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Fusion gene ID: 35240 |
FusionGeneSummary for SNX10_SEMA4A |
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Fusion gene information | Fusion gene name: SNX10_SEMA4A | Fusion gene ID: 35240 | Hgene | Tgene | Gene symbol | SNX10 | SEMA4A | Gene ID | 29887 | 64218 |
Gene name | sorting nexin 10 | semaphorin 4A | |
Synonyms | OPTB8 | CORD10|RP35|SEMAB|SEMB | |
Cytomap | 7p15.2 | 1q22 | |
Type of gene | protein-coding | protein-coding | |
Description | sorting nexin-10 | semaphorin-4Asema Bsema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4Asemaphorin-B | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | Q9Y5X0 | Q9H3S1 | |
Ensembl transtripts involved in fusion gene | ENST00000338523, ENST00000446848, ENST00000396376, ENST00000409367, ENST00000409838, ENST00000462993, | ENST00000355014, ENST00000368285, ENST00000368284, ENST00000368286, ENST00000368282, ENST00000487358, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 2 X 3=18 |
# samples | 1 | 4 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: SNX10 [Title/Abstract] AND SEMA4A [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DA982529 | SNX10 | chr7 | 26332580 | + | SEMA4A | chr1 | 156123451 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000338523 | ENST00000355014 | SNX10 | chr7 | 26332580 | + | SEMA4A | chr1 | 156123451 | + |
intron-5UTR | ENST00000338523 | ENST00000368285 | SNX10 | chr7 | 26332580 | + | SEMA4A | chr1 | 156123451 | + |
intron-5UTR | ENST00000338523 | ENST00000368284 | SNX10 | chr7 | 26332580 | + | SEMA4A | chr1 | 156123451 | + |
intron-5UTR | ENST00000338523 | ENST00000368286 | SNX10 | chr7 | 26332580 | + | SEMA4A | chr1 | 156123451 | + |
intron-intron | ENST00000338523 | ENST00000368282 | SNX10 | chr7 | 26332580 | + | SEMA4A | chr1 | 156123451 | + |
intron-intron | ENST00000338523 | ENST00000487358 | SNX10 | chr7 | 26332580 | + | SEMA4A | chr1 | 156123451 | + |
intron-intron | ENST00000446848 | ENST00000355014 | SNX10 | chr7 | 26332580 | + | SEMA4A | chr1 | 156123451 | + |
intron-5UTR | ENST00000446848 | ENST00000368285 | SNX10 | chr7 | 26332580 | + | SEMA4A | chr1 | 156123451 | + |
intron-5UTR | ENST00000446848 | ENST00000368284 | SNX10 | chr7 | 26332580 | + | SEMA4A | chr1 | 156123451 | + |
intron-5UTR | ENST00000446848 | ENST00000368286 | SNX10 | chr7 | 26332580 | + | SEMA4A | chr1 | 156123451 | + |
intron-intron | ENST00000446848 | ENST00000368282 | SNX10 | chr7 | 26332580 | + | SEMA4A | chr1 | 156123451 | + |
intron-intron | ENST00000446848 | ENST00000487358 | SNX10 | chr7 | 26332580 | + | SEMA4A | chr1 | 156123451 | + |
intron-intron | ENST00000396376 | ENST00000355014 | SNX10 | chr7 | 26332580 | + | SEMA4A | chr1 | 156123451 | + |
intron-5UTR | ENST00000396376 | ENST00000368285 | SNX10 | chr7 | 26332580 | + | SEMA4A | chr1 | 156123451 | + |
intron-5UTR | ENST00000396376 | ENST00000368284 | SNX10 | chr7 | 26332580 | + | SEMA4A | chr1 | 156123451 | + |
intron-5UTR | ENST00000396376 | ENST00000368286 | SNX10 | chr7 | 26332580 | + | SEMA4A | chr1 | 156123451 | + |
intron-intron | ENST00000396376 | ENST00000368282 | SNX10 | chr7 | 26332580 | + | SEMA4A | chr1 | 156123451 | + |
intron-intron | ENST00000396376 | ENST00000487358 | SNX10 | chr7 | 26332580 | + | SEMA4A | chr1 | 156123451 | + |
intron-intron | ENST00000409367 | ENST00000355014 | SNX10 | chr7 | 26332580 | + | SEMA4A | chr1 | 156123451 | + |
intron-5UTR | ENST00000409367 | ENST00000368285 | SNX10 | chr7 | 26332580 | + | SEMA4A | chr1 | 156123451 | + |
