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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35138

FusionGeneSummary for SNHG3_PARL

check button Fusion gene summary
Fusion gene informationFusion gene name: SNHG3_PARL
Fusion gene ID: 35138
HgeneTgene
Gene symbol

SNHG3

PARL

Gene ID

8420

55486

Gene namesmall nucleolar RNA host gene 3presenilin associated rhomboid like
SynonymsNCRNA00014|RNU17C|RNU17D|U17HG|U17HG-A|U17HG-ABPRO2207|PSARL|PSARL1|PSENIP2|RHBDS1
Cytomap

1p35.3

3q27.1

Type of genencRNAprotein-coding
DescriptionU17 small nucleolar RNA hostsmall nucleolar RNA host gene (non-protein coding) 3small nucleolar RNA host gene 3 (non-protein coding)presenilins-associated rhomboid-like protein, mitochondrialmitochondrial intramembrane-cleaving protease PARLrhomboid 7 homolog 1
Modification date2018051920180522
UniProtAcc

Q9H300

Ensembl transtripts involved in fusion geneENST00000364938, ENST00000317096, 
ENST00000311101, ENST00000435888, 
Fusion gene scores* DoF score15 X 7 X 4=4204 X 4 X 3=48
# samples 154
** MAII scorelog2(15/420*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SNHG3 [Title/Abstract] AND PARL [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CB145466SNHG3chr1

28834672

+PARLchr3

183580590

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000364938ENST00000317096SNHG3chr1

28834672

+PARLchr3

183580590

-
intron-3CDSENST00000364938ENST00000311101SNHG3chr1

28834672

+PARLchr3

183580590

-
intron-3CDSENST00000364938ENST00000435888SNHG3chr1

28834672

+PARLchr3

183580590

-

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FusionProtFeatures for SNHG3_PARL


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SNHG3

PARL

Q9H300

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Required for the control of apoptosis during postnatalgrowth. Essential for proteolytic processing of an antiapoptoticform of OPA1 which prevents the release of mitochondrialcytochrome c in response to intrinsic apoptoptic signals (Bysimilarity). Promotes changes in mitochondria morphology regulatedby phosphorylation of P-beta domain. {ECO:0000250,ECO:0000269|PubMed:14732705, ECO:0000269|PubMed:17116872}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SNHG3_PARL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SNHG3_PARL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SNHG3UTP23, TRIM25PARLPINK1, BSG, ENAH, EEF2KMT, CA10, HIST2H2AB, CHST10, RBFOX2, ERGIC3, C1orf85, SLC7A1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SNHG3_PARL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SNHG3_PARL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePARLC0036341Schizophrenia1PSYGENET