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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35054

FusionGeneSummary for SNAP25_IGSF9B

check button Fusion gene summary
Fusion gene informationFusion gene name: SNAP25_IGSF9B
Fusion gene ID: 35054
HgeneTgene
Gene symbol

SNAP25

IGSF9B

Gene ID

6616

22997

Gene namesynaptosome associated protein 25immunoglobulin superfamily member 9B
SynonymsCMS18|RIC-4|RIC4|SEC9|SNAP|SNAP-25|SUP|bA416N4.2|dJ1068F16.2-
Cytomap

20p12.2

11q25

Type of geneprotein-codingprotein-coding
Descriptionsynaptosomal-associated protein 25resistance to inhibitors of cholinesterase 4 homologsynaptosomal-associated protein, 25kDasynaptosome associated protein 25kDaprotein turtle homolog B
Modification date2018052320180523
UniProtAcc

P60880

Q9UPX0

Ensembl transtripts involved in fusion geneENST00000254976, ENST00000304886, 
ENST00000495883, 
ENST00000533871, 
ENST00000321016, ENST00000564347, 
Fusion gene scores* DoF score4 X 5 X 1=201 X 1 X 1=1
# samples 51
** MAII scorelog2(5/20*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: SNAP25 [Title/Abstract] AND IGSF9B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ340310SNAP25chr20

10287519

-IGSF9Bchr11

133802427

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000254976ENST00000533871SNAP25chr20

10287519

-IGSF9Bchr11

133802427

+
3UTR-intronENST00000254976ENST00000321016SNAP25chr20

10287519

-IGSF9Bchr11

133802427

+
3UTR-intronENST00000254976ENST00000564347SNAP25chr20

10287519

-IGSF9Bchr11

133802427

+
3UTR-intronENST00000304886ENST00000533871SNAP25chr20

10287519

-IGSF9Bchr11

133802427

+
3UTR-intronENST00000304886ENST00000321016SNAP25chr20

10287519

-IGSF9Bchr11

133802427

+
3UTR-intronENST00000304886ENST00000564347SNAP25chr20

10287519

-IGSF9Bchr11

133802427

+
3UTR-intronENST00000495883ENST00000533871SNAP25chr20

10287519

-IGSF9Bchr11

133802427

+
3UTR-intronENST00000495883ENST00000321016SNAP25chr20

10287519

-IGSF9Bchr11

133802427

+
3UTR-intronENST00000495883ENST00000564347SNAP25chr20

10287519

-IGSF9Bchr11

133802427

+

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FusionProtFeatures for SNAP25_IGSF9B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SNAP25

P60880

IGSF9B

Q9UPX0

Transmembrane protein which is abundantly expressed ininterneurons, where it may regulate inhibitory synapsedevelopment. May mediate homophilic cell adhesion.{ECO:0000250|UniProtKB:D3ZB51, ECO:0000250|UniProtKB:E9PZ19}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SNAP25_IGSF9B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SNAP25_IGSF9B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SNAP25_IGSF9B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneSNAP25P60880DB00083Botulinum Toxin Type ASynaptosomal-associated protein 25biotechapproved|investigational

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RelatedDiseases for SNAP25_IGSF9B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSNAP25C0005586Bipolar Disorder4CTD_human;PSYGENET
HgeneSNAP25C0011581Depressive disorder2CTD_human;PSYGENET
HgeneSNAP25C0011570Mental Depression1PSYGENET
HgeneSNAP25C0011853Diabetes Mellitus, Experimental1CTD_human
HgeneSNAP25C0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
HgeneSNAP25C0033975Psychotic Disorders1CTD_human
HgeneSNAP25C0278076Behavioral tic1CTD_human
HgeneSNAP25C0752252Neuromuscular Manifestations1CTD_human
HgeneSNAP25C4225364MYASTHENIC SYNDROME, CONGENITAL, 181UNIPROT