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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35241

FusionGeneSummary for SNX11_MED24

check button Fusion gene summary
Fusion gene informationFusion gene name: SNX11_MED24
Fusion gene ID: 35241
HgeneTgene
Gene symbol

SNX11

MED24

Gene ID

29916

9862

Gene namesorting nexin 11mediator complex subunit 24
Synonyms-ARC100|CRSP100|CRSP4|DRIP100|MED5|THRAP4|TRAP100
Cytomap

17q21.32

17q21.1

Type of geneprotein-codingprotein-coding
Descriptionsorting nexin-11mediator of RNA polymerase II transcription subunit 24CRSP complex subunit 4activator-recruited cofactor 100 kDa componentcofactor required for Sp1 transcriptional activation subunit 4cofactor required for Sp1 transcriptional activation, subunit 4, 10
Modification date2018052220180523
UniProtAcc

Q9Y5W9

O75448

Ensembl transtripts involved in fusion geneENST00000578861, ENST00000580219, 
ENST00000452859, ENST00000393405, 
ENST00000439357, ENST00000359238, 
ENST00000582104, 		ENST00000394126, 
ENST00000356271, ENST00000394128, 
ENST00000394127, ENST00000501516, 
ENST00000479829, 
Fusion gene scores* DoF score2 X 2 X 2=816 X 12 X 6=1152
# samples 217
** MAII scorelog2(2/8*10)=1.32192809488736log2(17/1152*10)=-2.76053406530461
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SNX11 [Title/Abstract] AND MED24 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMED24

GO:0006367

transcription initiation from RNA polymerase II promoter

12218053

TgeneMED24

GO:0030518

intracellular steroid hormone receptor signaling pathway

11867769

TgeneMED24

GO:0030521

androgen receptor signaling pathway

12218053

TgeneMED24

GO:0045893

positive regulation of transcription, DNA-templated

10198638


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVCESCTCGA-4J-AA1J-01ASNX11chr17

46196548

+MED24chr17

38192407

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000578861ENST00000394126SNX11chr17

