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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3525

FusionGeneSummary for ATP9B_ATP9B

check button Fusion gene summary
Fusion gene informationFusion gene name: ATP9B_ATP9B
Fusion gene ID: 3525
HgeneTgene
Gene symbol

ATP9B

ATP9B

Gene ID

374868

374868

Gene nameATPase phospholipid transporting 9B (putative)ATPase phospholipid transporting 9B (putative)
SynonymsATPASEP|ATPIIB|HUSSY-20|NEO1L|hMMR1ATPASEP|ATPIIB|HUSSY-20|NEO1L|hMMR1
Cytomap

18q23

18q23

Type of geneprotein-codingprotein-coding
Descriptionprobable phospholipid-transporting ATPase IIBATPase type IV, phospholipid transporting (P-type)ATPase, class II, type 9Bmacrophage MHC receptor 1probable phospholipid-transporting ATPase IIBATPase type IV, phospholipid transporting (P-type)ATPase, class II, type 9Bmacrophage MHC receptor 1
Modification date2018052320180523
UniProtAcc

O43861

O43861

Ensembl transtripts involved in fusion geneENST00000426216, ENST00000307671, 
ENST00000586722, ENST00000591464, 
ENST00000458297, ENST00000543761, 
ENST00000426216, ENST00000307671, 
ENST00000586722, ENST00000591464, 
ENST00000458297, ENST00000543761, 
Fusion gene scores* DoF score4 X 4 X 2=324 X 4 X 4=64
# samples 34
** MAII scorelog2(3/32*10)=-0.0931094043914815
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATP9B [Title/Abstract] AND ATP9B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ373598ATP9Bchr18

77121955

-ATP9Bchr18

77121902

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000426216ENST00000426216ATP9Bchr18

77121955

-ATP9Bchr18

77121902

+
intron-intronENST00000426216ENST00000307671ATP9Bchr18

77121955

-ATP9Bchr18

77121902

+
intron-intronENST00000426216ENST00000586722ATP9Bchr18

77121955

-ATP9Bchr18

77121902

+
intron-intronENST00000426216ENST00000591464ATP9Bchr18

77121955

-ATP9Bchr18

77121902

+
intron-intronENST00000426216ENST00000458297ATP9Bchr18

77121955

-ATP9Bchr18

77121902

+
intron-intronENST00000426216ENST00000543761ATP9Bchr18

77121955

-ATP9Bchr18

77121902

+
intron-intronENST00000307671ENST00000426216ATP9Bchr18

77121955

-ATP9Bchr18

77121902

+
intron-intronENST00000307671ENST00000307671ATP9Bchr18

77121955

-ATP9Bchr18

77121902

+
intron-intronENST00000307671ENST00000586722ATP9Bchr18

77121955

-ATP9Bchr18

77121902

+
intron-intronENST00000307671ENST00000591464ATP9Bchr18

77121955

-ATP9Bchr18

77121902

+
intron-intronENST00000307671ENST00000458297ATP9Bchr18

77121955

-ATP9Bchr18

77121902

+
intron-intronENST00000307671ENST00000543761ATP9Bchr18

77121955

-ATP9Bchr18

77121902

+
intron-intronENST00000586722ENST00000426216ATP9Bchr18

77121955

-ATP9Bchr18

77121902

+
intron-intronENST00000586722ENST00000307671ATP9Bchr18

77121955

-ATP9Bchr18

77121902

+
intron-intronENST00000586722ENST00000586722ATP9Bchr18

77121955

-ATP9Bchr18

77121902

+
intron-intronENST00000586722ENST00000591464ATP9Bchr18

77121955

-ATP9Bchr18

77121902

+
intron-intronENST00000586722ENST00000458297ATP9Bchr18

77121955

-ATP9Bchr18

77121902

+
intron-intronENST00000586722ENST00000543761ATP9Bchr18

77121955

-ATP9Bchr18

77121902

+
intron-intronENST00000591464ENST00000426216ATP9Bchr18

77121955

-ATP9Bchr18

77121902

+
intron-intronENST00000591464ENST00000307671ATP9Bchr18

77121955

-ATP9Bchr18

77121902

+
intron-intronENST00000591464ENST00000586722ATP9Bchr18

77121955

-ATP9Bchr18

77121902

+
intron-intronENST00000591464ENST00000591464ATP9Bchr18

77121955

-ATP9Bchr18

77121902

+
intron-intronENST00000591464ENST00000458297ATP9Bchr18

77121955

-ATP9Bchr18

77121902

+
intron-intronENST00000591464ENST00000543761ATP9Bchr18

77121955

-ATP9Bchr18

77121902

+
intron-intronENST00000458297ENST00000426216ATP9Bchr18

77121955

-ATP9Bchr18

77121902

+
intron-intronENST00000458297ENST00000307671ATP9Bchr18

77121955

-ATP9Bchr18

77121902

+
intron-intronENST00000458297ENST00000586722ATP9Bchr18

77121955

-ATP9Bchr18

77121902

+
intron-intronENST00000458297ENST00000591464ATP9Bchr18

77121955

-ATP9Bchr18

77121902

+
intron-intronENST00000458297ENST00000458297ATP9Bchr18

77121955

-ATP9Bchr18

77121902

+
intron-intronENST00000458297ENST00000543761ATP9Bchr18

77121955

-ATP9Bchr18

77121902

+
intron-intronENST00000543761ENST00000426216ATP9Bchr18

77121955

-ATP9Bchr18

77121902

+
intron-intronENST00000543761ENST00000307671ATP9Bchr18

77121955

-ATP9Bchr18

77121902

+
intron-intronENST00000543761ENST00000586722ATP9Bchr18

77121955

-ATP9Bchr18

77121902

+
intron-intronENST00000543761ENST00000591464ATP9Bchr18

77121955

-ATP9Bchr18

77121902

+
intron-intronENST00000543761ENST00000458297ATP9Bchr18

77121955

-ATP9Bchr18

77121902

+
intron-intronENST00000543761ENST00000543761ATP9Bchr18

77121955

-ATP9Bchr18

77121902

+

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FusionProtFeatures for ATP9B_ATP9B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATP9B

O43861

ATP9B

O43861


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ATP9B_ATP9B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ATP9B_ATP9B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ATP9B_ATP9B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ATP9B_ATP9B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneATP9BC0236736Cocaine-Related Disorders1CTD_human
TgeneATP9BC0236736Cocaine-Related Disorders1CTD_human