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Fusion gene ID: 35134 |
FusionGeneSummary for SNHG3_GNB1 |
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Fusion gene information | Fusion gene name: SNHG3_GNB1 | Fusion gene ID: 35134 | Hgene | Tgene | Gene symbol | SNHG3 | GNB1 | Gene ID | 8420 | 2782 |
Gene name | small nucleolar RNA host gene 3 | G protein subunit beta 1 | |
Synonyms | NCRNA00014|RNU17C|RNU17D|U17HG|U17HG-A|U17HG-AB | MRD42 | |
Cytomap | 1p35.3 | 1p36.33 | |
Type of gene | ncRNA | protein-coding | |
Description | U17 small nucleolar RNA hostsmall nucleolar RNA host gene (non-protein coding) 3small nucleolar RNA host gene 3 (non-protein coding) | guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1beta subunit, signal-transducing proteins GS/GIguanine nucleotide binding protein (G protein), beta polypeptide 1testicular tissue protein Li 72transducin beta chain 1 | |
Modification date | 20180519 | 20180522 | |
UniProtAcc | P62873 | ||
Ensembl transtripts involved in fusion gene | ENST00000364938, | ENST00000378609, ENST00000472614, | |
Fusion gene scores | * DoF score | 15 X 7 X 4=420 | 17 X 20 X 9=3060 |
# samples | 15 | 26 | |
** MAII score | log2(15/420*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(26/3060*10)=-3.55694812455156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SNHG3 [Title/Abstract] AND GNB1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DA645137 | SNHG3 | chr1 | 28834672 | + | GNB1 | chr1 | 1770678 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000364938 | ENST00000378609 | SNHG3 | chr1 | 28834672 | + | GNB1 | chr1 | 1770678 | - |
intron-5UTR | ENST00000364938 | ENST00000472614 | SNHG3 | chr1 | 28834672 | + | GNB1 | chr1 | 1770678 | - |
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FusionProtFeatures for SNHG3_GNB1 |
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Hgene | Tgene |
SNHG3 | GNB1 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Guanine nucleotide-binding proteins (G proteins) areinvolved as a modulator or transducer in various transmembranesignaling systems. The beta and gamma chains are required for theGTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SNHG3_GNB1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SNHG3_GNB1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SNHG3 | UTP23, TRIM25 | GNB1 | ARHGEF18, KCNJ3, GNG13, GNG10, GNG4, GNG11, GNGT1, GNGT2, GNG3, GNG5, GNG7, HDAC5, HDAC4, DISC1, ELAVL1, UBQLN1, PLEKHG2, WDR26, GNB2L1, GNG2, RGS6, GNG12, RADIL, RAP1A, PAK1, ATXN10, RASD1, MCF2, KALRN, MCF2L, ADRBK1, PDCL, CCT5, RASD2, SPAG1, BTK, ADRB2, AVPR2, ADRA2A, MRGPRX1, TBXA2R, GNAS, ARRB1, NR3C1, GNAI1, GNAI2, GNAI3, AKT1, ATP6V1B1, GNA11, ESR1, VCAM1, NCF2, MTNR1A, SVIL, PAN2, NOL11, AFP, EPHA7, CYFIP1, GNG8, MTOR, RICTOR, RPTOR, CCDC8, ABCE1, PIK3R5, PIK3CG, COX4I1, GNAQ, NTRK1, FYN, PTK2, CEP128, XPO1, PDLIM7, SYNPO, CUL4A, GLI1, ESRRB, PIK3R1, PIK3CA, DUSP9, COX15, HSD17B10, SOD1, TRIM25, AKT2, PIK3CB |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SNHG3_GNB1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SNHG3_GNB1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | GNB1 | C0003469 | Anxiety Disorders | 1 | CTD_human |
Tgene | GNB1 | C0011581 | Depressive disorder | 1 | CTD_human |