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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35257

FusionGeneSummary for SNX15_NAALADL1

check button Fusion gene summary
Fusion gene informationFusion gene name: SNX15_NAALADL1
Fusion gene ID: 35257
HgeneTgene
Gene symbol

SNX15

NAALADL1

Gene ID

29907

10004

Gene namesorting nexin 15N-acetylated alpha-linked acidic dipeptidase like 1
SynonymsHSAF001435I100|NAALADASEL
Cytomap

11q13.1

11q13.1

Type of geneprotein-codingprotein-coding
Descriptionsorting nexin-15clone iota unknown proteinN-acetylated-alpha-linked acidic dipeptidase-like protein100 kDa ileum brush border membrane proteinNAALADase Lileal dipeptidylpeptidaseileal peptidase I100peptidase homolog
Modification date2018051920180330
UniProtAcc

Q9NRS6

Q9UQQ1

Ensembl transtripts involved in fusion geneENST00000377244, ENST00000352068, 
ENST00000358658, ENST00000355369, 
ENST00000339885, ENST00000526799, 
ENST00000356632, ENST00000340252, 
ENST00000355721, ENST00000528884, 
Fusion gene scores* DoF score2 X 1 X 2=41 X 1 X 1=1
# samples 21
** MAII scorelog2(2/4*10)=2.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: SNX15 [Title/Abstract] AND NAALADL1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-22-5473-01ASNX15chr11

64795108

+NAALADL1chr11

64822210

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000377244ENST00000358658SNX15chr11

64795108

+NAALADL1chr11

64822210

-
In-frameENST00000377244ENST00000355369SNX15chr11

64795108

+NAALADL1chr11

64822210

-
In-frameENST00000377244ENST00000339885SNX15chr11

64795108

+NAALADL1chr11

64822210

-
5CDS-intronENST00000377244ENST00000526799SNX15chr11

64795108

+NAALADL1chr11

64822210

-
5CDS-intronENST00000377244ENST00000356632SNX15chr11

64795108

+NAALADL1chr11

64822210

-
5CDS-intronENST00000377244ENST00000340252SNX15chr11

64795108

+NAALADL1chr11

64822210

-
5CDS-intronENST00000377244ENST00000355721SNX15chr11

64795108

+NAALADL1chr11

64822210

-
5CDS-intronENST00000377244ENST00000528884SNX15chr11

64795108

+NAALADL1chr11

64822210

-
In-frameENST00000352068ENST00000358658SNX15chr11

64795108

+NAALADL1chr11

64822210

-
In-frameENST00000352068ENST00000355369SNX15chr11

64795108

+NAALADL1chr11

64822210

-
In-frameENST00000352068ENST00000339885SNX15chr11

64795108

+NAALADL1chr11

64822210

-
5CDS-intronENST00000352068ENST00000526799SNX15chr11

64795108

+NAALADL1chr11

64822210

-
5CDS-intronENST00000352068ENST00000356632SNX15chr11

64795108

+NAALADL1chr11

64822210

-
5CDS-intronENST00000352068ENST00000340252SNX15chr11

64795108

+NAALADL1chr11

64822210

-
5CDS-intronENST00000352068ENST00000355721SNX15chr11

64795108

+NAALADL1chr11

64822210

-
5CDS-intronENST00000352068ENST00000528884SNX15chr11

64795108

+NAALADL1chr11

64822210

-

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FusionProtFeatures for SNX15_NAALADL1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SNX15

Q9NRS6

NAALADL1

Q9UQQ1

May be involved in several stages of intracellulartrafficking. Overexpression of SNX15 disrupts the normaltrafficking of proteins from the plasma membrane to recyclingendosomes or the TGN. {ECO:0000269|PubMed:11085978}. NAALADase-like activity unknown. Has no NAAG hydrolyzingactivity. Exhibits a dipeptidyl-peptidase IV type activity. Invitro, cleaves Gly-Pro-AMC (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNAALADL1chr11:64795108chr11:64822210ENST00000340252-317263_579201792RegionNote=NAALADase
TgeneNAALADL1chr11:64795108chr11:64822210ENST00000355369-316263_579201646RegionNote=NAALADase
TgeneNAALADL1chr11:64795108chr11:64822210ENST00000355721-217263_579160700RegionNote=NAALADase
TgeneNAALADL1chr11:64795108chr11:64822210ENST00000358658-318263_579201741RegionNote=NAALADase

- In-frame and not-retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSNX15chr11:64795108chr11:64822210ENST00000377244+181_13033343DomainPX
HgeneSNX15chr11:64795108chr11:64822210ENST00000377244+18265_34233343DomainNote=MIT
TgeneNAALADL1chr11:64795108chr11:64822210ENST00000340252-3171_6201792Topological domainCytoplasmic
TgeneNAALADL1chr11:64795108chr11:64822210ENST00000340252-31729_740201792Topological domainExtracellular
TgeneNAALADL1chr11:64795108chr11:64822210ENST00000355369-3161_6201646Topological domainCytoplasmic
TgeneNAALADL1chr11:64795108chr11:64822210ENST00000355369-31629_740201646Topological domainExtracellular
TgeneNAALADL1chr11:64795108chr11:64822210ENST00000355721-2171_6160700Topological domainCytoplasmic
TgeneNAALADL1chr11:64795108chr11:64822210ENST00000355721-21729_740160700Topological domainExtracellular
TgeneNAALADL1chr11:64795108chr11:64822210ENST00000358658-3181_6201741Topological domainCytoplasmic
TgeneNAALADL1chr11:64795108chr11:64822210ENST00000358658-31829_740201741Topological domainExtracellular
TgeneNAALADL1chr11:64795108chr11:64822210ENST00000340252-3177_28201792TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneNAALADL1chr11:64795108chr11:64822210ENST00000355369-3167_28201646TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneNAALADL1chr11:64795108chr11:64822210ENST00000355721-2177_28160700TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneNAALADL1chr11:64795108chr11:64822210ENST00000358658-3187_28201741TransmembraneHelical%3B Signal-anchor for type II membrane protein


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FusionGeneSequence for SNX15_NAALADL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SNX15_NAALADL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SNX15RABAC1, METTL14, VPS36, FN1, KDM1A, ARL6IP1, RTN4, REEP6, HOXC10, NT5C2NAALADL1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SNX15_NAALADL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SNX15_NAALADL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource