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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 35035

FusionGeneSummary for SMYD3_TRIM58

check button Fusion gene summary
Fusion gene informationFusion gene name: SMYD3_TRIM58
Fusion gene ID: 35035
HgeneTgene
Gene symbol

SMYD3

TRIM58

Gene ID

64754

25893

Gene nameSET and MYND domain containing 3tripartite motif containing 58
SynonymsKMT3E|ZMYND1|ZNFN3A1|bA74P14.1BIA2
Cytomap

1q44

1q44

Type of geneprotein-codingprotein-coding
Descriptionhistone-lysine N-methyltransferase SMYD3SET and MYND domain-containing protein 3bA74P14.1 (novel protein)zinc finger MYND domain-containing protein 1zinc finger protein, subfamily 3A (MYND domain containing), 1zinc finger, MYND domain containing 1E3 ubiquitin-protein ligase TRIM58RING-type E3 ubiquitin transferase TRIM58tripartite motif-containing protein 58
Modification date2018051920180519
UniProtAcc

Q9H7B4

Q8NG06

Ensembl transtripts involved in fusion geneENST00000541742, ENST00000490107, 
ENST00000388985, ENST00000366517, 
ENST00000403792, 
ENST00000366481, 
Fusion gene scores* DoF score10 X 7 X 9=6304 X 3 X 3=36
# samples 124
** MAII scorelog2(12/630*10)=-2.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SMYD3 [Title/Abstract] AND TRIM58 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-EJ-7789-01ASMYD3chr1

246490503

-TRIM58chr1

248023919

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000541742ENST00000366481SMYD3chr1

246490503

-TRIM58chr1

248023919

+
In-frameENST00000490107ENST00000366481SMYD3chr1

246490503

-TRIM58chr1

248023919

+
In-frameENST00000388985ENST00000366481SMYD3chr1

246490503

-TRIM58chr1

248023919

+
intron-3CDSENST00000366517ENST00000366481SMYD3chr1

246490503

-TRIM58chr1

248023919

+
In-frameENST00000403792ENST00000366481SMYD3chr1

246490503

-TRIM58chr1

248023919

+

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FusionProtFeatures for SMYD3_TRIM58


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SMYD3

Q9H7B4

TRIM58

Q8NG06

Histone methyltransferase. Specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but notmonomethylation (PubMed:15235609, PubMed:22419068). Alsomethylates 'Lys-5' of histone H4 (PubMed:22419068). Plays animportant role in transcriptional activation as a member of an RNApolymerase complex (PubMed:15235609). Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences (PubMed:15235609).{ECO:0000269|PubMed:15235609, ECO:0000269|PubMed:22419068}. E3 ubiquitin ligase induced during late erythropoiesis.Directly binds and ubiquitinates the intermediate chain of themicrotubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating thedegradation of the dynein holoprotein complex. May participate inthe erythroblast enucleation process through regulation of nuclearpolarization. {ECO:0000269|PubMed:25241935}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SMYD3_TRIM58


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_SMYD3_ENST00000490107_chr1_246490503_-_TRIM58_ENST00000366481_chr1_248023919_+_465aa
MRCSQCRVAKYCSAKCQKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAPSESEKLYSFYDLESNINKLTEDKKEGLRQLVM
TFQHFMREEIQDASQLPPAFDLFEAFAKVKLQMALELMRKELEDALTQEANVGKKTVIWKEKVEMQRQRFRLEFEKHRGFLAQEEQRQLR
RLEAEERATLQRLRESKSRLVQQSKALKELADELQERCQRPALGLLEGVRGVLSRSKAVTRLEAENIPMELKTACCIPGRRELLRKFQVD
VKLDPATAHPSLLLTADLRSVQDGEPWRDVPNNPERFDTWPCILGLQSFSSGRHYWEVLVGEGAEWGLGVCQDTLPRKGETTPSPENGVW
ALWLLKGNEYMVLASPSVPLLQLESPRCIGIFLDYEAGEISFYNVTDGSYIYTFNQLFSGLLRPYFFICDATPLILPPTTIAGSGNWASR

>In-frame_SMYD3_ENST00000388985_chr1_246490503_-_TRIM58_ENST00000366481_chr1_248023919_+_524aa
MEPLKVEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLMRCSQCRVAKYCSAKCQKKAWPDHKRECKCL
KSCKPRYPPDSVRLLGRVVFKLMDGAPSESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVKL
QMALELMRKELEDALTQEANVGKKTVIWKEKVEMQRQRFRLEFEKHRGFLAQEEQRQLRRLEAEERATLQRLRESKSRLVQQSKALKELA
DELQERCQRPALGLLEGVRGVLSRSKAVTRLEAENIPMELKTACCIPGRRELLRKFQVDVKLDPATAHPSLLLTADLRSVQDGEPWRDVP
NNPERFDTWPCILGLQSFSSGRHYWEVLVGEGAEWGLGVCQDTLPRKGETTPSPENGVWALWLLKGNEYMVLASPSVPLLQLESPRCIGI

