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Fusion gene ID: 35035 |
FusionGeneSummary for SMYD3_TRIM58 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SMYD3_TRIM58 | Fusion gene ID: 35035 | Hgene | Tgene | Gene symbol | SMYD3 | TRIM58 | Gene ID | 64754 | 25893 |
| Gene name | SET and MYND domain containing 3 | tripartite motif containing 58 | |
| Synonyms | KMT3E|ZMYND1|ZNFN3A1|bA74P14.1 | BIA2 | |
| Cytomap | 1q44 | 1q44 | |
| Type of gene | protein-coding | protein-coding | |
| Description | histone-lysine N-methyltransferase SMYD3SET and MYND domain-containing protein 3bA74P14.1 (novel protein)zinc finger MYND domain-containing protein 1zinc finger protein, subfamily 3A (MYND domain containing), 1zinc finger, MYND domain containing 1 | E3 ubiquitin-protein ligase TRIM58RING-type E3 ubiquitin transferase TRIM58tripartite motif-containing protein 58 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q9H7B4 | Q8NG06 | |
| Ensembl transtripts involved in fusion gene | ENST00000541742, ENST00000490107, ENST00000388985, ENST00000366517, ENST00000403792, | ENST00000366481, | |
| Fusion gene scores | * DoF score | 10 X 7 X 9=630 | 4 X 3 X 3=36 |
| # samples | 12 | 4 | |
| ** MAII score | log2(12/630*10)=-2.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: SMYD3 [Title/Abstract] AND TRIM58 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-EJ-7789-01A | SMYD3 | chr1 | 246490503 | - | TRIM58 | chr1 | 248023919 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000541742 | ENST00000366481 | SMYD3 | chr1 | 246490503 | - | TRIM58 | chr1 | 248023919 | + |
| In-frame | ENST00000490107 | ENST00000366481 | SMYD3 | chr1 | 246490503 | - | TRIM58 | chr1 | 248023919 | + |
| In-frame | ENST00000388985 | ENST00000366481 | SMYD3 | chr1 | 246490503 | - | TRIM58 | chr1 | 248023919 | + |
| intron-3CDS | ENST00000366517 | ENST00000366481 | SMYD3 | chr1 | 246490503 | - | TRIM58 | chr1 | 248023919 | + |
| In-frame | ENST00000403792 | ENST00000366481 | SMYD3 | chr1 | 246490503 | - | TRIM58 | chr1 | 248023919 | + |
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FusionProtFeatures for SMYD3_TRIM58 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SMYD3 | TRIM58 |
