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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35171

FusionGeneSummary for SNRNP25_COPS4

check button Fusion gene summary
Fusion gene informationFusion gene name: SNRNP25_COPS4
Fusion gene ID: 35171
HgeneTgene
Gene symbol

SNRNP25

COPS4

Gene ID

79622

51138

Gene namesmall nuclear ribonucleoprotein U11/U12 subunit 25COP9 signalosome subunit 4
SynonymsC16orf33CSN4|SGN4
Cytomap

16p13.3

4q21.22

Type of geneprotein-codingprotein-coding
DescriptionU11/U12 small nuclear ribonucleoprotein 25 kDa proteinU11/U12 snRNP 25 kDa proteinU11/U12 snRNP 25Kminus-99 proteinsmall nuclear ribonucleoprotein 25kDa (U11/U12)small nuclear ribonucleoprotein, U11/U12 25kDa subunitCOP9 signalosome complex subunit 4COP9 constitutive photomorphogenic homolog subunit 4COP9 constitutive photomorphogenic-like protein subunit 4JAB1-containing signalosome subunit 4signalosome subunit 4testis tissue sperm-binding protein Li 42a
Modification date2018051920180523
UniProtAcc

Q9BV90

Q9BT78

Ensembl transtripts involved in fusion geneENST00000383018, ENST00000493672, 
ENST00000509093, ENST00000264389, 
ENST00000503682, ENST00000511653, 
ENST00000511708, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 3 X 3=27
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SNRNP25 [Title/Abstract] AND COPS4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCOPS4

GO:0000338

protein deneddylation

19141280


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BP394128SNRNP25chr16

107439

+COPS4chr4

83996775

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000383018ENST00000509093SNRNP25chr16

107439

+COPS4chr4

83996775

+
3UTR-3UTRENST00000383018ENST00000264389SNRNP25chr16

107439

+COPS4chr4

83996775

+
3UTR-3UTRENST00000383018ENST00000503682SNRNP25chr16

107439

+COPS4chr4

83996775

+
3UTR-3UTRENST00000383018ENST00000511653SNRNP25chr16

107439

+COPS4chr4

83996775

+
3UTR-intronENST00000383018ENST00000511708SNRNP25chr16

107439

+COPS4chr4

83996775

+
intron-3UTRENST00000493672ENST00000509093SNRNP25chr16

107439

+COPS4chr4

83996775

+
intron-3UTRENST00000493672ENST00000264389SNRNP25chr16

107439

+COPS4chr4

83996775

+
intron-3UTRENST00000493672ENST00000503682SNRNP25chr16

107439

+COPS4chr4

83996775

+
intron-3UTRENST00000493672ENST00000511653SNRNP25chr16

107439

+COPS4chr4

83996775

+
intron-intronENST00000493672ENST00000511708SNRNP25chr16

107439

+COPS4chr4

83996775

+

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FusionProtFeatures for SNRNP25_COPS4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SNRNP25

Q9BV90

COPS4

Q9BT78

Component of the COP9 signalosome complex (CSN), acomplex involved in various cellular and developmental processes.The CSN complex is an essential regulator of the ubiquitin (Ubl)conjugation pathway by mediating the deneddylation of the cullinsubunits of SCF-type E3 ligase complexes, leading to decrease theUbl ligase activity of SCF-type complexes such as SCF, CSA orDDB2. Also involved in the deneddylation of non-cullin subunitssuch as STON2. The complex is also involved in phosphorylation ofp53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP andSNAPIN, possibly via its association with CK2 and PKD kinases.CSN-dependent phosphorylation of TP53 and JUN promotes andprotects degradation by the Ubl system, respectively.{ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588,ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143,ECO:0000269|PubMed:21102408, ECO:0000269|PubMed:9535219}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SNRNP25_COPS4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SNRNP25_COPS4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SNRNP25_COPS4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SNRNP25_COPS4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource