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Fusion gene ID: 35024 |
FusionGeneSummary for SMYD2_MGST2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SMYD2_MGST2 | Fusion gene ID: 35024 | Hgene | Tgene | Gene symbol | SMYD2 | MGST2 | Gene ID | 56950 | 4258 |
| Gene name | SET and MYND domain containing 2 | microsomal glutathione S-transferase 2 | |
| Synonyms | HSKM-B|KMT3C|ZMYND14 | GST2|MGST-II | |
| Cytomap | 1q32.3 | 4q31.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | N-lysine methyltransferase SMYD2SET and MYND domain-containing protein 2histone methyltransferase SMYD2lysine N-methyltransferase 3Czinc finger, MYND domain containing 14 | microsomal glutathione S-transferase 2microsomal GST-2microsomal GST-II | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q9NRG4 | Q99735 | |
| Ensembl transtripts involved in fusion gene | ENST00000491455, ENST00000415093, ENST00000366957, | ENST00000515137, ENST00000265498, ENST00000506797, | |
| Fusion gene scores | * DoF score | 9 X 6 X 7=378 | 7 X 4 X 6=168 |
| # samples | 9 | 8 | |
| ** MAII score | log2(9/378*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/168*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SMYD2 [Title/Abstract] AND MGST2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SMYD2 | GO:0018026 | peptidyl-lysine monomethylation | 17108971|20870719 |
| Tgene | MGST2 | GO:0006629 | lipid metabolic process | 9278457 |
| Tgene | MGST2 | GO:0006750 | glutathione biosynthetic process | 8703034 |
| Tgene | MGST2 | GO:0019370 | leukotriene biosynthetic process | 8703034|9092565|23409838 |
| Tgene | MGST2 | GO:0046466 | membrane lipid catabolic process | 23409838 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PRAD | TCGA-KK-A6E0-01A | SMYD2 | chr1 | 214454770 | + | MGST2 | chr4 | 140616351 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3UTR | ENST00000491455 | ENST00000515137 | SMYD2 | chr1 | 214454770 | + | MGST2 | chr4 | 140616351 | + |
| 3UTR-3UTR | ENST00000491455 | ENST00000265498 | SMYD2 | chr1 | 214454770 | + | MGST2 | chr4 | 140616351 | + |
| 3UTR-intron | ENST00000491455 | ENST00000506797 | SMYD2 | chr1 | 214454770 | + | MGST2 | chr4 | 140616351 | + |
| 5CDS-3UTR | ENST00000415093 | ENST00000515137 | SMYD2 | chr1 | 214454770 | + | MGST2 | chr4 | 140616351 | + |
| 5CDS-3UTR | ENST00000415093 | ENST00000265498 | SMYD2 | chr1 | 214454770 | + | MGST2 | chr4 | 140616351 | + |
| 5CDS-intron | ENST00000415093 | ENST00000506797 | SMYD2 | chr1 | 214454770 | + | MGST2 | chr4 | 140616351 | + |
| 5CDS-3UTR | ENST00000366957 | ENST00000515137 | SMYD2 | chr1 | 214454770 | + | MGST2 | chr4 | 140616351 | + |
| 5CDS-3UTR | ENST00000366957 | ENST00000265498 | SMYD2 | chr1 | 214454770 | + | MGST2 | chr4 | 140616351 | + |
| 5CDS-intron | ENST00000366957 | ENST00000506797 | SMYD2 | chr1 | 214454770 | + | MGST2 | chr4 | 140616351 | + |
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FusionProtFeatures for SMYD2_MGST2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SMYD2 | MGST2 |
| Protein-lysine N-methyltransferase that methylates bothhistones and non-histone proteins, including p53/TP53 and RB1.Specifically methylates histone H3 'Lys-4' (H3K4me) anddimethylates histone H3 'Lys-36' (H3K36me2). Shows even highermethyltransferase activity on p53/TP53. Monomethylates 'Lys-370'of p53/TP53, leading to decreased DNA-binding activity andsubsequent transcriptional regulation activity of p53/TP53.Monomethylates RB1 at 'Lys-860'. {ECO:0000269|PubMed:17108971,ECO:0000269|PubMed:17805299, ECO:0000269|PubMed:18065756,ECO:0000269|PubMed:20870719, ECO:0000269|PubMed:21782458,ECO:0000269|PubMed:21880715}. | Can catalyze the production of LTC4 from LTA4 andreduced glutathione. Can catalyze the conjugation of 1-chloro-2,4-dinitrobenzene with reduced glutathione. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SMYD2_MGST2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SMYD2_MGST2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SMYD2 | GSK3B, EPB41L3, CLASP2, AKAP11, CDC37, IGF2BP1, AXIN1, TP53, HSP90AA1, RB1, HIST2H3C, MOV10, NXF1, ESR1, GOLGA4, SNX1, CPSF4, ZFC3H1, TXNDC9, CCSER1, ZNF408, NPPA, CELA1, FOXP3, JPH4, ICK | MGST2 | MGST2, RELL2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SMYD2_MGST2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | MGST2 | Q99735 | DB00143 | Glutathione | Microsomal glutathione S-transferase 2 | small molecule | approved|investigational|nutraceutical |
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RelatedDiseases for SMYD2_MGST2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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