| Histone methyltransferase. Specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but notmonomethylation (PubMed:15235609, PubMed:22419068). Alsomethylates 'Lys-5' of histone H4 (PubMed:22419068). Plays animportant role in transcriptional activation as a member of an RNApolymerase complex (PubMed:15235609). Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences (PubMed:15235609).{ECO:0000269|PubMed:15235609, ECO:0000269|PubMed:22419068}. | E3 ubiquitin ligase induced during late erythropoiesis.Directly binds and ubiquitinates the intermediate chain of themicrotubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating thedegradation of the dynein holoprotein complex. May participate inthe erythroblast enucleation process through regulation of nuclearpolarization. {ECO:0000269|PubMed:25241935}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SMYD3_TRIM58 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SMYD3_ENST00000490107_chr1_246490503_-_TRIM58_ENST00000366481_chr1_248023919_+_465aa MRCSQCRVAKYCSAKCQKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAPSESEKLYSFYDLESNINKLTEDKKEGLRQLVM TFQHFMREEIQDASQLPPAFDLFEAFAKVKLQMALELMRKELEDALTQEANVGKKTVIWKEKVEMQRQRFRLEFEKHRGFLAQEEQRQLR RLEAEERATLQRLRESKSRLVQQSKALKELADELQERCQRPALGLLEGVRGVLSRSKAVTRLEAENIPMELKTACCIPGRRELLRKFQVD VKLDPATAHPSLLLTADLRSVQDGEPWRDVPNNPERFDTWPCILGLQSFSSGRHYWEVLVGEGAEWGLGVCQDTLPRKGETTPSPENGVW ALWLLKGNEYMVLASPSVPLLQLESPRCIGIFLDYEAGEISFYNVTDGSYIYTFNQLFSGLLRPYFFICDATPLILPPTTIAGSGNWASR >In-frame_SMYD3_ENST00000388985_chr1_246490503_-_TRIM58_ENST00000366481_chr1_248023919_+_524aa MEPLKVEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLMRCSQCRVAKYCSAKCQKKAWPDHKRECKCL KSCKPRYPPDSVRLLGRVVFKLMDGAPSESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVKL QMALELMRKELEDALTQEANVGKKTVIWKEKVEMQRQRFRLEFEKHRGFLAQEEQRQLRRLEAEERATLQRLRESKSRLVQQSKALKELA DELQERCQRPALGLLEGVRGVLSRSKAVTRLEAENIPMELKTACCIPGRRELLRKFQVDVKLDPATAHPSLLLTADLRSVQDGEPWRDVP NNPERFDTWPCILGLQSFSSGRHYWEVLVGEGAEWGLGVCQDTLPRKGETTPSPENGVWALWLLKGNEYMVLASPSVPLLQLESPRCIGI >In-frame_SMYD3_ENST00000403792_chr1_246490503_-_TRIM58_ENST00000366481_chr1_248023919_+_524aa MEPLKVEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLMRCSQCRVAKYCSAKCQKKAWPDHKRECKCL KSCKPRYPPDSVRLLGRVVFKLMDGAPSESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVKL QMALELMRKELEDALTQEANVGKKTVIWKEKVEMQRQRFRLEFEKHRGFLAQEEQRQLRRLEAEERATLQRLRESKSRLVQQSKALKELA DELQERCQRPALGLLEGVRGVLSRSKAVTRLEAENIPMELKTACCIPGRRELLRKFQVDVKLDPATAHPSLLLTADLRSVQDGEPWRDVP NNPERFDTWPCILGLQSFSSGRHYWEVLVGEGAEWGLGVCQDTLPRKGETTPSPENGVWALWLLKGNEYMVLASPSVPLLQLESPRCIGI |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SMYD3_ENST00000490107_chr1_246490503_-_TRIM58_ENST00000366481_chr1_248023919_+_1395nt ATGCGATGCTCTCAGTGCCGCGTCGCCAAATACTGTAGTGCTAAGTGTCAGAAAAAAGCTTGGCCAGACCACAAGCGGGAATGCAAATGC CTTAAAAGCTGCAAACCCAGATATCCTCCAGACTCCGTTCGACTTCTTGGCAGAGTTGTCTTCAAACTTATGGATGGAGCACCTTCAGAA TCAGAGAAGCTTTACTCATTTTATGATCTGGAGTCAAATATTAACAAACTGACTGAAGATAAGAAAGAGGGCCTCAGGCAACTCGTAATG ACATTTCAACATTTCATGAGAGAAGAAATACAGGATGCCTCTCAGCTGCCACCTGCCTTTGACCTTTTTGAAGCCTTTGCAAAAGTAAAG CTCCAGATGGCTCTGGAACTTATGAGGAAAGAGTTGGAGGACGCCTTGACTCAGGAGGCCAACGTGGGGAAAAAGACTGTCATTTGGAAG GAGAAAGTGGAAATGCAGAGGCAGCGCTTCAGATTGGAGTTTGAGAAGCATCGTGGCTTTCTGGCCCAGGAGGAGCAACGGCAGCTGAGG CGGCTGGAGGCGGAGGAGCGAGCGACGCTGCAGAGACTGCGGGAGAGCAAGAGCCGGCTGGTCCAGCAGAGCAAGGCCCTGAAGGAGCTG GCGGATGAGCTGCAGGAGAGGTGCCAGCGCCCGGCCCTGGGTCTGCTGGAGGGTGTGAGAGGAGTCCTGAGCAGAAGTAAGGCTGTCACA AGGCTGGAAGCAGAGAACATCCCCATGGAACTGAAGACAGCATGCTGCATCCCTGGGAGGAGGGAGCTCTTAAGGAAGTTCCAAGTGGAT GTAAAGCTGGATCCCGCCACGGCGCACCCGAGTCTGCTCTTGACCGCCGACCTGCGCAGTGTGCAGGATGGAGAACCATGGAGGGATGTC CCCAACAACCCTGAGCGATTTGACACATGGCCCTGCATCCTGGGTTTGCAGAGCTTCTCATCAGGGAGGCATTACTGGGAGGTTCTGGTG GGAGAAGGAGCAGAGTGGGGTTTAGGGGTCTGTCAAGACACACTGCCAAGAAAGGGGGAAACCACGCCATCTCCTGAGAATGGGGTCTGG GCCCTGTGGCTGCTGAAAGGGAATGAGTACATGGTCCTTGCCTCCCCATCAGTGCCTCTTCTCCAACTGGAAAGTCCTCGCTGCATTGGG ATTTTCTTGGACTATGAAGCCGGTGAAATTTCATTCTACAATGTCACAGATGGATCTTATATCTACACATTCAACCAACTCTTCTCTGGT CTTCTTCGGCCTTACTTTTTCATCTGTGATGCAACTCCTCTTATCTTGCCACCCACAACAATAGCAGGGTCAGGAAATTGGGCATCCAGG >In-frame_SMYD3_ENST00000388985_chr1_246490503_-_TRIM58_ENST00000366481_chr1_248023919_+_1572nt ATGGAGCCGCTGAAGGTGGAAAAGTTCGCAACCGCCAAGAGGGGAAACGGGCTGCGCGCCGTGACCCCGCTGCGCCCCGGAGAGCTACTC TTCCGCTCGGATCCCTTGGCGTACACGGTGTGCAAGGGGAGTCGTGGCGTCGTCTGCGACCGCTGCCTTCTCGGGAAGGAAAAGCTGATG CGATGCTCTCAGTGCCGCGTCGCCAAATACTGTAGTGCTAAGTGTCAGAAAAAAGCTTGGCCAGACCACAAGCGGGAATGCAAATGCCTT AAAAGCTGCAAACCCAGATATCCTCCAGACTCCGTTCGACTTCTTGGCAGAGTTGTCTTCAAACTTATGGATGGAGCACCTTCAGAATCA GAGAAGCTTTACTCATTTTATGATCTGGAGTCAAATATTAACAAACTGACTGAAGATAAGAAAGAGGGCCTCAGGCAACTCGTAATGACA TTTCAACATTTCATGAGAGAAGAAATACAGGATGCCTCTCAGCTGCCACCTGCCTTTGACCTTTTTGAAGCCTTTGCAAAAGTAAAGCTC CAGATGGCTCTGGAACTTATGAGGAAAGAGTTGGAGGACGCCTTGACTCAGGAGGCCAACGTGGGGAAAAAGACTGTCATTTGGAAGGAG AAAGTGGAAATGCAGAGGCAGCGCTTCAGATTGGAGTTTGAGAAGCATCGTGGCTTTCTGGCCCAGGAGGAGCAACGGCAGCTGAGGCGG CTGGAGGCGGAGGAGCGAGCGACGCTGCAGAGACTGCGGGAGAGCAAGAGCCGGCTGGTCCAGCAGAGCAAGGCCCTGAAGGAGCTGGCG GATGAGCTGCAGGAGAGGTGCCAGCGCCCGGCCCTGGGTCTGCTGGAGGGTGTGAGAGGAGTCCTGAGCAGAAGTAAGGCTGTCACAAGG CTGGAAGCAGAGAACATCCCCATGGAACTGAAGACAGCATGCTGCATCCCTGGGAGGAGGGAGCTCTTAAGGAAGTTCCAAGTGGATGTA AAGCTGGATCCCGCCACGGCGCACCCGAGTCTGCTCTTGACCGCCGACCTGCGCAGTGTGCAGGATGGAGAACCATGGAGGGATGTCCCC AACAACCCTGAGCGATTTGACACATGGCCCTGCATCCTGGGTTTGCAGAGCTTCTCATCAGGGAGGCATTACTGGGAGGTTCTGGTGGGA GAAGGAGCAGAGTGGGGTTTAGGGGTCTGTCAAGACACACTGCCAAGAAAGGGGGAAACCACGCCATCTCCTGAGAATGGGGTCTGGGCC CTGTGGCTGCTGAAAGGGAATGAGTACATGGTCCTTGCCTCCCCATCAGTGCCTCTTCTCCAACTGGAAAGTCCTCGCTGCATTGGGATT