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Fusion gene ID: 3528 |
FusionGeneSummary for ATP9B_STK10 |
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Fusion gene information | Fusion gene name: ATP9B_STK10 | Fusion gene ID: 3528 | Hgene | Tgene | Gene symbol | ATP9B | STK10 | Gene ID | 374868 | 6793 |
Gene name | ATPase phospholipid transporting 9B (putative) | serine/threonine kinase 10 | |
Synonyms | ATPASEP|ATPIIB|HUSSY-20|NEO1L|hMMR1 | LOK|PRO2729 | |
Cytomap | 18q23 | 5q35.1 | |
Type of gene | protein-coding | protein-coding | |
Description | probable phospholipid-transporting ATPase IIBATPase type IV, phospholipid transporting (P-type)ATPase, class II, type 9Bmacrophage MHC receptor 1 | serine/threonine-protein kinase 10lymphocyte-oriented kinase | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | O43861 | O94804 | |
Ensembl transtripts involved in fusion gene | ENST00000426216, ENST00000307671, ENST00000586722, ENST00000591464, ENST00000458297, ENST00000543761, | ENST00000176763, ENST00000517775, | |
Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 10 X 10 X 4=400 |
# samples | 3 | 10 | |
** MAII score | log2(3/32*10)=-0.0931094043914815 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/400*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ATP9B [Title/Abstract] AND STK10 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | STK10 | GO:0046777 | protein autophosphorylation | 12639966|18239682 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DB028190 | ATP9B | chr18 | 77037194 | + | STK10 | chr5 | 171510239 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000426216 | ENST00000176763 | ATP9B | chr18 | 77037194 | + | STK10 | chr5 | 171510239 | + |
5CDS-intron | ENST00000426216 | ENST00000517775 | ATP9B | chr18 | 77037194 | + | STK10 | chr5 | 171510239 | + |
5CDS-intron | ENST00000307671 | ENST00000176763 | ATP9B | chr18 | 77037194 | + | STK10 | chr5 | 171510239 | + |
5CDS-intron | ENST00000307671 | ENST00000517775 | ATP9B | chr18 | 77037194 | + | STK10 | chr5 | 171510239 | + |
intron-intron | ENST00000586722 | ENST00000176763 | ATP9B | chr18 | 77037194 | + | STK10 | chr5 | 171510239 | + |
intron-intron | ENST00000586722 | ENST00000517775 | ATP9B | chr18 | 77037194 | + | STK10 | chr5 | 171510239 | + |
intron-intron | ENST00000591464 | ENST00000176763 | ATP9B | chr18 | 77037194 | + | STK10 | chr5 | 171510239 | + |
intron-intron | ENST00000591464 | ENST00000517775 | ATP9B | chr18 | 77037194 | + | STK10 | chr5 | 171510239 | + |
intron-intron | ENST00000458297 | ENST00000176763 | ATP9B | chr18 | 77037194 | + | STK10 | chr5 | 171510239 | + |
intron-intron | ENST00000458297 | ENST00000517775 | ATP9B | chr18 | 77037194 | + | STK10 | chr5 | 171510239 | + |
intron-intron | ENST00000543761 | ENST00000176763 | ATP9B | chr18 | 77037194 | + | STK10 | chr5 | 171510239 | + |
intron-intron | ENST00000543761 | ENST00000517775 | ATP9B | chr18 | 77037194 | + | STK10 | chr5 | 171510239 | + |
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FusionProtFeatures for ATP9B_STK10 |
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Hgene | Tgene |
ATP9B | STK10 |
Serine/threonine-protein kinase involved in regulationof lymphocyte migration. Phosphorylates MSN, and possibly PLK1.Involved in regulation of lymphocyte migration by mediatingphosphorylation of ERM proteins such as MSN. Acts as a negativeregulator of MAP3K1/MEKK1. May also act as a cell cycle regulatorby acting as a polo kinase kinase: mediates phosphorylation ofPLK1 in vitro; however such data require additional evidences invivo. {ECO:0000269|PubMed:11903060, ECO:0000269|PubMed:12639966,ECO:0000269|PubMed:19255442}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ATP9B_STK10 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ATP9B_STK10 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ATP9B_STK10 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ATP9B_STK10 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ATP9B | C0236736 | Cocaine-Related Disorders | 1 | CTD_human |
Tgene | STK10 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | STK10 | C1336708 | Testicular Germ Cell Tumor | 1 | UNIPROT |