intron-5UTR | ENST00000409367 | ENST00000368284 | SNX10 | chr7 | 26332580 | + | SEMA4A | chr1 | 156123451 | + |
intron-5UTR | ENST00000409367 | ENST00000368286 | SNX10 | chr7 | 26332580 | + | SEMA4A | chr1 | 156123451 | + |
intron-intron | ENST00000409367 | ENST00000368282 | SNX10 | chr7 | 26332580 | + | SEMA4A | chr1 | 156123451 | + |
intron-intron | ENST00000409367 | ENST00000487358 | SNX10 | chr7 | 26332580 | + | SEMA4A | chr1 | 156123451 | + |
intron-intron | ENST00000409838 | ENST00000355014 | SNX10 | chr7 | 26332580 | + | SEMA4A | chr1 | 156123451 | + |
intron-5UTR | ENST00000409838 | ENST00000368285 | SNX10 | chr7 | 26332580 | + | SEMA4A | chr1 | 156123451 | + |
intron-5UTR | ENST00000409838 | ENST00000368284 | SNX10 | chr7 | 26332580 | + | SEMA4A | chr1 | 156123451 | + |
intron-5UTR | ENST00000409838 | ENST00000368286 | SNX10 | chr7 | 26332580 | + | SEMA4A | chr1 | 156123451 | + |
intron-intron | ENST00000409838 | ENST00000368282 | SNX10 | chr7 | 26332580 | + | SEMA4A | chr1 | 156123451 | + |
intron-intron | ENST00000409838 | ENST00000487358 | SNX10 | chr7 | 26332580 | + | SEMA4A | chr1 | 156123451 | + |
intron-intron | ENST00000462993 | ENST00000355014 | SNX10 | chr7 | 26332580 | + | SEMA4A | chr1 | 156123451 | + |
intron-5UTR | ENST00000462993 | ENST00000368285 | SNX10 | chr7 | 26332580 | + | SEMA4A | chr1 | 156123451 | + |
intron-5UTR | ENST00000462993 | ENST00000368284 | SNX10 | chr7 | 26332580 | + | SEMA4A | chr1 | 156123451 | + |
intron-5UTR | ENST00000462993 | ENST00000368286 | SNX10 | chr7 | 26332580 | + | SEMA4A | chr1 | 156123451 | + |
intron-intron | ENST00000462993 | ENST00000368282 | SNX10 | chr7 | 26332580 | + | SEMA4A | chr1 | 156123451 | + |
intron-intron | ENST00000462993 | ENST00000487358 | SNX10 | chr7 | 26332580 | + | SEMA4A | chr1 | 156123451 | + |
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FusionProtFeatures for SNX10_SEMA4A |
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Hgene | Tgene |
SNX10 | SEMA4A |
Probable phosphoinositide-binding protein involved inprotein sorting and membrane trafficking in endosomes. Plays arole in cilium biogenesis through regulation of the transport andthe localization of proteins to the cilium. Required for thelocalization to the cilium of V-ATPase subunit ATP6V1D andATP6V0D1, and RAB8A. Involved in osteoclast differentiation andtherefore bone resorption. {ECO:0000269|PubMed:17012226,ECO:0000269|PubMed:21844891, ECO:0000269|PubMed:22499339}. | Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 andPLXND1 that plays an important role in cell-cell signaling. Playsa role in priming antigen-specific T-cells, promotesdifferentiation of Th1 T-helper cells, and thereby contributes toadaptive immunity. Promotes phosphorylation of TIMD2. Inhibitsangiogenesis. Promotes axon growth cone collapse. Inhibits axonalextension by providing local signals to specify territoriesinaccessible for growing axons (By similarity).{ECO:0000250|UniProtKB:Q62178}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SNX10_SEMA4A |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SNX10_SEMA4A |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SNX10_SEMA4A |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SNX10_SEMA4A |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SNX10 | C3554478 | OSTEOPETROSIS, AUTOSOMAL RECESSIVE 8 | 2 | UNIPROT |
Tgene | SEMA4A | C1853214 | RETINITIS PIGMENTOSA 35 | 1 | CTD_human;UNIPROT |