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Fusion gene ID: 35239 |
FusionGeneSummary for SNW1_SNW1 |
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Fusion gene information | Fusion gene name: SNW1_SNW1 | Fusion gene ID: 35239 | Hgene | Tgene | Gene symbol | SNW1 | SNW1 | Gene ID | 22938 | 22938 |
Gene name | SNW domain containing 1 | SNW domain containing 1 | |
Synonyms | Bx42|FUN20|NCOA-62|PRPF45|Prp45|SKIIP|SKIP|SKIP1 | Bx42|FUN20|NCOA-62|PRPF45|Prp45|SKIIP|SKIP|SKIP1 | |
Cytomap | 14q24.3 | 14q24.3 | |
Type of gene | protein-coding | protein-coding | |
Description | SNW domain-containing protein 1SKI interacting proteinhomolog of Drosophila BX42nuclear protein SkiPnuclear receptor coactivator NCoA-62nuclear receptor coactivator, 62-kDski-interacting protein | SNW domain-containing protein 1SKI interacting proteinhomolog of Drosophila BX42nuclear protein SkiPnuclear receptor coactivator NCoA-62nuclear receptor coactivator, 62-kDski-interacting protein | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q13573 | Q13573 | |
Ensembl transtripts involved in fusion gene | ENST00000261531, ENST00000554775, ENST00000555761, | ENST00000261531, ENST00000554775, ENST00000555761, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 15 X 4 X 12=720 |
# samples | 1 | 16 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(16/720*10)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SNW1 [Title/Abstract] AND SNW1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | SNW1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 14985122 |
Hgene | SNW1 | GO:0000398 | mRNA splicing, via spliceosome | 15194481|28076346 |
Hgene | SNW1 | GO:0030511 | positive regulation of transforming growth factor beta receptor signaling pathway | 11278756 |
Hgene | SNW1 | GO:0043923 | positive regulation by host of viral transcription | 15905409 |
Hgene | SNW1 | GO:0045892 | negative regulation of transcription, DNA-templated | 10713164|15878163 |
Hgene | SNW1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 14985122|19934264 |
Hgene | SNW1 | GO:0048384 | retinoic acid receptor signaling pathway | 19934264 |
Hgene | SNW1 | GO:0048385 | regulation of retinoic acid receptor signaling pathway | 14985122 |
Hgene | SNW1 | GO:0070562 | regulation of vitamin D receptor signaling pathway | 14985122 |
Hgene | SNW1 | GO:0070564 | positive regulation of vitamin D receptor signaling pathway | 9632709|11514567 |
Hgene | SNW1 | GO:0071300 | cellular response to retinoic acid | 19934264 |
Tgene | SNW1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 14985122 |
Tgene | SNW1 | GO:0000398 | mRNA splicing, via spliceosome | 15194481|28076346 |
Tgene | SNW1 | GO:0030511 | positive regulation of transforming growth factor beta receptor signaling pathway | 11278756 |
Tgene | SNW1 | GO:0043923 | positive regulation by host of viral transcription | 15905409 |
Tgene | SNW1 | GO:0045892 | negative regulation of transcription, DNA-templated | 10713164|15878163 |
Tgene | SNW1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 14985122|19934264 |
Tgene | SNW1 | GO:0048384 | retinoic acid receptor signaling pathway | 19934264 |
Tgene | SNW1 | GO:0048385 | regulation of retinoic acid receptor signaling pathway | 14985122 |
Tgene | SNW1 | GO:0070562 | regulation of vitamin D receptor signaling pathway | 14985122 |
Tgene | SNW1 | GO:0070564 | positive regulation of vitamin D receptor signaling pathway | 9632709|11514567 |
Tgene | SNW1 | GO:0071300 | cellular response to retinoic acid | 19934264 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BM450257 | SNW1 | chr14 | 78187128 | + | SNW1 | chr14 | 78184880 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000261531 | ENST00000261531 | SNW1 | chr14 | 78187128 | + | SNW1 | chr14 | 78184880 | - |
intron-intron | ENST00000261531 | ENST00000554775 | SNW1 | chr14 | 78187128 | + | SNW1 | chr14 | 78184880 | - |
intron-intron | ENST00000261531 | ENST00000555761 | SNW1 | chr14 | 78187128 | + | SNW1 | chr14 | 78184880 | - |
intron-intron | ENST00000554775 | ENST00000261531 | SNW1 | chr14 | 78187128 | + | SNW1 | chr14 | 78184880 | - |
intron-intron | ENST00000554775 | ENST00000554775 | SNW1 | chr14 | 78187128 | + | SNW1 | chr14 | 78184880 | - |
intron-intron | ENST00000554775 | ENST00000555761 | SNW1 | chr14 | 78187128 | + | SNW1 | chr14 | 78184880 | - |
intron-intron | ENST00000555761 | ENST00000261531 | SNW1 | chr14 | 78187128 | + | SNW1 | chr14 | 78184880 | - |
intron-intron | ENST00000555761 | ENST00000554775 | SNW1 | chr14 | 78187128 | + | SNW1 | chr14 | 78184880 | - |
intron-intron | ENST00000555761 | ENST00000555761 | SNW1 | chr14 | 78187128 | + | SNW1 | chr14 | 78184880 | - |
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FusionProtFeatures for SNW1_SNW1 |
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Hgene | Tgene |
SNW1 | SNW1 |
Involved in pre-mRNA splicing as component of thespliceosome (PubMed:11991638, PubMed:28502770, PubMed:28076346).Is required in the specific splicing of CDKN1A pre-mRNA; thefunction probably involves the recruitment of U2AF2 to the mRNA.Is proposed to recruit PPIL1 to the spliceosome. May be involvedin cyclin-D1/CCND1 mRNA stability through the SNARP complex whichassociates with both the 3'end of the CCND1 gene and its mRNA.Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediatedtranscriptional repression, and retinoid-X receptor (RXR)- andvitamin D receptor (VDR)-dependent gene transcription in a cellline-specific manner probably involving coactivators NCOA1 andGRIP1. Is involved in NOTCH1-mediated transcriptional activation.Binds to multimerized forms of Notch intracellular domain (NICD)and is proposed to recruit transcriptional coactivators such asMAML1 to form an intermediate preactivation complex whichassociates with DNA-bound CBF-1/RBPJ to form a transcriptionalactivation complex by releasing SNW1 and redundant NOTCH1 NICD.{ECO:0000269|PubMed:10644367, ECO:0000269|PubMed:11278756,ECO:0000269|PubMed:11371506, ECO:0000269|PubMed:11514567,ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12840015,ECO:0000269|PubMed:14985122, ECO:0000269|PubMed:15194481,ECO:0000269|PubMed:15905409, ECO:0000269|PubMed:18794151,ECO:0000269|PubMed:19818711, ECO:0000269|PubMed:21245387,ECO:0000269|PubMed:21460037, ECO:0000269|PubMed:28076346,ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:9632709}. (Microbial infection) Is recruited by HIV-1 Tat toTat:P-TEFb:TAR RNA complexes and is involved in Tat transcriptionby recruitment of MYC, MEN1 and TRRAP to the HIV promoter.{ECO:0000269|PubMed:15905409, ECO:0000269|PubMed:19818711}. (Microbial infection) Proposed to be involved intranscriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressedpromoters. {ECO:0000269|PubMed:10644367}. | Involved in pre-mRNA splicing as component of thespliceosome (PubMed:11991638, PubMed:28502770, PubMed:28076346).Is required in the specific splicing of CDKN1A pre-mRNA; thefunction probably involves the recruitment of U2AF2 to the mRNA.Is proposed to recruit PPIL1 to the spliceosome. May be involvedin cyclin-D1/CCND1 mRNA stability through the SNARP complex whichassociates with both the 3'end of the CCND1 gene and its mRNA.Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediatedtranscriptional repression, and retinoid-X receptor (RXR)- andvitamin D receptor (VDR)-dependent gene transcription in a cellline-specific manner probably involving coactivators NCOA1 andGRIP1. Is involved in NOTCH1-mediated transcriptional activation.Binds to multimerized forms of Notch intracellular domain (NICD)and is proposed to recruit transcriptional coactivators such asMAML1 to form an intermediate preactivation complex whichassociates with DNA-bound CBF-1/RBPJ to form a transcriptionalactivation complex by releasing SNW1 and redundant NOTCH1 NICD.{ECO:0000269|PubMed:10644367, ECO:0000269|PubMed:11278756,ECO:0000269|PubMed:11371506, ECO:0000269|PubMed:11514567,ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12840015,ECO:0000269|PubMed:14985122, ECO:0000269|PubMed:15194481,ECO:0000269|PubMed:15905409, ECO:0000269|PubMed:18794151,ECO:0000269|PubMed:19818711, ECO:0000269|PubMed:21245387,ECO:0000269|PubMed:21460037, ECO:0000269|PubMed:28076346,ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:9632709}. (Microbial infection) Is recruited by HIV-1 Tat toTat:P-TEFb:TAR RNA complexes and is involved in Tat transcriptionby recruitment of MYC, MEN1 and TRRAP to the HIV promoter.{ECO:0000269|PubMed:15905409, ECO:0000269|PubMed:19818711}. (Microbial infection) Proposed to be involved intranscriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressedpromoters. {ECO:0000269|PubMed:10644367}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SNW1_SNW1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SNW1_SNW1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SNW1_SNW1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SNW1_SNW1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |