCAGGCAGGGCGAGCACGCGCCGGGAGGCCTTGGAGGCGTAGG GGGCGGGGGTACGGCTCGCCTGCTCGCAAGATGGCGGACGAGGACGGGGAAGGGATTCATCCCTCAGCCCCTCACAGGAACGGAGGTGGC GGCGGCGGCGGGGGGTCTGGGCTCCACTGCGCCGGGAACGGCGGCGGGGGAGGCGGCGGCCCGCGGGTCGTGCGCATCGTCAAGTCCGAG TCCGGCTACGGCTTCAACGTGCGGGGCCAAGTGAGCGAGGGCGGGCAACTGCGGAGCATCAACGGGGAGCTGTACGCGCCGCTGCAGCAT GTGAGCGCCGTGCTGCCCGGGGGGGCGGCCGATCGGGCCGGGGTGCGCAAGGGGGACCGCATCCTGGAGGTCTGCTATGGAGGACTTGGG AGATCTTGTCTTGTAGCTGCTTGTCTCCTACTATACCTGTCTGACACAATATCACCAGAGCAAGCCATAGACAGCCTGCGAGACCTAAGA GGATCCGGGGCAATACAGACCATCAAGCAATACAATTATCTTCATGAGTTTCGGGACAAATTAGCTGCACATCTATCATCAAGAGATTCA CAATCAAGATCTGTATCAAGATAAAGGAATTCAAATAGCATATATATGACCATGTCTGAAATGTCAGTTCTCTAGCATAATTTGTATTGA >In-frame_SNX27_ENST00000368843_chr1_151584988_+_CDKN3_ENST00000335183_chr14_54882617_+_794nt TCCCGCGGCCGGCGGATCGGGCGCGCGCGTCGGGGGTCGTCCGGCTGCCAGGCAGGGCGAGCACGCGCCGGGAGGCCTTGGAGGCGTAGG GGGCGGGGGTACGGCTCGCCTGCTCGCAAGATGGCGGACGAGGACGGGGAAGGGATTCATCCCTCAGCCCCTCACAGGAACGGAGGTGGC GGCGGCGGCGGGGGGTCTGGGCTCCACTGCGCCGGGAACGGCGGCGGGGGAGGCGGCGGCCCGCGGGTCGTGCGCATCGTCAAGTCCGAG TCCGGCTACGGCTTCAACGTGCGGGGCCAAGTGAGCGAGGGCGGGCAACTGCGGAGCATCAACGGGGAGCTGTACGCGCCGCTGCAGCAT GTGAGCGCCGTGCTGCCCGGGGGGGCGGCCGATCGGGCCGGGGTGCGCAAGGGGGACCGCATCCTGGAGGTCTGCTATGGAGGACTTGGG AGATCTTGTCTTGTAGCTGCTTGTCTCCTACTATACCTGTCTGACACAATATCACCAGAGCAAGCCATAGACAGCCTGCGAGACCTAAGA GGATCCGGGGCAATACAGACCATCAAGCAATACAATTATCTTCATGAGTTTCGGGACAAATTAGCTGCACATCTATCATCAAGAGATTCA CAATCAAGATCTGTATCAAGATAAAGGAATTCAAATAGCATATATATGACCATGTCTGAAATGTCAGTTCTCTAGCATAATTTGTATTGA |
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FusionGenePPI for SNX27_CDKN3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SNX27 | PHLPP2, PHLPP1, ELAVL1, PNPLA3, AKT2, HLCS, ABCC4, SELP, INSR, NTRK1, APP, VPS26B, RASSF1, CDK16, MSH2, CENPJ, USB1, TIGD6, APOA1, CDS1, CP, HP, C3, IGHA2, BPIFA1, C4A, IGHG3, LTF, PRR4, FIG4, SERPINA1, PIGR, FGB, LACRT, ORM1, FGA, FGG, AHSG, SCGB2A1, IGHM, LRRC36, GPR156, IGHG2, MRAP2, APOA4, BPIFB1, IGHG4, IGLC2, TF, LCN2, PROSER2, C6orf58, HPX, FAM19A3, SERPINA3, CST1, IGHA1, DMBT1, TTR, ZG16B, IGJ, KNG1, SCGB1D1, CHRDL1, IGLL5, ALB, LYZ, LCN1, CST4, IGHG1, PTPRQ, PIBF1, EEA1, TRIM25 | CDKN3 | CDK2, CDK1, MS4A3, NCOA3, BMI1, ROCK2, ROCK1, CDC42BPB, PPP1R12A, CDKN3, RAD23B, CLPB, GOPC, RAD23A, HAX1, BAG6, ARHGEF28, CECR5, DLAT, NAP1L4, DIS3L, SEC63 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | CDKN3 | chr1:151584988 | chr14:54882617 | ENST00000335183 | + | 4 | 8 | 1_34 | 138 | 213 | CDK2 |
| Tgene | CDKN3 | chr1:151584988 | chr14:54882617 | ENST00000442975 | + | 3 | 7 | 1_34 | 98 | 173 | CDK2 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SNX27_CDKN3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SNX27_CDKN3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | CDKN3 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | CDKN3 | C2239176 | Liver carcinoma | 1 | UNIPROT |
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