TTCTTGGACTATGAAGCCGGTGAAATTTCATTCTACAATGTCACAGATGGATCTTATATCTACACATTCAACCAACTCTTCTCTGGTCTT CTTCGGCCTTACTTTTTCATCTGTGATGCAACTCCTCTTATCTTGCCACCCACAACAATAGCAGGGTCAGGAAATTGGGCATCCAGGGAT >In-frame_SMYD3_ENST00000403792_chr1_246490503_-_TRIM58_ENST00000366481_chr1_248023919_+_1572nt ATGGAGCCGCTGAAGGTGGAAAAGTTCGCAACCGCCAAGAGGGGAAACGGGCTGCGCGCCGTGACCCCGCTGCGCCCCGGAGAGCTACTC TTCCGCTCGGATCCCTTGGCGTACACGGTGTGCAAGGGGAGTCGTGGCGTCGTCTGCGACCGCTGCCTTCTCGGGAAGGAAAAGCTGATG CGATGCTCTCAGTGCCGCGTCGCCAAATACTGTAGTGCTAAGTGTCAGAAAAAAGCTTGGCCAGACCACAAGCGGGAATGCAAATGCCTT AAAAGCTGCAAACCCAGATATCCTCCAGACTCCGTTCGACTTCTTGGCAGAGTTGTCTTCAAACTTATGGATGGAGCACCTTCAGAATCA GAGAAGCTTTACTCATTTTATGATCTGGAGTCAAATATTAACAAACTGACTGAAGATAAGAAAGAGGGCCTCAGGCAACTCGTAATGACA TTTCAACATTTCATGAGAGAAGAAATACAGGATGCCTCTCAGCTGCCACCTGCCTTTGACCTTTTTGAAGCCTTTGCAAAAGTAAAGCTC CAGATGGCTCTGGAACTTATGAGGAAAGAGTTGGAGGACGCCTTGACTCAGGAGGCCAACGTGGGGAAAAAGACTGTCATTTGGAAGGAG AAAGTGGAAATGCAGAGGCAGCGCTTCAGATTGGAGTTTGAGAAGCATCGTGGCTTTCTGGCCCAGGAGGAGCAACGGCAGCTGAGGCGG CTGGAGGCGGAGGAGCGAGCGACGCTGCAGAGACTGCGGGAGAGCAAGAGCCGGCTGGTCCAGCAGAGCAAGGCCCTGAAGGAGCTGGCG GATGAGCTGCAGGAGAGGTGCCAGCGCCCGGCCCTGGGTCTGCTGGAGGGTGTGAGAGGAGTCCTGAGCAGAAGTAAGGCTGTCACAAGG CTGGAAGCAGAGAACATCCCCATGGAACTGAAGACAGCATGCTGCATCCCTGGGAGGAGGGAGCTCTTAAGGAAGTTCCAAGTGGATGTA AAGCTGGATCCCGCCACGGCGCACCCGAGTCTGCTCTTGACCGCCGACCTGCGCAGTGTGCAGGATGGAGAACCATGGAGGGATGTCCCC AACAACCCTGAGCGATTTGACACATGGCCCTGCATCCTGGGTTTGCAGAGCTTCTCATCAGGGAGGCATTACTGGGAGGTTCTGGTGGGA GAAGGAGCAGAGTGGGGTTTAGGGGTCTGTCAAGACACACTGCCAAGAAAGGGGGAAACCACGCCATCTCCTGAGAATGGGGTCTGGGCC CTGTGGCTGCTGAAAGGGAATGAGTACATGGTCCTTGCCTCCCCATCAGTGCCTCTTCTCCAACTGGAAAGTCCTCGCTGCATTGGGATT TTCTTGGACTATGAAGCCGGTGAAATTTCATTCTACAATGTCACAGATGGATCTTATATCTACACATTCAACCAACTCTTCTCTGGTCTT CTTCGGCCTTACTTTTTCATCTGTGATGCAACTCCTCTTATCTTGCCACCCACAACAATAGCAGGGTCAGGAAATTGGGCATCCAGGGAT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SMYD3_ENST00000490107_chr1_246490503_-_TRIM58_ENST00000366481_chr1_248023919_+_3328nt GGACGCGGGTAGCCGTCTGAGGTGCCGGAGCTGCGGGAGGATGGAGCCGCTGAAGGTGGAAAAGTTCGCAACCGCCAAGAGGGGAAACGG GCTGCGCGCCGTGACCCCGCTGCGCCCCGGAGAGCTACTCTTCCGCTCGGATCCCTTGGCGTACACGGTGTGCAAGGGGAGTCGTGGCGT CGTCTGCGACCGCTGCCTTCTCGGGAAGGAAAAGCTGATGCGATGCTCTCAGTGCCGCGTCGCCAAATACTGTAGTGCTAAGTGTCAGAA AAAAGCTTGGCCAGACCACAAGCGGGAATGCAAATGCCTTAAAAGCTGCAAACCCAGATATCCTCCAGACTCCGTTCGACTTCTTGGCAG AGTTGTCTTCAAACTTATGGATGGAGCACCTTCAGAATCAGAGAAGCTTTACTCATTTTATGATCTGGAGTCAAATATTAACAAACTGAC TGAAGATAAGAAAGAGGGCCTCAGGCAACTCGTAATGACATTTCAACATTTCATGAGAGAAGAAATACAGGATGCCTCTCAGCTGCCACC TGCCTTTGACCTTTTTGAAGCCTTTGCAAAAGTAAAGCTCCAGATGGCTCTGGAACTTATGAGGAAAGAGTTGGAGGACGCCTTGACTCA GGAGGCCAACGTGGGGAAAAAGACTGTCATTTGGAAGGAGAAAGTGGAAATGCAGAGGCAGCGCTTCAGATTGGAGTTTGAGAAGCATCG TGGCTTTCTGGCCCAGGAGGAGCAACGGCAGCTGAGGCGGCTGGAGGCGGAGGAGCGAGCGACGCTGCAGAGACTGCGGGAGAGCAAGAG CCGGCTGGTCCAGCAGAGCAAGGCCCTGAAGGAGCTGGCGGATGAGCTGCAGGAGAGGTGCCAGCGCCCGGCCCTGGGTCTGCTGGAGGG TGTGAGAGGAGTCCTGAGCAGAAGTAAGGCTGTCACAAGGCTGGAAGCAGAGAACATCCCCATGGAACTGAAGACAGCATGCTGCATCCC TGGGAGGAGGGAGCTCTTAAGGAAGTTCCAAGTGGATGTAAAGCTGGATCCCGCCACGGCGCACCCGAGTCTGCTCTTGACCGCCGACCT GCGCAGTGTGCAGGATGGAGAACCATGGAGGGATGTCCCCAACAACCCTGAGCGATTTGACACATGGCCCTGCATCCTGGGTTTGCAGAG CTTCTCATCAGGGAGGCATTACTGGGAGGTTCTGGTGGGAGAAGGAGCAGAGTGGGGTTTAGGGGTCTGTCAAGACACACTGCCAAGAAA GGGGGAAACCACGCCATCTCCTGAGAATGGGGTCTGGGCCCTGTGGCTGCTGAAAGGGAATGAGTACATGGTCCTTGCCTCCCCATCAGT GCCTCTTCTCCAACTGGAAAGTCCTCGCTGCATTGGGATTTTCTTGGACTATGAAGCCGGTGAAATTTCATTCTACAATGTCACAGATGG ATCTTATATCTACACATTCAACCAACTCTTCTCTGGTCTTCTTCGGCCTTACTTTTTCATCTGTGATGCAACTCCTCTTATCTTGCCACC CACAACAATAGCAGGGTCAGGAAATTGGGCATCCAGGGATCATTTAGATCCTGCTTCTGATGTAAGAGATGATCATCTCTAAAATTCTGT TCCCAAGATGCAGTCCTAGCGTAGCGAACGTTCCTGGAGTGGGGTGAAGGATATCAATATACTAAGTTTTAACAGATACCCCATTTAGGT CAGCACTTGATTCGTTGTTGCTGTGAAATATGTCCATGGGACAAAAGAGGGAATATGAAATATTTGCATATGGGAAGATTATAGAGCATA ATAATTTTGTAAATGGAGCAATCTCAACCTCTATTTCTAGATCACATTTTCTTGATGTCTTCCTTCAAATTAATGACCTTGGATTACATA AGGATTTCTATGCATTCATTATAATTTGTTATTCCTTTCAATATCCTTGTATTTCAAATCTTCCATATAAGAATTAGACATGGCAATTCT TAAATTGATTCAGAATGGTCTGATACTATTCCAGTATCACCTCCTTAATTCTGTTTCTCCTCGTTTTCCTGATTTTCCTTCTCATTCTCT CCTTCCCCGCTCTGTCTCTCTCTCCCTGTCACTCTCTCTCTCTTGTTCCTTATTTTTTGTTTCTTACCTCTTACTGTTTAACCTGTTGCT TCCTTCTGGATTAATACATTTAGAGCCATTCCTTTATATGGTCACATTTCCTATGACTTTACTCAATTACTTTTAAAATCCTTTCTATTC TGAGACTAATTTTTAAGAATTACAAAGCTCATTCTTCTGAATCTAATATCACTAACTCCTAGACTTTTTCCGTTTTCTTTGGATACACTT TAAGTAGGAATTTATCAGAATTTTCATTCAACTCGTTCTTTAATGCAGATATTTACTAGTTATAAGACCTTAAGGCTGGGTGCAGTGGCT CACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGATCACAAGCTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACC CTGTCTCTACTAAAAAAAAAAAAAAAATAGAAAAATTAGCTGGGCATGGTGGCAGGAGCCTGTAATCCCAGCTATTCTGGAGGTGGAGAC AGGAGAATTGCTTGAACCCTGGAGGCGGAGGTTGCAGTGAGCCAATATCTCACCACTGTACTCCAGCCCAGTGCGAGACTCCATCTCAAA AAAGAAAAAAGACCTCAAACAACACTTCTCTCTCTCTTTTAGCTGCTTGTTATGGTTCCTATACATGGAACAATTATACTGGCCTCACTG TGTTATGGTAAATATTTAAGGTCATATTTGATATTGCTGGTTTGAATTCAGCTTTTCCATTTAAATACATTATAATGATGATGATGAAAT CATGATAATATTTAACTTATTTTTAAAGTATATTCTGTACCTTTCCAACAAAAAGGTTAAAAGTCATTGAAGGCTAACCTTACTGCCTTC TTTGTATCACTGTCTTCTAAATAATTATTATGTCTGGGTACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCAG ATCACGAGGTCAGGAGATTGAGACCATCCTGGCTAACACAGTGAAACCCCGTCTCTACTAAAAATACAAAAAGAAATTAGCTGGGCGTGG TGGTGGGTGCCTGTTGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATGGCATGAACCCAGGAGGCAGAGCTTGTAGTGAGCCGAGATC >In-frame_SMYD3_ENST00000388985_chr1_246490503_-_TRIM58_ENST00000366481_chr1_248023919_+_3288nt ATGGAGCCGCTGAAGGTGGAAAAGTTCGCAACCGCCAAGAGGGGAAACGGGCTGCGCGCCGTGACCCCGCTGCGCCCCGGAGAGCTACTC TTCCGCTCGGATCCCTTGGCGTACACGGTGTGCAAGGGGAGTCGTGGCGTCGTCTGCGACCGCTGCCTTCTCGGGAAGGAAAAGCTGATG CGATGCTCTCAGTGCCGCGTCGCCAAATACTGTAGTGCTAAGTGTCAGAAAAAAGCTTGGCCAGACCACAAGCGGGAATGCAAATGCCTT AAAAGCTGCAAACCCAGATATCCTCCAGACTCCGTTCGACTTCTTGGCAGAGTTGTCTTCAAACTTATGGATGGAGCACCTTCAGAATCA GAGAAGCTTTACTCATTTTATGATCTGGAGTCAAATATTAACAAACTGACTGAAGATAAGAAAGAGGGCCTCAGGCAACTCGTAATGACA TTTCAACATTTCATGAGAGAAGAAATACAGGATGCCTCTCAGCTGCCACCTGCCTTTGACCTTTTTGAAGCCTTTGCAAAAGTAAAGCTC CAGATGGCTCTGGAACTTATGAGGAAAGAGTTGGAGGACGCCTTGACTCAGGAGGCCAACGTGGGGAAAAAGACTGTCATTTGGAAGGAG AAAGTGGAAATGCAGAGGCAGCGCTTCAGATTGGAGTTTGAGAAGCATCGTGGCTTTCTGGCCCAGGAGGAGCAACGGCAGCTGAGGCGG CTGGAGGCGGAGGAGCGAGCGACGCTGCAGAGACTGCGGGAGAGCAAGAGCCGGCTGGTCCAGCAGAGCAAGGCCCTGAAGGAGCTGGCG GATGAGCTGCAGGAGAGGTGCCAGCGCCCGGCCCTGGGTCTGCTGGAGGGTGTGAGAGGAGTCCTGAGCAGAAGTAAGGCTGTCACAAGG CTGGAAGCAGAGAACATCCCCATGGAACTGAAGACAGCATGCTGCATCCCTGGGAGGAGGGAGCTCTTAAGGAAGTTCCAAGTGGATGTA AAGCTGGATCCCGCCACGGCGCACCCGAGTCTGCTCTTGACCGCCGACCTGCGCAGTGTGCAGGATGGAGAACCATGGAGGGATGTCCCC AACAACCCTGAGCGATTTGACACATGGCCCTGCATCCTGGGTTTGCAGAGCTTCTCATCAGGGAGGCATTACTGGGAGGTTCTGGTGGGA GAAGGAGCAGAGTGGGGTTTAGGGGTCTGTCAAGACACACTGCCAAGAAAGGGGGAAACCACGCCATCTCCTGAGAATGGGGTCTGGGCC CTGTGGCTGCTGAAAGGGAATGAGTACATGGTCCTTGCCTCCCCATCAGTGCCTCTTCTCCAACTGGAAAGTCCTCGCTGCATTGGGATT TTCTTGGACTATGAAGCCGGTGAAATTTCATTCTACAATGTCACAGATGGATCTTATATCTACACATTCAACCAACTCTTCTCTGGTCTT CTTCGGCCTTACTTTTTCATCTGTGATGCAACTCCTCTTATCTTGCCACCCACAACAATAGCAGGGTCAGGAAATTGGGCATCCAGGGAT CATTTAGATCCTGCTTCTGATGTAAGAGATGATCATCTCTAAAATTCTGTTCCCAAGATGCAGTCCTAGCGTAGCGAACGTTCCTGGAGT GGGGTGAAGGATATCAATATACTAAGTTTTAACAGATACCCCATTTAGGTCAGCACTTGATTCGTTGTTGCTGTGAAATATGTCCATGGG ACAAAAGAGGGAATATGAAATATTTGCATATGGGAAGATTATAGAGCATAATAATTTTGTAAATGGAGCAATCTCAACCTCTATTTCTAG ATCACATTTTCTTGATGTCTTCCTTCAAATTAATGACCTTGGATTACATAAGGATTTCTATGCATTCATTATAATTTGTTATTCCTTTCA ATATCCTTGTATTTCAAATCTTCCATATAAGAATTAGACATGGCAATTCTTAAATTGATTCAGAATGGTCTGATACTATTCCAGTATCAC CTCCTTAATTCTGTTTCTCCTCGTTTTCCTGATTTTCCTTCTCATTCTCTCCTTCCCCGCTCTGTCTCTCTCTCCCTGTCACTCTCTCTC TCTTGTTCCTTATTTTTTGTTTCTTACCTCTTACTGTTTAACCTGTTGCTTCCTTCTGGATTAATACATTTAGAGCCATTCCTTTATATG GTCACATTTCCTATGACTTTACTCAATTACTTTTAAAATCCTTTCTATTCTGAGACTAATTTTTAAGAATTACAAAGCTCATTCTTCTGA ATCTAATATCACTAACTCCTAGACTTTTTCCGTTTTCTTTGGATACACTTTAAGTAGGAATTTATCAGAATTTTCATTCAACTCGTTCTT