46196548

+MED24chr17

38192407

-
intron-intronENST00000578861ENST00000356271SNX11chr17

46196548

+MED24chr17

38192407

-
intron-intronENST00000578861ENST00000394128SNX11chr17

46196548

+MED24chr17

38192407

-
intron-intronENST00000578861ENST00000394127SNX11chr17

46196548

+MED24chr17

38192407

-
intron-intronENST00000578861ENST00000501516SNX11chr17

46196548

+MED24chr17

38192407

-
intron-5UTRENST00000578861ENST00000479829SNX11chr17

46196548

+MED24chr17

38192407

-
Frame-shiftENST00000580219ENST00000394126SNX11chr17

46196548

+MED24chr17

38192407

-
5CDS-intronENST00000580219ENST00000356271SNX11chr17

46196548

+MED24chr17

38192407

-
5CDS-intronENST00000580219ENST00000394128SNX11chr17

46196548

+MED24chr17

38192407

-
5CDS-intronENST00000580219ENST00000394127SNX11chr17

46196548

+MED24chr17

38192407

-
5CDS-intronENST00000580219ENST00000501516SNX11chr17

46196548

+MED24chr17

38192407

-
5CDS-5UTRENST00000580219ENST00000479829SNX11chr17

46196548

+MED24chr17

38192407

-
Frame-shiftENST00000452859ENST00000394126SNX11chr17

46196548

+MED24chr17

38192407

-
5CDS-intronENST00000452859ENST00000356271SNX11chr17

46196548

+MED24chr17

38192407

-
5CDS-intronENST00000452859ENST00000394128SNX11chr17

46196548

+MED24chr17

38192407

-
5CDS-intronENST00000452859ENST00000394127SNX11chr17

46196548

+MED24chr17

38192407

-
5CDS-intronENST00000452859ENST00000501516SNX11chr17

46196548

+MED24chr17

38192407

-
5CDS-5UTRENST00000452859ENST00000479829SNX11chr17

46196548

+MED24chr17

38192407

-
Frame-shiftENST00000393405ENST00000394126SNX11chr17

46196548

+MED24chr17

38192407

-
5CDS-intronENST00000393405ENST00000356271SNX11chr17

46196548

+MED24chr17

38192407

-
5CDS-intronENST00000393405ENST00000394128SNX11chr17

46196548

+MED24chr17

38192407

-
5CDS-intronENST00000393405ENST00000394127SNX11chr17

46196548

+MED24chr17

38192407

-
5CDS-intronENST00000393405ENST00000501516SNX11chr17

46196548

+MED24chr17

38192407

-
5CDS-5UTRENST00000393405ENST00000479829SNX11chr17

46196548

+MED24chr17

38192407

-
Frame-shiftENST00000439357ENST00000394126SNX11chr17

46196548

+MED24chr17

38192407

-
5CDS-intronENST00000439357ENST00000356271SNX11chr17

46196548

+MED24chr17

38192407

-
5CDS-intronENST00000439357ENST00000394128SNX11chr17

46196548

+MED24chr17

38192407

-
5CDS-intronENST00000439357ENST00000394127SNX11chr17

46196548

+MED24chr17

38192407

-
5CDS-intronENST00000439357ENST00000501516SNX11chr17

46196548

+MED24chr17

38192407

-
5CDS-5UTRENST00000439357ENST00000479829SNX11chr17

46196548

+MED24chr17

38192407

-
Frame-shiftENST00000359238ENST00000394126SNX11chr17

46196548

+MED24chr17

38192407

-
5CDS-intronENST00000359238ENST00000356271SNX11chr17

46196548

+MED24chr17

38192407

-
5CDS-intronENST00000359238ENST00000394128SNX11chr17

46196548

+MED24chr17

38192407

-
5CDS-intronENST00000359238ENST00000394127SNX11chr17

46196548

+MED24chr17

38192407

-
5CDS-intronENST00000359238ENST00000501516SNX11chr17

46196548

+MED24chr17

38192407

-
5CDS-5UTRENST00000359238ENST00000479829SNX11chr17

46196548

+MED24chr17

38192407

-
Frame-shiftENST00000582104ENST00000394126SNX11chr17

46196548

+MED24chr17

38192407

-
5CDS-intronENST00000582104ENST00000356271SNX11chr17

46196548

+MED24chr17

38192407

-
5CDS-intronENST00000582104ENST00000394128SNX11chr17

46196548

+MED24chr17

38192407

-
5CDS-intronENST00000582104ENST00000394127SNX11chr17

46196548

+MED24chr17

38192407

-
5CDS-intronENST00000582104ENST00000501516SNX11chr17

46196548

+MED24chr17

38192407

-
5CDS-5UTRENST00000582104ENST00000479829SNX11chr17

46196548

+MED24chr17

38192407

-

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FusionProtFeatures for SNX11_MED24


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SNX11

Q9Y5W9

MED24

O75448

Phosphoinositide-binding protein involved in proteinsorting and membrane trafficking in endosomes.{ECO:0000269|PubMed:23615901}. Component of the Mediator complex, a coactivatorinvolved in the regulated transcription of nearly all RNApolymerase II-dependent genes. Mediator functions as a bridge toconvey information from gene-specific regulatory proteins to thebasal RNA polymerase II transcription machinery. Mediator isrecruited to promoters by direct interactions with regulatoryproteins and serves as a scaffold for the assembly of a functionalpreinitiation complex with RNA polymerase II and the generaltranscription factors. {ECO:0000269|PubMed:12218053,ECO:0000269|PubMed:16595664}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SNX11_MED24


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SNX11_MED24


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SNX11RABAC1, ARL6IP1, STK40, NPHP3, PML, AP3B1, BMPR1A, FGFR3, CHEK1, ZG16B, PYCRL, DCAF10, ORC3, CTU1, C18orf8, PLCG1, TNFRSF9, PNPLA4, MRPL16, SUSD3, AREG, GLIPR1L2, RAB34MED24MED10, MED9, MED29, MED19, MED28, MED26, CDK8, THRA, VDR, PPARA, PPARG, RXRA, MED1, HNF4A, ESR1, ESR2, MED30, BRD4, RPAP2, AR, PARP1, SMAD1, SMAD2, SMAD3, TRRAP, SREBF1, MED12, MED18, ZC3H13, TRIP4, OBFC1, QKI, TRA, MED14, GSK3B, TNFSF11, RPS6KA6, CTDP1, APP, MED13, MED8, MED16, MED17, MED4, MED11, MED21, MED22, PPP6R1, TFIP11, FBXW7, EPAS1, CDK19, MED7, CCNC, NR1I3, TCL1B, MED15, MED20, MED23, MED6, MED25, MED27, KPNB1, XRCC3, EMC2, PPP4R1, ZWINT, KIFAP3, MMGT1, SUCO, LMO2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SNX11_MED24


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SNX11_MED24


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource