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Fusion gene ID: 35131 |
FusionGeneSummary for SNHG3_CUL2 |
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Fusion gene information | Fusion gene name: SNHG3_CUL2 | Fusion gene ID: 35131 | Hgene | Tgene | Gene symbol | SNHG3 | CUL2 | Gene ID | 8420 | 8453 |
Gene name | small nucleolar RNA host gene 3 | cullin 2 | |
Synonyms | NCRNA00014|RNU17C|RNU17D|U17HG|U17HG-A|U17HG-AB | - | |
Cytomap | 1p35.3 | 10p11.21 | |
Type of gene | ncRNA | protein-coding | |
Description | U17 small nucleolar RNA hostsmall nucleolar RNA host gene (non-protein coding) 3small nucleolar RNA host gene 3 (non-protein coding) | cullin-2CUL-2testis secretory sperm-binding protein Li 238E | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q13617 | ||
Ensembl transtripts involved in fusion gene | ENST00000364938, | ENST00000374746, ENST00000374748, ENST00000374749, ENST00000374751, ENST00000602371, ENST00000374742, ENST00000537177, ENST00000478044, | |
Fusion gene scores | * DoF score | 15 X 7 X 4=420 | 4 X 4 X 4=64 |
# samples | 15 | 5 | |
** MAII score | log2(15/420*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/64*10)=-0.356143810225275 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SNHG3 [Title/Abstract] AND CUL2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BG256861 | SNHG3 | chr1 | 28834672 | + | CUL2 | chr10 | 35360268 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000364938 | ENST00000374746 | SNHG3 | chr1 | 28834672 | + | CUL2 | chr10 | 35360268 | - |
intron-5UTR | ENST00000364938 | ENST00000374748 | SNHG3 | chr1 | 28834672 | + | CUL2 | chr10 | 35360268 | - |
intron-5UTR | ENST00000364938 | ENST00000374749 | SNHG3 | chr1 | 28834672 | + | CUL2 | chr10 | 35360268 | - |
intron-5UTR | ENST00000364938 | ENST00000374751 | SNHG3 | chr1 | 28834672 | + | CUL2 | chr10 | 35360268 | - |
intron-5UTR | ENST00000364938 | ENST00000602371 | SNHG3 | chr1 | 28834672 | + | CUL2 | chr10 | 35360268 | - |
intron-5UTR | ENST00000364938 | ENST00000374742 | SNHG3 | chr1 | 28834672 | + | CUL2 | chr10 | 35360268 | - |
intron-5UTR | ENST00000364938 | ENST00000537177 | SNHG3 | chr1 | 28834672 | + | CUL2 | chr10 | 35360268 | - |
intron-5UTR | ENST00000364938 | ENST00000478044 | SNHG3 | chr1 | 28834672 | + | CUL2 | chr10 | 35360268 | - |
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FusionProtFeatures for SNHG3_CUL2 |
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Hgene | Tgene |
SNHG3 | CUL2 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Core component of multiple cullin-RING-based ECS(ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligasecomplexes, which mediate the ubiquitination of target proteins.ECS complexes and ARIH1 collaborate in tandem to mediateubiquitination of target proteins (PubMed:27565346). May serve asa rigid scaffold in the complex and may contribute to catalysisthrough positioning of the substrate and the ubiquitin-conjugatingenzyme. The E3 ubiquitin-protein ligase activity of the complex isdependent on the neddylation of the cullin subunit and isinhibited by the association of the deneddylated cullin subunitwith TIP120A/CAND1. The functional specificity of the ECS complexdepends on the substrate recognition component. ECS(VHL) mediatesthe ubiquitination of hypoxia-inducible factor (HIF).