TAATGCAGATATTTACTAGTTATAAGACCTTAAGGCTGGGTGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGT GGATCACAAGCTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAAAAAAAAAAAAATAGAAAAATTAGC TGGGCATGGTGGCAGGAGCCTGTAATCCCAGCTATTCTGGAGGTGGAGACAGGAGAATTGCTTGAACCCTGGAGGCGGAGGTTGCAGTGA GCCAATATCTCACCACTGTACTCCAGCCCAGTGCGAGACTCCATCTCAAAAAAGAAAAAAGACCTCAAACAACACTTCTCTCTCTCTTTT AGCTGCTTGTTATGGTTCCTATACATGGAACAATTATACTGGCCTCACTGTGTTATGGTAAATATTTAAGGTCATATTTGATATTGCTGG TTTGAATTCAGCTTTTCCATTTAAATACATTATAATGATGATGATGAAATCATGATAATATTTAACTTATTTTTAAAGTATATTCTGTAC CTTTCCAACAAAAAGGTTAAAAGTCATTGAAGGCTAACCTTACTGCCTTCTTTGTATCACTGTCTTCTAAATAATTATTATGTCTGGGTA CAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCAGATCACGAGGTCAGGAGATTGAGACCATCCTGGCTAACACA GTGAAACCCCGTCTCTACTAAAAATACAAAAAGAAATTAGCTGGGCGTGGTGGTGGGTGCCTGTTGTCCCAGCTACTTGGGAGGCTGAGG CAGGAGAATGGCATGAACCCAGGAGGCAGAGCTTGTAGTGAGCCGAGATCGCGCCACTGCACTCCAGCCGGGGCAACAGAGCAAGACTCC >In-frame_SMYD3_ENST00000403792_chr1_246490503_-_TRIM58_ENST00000366481_chr1_248023919_+_3383nt GTGCGCGCAGGGCGCAGGCGCGCGGGTCCCGGCAGCCCGTGAGACGCCCGCTGCTGGACGCGGGTAGCCGTCTGAGGTGCCGGAGCTGCG GGAGGATGGAGCCGCTGAAGGTGGAAAAGTTCGCAACCGCCAAGAGGGGAAACGGGCTGCGCGCCGTGACCCCGCTGCGCCCCGGAGAGC TACTCTTCCGCTCGGATCCCTTGGCGTACACGGTGTGCAAGGGGAGTCGTGGCGTCGTCTGCGACCGCTGCCTTCTCGGGAAGGAAAAGC TGATGCGATGCTCTCAGTGCCGCGTCGCCAAATACTGTAGTGCTAAGTGTCAGAAAAAAGCTTGGCCAGACCACAAGCGGGAATGCAAAT GCCTTAAAAGCTGCAAACCCAGATATCCTCCAGACTCCGTTCGACTTCTTGGCAGAGTTGTCTTCAAACTTATGGATGGAGCACCTTCAG AATCAGAGAAGCTTTACTCATTTTATGATCTGGAGTCAAATATTAACAAACTGACTGAAGATAAGAAAGAGGGCCTCAGGCAACTCGTAA TGACATTTCAACATTTCATGAGAGAAGAAATACAGGATGCCTCTCAGCTGCCACCTGCCTTTGACCTTTTTGAAGCCTTTGCAAAAGTAA AGCTCCAGATGGCTCTGGAACTTATGAGGAAAGAGTTGGAGGACGCCTTGACTCAGGAGGCCAACGTGGGGAAAAAGACTGTCATTTGGA AGGAGAAAGTGGAAATGCAGAGGCAGCGCTTCAGATTGGAGTTTGAGAAGCATCGTGGCTTTCTGGCCCAGGAGGAGCAACGGCAGCTGA GGCGGCTGGAGGCGGAGGAGCGAGCGACGCTGCAGAGACTGCGGGAGAGCAAGAGCCGGCTGGTCCAGCAGAGCAAGGCCCTGAAGGAGC TGGCGGATGAGCTGCAGGAGAGGTGCCAGCGCCCGGCCCTGGGTCTGCTGGAGGGTGTGAGAGGAGTCCTGAGCAGAAGTAAGGCTGTCA CAAGGCTGGAAGCAGAGAACATCCCCATGGAACTGAAGACAGCATGCTGCATCCCTGGGAGGAGGGAGCTCTTAAGGAAGTTCCAAGTGG ATGTAAAGCTGGATCCCGCCACGGCGCACCCGAGTCTGCTCTTGACCGCCGACCTGCGCAGTGTGCAGGATGGAGAACCATGGAGGGATG TCCCCAACAACCCTGAGCGATTTGACACATGGCCCTGCATCCTGGGTTTGCAGAGCTTCTCATCAGGGAGGCATTACTGGGAGGTTCTGG TGGGAGAAGGAGCAGAGTGGGGTTTAGGGGTCTGTCAAGACACACTGCCAAGAAAGGGGGAAACCACGCCATCTCCTGAGAATGGGGTCT GGGCCCTGTGGCTGCTGAAAGGGAATGAGTACATGGTCCTTGCCTCCCCATCAGTGCCTCTTCTCCAACTGGAAAGTCCTCGCTGCATTG GGATTTTCTTGGACTATGAAGCCGGTGAAATTTCATTCTACAATGTCACAGATGGATCTTATATCTACACATTCAACCAACTCTTCTCTG GTCTTCTTCGGCCTTACTTTTTCATCTGTGATGCAACTCCTCTTATCTTGCCACCCACAACAATAGCAGGGTCAGGAAATTGGGCATCCA GGGATCATTTAGATCCTGCTTCTGATGTAAGAGATGATCATCTCTAAAATTCTGTTCCCAAGATGCAGTCCTAGCGTAGCGAACGTTCCT GGAGTGGGGTGAAGGATATCAATATACTAAGTTTTAACAGATACCCCATTTAGGTCAGCACTTGATTCGTTGTTGCTGTGAAATATGTCC ATGGGACAAAAGAGGGAATATGAAATATTTGCATATGGGAAGATTATAGAGCATAATAATTTTGTAAATGGAGCAATCTCAACCTCTATT TCTAGATCACATTTTCTTGATGTCTTCCTTCAAATTAATGACCTTGGATTACATAAGGATTTCTATGCATTCATTATAATTTGTTATTCC TTTCAATATCCTTGTATTTCAAATCTTCCATATAAGAATTAGACATGGCAATTCTTAAATTGATTCAGAATGGTCTGATACTATTCCAGT ATCACCTCCTTAATTCTGTTTCTCCTCGTTTTCCTGATTTTCCTTCTCATTCTCTCCTTCCCCGCTCTGTCTCTCTCTCCCTGTCACTCT CTCTCTCTTGTTCCTTATTTTTTGTTTCTTACCTCTTACTGTTTAACCTGTTGCTTCCTTCTGGATTAATACATTTAGAGCCATTCCTTT ATATGGTCACATTTCCTATGACTTTACTCAATTACTTTTAAAATCCTTTCTATTCTGAGACTAATTTTTAAGAATTACAAAGCTCATTCT TCTGAATCTAATATCACTAACTCCTAGACTTTTTCCGTTTTCTTTGGATACACTTTAAGTAGGAATTTATCAGAATTTTCATTCAACTCG TTCTTTAATGCAGATATTTACTAGTTATAAGACCTTAAGGCTGGGTGCAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGG CGGGTGGATCACAAGCTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAAAAAAAAAAAAATAGAAAAA TTAGCTGGGCATGGTGGCAGGAGCCTGTAATCCCAGCTATTCTGGAGGTGGAGACAGGAGAATTGCTTGAACCCTGGAGGCGGAGGTTGC AGTGAGCCAATATCTCACCACTGTACTCCAGCCCAGTGCGAGACTCCATCTCAAAAAAGAAAAAAGACCTCAAACAACACTTCTCTCTCT CTTTTAGCTGCTTGTTATGGTTCCTATACATGGAACAATTATACTGGCCTCACTGTGTTATGGTAAATATTTAAGGTCATATTTGATATT GCTGGTTTGAATTCAGCTTTTCCATTTAAATACATTATAATGATGATGATGAAATCATGATAATATTTAACTTATTTTTAAAGTATATTC TGTACCTTTCCAACAAAAAGGTTAAAAGTCATTGAAGGCTAACCTTACTGCCTTCTTTGTATCACTGTCTTCTAAATAATTATTATGTCT GGGTACAGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCAGATCACGAGGTCAGGAGATTGAGACCATCCTGGCTA ACACAGTGAAACCCCGTCTCTACTAAAAATACAAAAAGAAATTAGCTGGGCGTGGTGGTGGGTGCCTGTTGTCCCAGCTACTTGGGAGGC TGAGGCAGGAGAATGGCATGAACCCAGGAGGCAGAGCTTGTAGTGAGCCGAGATCGCGCCACTGCACTCCAGCCGGGGCAACAGAGCAAG |
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FusionGenePPI for SMYD3_TRIM58 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SMYD3 | MEST, HELZ, POLR2A, HSP90AA1, HIST3H3, ESR1, EZH2, EED, APP, CAMK2B, NDUFAB1, NFYB, CYP39A1, VANGL1, H3F3C, TRIT1, ZNF557, CDC37, HSP90AB1, HSP90AB4P, HSP90AB3P, HSP90AA5P, MAGED4B, KDM3B, RCAN3, PLCB3, TRMT2A, KMT2E | TRIM58 | DYNC1H1, DYNC1I1, DYNC2LI1, DYNC1LI2, TRIM58, UBE2D3, FBXW7 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SMYD3_TRIM58 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SMYD3_TRIM58 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SMYD3 | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |
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