|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 35089 |
FusionGeneSummary for SND1_MYOG |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SND1_MYOG | Fusion gene ID: 35089 | Hgene | Tgene | Gene symbol | SND1 | MYOG | Gene ID | 27044 | 4656 |
| Gene name | staphylococcal nuclease and tudor domain containing 1 | myogenin | |
| Synonyms | TDRD11|Tudor-SN|p100 | MYF4|bHLHc3|myf-4 | |
| Cytomap | 7q32.1 | 1q32.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | staphylococcal nuclease domain-containing protein 1EBNA2 coactivator p100testis tissue sperm-binding protein Li 82Ptudor domain-containing protein 11 | myogeninclass C basic helix-loop-helix protein 3myogenic factor 4 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q7KZF4 | P15173 | |
| Ensembl transtripts involved in fusion gene | ENST00000354725, ENST00000467238, | ENST00000241651, | |
| Fusion gene scores | * DoF score | 13 X 14 X 7=1274 | 1 X 1 X 1=1 |
| # samples | 20 | 4 | |
| ** MAII score | log2(20/1274*10)=-2.67129337248158 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/1*10)=5.32192809488736 | |
| Context | PubMed: SND1 [Title/Abstract] AND MYOG [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | MYOG | GO:0045944 | positive regulation of transcription by RNA polymerase II | 11076940 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BC006347 | SND1 | chr7 | 127527996 | - | MYOG | chr1 | 203055113 | - | ||
| ChiTaRS3.1 | BF308961 | SND1 | chr7 | 127527996 | - | MYOG | chr1 | 203055113 | - | ||
| ChiTaRS3.1 | BF309401 | SND1 | chr7 | 127527996 | - | MYOG | chr1 | 203055113 | - | ||
| ChiTaRS3.1 | BF204429 | SND1 | chr7 | 127527996 | - | MYOG | chr1 | 203055113 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000354725 | ENST00000241651 | SND1 | chr7 | 127527996 | - | MYOG | chr1 | 203055113 | - |
| intron-5UTR | ENST00000467238 | ENST00000241651 | SND1 | chr7 | 127527996 | - | MYOG | chr1 | 203055113 | - |
Top |
FusionProtFeatures for SND1_MYOG |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SND1 | MYOG |
| Functions as a bridging factor between STAT6 and thebasal transcription factor. Plays a role in PIM1 regulation of MYBactivity. Functions as a transcriptional coactivator for theEpstein-Barr virus nuclear antigen 2 (EBNA2).{ECO:0000269|PubMed:7651391}. | Acts as a transcriptional activator that promotestranscription of muscle-specific target genes and plays a role inmuscle differentiation, cell cycle exit and muscle atrophy.Essential for the development of functional embryonic skeletalfiber muscle differentiation. However is dispensable for postnatalskeletal muscle growth; phosphorylation by CAMK2G inhibits itstranscriptional activity in respons to muscle activity. Requiredfor the recruitment of the FACT complex to muscle-specificpromoter regions, thus promoting gene expression initiation.During terminal myoblast differentiation, plays a role as a strongactivator of transcription at loci with an open chromatinstructure previously initiated by MYOD1. Together with MYF5 andMYOD1, co-occupies muscle-specific gene promoter core regionsduring myogenesis. Cooperates also with myocyte-specific enhancerfactor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin-remodeling enzymes to alter chromatin structure at myogenic lategene promoters. Facilitates cell cycle exit during terminal muscledifferentiation through the up-regulation of miR-20a expression,which in turn represses genes involved in cell cycle progression.Binds to the E-box containing (E1) promoter region of the miR-20agene. Plays also a role in preventing reversal of muscle celldifferentiation. Contributes to the atrophy-related geneexpression in adult denervated muscles. Induces fibroblasts todifferentiate into myoblasts (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for SND1_MYOG |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for SND1_MYOG |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for SND1_MYOG |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for SND1_MYOG |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SND1 | C0004352 | Autistic Disorder | 1 | CTD_human |
| Hgene | SND1 | C0024121 | Lung Neoplasms | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|