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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35090

FusionGeneSummary for SND1_NRXN3

check button Fusion gene summary
Fusion gene informationFusion gene name: SND1_NRXN3
Fusion gene ID: 35090
HgeneTgene
Gene symbol

SND1

NRXN3

Gene ID

27044

9369

Gene namestaphylococcal nuclease and tudor domain containing 1neurexin 3
SynonymsTDRD11|Tudor-SN|p100C14orf60
Cytomap

7q32.1

14q24.3-q31.1

Type of geneprotein-codingprotein-coding
Descriptionstaphylococcal nuclease domain-containing protein 1EBNA2 coactivator p100testis tissue sperm-binding protein Li 82Ptudor domain-containing protein 11neurexin 3neurexin IIIneurexin-3-alpha
Modification date2018052320180519
UniProtAcc

Q7KZF4

Q9Y4C0

Ensembl transtripts involved in fusion geneENST00000354725, ENST00000467238, 
ENST00000554719, ENST00000335750, 
ENST00000557594, ENST00000281127, 
ENST00000428277, ENST00000556003, 
Fusion gene scores* DoF score13 X 14 X 7=12744 X 4 X 2=32
# samples 204
** MAII scorelog2(20/1274*10)=-2.67129337248158
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SND1 [Title/Abstract] AND NRXN3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG000348SND1chr7

127399110

-NRXN3chr14

79376210

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000354725ENST00000554719SND1chr7

127399110

-NRXN3chr14

79376210

+
intron-intronENST00000354725ENST00000335750SND1chr7

127399110

-NRXN3chr14

79376210

+
intron-intronENST00000354725ENST00000557594SND1chr7

127399110

-NRXN3chr14

79376210

+
intron-intronENST00000354725ENST00000281127SND1chr7

127399110

-NRXN3chr14

79376210

+
intron-intronENST00000354725ENST00000428277SND1chr7

127399110

-NRXN3chr14

79376210

+
intron-intronENST00000354725ENST00000556003SND1chr7

127399110

-NRXN3chr14

79376210

+
intron-intronENST00000467238ENST00000554719SND1chr7

127399110

-NRXN3chr14

79376210

+
intron-intronENST00000467238ENST00000335750SND1chr7

127399110

-NRXN3chr14

79376210

+
intron-intronENST00000467238ENST00000557594SND1chr7

127399110

-NRXN3chr14

79376210

+
intron-intronENST00000467238ENST00000281127SND1chr7

127399110

-NRXN3chr14

79376210

+
intron-intronENST00000467238ENST00000428277SND1chr7

127399110

-NRXN3chr14

79376210

+
intron-intronENST00000467238ENST00000556003SND1chr7

127399110

-NRXN3chr14

79376210

+

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FusionProtFeatures for SND1_NRXN3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SND1

Q7KZF4

NRXN3

Q9Y4C0

Functions as a bridging factor between STAT6 and thebasal transcription factor. Plays a role in PIM1 regulation of MYBactivity. Functions as a transcriptional coactivator for theEpstein-Barr virus nuclear antigen 2 (EBNA2).{ECO:0000269|PubMed:7651391}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SND1_NRXN3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SND1_NRXN3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SND1_NRXN3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SND1_NRXN3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSND1C0004352Autistic Disorder1CTD_human
HgeneSND1C0024121Lung Neoplasms1CTD_human
TgeneNRXN3C0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneNRXN3C0036341Schizophrenia1PSYGENET
TgeneNRXN3C0236969Substance-Related Disorders1CTD_human
TgeneNRXN3C0853193Bipolar I disorder1PSYGENET