>In-frame_SMYD3_ENST00000403792_chr1_246490503_-_TRIM58_ENST00000366481_chr1_248023919_+_524aa
MEPLKVEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLMRCSQCRVAKYCSAKCQKKAWPDHKRECKCL
KSCKPRYPPDSVRLLGRVVFKLMDGAPSESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVKL
QMALELMRKELEDALTQEANVGKKTVIWKEKVEMQRQRFRLEFEKHRGFLAQEEQRQLRRLEAEERATLQRLRESKSRLVQQSKALKELA
DELQERCQRPALGLLEGVRGVLSRSKAVTRLEAENIPMELKTACCIPGRRELLRKFQVDVKLDPATAHPSLLLTADLRSVQDGEPWRDVP
NNPERFDTWPCILGLQSFSSGRHYWEVLVGEGAEWGLGVCQDTLPRKGETTPSPENGVWALWLLKGNEYMVLASPSVPLLQLESPRCIGI


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_SMYD3_ENST00000490107_chr1_246490503_-_TRIM58_ENST00000366481_chr1_248023919_+_1395nt
ATGCGATGCTCTCAGTGCCGCGTCGCCAAATACTGTAGTGCTAAGTGTCAGAAAAAAGCTTGGCCAGACCACAAGCGGGAATGCAAATGC
CTTAAAAGCTGCAAACCCAGATATCCTCCAGACTCCGTTCGACTTCTTGGCAGAGTTGTCTTCAAACTTATGGATGGAGCACCTTCAGAA
TCAGAGAAGCTTTACTCATTTTATGATCTGGAGTCAAATATTAACAAACTGACTGAAGATAAGAAAGAGGGCCTCAGGCAACTCGTAATG
ACATTTCAACATTTCATGAGAGAAGAAATACAGGATGCCTCTCAGCTGCCACCTGCCTTTGACCTTTTTGAAGCCTTTGCAAAAGTAAAG
CTCCAGATGGCTCTGGAACTTATGAGGAAAGAGTTGGAGGACGCCTTGACTCAGGAGGCCAACGTGGGGAAAAAGACTGTCATTTGGAAG
GAGAAAGTGGAAATGCAGAGGCAGCGCTTCAGATTGGAGTTTGAGAAGCATCGTGGCTTTCTGGCCCAGGAGGAGCAACGGCAGCTGAGG
CGGCTGGAGGCGGAGGAGCGAGCGACGCTGCAGAGACTGCGGGAGAGCAAGAGCCGGCTGGTCCAGCAGAGCAAGGCCCTGAAGGAGCTG
GCGGATGAGCTGCAGGAGAGGTGCCAGCGCCCGGCCCTGGGTCTGCTGGAGGGTGTGAGAGGAGTCCTGAGCAGAAGTAAGGCTGTCACA
AGGCTGGAAGCAGAGAACATCCCCATGGAACTGAAGACAGCATGCTGCATCCCTGGGAGGAGGGAGCTCTTAAGGAAGTTCCAAGTGGAT
GTAAAGCTGGATCCCGCCACGGCGCACCCGAGTCTGCTCTTGACCGCCGACCTGCGCAGTGTGCAGGATGGAGAACCATGGAGGGATGTC
CCCAACAACCCTGAGCGATTTGACACATGGCCCTGCATCCTGGGTTTGCAGAGCTTCTCATCAGGGAGGCATTACTGGGAGGTTCTGGTG
GGAGAAGGAGCAGAGTGGGGTTTAGGGGTCTGTCAAGACACACTGCCAAGAAAGGGGGAAACCACGCCATCTCCTGAGAATGGGGTCTGG
GCCCTGTGGCTGCTGAAAGGGAATGAGTACATGGTCCTTGCCTCCCCATCAGTGCCTCTTCTCCAACTGGAAAGTCCTCGCTGCATTGGG
ATTTTCTTGGACTATGAAGCCGGTGAAATTTCATTCTACAATGTCACAGATGGATCTTATATCTACACATTCAACCAACTCTTCTCTGGT
CTTCTTCGGCCTTACTTTTTCATCTGTGATGCAACTCCTCTTATCTTGCCACCCACAACAATAGCAGGGTCAGGAAATTGGGCATCCAGG

>In-frame_SMYD3_ENST00000388985_chr1_246490503_-_TRIM58_ENST00000366481_chr1_248023919_+_1572nt
ATGGAGCCGCTGAAGGTGGAAAAGTTCGCAACCGCCAAGAGGGGAAACGGGCTGCGCGCCGTGACCCCGCTGCGCCCCGGAGAGCTACTC
TTCCGCTCGGATCCCTTGGCGTACACGGTGTGCAAGGGGAGTCGTGGCGTCGTCTGCGACCGCTGCCTTCTCGGGAAGGAAAAGCTGATG
CGATGCTCTCAGTGCCGCGTCGCCAAATACTGTAGTGCTAAGTGTCAGAAAAAAGCTTGGCCAGACCACAAGCGGGAATGCAAATGCCTT
AAAAGCTGCAAACCCAGATATCCTCCAGACTCCGTTCGACTTCTTGGCAGAGTTGTCTTCAAACTTATGGATGGAGCACCTTCAGAATCA
GAGAAGCTTTACTCATTTTATGATCTGGAGTCAAATATTAACAAACTGACTGAAGATAAGAAAGAGGGCCTCAGGCAACTCGTAATGACA
TTTCAACATTTCATGAGAGAAGAAATACAGGATGCCTCTCAGCTGCCACCTGCCTTTGACCTTTTTGAAGCCTTTGCAAAAGTAAAGCTC
CAGATGGCTCTGGAACTTATGAGGAAAGAGTTGGAGGACGCCTTGACTCAGGAGGCCAACGTGGGGAAAAAGACTGTCATTTGGAAGGAG
AAAGTGGAAATGCAGAGGCAGCGCTTCAGATTGGAGTTTGAGAAGCATCGTGGCTTTCTGGCCCAGGAGGAGCAACGGCAGCTGAGGCGG
CTGGAGGCGGAGGAGCGAGCGACGCTGCAGAGACTGCGGGAGAGCAAGAGCCGGCTGGTCCAGCAGAGCAAGGCCCTGAAGGAGCTGGCG
GATGAGCTGCAGGAGAGGTGCCAGCGCCCGGCCCTGGGTCTGCTGGAGGGTGTGAGAGGAGTCCTGAGCAGAAGTAAGGCTGTCACAAGG
CTGGAAGCAGAGAACATCCCCATGGAACTGAAGACAGCATGCTGCATCCCTGGGAGGAGGGAGCTCTTAAGGAAGTTCCAAGTGGATGTA
AAGCTGGATCCCGCCACGGCGCACCCGAGTCTGCTCTTGACCGCCGACCTGCGCAGTGTGCAGGATGGAGAACCATGGAGGGATGTCCCC
AACAACCCTGAGCGATTTGACACATGGCCCTGCATCCTGGGTTTGCAGAGCTTCTCATCAGGGAGGCATTACTGGGAGGTTCTGGTGGGA
GAAGGAGCAGAGTGGGGTTTAGGGGTCTGTCAAGACACACTGCCAAGAAAGGGGGAAACCACGCCATCTCCTGAGAATGGGGTCTGGGCC
CTGTGGCTGCTGAAAGGGAATGAGTACATGGTCCTTGCCTCCCCATCAGTGCCTCTTCTCCAACTGGAAAGTCCTCGCTGCATTGGGATT
TTCTTGGACTATGAAGCCGGTGAAATTTCATTCTACAATGTCACAGATGGATCTTATATCTACACATTCAACCAACTCTTCTCTGGTCTT
CTTCGGCCTTACTTTTTCATCTGTGATGCAACTCCTCTTATCTTGCCACCCACAACAATAGCAGGGTCAGGAAATTGGGCATCCAGGGAT