{ECO:0000269|PubMed:10973499, ECO:0000269|PubMed:11384984,ECO:0000269|PubMed:27565346, ECO:0000269|PubMed:9122164}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SNHG3_CUL2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SNHG3_CUL2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SNHG3 | UTP23, TRIM25 | CUL2 | RNF7, VHL, P4HB, CAB39, TFE3, TIMM13, STOM, RPL35P5, PFKFB3, RNMTL1, KCTD5, CMBL, DLG3, CAND1, RBX1, TCEB2, TCEB1, DCUN1D1, SAP130, ASB4, COPS5, COPS6, TCEAL1, HIF1A, COMMD1, KLHDC10, SH3GLB1, COPS3, KEAP1, ARID1B, ARID1A, COPS2, UBE2D1, RELA, DNMT3B, ARNT, NSFL1C, FAF2, FAF1, UBXN7, UBXN1, VCP, KAT2A, ADRB2, ASB2, MED8, FBXW8, GLMN, PFDN5, SKP2, SQSTM1, NEDD8, PRAME, BCL2L11, TOP2A, ZYG11B, ZER1, FEM1B, APPBP2, KLHDC2, KLHDC3, PCMTD2, CUL5, ABCF1, ACLY, ACTA2, ACTB, ACTBL2, AGL, AIFM1, AKAP8L, FBF1, ALDOA, ANKRD39, ANXA2, ANXA2P2, APOD, ASPRV1, BAG4, BOLA2, BOLA2B, BRAP, BTG3, EDRF1, C11orf70, C14orf166, C1QBP, RTCB, VWA7, YAE1D1, DFFB, CARM1, CASP14, CDKN2A, CEP152, CIRBP, CLTC, COPS4, COPS7A, COPS7B, COPS8, LUC7L3, YBX3, CSTA, CTPS1, CTSD, CUL4B, DAZAP1, DCD, DDX1, DDX17, DDX56, DDX3X, DDX5, DERL2, DHX15, DHX9, DNAJA1, DNAJB6, DNAJC10, DSG1, DSP, EEF1A1, EEF1A2, EEF1B2, EEF1D, EEF1G, EGFLAM, AGO2, EIF5A, ELAVL1, EMD, ENO1, ENO2, EWSR1, FAM103A1, FAM98A, FEM1A, FEM1C, FLG, FLG2, FUS, GAPDH, GDPD3, GLDC, GPS1, GRSF1, GSTP1, HIST1H1C, HIST2H2BE, HNRNPA0, HNRNPA1, HNRNPA2B1, HNRNPA3, HNRNPAB, HNRNPC, HNRNPCL1, HNRNPD, HNRNPF, HNRNPH1, HNRNPH3, HNRNPK, HNRNPM, HNRNPR, HNRNPU, HNRNPUL1, HNRNPDL, HRNR, HSP90AA1, HSP90AA2P, HSP90AB1, HSP90AB2P, HSP90B1, HSPA1A, HSPA1B, HSPA1L, HSPA5, HSPA7, HSPA8, HSPA9, TRMT112, HSPD1, IGF2BP1, IGKV4-1, ILF2, ILF3, IRS4, JUP, KDELC1, KHSRP, KLC3, PPP1R21, KRT1, KRT10, KRT13, KRT14, KRT16, KRT2, KRT24, KRT5, KRT6A, KRT6C, KRT71, KRT75, KRT76, KRT78, KRT9, LARP1, LGALS3BP, IGHV3OR15-7, LOXL1, LRRC14, MCM3, MLPH, MORC2, MRTO4, MTHFD1, MTHFSD, MYEOV2, NAP1L1, NCL, NFRKB, NKAPL, NONO, NPM1, NUCB2, NUDT1, NUP214, NUP88, PABPC1, PABPC4, PABPN1, PARP14, PCBP1, PCBP2, PCMT1, PCNA, PDCD6, PEPD, PHGDH, PKM, PLOD1, POLR2A, POP7, PPFIA1, LRR1, PRDX1, PRDX2, PRDX3, PRDX4, PRMT1, PRPF39, PSMD4, PTOV1, QPCT, RANBP2, RBM14, RBM4, RBM3, RCBTB1, RNF187, RNMT, RNPS1, RPL10P16, RPL11, RPL12, RPL13, RPL13P12, RPL14, RPL15, RPL18, RPL19, RPL21P19, RPL21, RPL21P16, RPL22, RPL23, RPL23A, RPL24, RPL27, RPL27A, RPL28, RPL29P11, RPL29P30, RPL3, RPL31, RPL36, HNRNPH2, RPL36AP37, RPL38, RPL4, RPL5, RPL6, RPL7, RPL7P32, RPL7AP9, RPL7AP27, RPL8, RPL9, RPLP0, RPLP1, RPLP2, RPS13, RPS14, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS23, RPS24, RPS25, RPS27, RPS3, RPS3A, RPS4X, RPS6, RPS8, RPS9, RPSAP12, RPSAP55, S100A9, SAMHD1, SDHA, SDHB, SEC23A, SERPINB12, SERPINB3, SERPINB4, SF3B3, SRSF1, SRSF2, SRSF3, SRSF6, SRSF7, SLC16A1, SLC25A3, SLC25A5, SMAD6, SMC3, SMPD4, SNRNP200, SNRNP70, SNRPA, SNRPB, SNRPC, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNW1, SSB, SYNCRIP, TAF15, TBC1D15, TBC1D17, TBC1D4, TCEB1P3, TFG, ALYREF, TIA1, TIAL1, TMCC3, TNRC6B, TRA2B, TRIM28, TRIM44, TRIM9, TTN, TUBA1C, TUBA4A, TUBB, TUBB1, TUBB2A, TUBB4B, TUFM, TXN, UBC, UBE2M, UBR1, USP25, WDR77, YBX1, YWHAQ, YWHAZ, ZCCHC11, ZRANB3, HIST1H4J, HIST4H4, HIST1H4E, HIST1H4H, HIST1H4K, HIST2H4A, HIST1H4D, HIST1H4F, HIST2H4B, HIST1H4C, HIST1H4B, HIST1H4I, HIST1H4L, HIST1H4A, PTPN14, LAGE3, OSGEP, CISH, GNB2L1, KLF4, MKNK2, RFWD2, DCUN1D2, DCUN1D3, DCUN1D4, DCUN1D5, PLK1, FBXL2, CCDC22, AR, DLC1, ATP6V1B2, CTNNA1, DPYSL3, MSH2, NARS, ST13, XRCC5, XRCC6, KPNB1, NDRG1, CSNK1E, SHFM1, SHMT2, MOV10, NXF1, CDC34, SENP8, ARIH1, MRM1, SKAP1, TSGA10IP, RHOB, UNK, ATP6V1D, CIAPIN1, CUL3, NTRK1, TARDBP, EPOR, SLBP, PYCARD, OXT, PRAMEF17, IKZF1, AVP, SYCE3, RGS20, BRCA1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SNHG3_CUL2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SNHG3_CUL2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | CUL2 | C0021390 | Inflammatory Bowel Diseases | 1 | CTD_human |