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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35265

FusionGeneSummary for SNX19_CHRDL1

check button Fusion gene summary
Fusion gene informationFusion gene name: SNX19_CHRDL1
Fusion gene ID: 35265
HgeneTgene
Gene symbol

SNX19

CHRDL1

Gene ID

399979

91851

Gene namesorting nexin 19chordin like 1
SynonymsCHET8CHL|MGC1|MGCN|NRLN1|VOPT|dA141H5.1
Cytomap

11q24.3-q25

Xq23

Type of geneprotein-codingprotein-coding
Descriptionsorting nexin-19chordin-like protein 1neuralin-1neurogenesin-1ventroptin
Modification date2018051920180519
UniProtAcc

Q92543

Q9BU40

Ensembl transtripts involved in fusion geneENST00000265909, ENST00000534726, 
ENST00000545537, ENST00000426933, 
ENST00000533318, ENST00000530356, 
ENST00000539184, ENST00000528555, 
ENST00000533214, 
ENST00000372045, 
ENST00000218054, ENST00000434224, 
ENST00000394797, ENST00000372042, 
ENST00000482160, ENST00000444321, 
Fusion gene scores* DoF score5 X 4 X 3=602 X 2 X 1=4
# samples 52
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/4*10)=2.32192809488736
Context

PubMed: SNX19 [Title/Abstract] AND CHRDL1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA029156SNX19chr11

130780046

-CHRDL1chrX

109917723

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000265909ENST00000372045SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-3UTRENST00000265909ENST00000218054SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-3UTRENST00000265909ENST00000434224SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-intronENST00000265909ENST00000394797SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-intronENST00000265909ENST00000372042SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-intronENST00000265909ENST00000482160SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-intronENST00000265909ENST00000444321SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-3UTRENST00000534726ENST00000372045SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-3UTRENST00000534726ENST00000218054SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-3UTRENST00000534726ENST00000434224SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-intronENST00000534726ENST00000394797SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-intronENST00000534726ENST00000372042SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-intronENST00000534726ENST00000482160SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-intronENST00000534726ENST00000444321SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-3UTRENST00000545537ENST00000372045SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-3UTRENST00000545537ENST00000218054SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-3UTRENST00000545537ENST00000434224SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-intronENST00000545537ENST00000394797SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-intronENST00000545537ENST00000372042SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-intronENST00000545537ENST00000482160SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-intronENST00000545537ENST00000444321SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-3UTRENST00000426933ENST00000372045SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-3UTRENST00000426933ENST00000218054SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-3UTRENST00000426933ENST00000434224SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-intronENST00000426933ENST00000394797SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-intronENST00000426933ENST00000372042SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-intronENST00000426933ENST00000482160SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-intronENST00000426933ENST00000444321SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-3UTRENST00000533318ENST00000372045SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-3UTRENST00000533318ENST00000218054SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-3UTRENST00000533318ENST00000434224SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-intronENST00000533318ENST00000394797SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-intronENST00000533318ENST00000372042SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-intronENST00000533318ENST00000482160SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-intronENST00000533318ENST00000444321SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-3UTRENST00000530356ENST00000372045SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-3UTRENST00000530356ENST00000218054SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-3UTRENST00000530356ENST00000434224SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-intronENST00000530356ENST00000394797SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-intronENST00000530356ENST00000372042SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-intronENST00000530356ENST00000482160SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-intronENST00000530356ENST00000444321SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-3UTRENST00000539184ENST00000372045SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-3UTRENST00000539184ENST00000218054SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-3UTRENST00000539184ENST00000434224SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-intronENST00000539184ENST00000394797SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-intronENST00000539184ENST00000372042SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-intronENST00000539184ENST00000482160SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-intronENST00000539184ENST00000444321SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-3UTRENST00000528555ENST00000372045SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-3UTRENST00000528555ENST00000218054SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-3UTRENST00000528555ENST00000434224SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-intronENST00000528555ENST00000394797SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-intronENST00000528555ENST00000372042SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-intronENST00000528555ENST00000482160SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-intronENST00000528555ENST00000444321SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-3UTRENST00000533214ENST00000372045SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-3UTRENST00000533214ENST00000218054SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-3UTRENST00000533214ENST00000434224SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-intronENST00000533214ENST00000394797SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-intronENST00000533214ENST00000372042SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-intronENST00000533214ENST00000482160SNX19chr11

130780046

-CHRDL1chrX

109917723

-
intron-intronENST00000533214ENST00000444321SNX19chr11

130780046

-CHRDL1chrX

109917723

-

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FusionProtFeatures for SNX19_CHRDL1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SNX19

Q92543

CHRDL1

Q9BU40

Plays a role in intracellular vesicle trafficking andexocytosis (PubMed:24843546). May play a role in maintaininginsulin-containing dense core vesicles in pancreatic beta-cellsand in preventing their degradation. May play a role in insulinsecretion (PubMed:24843546). Interacts with membranes containingphosphatidylinositol 3-phosphate (PtdIns(3P)) (By similarity).{ECO:0000250|UniProtKB:Q6P4T1, ECO:0000269|PubMed:24843546}. Antagonizes the function of BMP4 by binding to it andpreventing its interaction with receptors. Alters the fatecommitment of neural stem cells from gliogenesis to neurogenesis.Contributes to neuronal differentiation of neural stem cells inthe brain by preventing the adoption of a glial fate. May play acrucial role in dorsoventral axis formation. May play a role inembryonic bone formation (By similarity). May also play animportant role in regulating retinal angiogenesis throughmodulation of BMP4 actions in endothelial cells. Plays a roleduring anterior segment eye development. {ECO:0000250,ECO:0000269|PubMed:18587495, ECO:0000269|PubMed:22284829}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SNX19_CHRDL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SNX19_CHRDL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SNX19_CHRDL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SNX19_CHRDL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCHRDL1C0344530Congenital keratoglobus1ORPHANET;UNIPROT