>In-frame_SMYD3_ENST00000403792_chr1_246490503_-_TRIM58_ENST00000366481_chr1_248023919_+_1572nt
ATGGAGCCGCTGAAGGTGGAAAAGTTCGCAACCGCCAAGAGGGGAAACGGGCTGCGCGCCGTGACCCCGCTGCGCCCCGGAGAGCTACTC
TTCCGCTCGGATCCCTTGGCGTACACGGTGTGCAAGGGGAGTCGTGGCGTCGTCTGCGACCGCTGCCTTCTCGGGAAGGAAAAGCTGATG
CGATGCTCTCAGTGCCGCGTCGCCAAATACTGTAGTGCTAAGTGTCAGAAAAAAGCTTGGCCAGACCACAAGCGGGAATGCAAATGCCTT
AAAAGCTGCAAACCCAGATATCCTCCAGACTCCGTTCGACTTCTTGGCAGAGTTGTCTTCAAACTTATGGATGGAGCACCTTCAGAATCA
GAGAAGCTTTACTCATTTTATGATCTGGAGTCAAATATTAACAAACTGACTGAAGATAAGAAAGAGGGCCTCAGGCAACTCGTAATGACA
TTTCAACATTTCATGAGAGAAGAAATACAGGATGCCTCTCAGCTGCCACCTGCCTTTGACCTTTTTGAAGCCTTTGCAAAAGTAAAGCTC
CAGATGGCTCTGGAACTTATGAGGAAAGAGTTGGAGGACGCCTTGACTCAGGAGGCCAACGTGGGGAAAAAGACTGTCATTTGGAAGGAG
AAAGTGGAAATGCAGAGGCAGCGCTTCAGATTGGAGTTTGAGAAGCATCGTGGCTTTCTGGCCCAGGAGGAGCAACGGCAGCTGAGGCGG
CTGGAGGCGGAGGAGCGAGCGACGCTGCAGAGACTGCGGGAGAGCAAGAGCCGGCTGGTCCAGCAGAGCAAGGCCCTGAAGGAGCTGGCG
GATGAGCTGCAGGAGAGGTGCCAGCGCCCGGCCCTGGGTCTGCTGGAGGGTGTGAGAGGAGTCCTGAGCAGAAGTAAGGCTGTCACAAGG
CTGGAAGCAGAGAACATCCCCATGGAACTGAAGACAGCATGCTGCATCCCTGGGAGGAGGGAGCTCTTAAGGAAGTTCCAAGTGGATGTA
AAGCTGGATCCCGCCACGGCGCACCCGAGTCTGCTCTTGACCGCCGACCTGCGCAGTGTGCAGGATGGAGAACCATGGAGGGATGTCCCC
AACAACCCTGAGCGATTTGACACATGGCCCTGCATCCTGGGTTTGCAGAGCTTCTCATCAGGGAGGCATTACTGGGAGGTTCTGGTGGGA
GAAGGAGCAGAGTGGGGTTTAGGGGTCTGTCAAGACACACTGCCAAGAAAGGGGGAAACCACGCCATCTCCTGAGAATGGGGTCTGGGCC
CTGTGGCTGCTGAAAGGGAATGAGTACATGGTCCTTGCCTCCCCATCAGTGCCTCTTCTCCAACTGGAAAGTCCTCGCTGCATTGGGATT
TTCTTGGACTATGAAGCCGGTGAAATTTCATTCTACAATGTCACAGATGGATCTTATATCTACACATTCAACCAACTCTTCTCTGGTCTT
CTTCGGCCTTACTTTTTCATCTGTGATGCAACTCCTCTTATCTTGCCACCCACAACAATAGCAGGGTCAGGAAATTGGGCATCCAGGGAT


