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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35024

FusionGeneSummary for SMYD2_MGST2

check button Fusion gene summary
Fusion gene informationFusion gene name: SMYD2_MGST2
Fusion gene ID: 35024
HgeneTgene
Gene symbol

SMYD2

MGST2

Gene ID

56950

4258

Gene nameSET and MYND domain containing 2microsomal glutathione S-transferase 2
SynonymsHSKM-B|KMT3C|ZMYND14GST2|MGST-II
Cytomap

1q32.3

4q31.1

Type of geneprotein-codingprotein-coding
DescriptionN-lysine methyltransferase SMYD2SET and MYND domain-containing protein 2histone methyltransferase SMYD2lysine N-methyltransferase 3Czinc finger, MYND domain containing 14microsomal glutathione S-transferase 2microsomal GST-2microsomal GST-II
Modification date2018052220180523
UniProtAcc

Q9NRG4

Q99735

Ensembl transtripts involved in fusion geneENST00000491455, ENST00000415093, 
ENST00000366957, 
ENST00000515137, 
ENST00000265498, ENST00000506797, 
Fusion gene scores* DoF score9 X 6 X 7=3787 X 4 X 6=168
# samples 98
** MAII scorelog2(9/378*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SMYD2 [Title/Abstract] AND MGST2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSMYD2

GO:0018026

peptidyl-lysine monomethylation

17108971|20870719

TgeneMGST2

GO:0006629

lipid metabolic process

9278457

TgeneMGST2

GO:0006750

glutathione biosynthetic process

8703034

TgeneMGST2

GO:0019370

leukotriene biosynthetic process

8703034|9092565|23409838

TgeneMGST2

GO:0046466

membrane lipid catabolic process

23409838


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-KK-A6E0-01ASMYD2chr1

214454770

+MGST2chr4

140616351

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000491455ENST00000515137SMYD2chr1

214454770

+MGST2chr4

140616351

+
3UTR-3UTRENST00000491455ENST00000265498SMYD2chr1

214454770

+MGST2chr4

140616351

+
3UTR-intronENST00000491455ENST00000506797SMYD2chr1

214454770

+MGST2chr4

140616351

+
5CDS-3UTRENST00000415093ENST00000515137SMYD2chr1

214454770

+MGST2chr4

140616351

+
5CDS-3UTRENST00000415093ENST00000265498SMYD2chr1

214454770

+MGST2chr4

140616351

+
5CDS-intronENST00000415093ENST00000506797SMYD2chr1

214454770

+MGST2chr4

140616351

+
5CDS-3UTRENST00000366957ENST00000515137SMYD2chr1

214454770

+MGST2chr4

140616351

+
5CDS-3UTRENST00000366957ENST00000265498SMYD2chr1

214454770

+MGST2chr4

140616351

+
5CDS-intronENST00000366957ENST00000506797SMYD2chr1

214454770

+MGST2chr4

140616351

+

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FusionProtFeatures for SMYD2_MGST2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SMYD2

Q9NRG4

MGST2

Q99735

Protein-lysine N-methyltransferase that methylates bothhistones and non-histone proteins, including p53/TP53 and RB1.Specifically methylates histone H3 'Lys-4' (H3K4me) anddimethylates histone H3 'Lys-36' (H3K36me2). Shows even highermethyltransferase activity on p53/TP53. Monomethylates 'Lys-370'of p53/TP53, leading to decreased DNA-binding activity andsubsequent transcriptional regulation activity of p53/TP53.Monomethylates RB1 at 'Lys-860'. {ECO:0000269|PubMed:17108971,ECO:0000269|PubMed:17805299, ECO:0000269|PubMed:18065756,ECO:0000269|PubMed:20870719, ECO:0000269|PubMed:21782458,ECO:0000269|PubMed:21880715}. Can catalyze the production of LTC4 from LTA4 andreduced glutathione. Can catalyze the conjugation of 1-chloro-2,4-dinitrobenzene with reduced glutathione.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SMYD2_MGST2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SMYD2_MGST2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SMYD2GSK3B, EPB41L3, CLASP2, AKAP11, CDC37, IGF2BP1, AXIN1, TP53, HSP90AA1, RB1, HIST2H3C, MOV10, NXF1, ESR1, GOLGA4, SNX1, CPSF4, ZFC3H1, TXNDC9, CCSER1, ZNF408, NPPA, CELA1, FOXP3, JPH4, ICKMGST2MGST2, RELL2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SMYD2_MGST2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneMGST2Q99735DB00143GlutathioneMicrosomal glutathione S-transferase 2small moleculeapproved|investigational|nutraceutical

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RelatedDiseases for SMYD2_MGST2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource