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Fusion gene ID: 35054 |
FusionGeneSummary for SNAP25_IGSF9B |
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Fusion gene information | Fusion gene name: SNAP25_IGSF9B | Fusion gene ID: 35054 | Hgene | Tgene | Gene symbol | SNAP25 | IGSF9B | Gene ID | 6616 | 22997 |
Gene name | synaptosome associated protein 25 | immunoglobulin superfamily member 9B | |
Synonyms | CMS18|RIC-4|RIC4|SEC9|SNAP|SNAP-25|SUP|bA416N4.2|dJ1068F16.2 | - | |
Cytomap | 20p12.2 | 11q25 | |
Type of gene | protein-coding | protein-coding | |
Description | synaptosomal-associated protein 25resistance to inhibitors of cholinesterase 4 homologsynaptosomal-associated protein, 25kDasynaptosome associated protein 25kDa | protein turtle homolog B | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P60880 | Q9UPX0 | |
Ensembl transtripts involved in fusion gene | ENST00000254976, ENST00000304886, ENST00000495883, | ENST00000533871, ENST00000321016, ENST00000564347, | |
Fusion gene scores | * DoF score | 4 X 5 X 1=20 | 1 X 1 X 1=1 |
# samples | 5 | 1 | |
** MAII score | log2(5/20*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: SNAP25 [Title/Abstract] AND IGSF9B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BQ340310 | SNAP25 | chr20 | 10287519 | - | IGSF9B | chr11 | 133802427 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-intron | ENST00000254976 | ENST00000533871 | SNAP25 | chr20 | 10287519 | - | IGSF9B | chr11 | 133802427 | + |
3UTR-intron | ENST00000254976 | ENST00000321016 | SNAP25 | chr20 | 10287519 | - | IGSF9B | chr11 | 133802427 | + |
3UTR-intron | ENST00000254976 | ENST00000564347 | SNAP25 | chr20 | 10287519 | - | IGSF9B | chr11 | 133802427 | + |
3UTR-intron | ENST00000304886 | ENST00000533871 | SNAP25 | chr20 | 10287519 | - | IGSF9B | chr11 | 133802427 | + |
3UTR-intron | ENST00000304886 | ENST00000321016 | SNAP25 | chr20 | 10287519 | - | IGSF9B | chr11 | 133802427 | + |
3UTR-intron | ENST00000304886 | ENST00000564347 | SNAP25 | chr20 | 10287519 | - | IGSF9B | chr11 | 133802427 | + |
3UTR-intron | ENST00000495883 | ENST00000533871 | SNAP25 | chr20 | 10287519 | - | IGSF9B | chr11 | 133802427 | + |
3UTR-intron | ENST00000495883 | ENST00000321016 | SNAP25 | chr20 | 10287519 | - | IGSF9B | chr11 | 133802427 | + |
3UTR-intron | ENST00000495883 | ENST00000564347 | SNAP25 | chr20 | 10287519 | - | IGSF9B | chr11 | 133802427 | + |
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FusionProtFeatures for SNAP25_IGSF9B |
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Hgene | Tgene |
SNAP25 | IGSF9B |
Transmembrane protein which is abundantly expressed ininterneurons, where it may regulate inhibitory synapsedevelopment. May mediate homophilic cell adhesion.{ECO:0000250|UniProtKB:D3ZB51, ECO:0000250|UniProtKB:E9PZ19}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SNAP25_IGSF9B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SNAP25_IGSF9B |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SNAP25_IGSF9B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | SNAP25 | P60880 | DB00083 | Botulinum Toxin Type A | Synaptosomal-associated protein 25 | biotech | approved|investigational |
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RelatedDiseases for SNAP25_IGSF9B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SNAP25 | C0005586 | Bipolar Disorder | 4 | CTD_human;PSYGENET |
Hgene | SNAP25 | C0011581 | Depressive disorder | 2 | CTD_human;PSYGENET |
Hgene | SNAP25 | C0011570 | Mental Depression | 1 | PSYGENET |
Hgene | SNAP25 | C0011853 | Diabetes Mellitus, Experimental | 1 | CTD_human |
Hgene | SNAP25 | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | CTD_human |
Hgene | SNAP25 | C0033975 | Psychotic Disorders | 1 | CTD_human |
Hgene | SNAP25 | C0278076 | Behavioral tic | 1 | CTD_human |
Hgene | SNAP25 | C0752252 | Neuromuscular Manifestations | 1 | CTD_human |
Hgene | SNAP25 | C4225364 | MYASTHENIC SYNDROME, CONGENITAL, 18 | 1 | UNIPROT |