* Fusion transcript sequences (Full-length transcript).
>In-frame_SMYD3_ENST00000490107_chr1_246490503_-_TRIM58_ENST00000366481_chr1_248023919_+_3328nt
GGACGCGGGTAGCCGTCTGAGGTGCCGGAGCTGCGGGAGGATGGAGCCGCTGAAGGTGGAAAAGTTCGCAACCGCCAAGAGGGGAAACGG
GCTGCGCGCCGTGACCCCGCTGCGCCCCGGAGAGCTACTCTTCCGCTCGGATCCCTTGGCGTACACGGTGTGCAAGGGGAGTCGTGGCGT
CGTCTGCGACCGCTGCCTTCTCGGGAAGGAAAAGCTGATGCGATGCTCTCAGTGCCGCGTCGCCAAATACTGTAGTGCTAAGTGTCAGAA
AAAAGCTTGGCCAGACCACAAGCGGGAATGCAAATGCCTTAAAAGCTGCAAACCCAGATATCCTCCAGACTCCGTTCGACTTCTTGGCAG
AGTTGTCTTCAAACTTATGGATGGAGCACCTTCAGAATCAGAGAAGCTTTACTCATTTTATGATCTGGAGTCAAATATTAACAAACTGAC
TGAAGATAAGAAAGAGGGCCTCAGGCAACTCGTAATGACATTTCAACATTTCATGAGAGAAGAAATACAGGATGCCTCTCAGCTGCCACC
TGCCTTTGACCTTTTTGAAGCCTTTGCAAAAGTAAAGCTCCAGATGGCTCTGGAACTTATGAGGAAAGAGTTGGAGGACGCCTTGACTCA
GGAGGCCAACGTGGGGAAAAAGACTGTCATTTGGAAGGAGAAAGTGGAAATGCAGAGGCAGCGCTTCAGATTGGAGTTTGAGAAGCATCG
TGGCTTTCTGGCCCAGGAGGAGCAACGGCAGCTGAGGCGGCTGGAGGCGGAGGAGCGAGCGACGCTGCAGAGACTGCGGGAGAGCAAGAG
CCGGCTGGTCCAGCAGAGCAAGGCCCTGAAGGAGCTGGCGGATGAGCTGCAGGAGAGGTGCCAGCGCCCGGCCCTGGGTCTGCTGGAGGG
TGTGAGAGGAGTCCTGAGCAGAAGTAAGGCTGTCACAAGGCTGGAAGCAGAGAACATCCCCATGGAACTGAAGACAGCATGCTGCATCCC
TGGGAGGAGGGAGCTCTTAAGGAAGTTCCAAGTGGATGTAAAGCTGGATCCCGCCACGGCGCACCCGAGTCTGCTCTTGACCGCCGACCT
GCGCAGTGTGCAGGATGGAGAACCATGGAGGGATGTCCCCAACAACCCTGAGCGATTTGACACATGGCCCTGCATCCTGGGTTTGCAGAG
CTTCTCATCAGGGAGGCATTACTGGGAGGTTCTGGTGGGAGAAGGAGCAGAGTGGGGTTTAGGGGTCTGTCAAGACACACTGCCAAGAAA
GGGGGAAACCACGCCATCTCCTGAGAATGGGGTCTGGGCCCTGTGGCTGCTGAAAGGGAATGAGTACATGGTCCTTGCCTCCCCATCAGT
GCCTCTTCTCCAACTGGAAAGTCCTCGCTGCATTGGGATTTTCTTGGACTATGAAGCCGGTGAAATTTCATTCTACAATGTCACAGATGG
ATCTTATATCTACACATTCAACCAACTCTTCTCTGGTCTTCTTCGGCCTTACTTTTTCATCTGTGATGCAACTCCTCTTATCTTGCCACC
CACAACAATAGCAGGGTCAGGAAATTGGGCATCCAGGGATCATTTAGATCCTGCTTCTGATGTAAGAGATGATCATCTCTAAAATTCTGT
TCCCAAGATGCAGTCCTAGCGTAGCGAACGTTCCTGGAGTGGGGTGAAGGATATCAATATACTAAGTTTTAACAGATACCCCATTTAGGT
CAGCACTTGATTCGTTGTTGCTGTGAAATATGTCCATGGGACAAAAGAGGGAATATGAAATATTTGCATATGGGAAGATTATAGAGCATA
ATAATTTTGTAAATGGAGCAATCTCAACCTCTATTTCTAGATCACATTTTCTTGATGTCTTCCTTCAAATTAATGACCTTGGATTACATA
AGGATTTCTATGCATTCATTATAATTTGTTATTCCTTTCAATATCCTTGTATTTCAAATCTTCCATATAAGAATTAGACATGGCAATTCT
TAAATTGATTCAGAATGGTCTGATACTATTCCAGTATCACCTCCTTAATTCTGTTTCTCCTCGTTTTCCTGATTTTCCTTCTCATTCTCT
CCTTCCCCGCTCTGTCTCTCTCTCCCTGTCACTCTCTCTCTCTTGTTCCTTATTTTTTGTTTCTTACCTCTTACTGTTTAACCTGTTGCT
TCCTTCTGGATTAATACATTTAGAGCCATTCCTTTATATGGTCACATTTCCTATGACTTTACTCAATTACTTTTAAAATCCTTTCTATTC
TGAGACTAATTTTTAAGAATTACAAAGCTCATTCTTCTGAATCTAATATCACTAACTCCTAGACTTTTTCCGTTTTCTTTGGATACACTT
TAAGTAGGAATTTATCAGAATTTTCATTCAACTCGTTCTTTAATGCAGATATTTACTAGTTATAAGACCTTAAGGCTGGGTGCAGTGGCT
CACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGATCACAAGCTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACC
CTGTCTCTACTAAAAAAAAAAAAAAAATAGAAAAATTAGCTGGGCATGGTGGCAGGAGCCTGTAATCCCAGCTATTCTGGAGGTGGAGAC
AGGAGAATTGCTTGAACCCTGGAGGCGGAGGTTGCAGTGAGCCAATATCTCACCACTGTACTCCAGCCCAGTGCGAGACTCCATCTCAAA
AAAGAAAAAAGACCTCAAACAACACTTCTCTCTCTCTTTTAGCTGCTTGTTATGGTTCCTATACATGGAACAATTATACTGGCCTCACTG
TGTTATGGTAAATATTTAAGGTCATATTTGATATTGCTGGTTTGAATTCAGCTTTTCCATTTAAATACATTATAATGATGATGATGAAAT
CATGATAATATTTAACTTATTTTTAAAGTATATTCTGTACCTTTCCAACAAAAAGGTTAAAAGTCATTGAAGGCTAACCTTACTGCCTTC
TTTGTATCACTGTCTTCTAAATAATTATTATGTCTGGGTACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCAG
ATCACGAGGTCAGGAGATTGAGACCATCCTGGCTAACACAGTGAAACCCCGTCTCTACTAAAAATACAAAAAGAAATTAGCTGGGCGTGG
TGGTGGGTGCCTGTTGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATGGCATGAACCCAGGAGGCAGAGCTTGTAGTGAGCCGAGATC

>In-frame_SMYD3_ENST00000388985_chr1_246490503_-_TRIM58_ENST00000366481_chr1_248023919_+_3288nt
ATGGAGCCGCTGAAGGTGGAAAAGTTCGCAACCGCCAAGAGGGGAAACGGGCTGCGCGCCGTGACCCCGCTGCGCCCCGGAGAGCTACTC
TTCCGCTCGGATCCCTTGGCGTACACGGTGTGCAAGGGGAGTCGTGGCGTCGTCTGCGACCGCTGCCTTCTCGGGAAGGAAAAGCTGATG
CGATGCTCTCAGTGCCGCGTCGCCAAATACTGTAGTGCTAAGTGTCAGAAAAAAGCTTGGCCAGACCACAAGCGGGAATGCAAATGCCTT
AAAAGCTGCAAACCCAGATATCCTCCAGACTCCGTTCGACTTCTTGGCAGAGTTGTCTTCAAACTTATGGATGGAGCACCTTCAGAATCA
GAGAAGCTTTACTCATTTTATGATCTGGAGTCAAATATTAACAAACTGACTGAAGATAAGAAAGAGGGCCTCAGGCAACTCGTAATGACA
TTTCAACATTTCATGAGAGAAGAAATACAGGATGCCTCTCAGCTGCCACCTGCCTTTGACCTTTTTGAAGCCTTTGCAAAAGTAAAGCTC
CAGATGGCTCTGGAACTTATGAGGAAAGAGTTGGAGGACGCCTTGACTCAGGAGGCCAACGTGGGGAAAAAGACTGTCATTTGGAAGGAG
AAAGTGGAAATGCAGAGGCAGCGCTTCAGATTGGAGTTTGAGAAGCATCGTGGCTTTCTGGCCCAGGAGGAGCAACGGCAGCTGAGGCGG
CTGGAGGCGGAGGAGCGAGCGACGCTGCAGAGACTGCGGGAGAGCAAGAGCCGGCTGGTCCAGCAGAGCAAGGCCCTGAAGGAGCTGGCG
GATGAGCTGCAGGAGAGGTGCCAGCGCCCGGCCCTGGGTCTGCTGGAGGGTGTGAGAGGAGTCCTGAGCAGAAGTAAGGCTGTCACAAGG
CTGGAAGCAGAGAACATCCCCATGGAACTGAAGACAGCATGCTGCATCCCTGGGAGGAGGGAGCTCTTAAGGAAGTTCCAAGTGGATGTA
AAGCTGGATCCCGCCACGGCGCACCCGAGTCTGCTCTTGACCGCCGACCTGCGCAGTGTGCAGGATGGAGAACCATGGAGGGATGTCCCC
AACAACCCTGAGCGATTTGACACATGGCCCTGCATCCTGGGTTTGCAGAGCTTCTCATCAGGGAGGCATTACTGGGAGGTTCTGGTGGGA
GAAGGAGCAGAGTGGGGTTTAGGGGTCTGTCAAGACACACTGCCAAGAAAGGGGGAAACCACGCCATCTCCTGAGAATGGGGTCTGGGCC
CTGTGGCTGCTGAAAGGGAATGAGTACATGGTCCTTGCCTCCCCATCAGTGCCTCTTCTCCAACTGGAAAGTCCTCGCTGCATTGGGATT
TTCTTGGACTATGAAGCCGGTGAAATTTCATTCTACAATGTCACAGATGGATCTTATATCTACACATTCAACCAACTCTTCTCTGGTCTT
CTTCGGCCTTACTTTTTCATCTGTGATGCAACTCCTCTTATCTTGCCACCCACAACAATAGCAGGGTCAGGAAATTGGGCATCCAGGGAT
CATTTAGATCCTGCTTCTGATGTAAGAGATGATCATCTCTAAAATTCTGTTCCCAAGATGCAGTCCTAGCGTAGCGAACGTTCCTGGAGT
GGGGTGAAGGATATCAATATACTAAGTTTTAACAGATACCCCATTTAGGTCAGCACTTGATTCGTTGTTGCTGTGAAATATGTCCATGGG
ACAAAAGAGGGAATATGAAATATTTGCATATGGGAAGATTATAGAGCATAATAATTTTGTAAATGGAGCAATCTCAACCTCTATTTCTAG
ATCACATTTTCTTGATGTCTTCCTTCAAATTAATGACCTTGGATTACATAAGGATTTCTATGCATTCATTATAATTTGTTATTCCTTTCA
ATATCCTTGTATTTCAAATCTTCCATATAAGAATTAGACATGGCAATTCTTAAATTGATTCAGAATGGTCTGATACTATTCCAGTATCAC
CTCCTTAATTCTGTTTCTCCTCGTTTTCCTGATTTTCCTTCTCATTCTCTCCTTCCCCGCTCTGTCTCTCTCTCCCTGTCACTCTCTCTC
TCTTGTTCCTTATTTTTTGTTTCTTACCTCTTACTGTTTAACCTGTTGCTTCCTTCTGGATTAATACATTTAGAGCCATTCCTTTATATG
GTCACATTTCCTATGACTTTACTCAATTACTTTTAAAATCCTTTCTATTCTGAGACTAATTTTTAAGAATTACAAAGCTCATTCTTCTGA
ATCTAATATCACTAACTCCTAGACTTTTTCCGTTTTCTTTGGATACACTTTAAGTAGGAATTTATCAGAATTTTCATTCAACTCGTTCTT
TAATGCAGATATTTACTAGTTATAAGACCTTAAGGCTGGGTGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGT
GGATCACAAGCTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAAAAAAAAAAAAATAGAAAAATTAGC
TGGGCATGGTGGCAGGAGCCTGTAATCCCAGCTATTCTGGAGGTGGAGACAGGAGAATTGCTTGAACCCTGGAGGCGGAGGTTGCAGTGA
GCCAATATCTCACCACTGTACTCCAGCCCAGTGCGAGACTCCATCTCAAAAAAGAAAAAAGACCTCAAACAACACTTCTCTCTCTCTTTT
AGCTGCTTGTTATGGTTCCTATACATGGAACAATTATACTGGCCTCACTGTGTTATGGTAAATATTTAAGGTCATATTTGATATTGCTGG
TTTGAATTCAGCTTTTCCATTTAAATACATTATAATGATGATGATGAAATCATGATAATATTTAACTTATTTTTAAAGTATATTCTGTAC
CTTTCCAACAAAAAGGTTAAAAGTCATTGAAGGCTAACCTTACTGCCTTCTTTGTATCACTGTCTTCTAAATAATTATTATGTCTGGGTA
CAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCAGATCACGAGGTCAGGAGATTGAGACCATCCTGGCTAACACA
GTGAAACCCCGTCTCTACTAAAAATACAAAAAGAAATTAGCTGGGCGTGGTGGTGGGTGCCTGTTGTCCCAGCTACTTGGGAGGCTGAGG
CAGGAGAATGGCATGAACCCAGGAGGCAGAGCTTGTAGTGAGCCGAGATCGCGCCACTGCACTCCAGCCGGGGCAACAGAGCAAGACTCC

