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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35214

FusionGeneSummary for SNRPN_RREB1

check button Fusion gene summary
Fusion gene informationFusion gene name: SNRPN_RREB1
Fusion gene ID: 35214
HgeneTgene
Gene symbol

SNRPN

RREB1

Gene ID

6638

6239

Gene namesmall nuclear ribonucleoprotein polypeptide Nras responsive element binding protein 1
SynonymsHCERN3|PWCR|RT-LI|SM-D|SMN|SNRNP-N|SNURF-SNRPN|sm-NFINB|HNT|LZ321|RREB-1|Zep-1
Cytomap

15q11.2

6p24.3

Type of geneprotein-codingprotein-coding
Descriptionsmall nuclear ribonucleoprotein-associated protein NSM protein Nsm protein Dtissue-specific splicing proteinras-responsive element-binding protein 1DNA-binding proteinfinger protein in nuclear bodieshindsight homolograf-responsive zinc finger protein LZ321zinc finger motif enhancer-binding protein 1
Modification date2018052320180523
UniProtAcc

P63162

Q92766

Ensembl transtripts involved in fusion geneENST00000400098, ENST00000400100, 
ENST00000400097, ENST00000553597, 
ENST00000390687, ENST00000346403, 
ENST00000554227, ENST00000577565, 
ENST00000444203, 
ENST00000379933, 
ENST00000379938, ENST00000334984, 
ENST00000349384, 
Fusion gene scores* DoF score10 X 13 X 2=2609 X 7 X 4=252
# samples 149
** MAII scorelog2(14/260*10)=-0.893084796083488
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/252*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SNRPN [Title/Abstract] AND RREB1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRREB1

GO:0045944

positive regulation of transcription by RNA polymerase II

8816445


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1T19462SNRPNchr15

25223436

+RREB1chr6

7108259

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000400098ENST00000379933SNRPNchr15

25223436

+RREB1chr6

7108259

+
5CDS-5UTRENST00000400098ENST00000379938SNRPNchr15

25223436

+RREB1chr6

7108259

+
5CDS-5UTRENST00000400098ENST00000334984SNRPNchr15

25223436

+RREB1chr6

7108259

+
5CDS-5UTRENST00000400098ENST00000349384SNRPNchr15

25223436

+RREB1chr6

7108259

+
5CDS-intronENST00000400100ENST00000379933SNRPNchr15

25223436

+RREB1chr6

7108259

+
5CDS-5UTRENST00000400100ENST00000379938SNRPNchr15

25223436

+RREB1chr6

7108259

+
5CDS-5UTRENST00000400100ENST00000334984SNRPNchr15

25223436

+RREB1chr6

7108259

+
5CDS-5UTRENST00000400100ENST00000349384SNRPNchr15

25223436

+RREB1chr6

7108259

+
5CDS-intronENST00000400097ENST00000379933SNRPNchr15

25223436

+RREB1chr6

7108259

+
5CDS-5UTRENST00000400097ENST00000379938SNRPNchr15

25223436

+RREB1chr6

7108259

+
5CDS-5UTRENST00000400097ENST00000334984SNRPNchr15

25223436

+RREB1chr6

7108259

+
5CDS-5UTRENST00000400097ENST00000349384SNRPNchr15

25223436

+RREB1chr6

7108259

+
intron-intronENST00000553597ENST00000379933SNRPNchr15

25223436

+RREB1chr6

7108259

+
intron-5UTRENST00000553597ENST00000379938SNRPNchr15

25223436

+RREB1chr6

7108259

+
intron-5UTRENST00000553597ENST00000334984SNRPNchr15

25223436

+RREB1chr6

7108259

+
intron-5UTRENST00000553597ENST00000349384SNRPNchr15

25223436

+RREB1chr6

7108259

+
5CDS-intronENST00000390687ENST00000379933SNRPNchr15

25223436

+RREB1chr6

7108259

+
5CDS-5UTRENST00000390687ENST00000379938SNRPNchr15

25223436

+RREB1chr6

7108259

+
5CDS-5UTRENST00000390687ENST00000334984SNRPNchr15

25223436

+RREB1chr6

7108259

+
5CDS-5UTRENST00000390687ENST00000349384SNRPNchr15

25223436

+RREB1chr6

7108259

+
5CDS-intronENST00000346403ENST00000379933SNRPNchr15

25223436

+RREB1chr6

7108259

+
5CDS-5UTRENST00000346403ENST00000379938SNRPNchr15

25223436

+RREB1chr6

7108259

+
5CDS-5UTRENST00000346403ENST00000334984SNRPNchr15

25223436

+RREB1chr6

7108259

+
5CDS-5UTRENST00000346403ENST00000349384SNRPNchr15

25223436

+RREB1chr6

7108259

+
5CDS-intronENST00000554227ENST00000379933SNRPNchr15

25223436

+RREB1chr6

7108259

+
5CDS-5UTRENST00000554227ENST00000379938SNRPNchr15

25223436

+RREB1chr6

7108259

+
5CDS-5UTRENST00000554227ENST00000334984SNRPNchr15

25223436

+RREB1chr6

7108259

+
5CDS-5UTRENST00000554227ENST00000349384SNRPNchr15

25223436

+RREB1chr6

7108259

+
5CDS-intronENST00000577565ENST00000379933SNRPNchr15

25223436

+RREB1chr6

7108259

+
5CDS-5UTRENST00000577565ENST00000379938SNRPNchr15

25223436

+RREB1chr6

7108259

+
5CDS-5UTRENST00000577565ENST00000334984SNRPNchr15

25223436

+RREB1chr6

7108259

+
5CDS-5UTRENST00000577565ENST00000349384SNRPNchr15

25223436

+RREB1chr6

7108259

+
5CDS-intronENST00000444203ENST00000379933SNRPNchr15

25223436

+RREB1chr6

7108259

+
5CDS-5UTRENST00000444203ENST00000379938SNRPNchr15

25223436

+RREB1chr6

7108259

+
5CDS-5UTRENST00000444203ENST00000334984SNRPNchr15

25223436

+RREB1chr6

7108259

+
5CDS-5UTRENST00000444203ENST00000349384SNRPNchr15

25223436

+RREB1chr6

7108259

+

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FusionProtFeatures for SNRPN_RREB1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SNRPN

P63162

RREB1

Q92766

May be involved in tissue-specific alternative RNAprocessing events.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SNRPN_RREB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SNRPN_RREB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SNRPN_RREB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SNRPN_RREB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource