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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35240

FusionGeneSummary for SNX10_SEMA4A

check button Fusion gene summary
Fusion gene informationFusion gene name: SNX10_SEMA4A
Fusion gene ID: 35240
HgeneTgene
Gene symbol

SNX10

SEMA4A

Gene ID

29887

64218

Gene namesorting nexin 10semaphorin 4A
SynonymsOPTB8CORD10|RP35|SEMAB|SEMB
Cytomap

7p15.2

1q22

Type of geneprotein-codingprotein-coding
Descriptionsorting nexin-10semaphorin-4Asema Bsema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4Asemaphorin-B
Modification date2018052220180523
UniProtAcc

Q9Y5X0

Q9H3S1

Ensembl transtripts involved in fusion geneENST00000338523, ENST00000446848, 
ENST00000396376, ENST00000409367, 
ENST00000409838, ENST00000462993, 
ENST00000355014, ENST00000368285, 
ENST00000368284, ENST00000368286, 
ENST00000368282, ENST00000487358, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 2 X 3=18
# samples 14
** MAII scorelog2(1/1*10)=3.32192809488736log2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SNX10 [Title/Abstract] AND SEMA4A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA982529SNX10chr7

26332580

+SEMA4Achr1

156123451

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000338523ENST00000355014SNX10chr7

26332580

+SEMA4Achr1

156123451

+
intron-5UTRENST00000338523ENST00000368285SNX10chr7

26332580

+SEMA4Achr1

156123451

+
intron-5UTRENST00000338523ENST00000368284SNX10chr7

26332580

+SEMA4Achr1

156123451

+
intron-5UTRENST00000338523ENST00000368286SNX10chr7

26332580

+SEMA4Achr1

156123451

+
intron-intronENST00000338523ENST00000368282SNX10chr7

26332580

+SEMA4Achr1

156123451

+
intron-intronENST00000338523ENST00000487358SNX10chr7

26332580

+SEMA4Achr1

156123451

+
intron-intronENST00000446848ENST00000355014SNX10chr7

26332580

+SEMA4Achr1

156123451

+
intron-5UTRENST00000446848ENST00000368285SNX10chr7

26332580

+SEMA4Achr1

156123451

+
intron-5UTRENST00000446848ENST00000368284SNX10chr7

26332580

+SEMA4Achr1

156123451

+
intron-5UTRENST00000446848ENST00000368286SNX10chr7

26332580

+SEMA4Achr1

156123451

+
intron-intronENST00000446848ENST00000368282SNX10chr7

26332580

+SEMA4Achr1

156123451

+
intron-intronENST00000446848ENST00000487358SNX10chr7

26332580

+SEMA4Achr1

156123451

+
intron-intronENST00000396376ENST00000355014SNX10chr7

26332580

+SEMA4Achr1

156123451

+
intron-5UTRENST00000396376ENST00000368285SNX10chr7

26332580

+SEMA4Achr1

156123451

+
intron-5UTRENST00000396376ENST00000368284SNX10chr7

26332580

+SEMA4Achr1

156123451

+
intron-5UTRENST00000396376ENST00000368286SNX10chr7

26332580

+SEMA4Achr1

156123451

+
intron-intronENST00000396376ENST00000368282SNX10chr7

26332580

+SEMA4Achr1

156123451

+
intron-intronENST00000396376ENST00000487358SNX10chr7

26332580

+SEMA4Achr1

156123451

+
intron-intronENST00000409367ENST00000355014SNX10chr7

26332580

+SEMA4Achr1

156123451

+
intron-5UTRENST00000409367ENST00000368285SNX10chr7

26332580

+SEMA4Achr1

156123451

+
intron-5UTRENST00000409367ENST00000368284SNX10chr7

26332580

+SEMA4Achr1

156123451

+
intron-5UTRENST00000409367ENST00000368286SNX10chr7

26332580

+SEMA4Achr1

156123451

+
intron-intronENST00000409367ENST00000368282SNX10chr7

26332580

+SEMA4Achr1

156123451

+
intron-intronENST00000409367ENST00000487358SNX10chr7

26332580

+SEMA4Achr1

156123451

+
intron-intronENST00000409838ENST00000355014SNX10chr7

26332580

+SEMA4Achr1

156123451

+
intron-5UTRENST00000409838ENST00000368285SNX10chr7

26332580

+SEMA4Achr1

156123451

+
intron-5UTRENST00000409838ENST00000368284SNX10chr7

26332580

+SEMA4Achr1

156123451

+
intron-5UTRENST00000409838ENST00000368286SNX10chr7

26332580

+SEMA4Achr1

156123451

+
intron-intronENST00000409838ENST00000368282SNX10chr7

26332580

+SEMA4Achr1

156123451

+
intron-intronENST00000409838ENST00000487358SNX10chr7

26332580

+SEMA4Achr1

156123451

+
intron-intronENST00000462993ENST00000355014SNX10chr7

26332580

+SEMA4Achr1

156123451

+
intron-5UTRENST00000462993ENST00000368285SNX10chr7

26332580

+SEMA4Achr1

156123451

+
intron-5UTRENST00000462993ENST00000368284SNX10chr7

26332580

+SEMA4Achr1

156123451

+
intron-5UTRENST00000462993ENST00000368286SNX10chr7

26332580

+SEMA4Achr1

156123451

+
intron-intronENST00000462993ENST00000368282SNX10chr7

26332580

+SEMA4Achr1

156123451

+
intron-intronENST00000462993ENST00000487358SNX10chr7

26332580

+SEMA4Achr1

156123451

+

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FusionProtFeatures for SNX10_SEMA4A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SNX10

Q9Y5X0

SEMA4A

Q9H3S1

Probable phosphoinositide-binding protein involved inprotein sorting and membrane trafficking in endosomes. Plays arole in cilium biogenesis through regulation of the transport andthe localization of proteins to the cilium. Required for thelocalization to the cilium of V-ATPase subunit ATP6V1D andATP6V0D1, and RAB8A. Involved in osteoclast differentiation andtherefore bone resorption. {ECO:0000269|PubMed:17012226,ECO:0000269|PubMed:21844891, ECO:0000269|PubMed:22499339}. Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 andPLXND1 that plays an important role in cell-cell signaling. Playsa role in priming antigen-specific T-cells, promotesdifferentiation of Th1 T-helper cells, and thereby contributes toadaptive immunity. Promotes phosphorylation of TIMD2. Inhibitsangiogenesis. Promotes axon growth cone collapse. Inhibits axonalextension by providing local signals to specify territoriesinaccessible for growing axons (By similarity).{ECO:0000250|UniProtKB:Q62178}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SNX10_SEMA4A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SNX10_SEMA4A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SNX10_SEMA4A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SNX10_SEMA4A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSNX10C3554478OSTEOPETROSIS, AUTOSOMAL RECESSIVE 82UNIPROT
TgeneSEMA4AC1853214RETINITIS PIGMENTOSA 351CTD_human;UNIPROT