>In-frame_SMYD3_ENST00000403792_chr1_246490503_-_TRIM58_ENST00000366481_chr1_248023919_+_3383nt
GTGCGCGCAGGGCGCAGGCGCGCGGGTCCCGGCAGCCCGTGAGACGCCCGCTGCTGGACGCGGGTAGCCGTCTGAGGTGCCGGAGCTGCG
GGAGGATGGAGCCGCTGAAGGTGGAAAAGTTCGCAACCGCCAAGAGGGGAAACGGGCTGCGCGCCGTGACCCCGCTGCGCCCCGGAGAGC
TACTCTTCCGCTCGGATCCCTTGGCGTACACGGTGTGCAAGGGGAGTCGTGGCGTCGTCTGCGACCGCTGCCTTCTCGGGAAGGAAAAGC
TGATGCGATGCTCTCAGTGCCGCGTCGCCAAATACTGTAGTGCTAAGTGTCAGAAAAAAGCTTGGCCAGACCACAAGCGGGAATGCAAAT
GCCTTAAAAGCTGCAAACCCAGATATCCTCCAGACTCCGTTCGACTTCTTGGCAGAGTTGTCTTCAAACTTATGGATGGAGCACCTTCAG
AATCAGAGAAGCTTTACTCATTTTATGATCTGGAGTCAAATATTAACAAACTGACTGAAGATAAGAAAGAGGGCCTCAGGCAACTCGTAA
TGACATTTCAACATTTCATGAGAGAAGAAATACAGGATGCCTCTCAGCTGCCACCTGCCTTTGACCTTTTTGAAGCCTTTGCAAAAGTAA
AGCTCCAGATGGCTCTGGAACTTATGAGGAAAGAGTTGGAGGACGCCTTGACTCAGGAGGCCAACGTGGGGAAAAAGACTGTCATTTGGA
AGGAGAAAGTGGAAATGCAGAGGCAGCGCTTCAGATTGGAGTTTGAGAAGCATCGTGGCTTTCTGGCCCAGGAGGAGCAACGGCAGCTGA
GGCGGCTGGAGGCGGAGGAGCGAGCGACGCTGCAGAGACTGCGGGAGAGCAAGAGCCGGCTGGTCCAGCAGAGCAAGGCCCTGAAGGAGC
TGGCGGATGAGCTGCAGGAGAGGTGCCAGCGCCCGGCCCTGGGTCTGCTGGAGGGTGTGAGAGGAGTCCTGAGCAGAAGTAAGGCTGTCA
CAAGGCTGGAAGCAGAGAACATCCCCATGGAACTGAAGACAGCATGCTGCATCCCTGGGAGGAGGGAGCTCTTAAGGAAGTTCCAAGTGG
ATGTAAAGCTGGATCCCGCCACGGCGCACCCGAGTCTGCTCTTGACCGCCGACCTGCGCAGTGTGCAGGATGGAGAACCATGGAGGGATG
TCCCCAACAACCCTGAGCGATTTGACACATGGCCCTGCATCCTGGGTTTGCAGAGCTTCTCATCAGGGAGGCATTACTGGGAGGTTCTGG
TGGGAGAAGGAGCAGAGTGGGGTTTAGGGGTCTGTCAAGACACACTGCCAAGAAAGGGGGAAACCACGCCATCTCCTGAGAATGGGGTCT
GGGCCCTGTGGCTGCTGAAAGGGAATGAGTACATGGTCCTTGCCTCCCCATCAGTGCCTCTTCTCCAACTGGAAAGTCCTCGCTGCATTG
GGATTTTCTTGGACTATGAAGCCGGTGAAATTTCATTCTACAATGTCACAGATGGATCTTATATCTACACATTCAACCAACTCTTCTCTG
GTCTTCTTCGGCCTTACTTTTTCATCTGTGATGCAACTCCTCTTATCTTGCCACCCACAACAATAGCAGGGTCAGGAAATTGGGCATCCA
GGGATCATTTAGATCCTGCTTCTGATGTAAGAGATGATCATCTCTAAAATTCTGTTCCCAAGATGCAGTCCTAGCGTAGCGAACGTTCCT
GGAGTGGGGTGAAGGATATCAATATACTAAGTTTTAACAGATACCCCATTTAGGTCAGCACTTGATTCGTTGTTGCTGTGAAATATGTCC
ATGGGACAAAAGAGGGAATATGAAATATTTGCATATGGGAAGATTATAGAGCATAATAATTTTGTAAATGGAGCAATCTCAACCTCTATT
TCTAGATCACATTTTCTTGATGTCTTCCTTCAAATTAATGACCTTGGATTACATAAGGATTTCTATGCATTCATTATAATTTGTTATTCC
TTTCAATATCCTTGTATTTCAAATCTTCCATATAAGAATTAGACATGGCAATTCTTAAATTGATTCAGAATGGTCTGATACTATTCCAGT
ATCACCTCCTTAATTCTGTTTCTCCTCGTTTTCCTGATTTTCCTTCTCATTCTCTCCTTCCCCGCTCTGTCTCTCTCTCCCTGTCACTCT
CTCTCTCTTGTTCCTTATTTTTTGTTTCTTACCTCTTACTGTTTAACCTGTTGCTTCCTTCTGGATTAATACATTTAGAGCCATTCCTTT
ATATGGTCACATTTCCTATGACTTTACTCAATTACTTTTAAAATCCTTTCTATTCTGAGACTAATTTTTAAGAATTACAAAGCTCATTCT
TCTGAATCTAATATCACTAACTCCTAGACTTTTTCCGTTTTCTTTGGATACACTTTAAGTAGGAATTTATCAGAATTTTCATTCAACTCG
TTCTTTAATGCAGATATTTACTAGTTATAAGACCTTAAGGCTGGGTGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGG
CGGGTGGATCACAAGCTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAAAAAAAAAAAAATAGAAAAA
TTAGCTGGGCATGGTGGCAGGAGCCTGTAATCCCAGCTATTCTGGAGGTGGAGACAGGAGAATTGCTTGAACCCTGGAGGCGGAGGTTGC
AGTGAGCCAATATCTCACCACTGTACTCCAGCCCAGTGCGAGACTCCATCTCAAAAAAGAAAAAAGACCTCAAACAACACTTCTCTCTCT
CTTTTAGCTGCTTGTTATGGTTCCTATACATGGAACAATTATACTGGCCTCACTGTGTTATGGTAAATATTTAAGGTCATATTTGATATT
GCTGGTTTGAATTCAGCTTTTCCATTTAAATACATTATAATGATGATGATGAAATCATGATAATATTTAACTTATTTTTAAAGTATATTC
TGTACCTTTCCAACAAAAAGGTTAAAAGTCATTGAAGGCTAACCTTACTGCCTTCTTTGTATCACTGTCTTCTAAATAATTATTATGTCT
GGGTACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCAGATCACGAGGTCAGGAGATTGAGACCATCCTGGCTA
ACACAGTGAAACCCCGTCTCTACTAAAAATACAAAAAGAAATTAGCTGGGCGTGGTGGTGGGTGCCTGTTGTCCCAGCTACTTGGGAGGC
TGAGGCAGGAGAATGGCATGAACCCAGGAGGCAGAGCTTGTAGTGAGCCGAGATCGCGCCACTGCACTCCAGCCGGGGCAACAGAGCAAG


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FusionGenePPI for SMYD3_TRIM58


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SMYD3MEST, HELZ, POLR2A, HSP90AA1, HIST3H3, ESR1, EZH2, EED, APP, CAMK2B, NDUFAB1, NFYB, CYP39A1, VANGL1, H3F3C, TRIT1, ZNF557, CDC37, HSP90AB1, HSP90AB4P, HSP90AB3P, HSP90AA5P, MAGED4B, KDM3B, RCAN3, PLCB3, TRMT2A, KMT2ETRIM58DYNC1H1, DYNC1I1, DYNC2LI1, DYNC1LI2, TRIM58, UBE2D3, FBXW7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SMYD3_TRIM58


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SMYD3_TRIM58


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSMYD3C0236733Amphetamine-Related Disorders1CTD_human