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Fusion gene ID: 35084 |
FusionGeneSummary for SND1_BRAF |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SND1_BRAF | Fusion gene ID: 35084 | Hgene | Tgene | Gene symbol | SND1 | BRAF | Gene ID | 27044 | 673 |
| Gene name | staphylococcal nuclease and tudor domain containing 1 | B-Raf proto-oncogene, serine/threonine kinase | |
| Synonyms | TDRD11|Tudor-SN|p100 | B-RAF1|B-raf|BRAF1|NS7|RAFB1 | |
| Cytomap | 7q32.1 | 7q34 | |
| Type of gene | protein-coding | protein-coding | |
| Description | staphylococcal nuclease domain-containing protein 1EBNA2 coactivator p100testis tissue sperm-binding protein Li 82Ptudor domain-containing protein 11 | serine/threonine-protein kinase B-raf94 kDa B-raf proteinB-Raf proto-oncogene serine/threonine-protein kinase (p94)B-Raf serine/threonine-proteinmurine sarcoma viral (v-raf) oncogene homolog B1proto-oncogene B-Rafv-raf murine sarcoma viral oncogene | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | Q7KZF4 | P15056 | |
| Ensembl transtripts involved in fusion gene | ENST00000354725, ENST00000467238, | ENST00000288602, | |
| Fusion gene scores | * DoF score | 13 X 14 X 7=1274 | 24 X 11 X 10=2640 |
| # samples | 20 | 35 | |
| ** MAII score | log2(20/1274*10)=-2.67129337248158 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(35/2640*10)=-2.91511110241349 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SND1 [Title/Abstract] AND BRAF [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | BRAF | GO:0006468 | protein phosphorylation | 17563371 |
| Tgene | BRAF | GO:0010828 | positive regulation of glucose transmembrane transport | 23010278 |
| Tgene | BRAF | GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 19667065 |
| Tgene | BRAF | GO:0043066 | negative regulation of apoptotic process | 19667065 |
| Tgene | BRAF | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 22065586 |
| Tgene | BRAF | GO:0071277 | cellular response to calcium ion | 18567582 |
| Tgene | BRAF | GO:0090150 | establishment of protein localization to membrane | 23010278 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | THCA | TCGA-DJ-A3UZ-01A | SND1 | chr7 | 127361454 | + | BRAF | chr7 | 140487384 | - |
| TCGA | RV | THCA | TCGA-EL-A3ZK-01A | SND1 | chr7 | 127721553 | + | BRAF | chr7 | 140482957 | - |
| TCGA | RV | THCA | TCGA-FY-A40N-01A | SND1 | chr7 | 127361454 | + | BRAF | chr7 | 140487384 | - |
| ChiTaRS3.1 | JX013981 | SND1 | chr7 | 127631110 | + | BRAF | chr7 | 140487386 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000354725 | ENST00000288602 | SND1 | chr7 | 127361454 | + | BRAF | chr7 | 140487384 | - |
| intron-3CDS | ENST00000467238 | ENST00000288602 | SND1 | chr7 | 127361454 | + | BRAF | chr7 | 140487384 | - |
| In-frame | ENST00000354725 | ENST00000288602 | SND1 | chr7 | 127721553 | + | BRAF | chr7 | 140482957 | - |
| intron-3CDS | ENST00000467238 | ENST00000288602 | SND1 | chr7 | 127721553 | + | BRAF | chr7 | 140482957 | - |
| In-frame | ENST00000354725 | ENST00000288602 | SND1 | chr7 | 127631110 | + | BRAF | chr7 | 140487386 | - |
| 3UTR-3CDS | ENST00000467238 | ENST00000288602 | SND1 | chr7 | 127631110 | + | BRAF | chr7 | 140487386 | - |
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FusionProtFeatures for SND1_BRAF |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SND1 | BRAF |
| Functions as a bridging factor between STAT6 and thebasal transcription factor. Plays a role in PIM1 regulation of MYBactivity. Functions as a transcriptional coactivator for theEpstein-Barr virus nuclear antigen 2 (EBNA2).{ECO:0000269|PubMed:7651391}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | SND1 | chr7:127361454 | chr7:140487384 | ENST00000354725 | + | 10 | 24 | 18_166 | 384 | 911 | Domain | TNase-like 1 |
| Hgene | SND1 | chr7:127361454 | chr7:140487384 | ENST00000354725 | + | 10 | 24 | 193_328 | 384 | 911 | Domain | TNase-like 2 |
| Hgene | SND1 | chr7:127631110 | chr7:140487386 | ENST00000354725 | + | 16 | 24 | 18_166 | 593 | 911 | Domain | TNase-like 1 |
| Hgene | SND1 | chr7:127631110 | chr7:140487386 | ENST00000354725 | + | 16 | 24 | 193_328 | 593 | 911 | Domain | TNase-like 2 |
| Hgene | SND1 | chr7:127631110 | chr7:140487386 | ENST00000354725 | + | 16 | 24 | 341_496 | 593 | 911 | Domain | TNase-like 3 |
| Hgene | SND1 | chr7:127721553 | chr7:140482957 | ENST00000354725 | + | 18 | 24 | 18_166 | 703 | 911 | Domain | TNase-like 1 |
| Hgene | SND1 | chr7:127721553 | chr7:140482957 | ENST00000354725 | + | 18 | 24 | 193_328 | 703 | 911 | Domain | TNase-like 2 |
| Hgene | SND1 | chr7:127721553 | chr7:140482957 | ENST00000354725 | + | 18 | 24 | 341_496 | 703 | 911 | Domain | TNase-like 3 |
| Hgene | SND1 | chr7:127721553 | chr7:140482957 | ENST00000354725 | + | 18 | 24 | 525_660 | 703 | 911 | Domain | TNase-like 4 |
| Hgene | SND1 | chr7:127361454 | chr7:140487384 | ENST00000354725 | + | 10 | 24 | 321_325 | 384 | 911 | Motif | Nuclear localization signal |
| Hgene | SND1 | chr7:127631110 | chr7:140487386 | ENST00000354725 | + | 16 | 24 | 321_325 | 593 | 911 | Motif | Nuclear localization signal |
| Hgene | SND1 | chr7:127631110 | chr7:140487386 | ENST00000354725 | + | 16 | 24 | 388_392 | 593 | 911 | Motif | Nuclear localization signal |
| Hgene | SND1 | chr7:127721553 | chr7:140482957 | ENST00000354725 | + | 18 | 24 | 321_325 | 703 | 911 | Motif | Nuclear localization signal |
| Hgene | SND1 | chr7:127721553 | chr7:140482957 | ENST00000354725 | + | 18 | 24 | 388_392 | 703 | 911 | Motif | Nuclear localization signal |
| Tgene | >BRAF | chr7:127361454 | chr7:140487384 | ENST00000288602 | - | 7 | 18 | 428_432 | 380 | 767 | Compositional bias | Note=Poly-Ser |
| Tgene | >BRAF | chr7:127631110 | chr7:140487386 | ENST00000288602 | - | 7 | 18 | 428_432 | 380 | 767 | Compositional bias | Note=Poly-Ser |
| Tgene | >BRAF | chr7:127721553 | chr7:140482957 | ENST00000288602 | - | 8 | 18 | 428_432 | 392 | 767 | Compositional bias | Note=Poly-Ser |
| Tgene | >BRAF | chr7:127361454 | chr7:140487384 | ENST00000288602 | - | 7 | 18 | 457_717 | 380 | 767 | Domain | Protein kinase |
| Tgene | >BRAF | chr7:127631110 | chr7:140487386 | ENST00000288602 | - | 7 | 18 | 457_717 | 380 | 767 | Domain | Protein kinase |
| Tgene | >BRAF | chr7:127721553 | chr7:140482957 | ENST00000288602 | - | 8 | 18 | 457_717 | 392 | 767 | Domain | Protein kinase |
| Tgene | >BRAF | chr7:127361454 | chr7:140487384 | ENST00000288602 | - | 7 | 18 | 463_471 | 380 | 767 | Nucleotide binding | ATP |
| Tgene | >BRAF | chr7:127631110 | chr7:140487386 | ENST00000288602 | - | 7 | 18 | 463_471 | 380 | 767 | Nucleotide binding | ATP |
| Tgene | >BRAF | chr7:127721553 | chr7:140482957 | ENST00000288602 | - | 8 | 18 | 463_471 | 392 | 767 | Nucleotide binding | ATP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >SND1 | chr7:127361454 | chr7:140487384 | ENST00000354725 | + | 10 | 24 | 341_496 | 384 | 911 | Domain | TNase-like 3 |
| Hgene | >SND1 | chr7:127361454 | chr7:140487384 | ENST00000354725 | + | 10 | 24 | 525_660 | 384 | 911 | Domain | TNase-like 4 |
| Hgene | >SND1 | chr7:127361454 | chr7:140487384 | ENST00000354725 | + | 10 | 24 | 729_787 | 384 | 911 | Domain | Tudor |
| Hgene | >SND1 | chr7:127631110 | chr7:140487386 | ENST00000354725 | + | 16 | 24 | 525_660 | 593 | 911 | Domain | TNase-like 4 |
| Hgene | >SND1 | chr7:127631110 | chr7:140487386 | ENST00000354725 | + | 16 | 24 | 729_787 | 593 | 911 | Domain | Tudor |
| Hgene | >SND1 | chr7:127721553 | chr7:140482957 | ENST00000354725 | + | 18 | 24 | 729_787 | 703 | 911 | Domain | Tudor |
| Hgene | >SND1 | chr7:127361454 | chr7:140487384 | ENST00000354725 | + | 10 | 24 | 388_392 | 384 | 911 | Motif | Nuclear localization signal |
| Tgene | BRAF | chr7:127361454 | chr7:140487384 | ENST00000288602 | - | 7 | 18 | 122_129 | 380 | 767 | Compositional bias | Note=Poly-Ser |
| Tgene | BRAF | chr7:127361454 | chr7:140487384 | ENST00000288602 | - | 7 | 18 | 6_11 | 380 | 767 | Compositional bias | Note=Poly-Gly |
| Tgene | BRAF | chr7:127631110 | chr7:140487386 | ENST00000288602 | - | 7 | 18 | 122_129 | 380 | 767 | Compositional bias | Note=Poly-Ser |
| Tgene | BRAF | chr7:127631110 | chr7:140487386 | ENST00000288602 | - | 7 | 18 | 6_11 | 380 | 767 | Compositional bias | Note=Poly-Gly |
| Tgene | BRAF | chr7:127721553 | chr7:140482957 | ENST00000288602 | - | 8 | 18 | 122_129 | 392 | 767 | Compositional bias | Note=Poly-Ser |
| Tgene | BRAF | chr7:127721553 | chr7:140482957 | ENST00000288602 | - | 8 | 18 | 6_11 | 392 | 767 | Compositional bias | Note=Poly-Gly |
| Tgene | BRAF | chr7:127361454 | chr7:140487384 | ENST00000288602 | - | 7 | 18 | 155_227 | 380 | 767 | Domain | RBD |
| Tgene | BRAF | chr7:127631110 | chr7:140487386 | ENST00000288602 | - | 7 | 18 | 155_227 | 380 | 767 | Domain | RBD |
| Tgene | BRAF | chr7:127721553 | chr7:140482957 | ENST00000288602 | - | 8 | 18 | 155_227 | 392 | 767 | Domain | RBD |
| Tgene | BRAF | chr7:127361454 | chr7:140487384 | ENST00000288602 | - | 7 | 18 | 234_280 | 380 | 767 | Zinc finger | Phorbol-ester/DAG-type |
| Tgene | BRAF | chr7:127631110 | chr7:140487386 | ENST00000288602 | - | 7 | 18 | 234_280 | 380 | 767 | Zinc finger | Phorbol-ester/DAG-type |
| Tgene | BRAF | chr7:127721553 | chr7:140482957 | ENST00000288602 | - | 8 | 18 | 234_280 | 392 | 767 | Zinc finger | Phorbol-ester/DAG-type |
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FusionGeneSequence for SND1_BRAF |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SND1_ENST00000354725_chr7_127361454_+_BRAF_ENST00000288602_chr7_140487384_-_771aa MASSAQSGGSSGGPAVPTVQRGIIKMVLSGCAIIVRGQPRGGPPPERQINLSNIRAGNLARRAAATQPDAKDTPDEPWAFPAREFLRKKL IGKEVCFTIENKTPQGREYGMIYLGKDTNGENIAESLVAEGLATRREGMRANNPEQNRLSECEEQAKAAKKGMWSEGNGSHTIRDLKYTI ENPRHFVDSHHQKPVNAIIEHVRDGSVVRALLLPDYYLVTVMLSGIKCPTFRREADGSETPEPFAAEAKFFTESRLLQRDVQIILESCHN QNILGTILHPNGNITELLLKEGFARCVDWSIAVYTRGAEKLRAAERFAKERRLRIWRDYVAPTANLDQKDKQFVAKVMQVLNADAIVVKL NSGDYKTIHLSSIRPPRLEGENTQDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDS SDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSS LYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIR MQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIEL >In-frame_SND1_ENST00000354725_chr7_127721553_+_BRAF_ENST00000288602_chr7_140482957_-_1078aa MASSAQSGGSSGGPAVPTVQRGIIKMVLSGCAIIVRGQPRGGPPPERQINLSNIRAGNLARRAAATQPDAKDTPDEPWAFPAREFLRKKL IGKEVCFTIENKTPQGREYGMIYLGKDTNGENIAESLVAEGLATRREGMRANNPEQNRLSECEEQAKAAKKGMWSEGNGSHTIRDLKYTI ENPRHFVDSHHQKPVNAIIEHVRDGSVVRALLLPDYYLVTVMLSGIKCPTFRREADGSETPEPFAAEAKFFTESRLLQRDVQIILESCHN QNILGTILHPNGNITELLLKEGFARCVDWSIAVYTRGAEKLRAAERFAKERRLRIWRDYVAPTANLDQKDKQFVAKVMQVLNADAIVVKL NSGDYKTIHLSSIRPPRLEGENTQDKNKKLRPLYDIPYMFEAREFLRKKLIGKKVNVTVDYIRPASPATETVPAFSERTCATVTIGGINI AEALVSKGLATVIRYRQDDDQRSSHYDELLAAEARAIKNGKGLHSKKEVPIHRVADISGDTQKAKQFLPFLQRAGRSEAVVEYVFSGSRL KLYLPKETCLITFLLAGIECPRGARNLPGLVQEGEPFSEEATLFTKELVLQREVEVEVESMDKAGNFIGWLHIDGANLSVLLVEHALSKV HFTAERSSYYKSLLSAEEAAKQKKEKVWAHYEEQPVEEVMPVLEEKERSASYKPVFVTEITDDLHFYVQDVETGSTTGLSATPPASLPGS LTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFK NEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLT VKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SND1_ENST00000354725_chr7_127361454_+_BRAF_ENST00000288602_chr7_140487384_-_2313nt ATGGCGTCCTCCGCGCAGAGCGGCGGCTCCTCCGGGGGACCCGCGGTCCCCACCGTGCAGCGGGGCATCATCAAGATGGTCCTCTCAGGG TGCGCCATCATTGTCCGAGGTCAGCCTCGTGGTGGGCCTCCTCCTGAGCGGCAGATCAACCTCAGCAACATTCGTGCTGGAAATCTTGCT CGCCGGGCAGCCGCCACACAACCTGATGCAAAGGATACCCCTGATGAGCCCTGGGCATTTCCAGCTCGAGAGTTCCTTCGAAAGAAGCTG ATTGGGAAGGAAGTCTGTTTCACGATAGAAAACAAGACTCCCCAGGGGCGAGAGTATGGCATGATCTACCTTGGAAAAGATACCAATGGG GAAAACATTGCAGAATCACTGGTTGCAGAGGGCTTAGCCACCCGGAGAGAAGGCATGAGAGCTAATAATCCTGAGCAGAACCGGCTTTCA GAATGTGAAGAACAAGCAAAGGCAGCCAAGAAAGGGATGTGGAGTGAGGGGAACGGTTCACATACTATCCGGGATCTCAAGTATACCATT GAAAACCCAAGGCACTTTGTGGACTCACACCACCAGAAGCCTGTTAATGCTATCATCGAGCATGTGCGGGACGGCAGTGTGGTCAGGGCC CTGCTCCTCCCAGATTACTACCTGGTTACAGTCATGCTGTCAGGCATCAAGTGCCCAACTTTTCGACGGGAAGCAGATGGCAGTGAAACT CCAGAGCCTTTTGCTGCAGAAGCCAAATTTTTCACTGAGTCGCGACTGCTTCAGAGAGATGTTCAGATCATTCTGGAGAGCTGCCACAAC CAGAACATTCTGGGTACCATCCTTCATCCAAATGGCAACATCACAGAGCTCCTCCTGAAGGAAGGTTTCGCACGCTGTGTGGACTGGTCG ATTGCAGTTTACACCCGGGGCGCAGAAAAGCTGAGGGCGGCAGAGAGGTTTGCCAAAGAGCGCAGGCTGAGAATATGGAGAGACTATGTG GCTCCCACAGCTAATTTGGACCAAAAGGACAAGCAGTTTGTTGCCAAGGTGATGCAGGTTCTGAATGCTGATGCCATTGTTGTGAAGCTG AACTCAGGCGATTACAAGACGATTCACCTGTCCAGCATCCGACCACCGAGGCTGGAGGGGGAGAACACCCAGGACTTGATTAGAGACCAA GGATTTCGTGGTGATGGAGGATCAACCACAGGTTTGTCTGCTACCCCCCCTGCCTCATTACCTGGCTCACTAACTAACGTGAAAGCCTTA CAGAAATCTCCAGGACCTCAGCGAGAAAGGAAGTCATCTTCATCCTCAGAAGACAGGAATCGAATGAAAACACTTGGTAGACGGGACTCG AGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGGATCATTTGGAACAGTCTACAAGGGAAAGTGG CATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACAAGCCTTCAAAAATGAAGTAGGAGTACTCAGG AAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGCTATTGTTACCCAGTGGTGTGAGGGCTCCAGC TTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATATTGCACGACAGACTGCACAGGGCATGGATTAC TTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATGAAGACCTCACAGTAAAAATAGGTGATTTTGGT CTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATCCATTTTGTGGATGGCACCAGAAGTCATCAGA ATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTCTGTATGAATTGATGACTGGACAGTTACCTTAT TCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCCAGATCTCAGTAAGGTACGGAGTAACTGTCCA AAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACTCTTTCCCCAAATTCTCGCCTCTATTGAGCTG CTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGCTGGTTTCCAAACAGAGGATTTTAGTCTATAT >In-frame_SND1_ENST00000354725_chr7_127721553_+_BRAF_ENST00000288602_chr7_140482957_-_3234nt ATGGCGTCCTCCGCGCAGAGCGGCGGCTCCTCCGGGGGACCCGCGGTCCCCACCGTGCAGCGGGGCATCATCAAGATGGTCCTCTCAGGG TGCGCCATCATTGTCCGAGGTCAGCCTCGTGGTGGGCCTCCTCCTGAGCGGCAGATCAACCTCAGCAACATTCGTGCTGGAAATCTTGCT CGCCGGGCAGCCGCCACACAACCTGATGCAAAGGATACCCCTGATGAGCCCTGGGCATTTCCAGCTCGAGAGTTCCTTCGAAAGAAGCTG ATTGGGAAGGAAGTCTGTTTCACGATAGAAAACAAGACTCCCCAGGGGCGAGAGTATGGCATGATCTACCTTGGAAAAGATACCAATGGG GAAAACATTGCAGAATCACTGGTTGCAGAGGGCTTAGCCACCCGGAGAGAAGGCATGAGAGCTAATAATCCTGAGCAGAACCGGCTTTCA GAATGTGAAGAACAAGCAAAGGCAGCCAAGAAAGGGATGTGGAGTGAGGGGAACGGTTCACATACTATCCGGGATCTCAAGTATACCATT GAAAACCCAAGGCACTTTGTGGACTCACACCACCAGAAGCCTGTTAATGCTATCATCGAGCATGTGCGGGACGGCAGTGTGGTCAGGGCC CTGCTCCTCCCAGATTACTACCTGGTTACAGTCATGCTGTCAGGCATCAAGTGCCCAACTTTTCGACGGGAAGCAGATGGCAGTGAAACT CCAGAGCCTTTTGCTGCAGAAGCCAAATTTTTCACTGAGTCGCGACTGCTTCAGAGAGATGTTCAGATCATTCTGGAGAGCTGCCACAAC CAGAACATTCTGGGTACCATCCTTCATCCAAATGGCAACATCACAGAGCTCCTCCTGAAGGAAGGTTTCGCACGCTGTGTGGACTGGTCG ATTGCAGTTTACACCCGGGGCGCAGAAAAGCTGAGGGCGGCAGAGAGGTTTGCCAAAGAGCGCAGGCTGAGAATATGGAGAGACTATGTG GCTCCCACAGCTAATTTGGACCAAAAGGACAAGCAGTTTGTTGCCAAGGTGATGCAGGTTCTGAATGCTGATGCCATTGTTGTGAAGCTG AACTCAGGCGATTACAAGACGATTCACCTGTCCAGCATCCGACCACCGAGGCTGGAGGGGGAGAACACCCAGGATAAGAACAAGAAACTG CGTCCCCTGTATGACATTCCTTACATGTTTGAGGCCCGGGAATTTCTTCGAAAAAAGCTTATTGGGAAGAAGGTCAATGTGACGGTGGAC TACATTAGACCAGCCAGCCCAGCCACAGAGACAGTGCCTGCCTTTTCAGAGCGTACCTGTGCCACTGTCACCATTGGAGGAATAAACATT GCTGAGGCTCTTGTCAGCAAAGGTCTAGCCACAGTGATCAGATACCGGCAGGATGATGACCAGAGATCATCACACTACGATGAACTGCTT GCTGCAGAGGCCAGAGCTATTAAGAATGGCAAAGGATTGCATAGCAAGAAGGAAGTGCCTATCCACCGTGTTGCAGATATATCTGGGGAT ACCCAAAAAGCAAAGCAGTTCCTGCCTTTTCTTCAGCGGGCAGGTCGTTCTGAAGCTGTGGTGGAATACGTCTTCAGTGGTTCTCGTCTC AAACTCTATTTGCCAAAGGAAACTTGCCTTATCACCTTCTTGCTTGCAGGCATTGAATGCCCCAGAGGAGCCCGAAACCTCCCAGGCTTG GTGCAGGAAGGAGAGCCCTTCAGCGAGGAAGCTACACTTTTCACCAAGGAACTGGTGCTGCAGCGAGAGGTGGAGGTGGAGGTGGAGAGC ATGGACAAGGCCGGCAACTTTATCGGCTGGCTGCACATCGACGGTGCCAACCTGTCCGTCCTGCTGGTGGAGCACGCGCTCTCCAAGGTC CACTTCACCGCCGAACGCAGCTCCTACTACAAGTCCCTGCTGTCTGCCGAGGAGGCCGCAAAGCAGAAGAAAGAGAAGGTCTGGGCCCAC TATGAGGAGCAGCCCGTGGAGGAGGTGATGCCAGTGCTGGAGGAGAAGGAGCGATCTGCTAGCTACAAGCCCGTGTTTGTGACTGAGATC ACTGATGACCTGCACTTCTACGTGCAGGATGTGGAGACCGGATCAACCACAGGTTTGTCTGCTACCCCCCCTGCCTCATTACCTGGCTCA CTAACTAACGTGAAAGCCTTACAGAAATCTCCAGGACCTCAGCGAGAAAGGAAGTCATCTTCATCCTCAGAAGACAGGAATCGAATGAAA ACACTTGGTAGACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGGATCATTTGGA ACAGTCTACAAGGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACAAGCCTTCAAA AATGAAGTAGGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGCTATTGTTACC CAGTGGTGTGAGGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATATTGCACGACAG ACTGCACAGGGCATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATGAAGACCTCACA GTAAAAATAGGTGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATCCATTTTGTGG ATGGCACCAGAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTCTGTATGAATTG ATGACTGGACAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCCAGATCTCAGT AAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACTCTTTCCCCAA ATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGCTGGTTTCCAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SND1_ENST00000354725_chr7_127361454_+_BRAF_ENST00000288602_chr7_140487384_-_2625nt GGCGGAGATCGCGTCTCTTTCGCTCCGTGTCCCGCTGCTGCTCCTGTGAGCGCCCGGCGAGTCCGTCCCGTCCACCGTCCGCAGCTGGTA GCCAGCCTGCCCCTCGCCTCGACTCCCTTTCACCAACACCGACACCCACATTGACACCTCCAGTCCGGCCAGCCGCTCCACTCGTTGCCT TTGCATCTCCACACATGGCGTCCTCCGCGCAGAGCGGCGGCTCCTCCGGGGGACCCGCGGTCCCCACCGTGCAGCGGGGCATCATCAAGA TGGTCCTCTCAGGGTGCGCCATCATTGTCCGAGGTCAGCCTCGTGGTGGGCCTCCTCCTGAGCGGCAGATCAACCTCAGCAACATTCGTG CTGGAAATCTTGCTCGCCGGGCAGCCGCCACACAACCTGATGCAAAGGATACCCCTGATGAGCCCTGGGCATTTCCAGCTCGAGAGTTCC TTCGAAAGAAGCTGATTGGGAAGGAAGTCTGTTTCACGATAGAAAACAAGACTCCCCAGGGGCGAGAGTATGGCATGATCTACCTTGGAA AAGATACCAATGGGGAAAACATTGCAGAATCACTGGTTGCAGAGGGCTTAGCCACCCGGAGAGAAGGCATGAGAGCTAATAATCCTGAGC AGAACCGGCTTTCAGAATGTGAAGAACAAGCAAAGGCAGCCAAGAAAGGGATGTGGAGTGAGGGGAACGGTTCACATACTATCCGGGATC TCAAGTATACCATTGAAAACCCAAGGCACTTTGTGGACTCACACCACCAGAAGCCTGTTAATGCTATCATCGAGCATGTGCGGGACGGCA GTGTGGTCAGGGCCCTGCTCCTCCCAGATTACTACCTGGTTACAGTCATGCTGTCAGGCATCAAGTGCCCAACTTTTCGACGGGAAGCAG ATGGCAGTGAAACTCCAGAGCCTTTTGCTGCAGAAGCCAAATTTTTCACTGAGTCGCGACTGCTTCAGAGAGATGTTCAGATCATTCTGG AGAGCTGCCACAACCAGAACATTCTGGGTACCATCCTTCATCCAAATGGCAACATCACAGAGCTCCTCCTGAAGGAAGGTTTCGCACGCT GTGTGGACTGGTCGATTGCAGTTTACACCCGGGGCGCAGAAAAGCTGAGGGCGGCAGAGAGGTTTGCCAAAGAGCGCAGGCTGAGAATAT GGAGAGACTATGTGGCTCCCACAGCTAATTTGGACCAAAAGGACAAGCAGTTTGTTGCCAAGGTGATGCAGGTTCTGAATGCTGATGCCA TTGTTGTGAAGCTGAACTCAGGCGATTACAAGACGATTCACCTGTCCAGCATCCGACCACCGAGGCTGGAGGGGGAGAACACCCAGGACT TGATTAGAGACCAAGGATTTCGTGGTGATGGAGGATCAACCACAGGTTTGTCTGCTACCCCCCCTGCCTCATTACCTGGCTCACTAACTA ACGTGAAAGCCTTACAGAAATCTCCAGGACCTCAGCGAGAAAGGAAGTCATCTTCATCCTCAGAAGACAGGAATCGAATGAAAACACTTG GTAGACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGGATCATTTGGAACAGTCT ACAAGGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACAAGCCTTCAAAAATGAAG TAGGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGCTATTGTTACCCAGTGGT GTGAGGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATATTGCACGACAGACTGCAC AGGGCATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATGAAGACCTCACAGTAAAAA TAGGTGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATCCATTTTGTGGATGGCAC CAGAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTCTGTATGAATTGATGACTG GACAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCCAGATCTCAGTAAGGTAC GGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACTCTTTCCCCAAATTCTCG CCTCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGCTGGTTTCCAAACAGAGG ATTTTAGTCTATATGCTTGTGCTTCTCCAAAAACACCCATCCAGGCAGGGGGATATGGTGCGTTTCCTGTCCACTGAAACAAATGAGTGA GAGAGTTCAGGAGAGTAGCAACAAAAGGAAAATAAATGAACATATGTTTGCTTATATGTTAAATTGAATAAAATACTCTCTTTTTTTTTA >In-frame_SND1_ENST00000354725_chr7_127721553_+_BRAF_ENST00000288602_chr7_140482957_-_3546nt GGCGGAGATCGCGTCTCTTTCGCTCCGTGTCCCGCTGCTGCTCCTGTGAGCGCCCGGCGAGTCCGTCCCGTCCACCGTCCGCAGCTGGTA GCCAGCCTGCCCCTCGCCTCGACTCCCTTTCACCAACACCGACACCCACATTGACACCTCCAGTCCGGCCAGCCGCTCCACTCGTTGCCT TTGCATCTCCACACATGGCGTCCTCCGCGCAGAGCGGCGGCTCCTCCGGGGGACCCGCGGTCCCCACCGTGCAGCGGGGCATCATCAAGA TGGTCCTCTCAGGGTGCGCCATCATTGTCCGAGGTCAGCCTCGTGGTGGGCCTCCTCCTGAGCGGCAGATCAACCTCAGCAACATTCGTG CTGGAAATCTTGCTCGCCGGGCAGCCGCCACACAACCTGATGCAAAGGATACCCCTGATGAGCCCTGGGCATTTCCAGCTCGAGAGTTCC TTCGAAAGAAGCTGATTGGGAAGGAAGTCTGTTTCACGATAGAAAACAAGACTCCCCAGGGGCGAGAGTATGGCATGATCTACCTTGGAA AAGATACCAATGGGGAAAACATTGCAGAATCACTGGTTGCAGAGGGCTTAGCCACCCGGAGAGAAGGCATGAGAGCTAATAATCCTGAGC AGAACCGGCTTTCAGAATGTGAAGAACAAGCAAAGGCAGCCAAGAAAGGGATGTGGAGTGAGGGGAACGGTTCACATACTATCCGGGATC TCAAGTATACCATTGAAAACCCAAGGCACTTTGTGGACTCACACCACCAGAAGCCTGTTAATGCTATCATCGAGCATGTGCGGGACGGCA GTGTGGTCAGGGCCCTGCTCCTCCCAGATTACTACCTGGTTACAGTCATGCTGTCAGGCATCAAGTGCCCAACTTTTCGACGGGAAGCAG ATGGCAGTGAAACTCCAGAGCCTTTTGCTGCAGAAGCCAAATTTTTCACTGAGTCGCGACTGCTTCAGAGAGATGTTCAGATCATTCTGG AGAGCTGCCACAACCAGAACATTCTGGGTACCATCCTTCATCCAAATGGCAACATCACAGAGCTCCTCCTGAAGGAAGGTTTCGCACGCT GTGTGGACTGGTCGATTGCAGTTTACACCCGGGGCGCAGAAAAGCTGAGGGCGGCAGAGAGGTTTGCCAAAGAGCGCAGGCTGAGAATAT GGAGAGACTATGTGGCTCCCACAGCTAATTTGGACCAAAAGGACAAGCAGTTTGTTGCCAAGGTGATGCAGGTTCTGAATGCTGATGCCA TTGTTGTGAAGCTGAACTCAGGCGATTACAAGACGATTCACCTGTCCAGCATCCGACCACCGAGGCTGGAGGGGGAGAACACCCAGGATA AGAACAAGAAACTGCGTCCCCTGTATGACATTCCTTACATGTTTGAGGCCCGGGAATTTCTTCGAAAAAAGCTTATTGGGAAGAAGGTCA ATGTGACGGTGGACTACATTAGACCAGCCAGCCCAGCCACAGAGACAGTGCCTGCCTTTTCAGAGCGTACCTGTGCCACTGTCACCATTG GAGGAATAAACATTGCTGAGGCTCTTGTCAGCAAAGGTCTAGCCACAGTGATCAGATACCGGCAGGATGATGACCAGAGATCATCACACT ACGATGAACTGCTTGCTGCAGAGGCCAGAGCTATTAAGAATGGCAAAGGATTGCATAGCAAGAAGGAAGTGCCTATCCACCGTGTTGCAG ATATATCTGGGGATACCCAAAAAGCAAAGCAGTTCCTGCCTTTTCTTCAGCGGGCAGGTCGTTCTGAAGCTGTGGTGGAATACGTCTTCA GTGGTTCTCGTCTCAAACTCTATTTGCCAAAGGAAACTTGCCTTATCACCTTCTTGCTTGCAGGCATTGAATGCCCCAGAGGAGCCCGAA ACCTCCCAGGCTTGGTGCAGGAAGGAGAGCCCTTCAGCGAGGAAGCTACACTTTTCACCAAGGAACTGGTGCTGCAGCGAGAGGTGGAGG TGGAGGTGGAGAGCATGGACAAGGCCGGCAACTTTATCGGCTGGCTGCACATCGACGGTGCCAACCTGTCCGTCCTGCTGGTGGAGCACG CGCTCTCCAAGGTCCACTTCACCGCCGAACGCAGCTCCTACTACAAGTCCCTGCTGTCTGCCGAGGAGGCCGCAAAGCAGAAGAAAGAGA AGGTCTGGGCCCACTATGAGGAGCAGCCCGTGGAGGAGGTGATGCCAGTGCTGGAGGAGAAGGAGCGATCTGCTAGCTACAAGCCCGTGT TTGTGACTGAGATCACTGATGACCTGCACTTCTACGTGCAGGATGTGGAGACCGGATCAACCACAGGTTTGTCTGCTACCCCCCCTGCCT CATTACCTGGCTCACTAACTAACGTGAAAGCCTTACAGAAATCTCCAGGACCTCAGCGAGAAAGGAAGTCATCTTCATCCTCAGAAGACA GGAATCGAATGAAAACACTTGGTAGACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGAT CTGGATCATTTGGAACAGTCTACAAGGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGT TACAAGCCTTCAAAAATGAAGTAGGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAAC TGGCTATTGTTACCCAGTGGTGTGAGGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAG ATATTGCACGACAGACTGCACAGGGCATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTC ATGAAGACCTCACAGTAAAAATAGGTGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTG GATCCATTTTGTGGATGGCACCAGAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTG TTCTGTATGAATTGATGACTGGACAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGT CTCCAGATCTCAGTAAGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGAC CACTCTTTCCCCAAATTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATC GGGCTGGTTTCCAAACAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCAAAAACACCCATCCAGGCAGGGGGATATGGTGCGTTTCCTG TCCACTGAAACAAATGAGTGAGAGAGTTCAGGAGAGTAGCAACAAAAGGAAAATAAATGAACATATGTTTGCTTATATGTTAAATTGAAT |
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FusionGenePPI for SND1_BRAF |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SND1 | IKBKE, SNW1, RBPJ, GTF2E2, GTF2E1, MYB, PIM1, STAT6, POLR2A, USP22, PDPK1, PRKAA1, UBA5, LZTR1, DHX9, CREBBP, RBM39, SIRT7, CUL3, CDK2, CAND1, APP, RPS3, HNRNPM, TOMM22, RPL19, MYBBP1A, SMNDC1, RPS20, NENF, RPL4, VDAC2, ILF2, SRSF3, HNRNPU, RPN1, HNRNPR, SSR3, FN1, VCAM1, CSNK2A1, ITGA4, G3BP1, PRPF8, RNU1-1, RNU2-1, RNU4-1, RNU6-1, RNU5A-1, MAK, TARDBP, EIF3CL, RPS11, RPS2, RPS6, RPS9, DDX3X, RPL23A, RPL35, RPS16, RPS26, RPS27, RPS3A, SHFM1, LIN28A, HUWE1, RAPGEF2, MDM2, CUL7, OBSL1, CCDC8, UBE2I, ESR1, MMP28, TDRD3, TXNDC5, NTRK1, NPM1, RPL10, CNOT1, MCM2, U2AF2, CDH1, PTP4A1, MTDH, PA2G4, TRAP1, ANXA5, SNRPB2, EIF5B, GPI, IDH2, PDIA3, UBE2N, MRPL12, CRNN, ZNF207, CPNE3, CS, PYGL, SF3A3, DNAJC8, PLS3, CPSF6, NANS, SF3A1, ECHS1, SRP68, MYL12B, AIMP1, CYLD, DLD, DLST, PDHA1, SOD1, TRIM25, BRCA1, YAP1 | BRAF | YWHAB, YWHAG, YWHAQ, YWHAZ, SFN, HRAS, AKT1, MAPK3, RAP1GAP, RAF1, MRAS, RAP1A, PAK2, TERF1, CCDC88A, NEDD4L, MAP2K1, RNF149, KSR1, BRAP, PRKCE, RPS6KB2, HSP90AA1, BRAF, YWHAE, HSPA5, MAP2K2, HSPA1A, HSPA8, YWHAH, HSPA9, ARAF, CDC37, HSP90AB1, PHKB, LIMK1, IQGAP1, MAPK1, BAD, LIPF, MUS81, FBXW7, FGFR2, BRCA2, VHL, FNTA, HDAC2, PIK3CA, EGFR, PTEN, FNIP1, FNIP2, RAB3GAP1, KRAS, KIAA0141, FKBPL, ARMCX3, KCNC4, RPTOR, CYLD, NRAS |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SND1_BRAF |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | BRAF | P15056 | DB08881 | Vemurafenib | Serine/threonine-protein kinase B-raf | small molecule | approved |
| Tgene | BRAF | P15056 | DB08896 | Regorafenib | Serine/threonine-protein kinase B-raf | small molecule | approved |
| Tgene | BRAF | P15056 | DB00398 | Sorafenib | Serine/threonine-protein kinase B-raf | small molecule | approved|investigational |
| Tgene | BRAF | P15056 | DB08912 | Dabrafenib | Serine/threonine-protein kinase B-raf | small molecule | approved|investigational |
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RelatedDiseases for SND1_BRAF |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SND1 | C0004352 | Autistic Disorder | 1 | CTD_human |
| Hgene | SND1 | C0024121 | Lung Neoplasms | 1 | CTD_human |
| Tgene | BRAF | C0025202 | melanoma | 21 | CTD_human |
| Tgene | BRAF | C1527249 | Colorectal Cancer | 8 | UNIPROT |
| Tgene | BRAF | C1275081 | Cardio-facio-cutaneous syndrome | 6 | CTD_human;ORPHANET;UNIPROT |
| Tgene | BRAF | C0009404 | Colorectal Neoplasms | 4 | CTD_human |
| Tgene | BRAF | C0040136 | Thyroid Neoplasm | 4 | CTD_human |
| Tgene | BRAF | C0024305 | Lymphoma, Non-Hodgkin | 3 | UNIPROT |
| Tgene | BRAF | C0684249 | Carcinoma of lung | 3 | UNIPROT |
| Tgene | BRAF | C3150970 | NOONAN SYNDROME 7 | 3 | CTD_human;UNIPROT |
| Tgene | BRAF | C0152013 | Adenocarcinoma of lung (disorder) | 2 | CTD_human |
| Tgene | BRAF | C0002448 | Ameloblastoma | 1 | CTD_human |
| Tgene | BRAF | C0004114 | Astrocytoma | 1 | CTD_human |
| Tgene | BRAF | C0010276 | Craniopharyngioma | 1 | CTD_human;ORPHANET |
| Tgene | BRAF | C0017638 | Glioma | 1 | CTD_human |
| Tgene | BRAF | C0022665 | Kidney Neoplasm | 1 | CTD_human |
| Tgene | BRAF | C0023903 | Liver neoplasms | 1 | CTD_human |
| Tgene | BRAF | C0024694 | Mandibular Neoplasms | 1 | CTD_human |
| Tgene | BRAF | C0028326 | Noonan Syndrome | 1 | CTD_human;ORPHANET |
| Tgene | BRAF | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Tgene | BRAF | C0036920 | Sezary Syndrome | 1 | CTD_human |
| Tgene | BRAF | C0079773 | Lymphoma, T-Cell, Cutaneous | 1 | CTD_human |
| Tgene | BRAF | C0206686 | Adrenocortical carcinoma | 1 | CTD_human |
| Tgene | BRAF | C0206754 | Neuroendocrine Tumors | 1 | CTD_human |
| Tgene | BRAF | C0238463 | Papillary thyroid carcinoma | 1 | CTD_human;ORPHANET |
| Tgene | BRAF | C0587248 | Costello syndrome (disorder) | 1 | CTD_human |
| Tgene | BRAF | C0596263 | Carcinogenesis | 1 | CTD_human |
| Tgene | BRAF | C0920269 | Microsatellite Instability | 1 | CTD_human |
| Tgene | BRAF | C2239176 | Liver carcinoma | 1 | CTD_human |
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