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Fusion gene ID: 35128 |
FusionGeneSummary for SNHG3_ADAM23 |
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Fusion gene information | Fusion gene name: SNHG3_ADAM23 | Fusion gene ID: 35128 | Hgene | Tgene | Gene symbol | SNHG3 | ADAM23 | Gene ID | 8420 | 8745 |
Gene name | small nucleolar RNA host gene 3 | ADAM metallopeptidase domain 23 | |
Synonyms | NCRNA00014|RNU17C|RNU17D|U17HG|U17HG-A|U17HG-AB | MDC-3|MDC3 | |
Cytomap | 1p35.3 | 2q33.3 | |
Type of gene | ncRNA | protein-coding | |
Description | U17 small nucleolar RNA hostsmall nucleolar RNA host gene (non-protein coding) 3small nucleolar RNA host gene 3 (non-protein coding) | disintegrin and metalloproteinase domain-containing protein 23metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | O75077 | ||
Ensembl transtripts involved in fusion gene | ENST00000364938, | ENST00000264377, ENST00000374416, ENST00000374415, | |
Fusion gene scores | * DoF score | 15 X 7 X 4=420 | 3 X 2 X 2=12 |
# samples | 15 | 2 | |
** MAII score | log2(15/420*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/12*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: SNHG3 [Title/Abstract] AND ADAM23 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUSC | TCGA-63-A5MB-01A | SNHG3 | chr1 | 28836616 | + | ADAM23 | chr2 | 207437845 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000364938 | ENST00000264377 | SNHG3 | chr1 | 28836616 | + | ADAM23 | chr2 | 207437845 | + |
intron-3CDS | ENST00000364938 | ENST00000374416 | SNHG3 | chr1 | 28836616 | + | ADAM23 | chr2 | 207437845 | + |
intron-3CDS | ENST00000364938 | ENST00000374415 | SNHG3 | chr1 | 28836616 | + | ADAM23 | chr2 | 207437845 | + |
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FusionProtFeatures for SNHG3_ADAM23 |
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Hgene | Tgene |
SNHG3 | ADAM23 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | May play a role in cell-cell and cell-matrixinteractions. This is a non-catalytic metalloprotease-likeprotein. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SNHG3_ADAM23 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SNHG3_ADAM23 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SNHG3 | UTP23, TRIM25 | ADAM23 | ELAVL1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SNHG3_ADAM23 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SNHG3_ADAM23 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |