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Fusion gene ID: 35265 |
FusionGeneSummary for SNX19_CHRDL1 |
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Fusion gene information | Fusion gene name: SNX19_CHRDL1 | Fusion gene ID: 35265 | Hgene | Tgene | Gene symbol | SNX19 | CHRDL1 | Gene ID | 399979 | 91851 |
Gene name | sorting nexin 19 | chordin like 1 | |
Synonyms | CHET8 | CHL|MGC1|MGCN|NRLN1|VOPT|dA141H5.1 | |
Cytomap | 11q24.3-q25 | Xq23 | |
Type of gene | protein-coding | protein-coding | |
Description | sorting nexin-19 | chordin-like protein 1neuralin-1neurogenesin-1ventroptin | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q92543 | Q9BU40 | |
Ensembl transtripts involved in fusion gene | ENST00000265909, ENST00000534726, ENST00000545537, ENST00000426933, ENST00000533318, ENST00000530356, ENST00000539184, ENST00000528555, ENST00000533214, | ENST00000372045, ENST00000218054, ENST00000434224, ENST00000394797, ENST00000372042, ENST00000482160, ENST00000444321, | |
Fusion gene scores | * DoF score | 5 X 4 X 3=60 | 2 X 2 X 1=4 |
# samples | 5 | 2 | |
** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: SNX19 [Title/Abstract] AND CHRDL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AA029156 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000265909 | ENST00000372045 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-3UTR | ENST00000265909 | ENST00000218054 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-3UTR | ENST00000265909 | ENST00000434224 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-intron | ENST00000265909 | ENST00000394797 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-intron | ENST00000265909 | ENST00000372042 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-intron | ENST00000265909 | ENST00000482160 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-intron | ENST00000265909 | ENST00000444321 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-3UTR | ENST00000534726 | ENST00000372045 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-3UTR | ENST00000534726 | ENST00000218054 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-3UTR | ENST00000534726 | ENST00000434224 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-intron | ENST00000534726 | ENST00000394797 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-intron | ENST00000534726 | ENST00000372042 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-intron | ENST00000534726 | ENST00000482160 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-intron | ENST00000534726 | ENST00000444321 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-3UTR | ENST00000545537 | ENST00000372045 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-3UTR | ENST00000545537 | ENST00000218054 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-3UTR | ENST00000545537 | ENST00000434224 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-intron | ENST00000545537 | ENST00000394797 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-intron | ENST00000545537 | ENST00000372042 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-intron | ENST00000545537 | ENST00000482160 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-intron | ENST00000545537 | ENST00000444321 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-3UTR | ENST00000426933 | ENST00000372045 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-3UTR | ENST00000426933 | ENST00000218054 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-3UTR | ENST00000426933 | ENST00000434224 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-intron | ENST00000426933 | ENST00000394797 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-intron | ENST00000426933 | ENST00000372042 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-intron | ENST00000426933 | ENST00000482160 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-intron | ENST00000426933 | ENST00000444321 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-3UTR | ENST00000533318 | ENST00000372045 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-3UTR | ENST00000533318 | ENST00000218054 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-3UTR | ENST00000533318 | ENST00000434224 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-intron | ENST00000533318 | ENST00000394797 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-intron | ENST00000533318 | ENST00000372042 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-intron | ENST00000533318 | ENST00000482160 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-intron | ENST00000533318 | ENST00000444321 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-3UTR | ENST00000530356 | ENST00000372045 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-3UTR | ENST00000530356 | ENST00000218054 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-3UTR | ENST00000530356 | ENST00000434224 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-intron | ENST00000530356 | ENST00000394797 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-intron | ENST00000530356 | ENST00000372042 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-intron | ENST00000530356 | ENST00000482160 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-intron | ENST00000530356 | ENST00000444321 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-3UTR | ENST00000539184 | ENST00000372045 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-3UTR | ENST00000539184 | ENST00000218054 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-3UTR | ENST00000539184 | ENST00000434224 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-intron | ENST00000539184 | ENST00000394797 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-intron | ENST00000539184 | ENST00000372042 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-intron | ENST00000539184 | ENST00000482160 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-intron | ENST00000539184 | ENST00000444321 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-3UTR | ENST00000528555 | ENST00000372045 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-3UTR | ENST00000528555 | ENST00000218054 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-3UTR | ENST00000528555 | ENST00000434224 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-intron | ENST00000528555 | ENST00000394797 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-intron | ENST00000528555 | ENST00000372042 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-intron | ENST00000528555 | ENST00000482160 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-intron | ENST00000528555 | ENST00000444321 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-3UTR | ENST00000533214 | ENST00000372045 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-3UTR | ENST00000533214 | ENST00000218054 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-3UTR | ENST00000533214 | ENST00000434224 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-intron | ENST00000533214 | ENST00000394797 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-intron | ENST00000533214 | ENST00000372042 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-intron | ENST00000533214 | ENST00000482160 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
intron-intron | ENST00000533214 | ENST00000444321 | SNX19 | chr11 | 130780046 | - | CHRDL1 | chrX | 109917723 | - |
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FusionProtFeatures for SNX19_CHRDL1 |
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Hgene | Tgene |
SNX19 | CHRDL1 |
Plays a role in intracellular vesicle trafficking andexocytosis (PubMed:24843546). May play a role in maintaininginsulin-containing dense core vesicles in pancreatic beta-cellsand in preventing their degradation. May play a role in insulinsecretion (PubMed:24843546). Interacts with membranes containingphosphatidylinositol 3-phosphate (PtdIns(3P)) (By similarity).{ECO:0000250|UniProtKB:Q6P4T1, ECO:0000269|PubMed:24843546}. | Antagonizes the function of BMP4 by binding to it andpreventing its interaction with receptors. Alters the fatecommitment of neural stem cells from gliogenesis to neurogenesis.Contributes to neuronal differentiation of neural stem cells inthe brain by preventing the adoption of a glial fate. May play acrucial role in dorsoventral axis formation. May play a role inembryonic bone formation (By similarity). May also play animportant role in regulating retinal angiogenesis throughmodulation of BMP4 actions in endothelial cells. Plays a roleduring anterior segment eye development. {ECO:0000250,ECO:0000269|PubMed:18587495, ECO:0000269|PubMed:22284829}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SNX19_CHRDL1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SNX19_CHRDL1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SNX19_CHRDL1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SNX19_CHRDL1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | CHRDL1 | C0344530 | Congenital keratoglobus | 1 | ORPHANET;UNIPROT |