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Fusion gene ID: 35140 |
FusionGeneSummary for SNHG3_PPP1R3B |
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Fusion gene information | Fusion gene name: SNHG3_PPP1R3B | Fusion gene ID: 35140 | Hgene | Tgene | Gene symbol | SNHG3 | PPP1R3B | Gene ID | 8420 | 79660 |
Gene name | small nucleolar RNA host gene 3 | protein phosphatase 1 regulatory subunit 3B | |
Synonyms | NCRNA00014|RNU17C|RNU17D|U17HG|U17HG-A|U17HG-AB | GL|PPP1R4|PTG | |
Cytomap | 1p35.3 | 8p23.1 | |
Type of gene | ncRNA | protein-coding | |
Description | U17 small nucleolar RNA hostsmall nucleolar RNA host gene (non-protein coding) 3small nucleolar RNA host gene 3 (non-protein coding) | protein phosphatase 1 regulatory subunit 3BPP1 subunit R4hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GLhepatic glycogen-targeting subunit, G(L)protein phosphatase 1 regulatory subunit 4protein phosphatase 1, regulatory (inhibi | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q86XI6 | ||
Ensembl transtripts involved in fusion gene | ENST00000364938, | ENST00000310455, ENST00000519699, | |
Fusion gene scores | * DoF score | 15 X 7 X 4=420 | 1 X 1 X 1=1 |
# samples | 15 | 1 | |
** MAII score | log2(15/420*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: SNHG3 [Title/Abstract] AND PPP1R3B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | PPP1R3B | GO:0005981 | regulation of glycogen catabolic process | 22225877 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BM474506 | SNHG3 | chr1 | 28835849 | + | PPP1R3B | chr8 | 8997180 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000364938 | ENST00000310455 | SNHG3 | chr1 | 28835849 | + | PPP1R3B | chr8 | 8997180 | - |
intron-3UTR | ENST00000364938 | ENST00000519699 | SNHG3 | chr1 | 28835849 | + | PPP1R3B | chr8 | 8997180 | - |
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FusionProtFeatures for SNHG3_PPP1R3B |
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Hgene | Tgene |
SNHG3 | PPP1R3B |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Acts as a glycogen-targeting subunit for phosphatasePP1. Facilitates interaction of the PP1 with enzymes of theglycogen metabolism and regulates its activity. Suppresses therate at which PP1 dephosphorylates (inactivates) glycogenphosphorylase and enhances the rate at which it activates glycogensynthase and therefore limits glycogen breakdown. Its activity isinhibited by PYGL, resulting in inhibition of the glycogensynthase and glycogen phosphorylase phosphatase activities of PP1.Dramatically increases basal and insulin-stimulated glycogensynthesis upon overexpression in hepatocytes (By similarity).{ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SNHG3_PPP1R3B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SNHG3_PPP1R3B |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SNHG3_PPP1R3B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SNHG3_PPP1R3B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | PPP1R3B | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |