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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 35020

FusionGeneSummary for SMYD2_ASNA1

check button Fusion gene summary
Fusion gene informationFusion gene name: SMYD2_ASNA1
Fusion gene ID: 35020
HgeneTgene
Gene symbol

SMYD2

ASNA1

Gene ID

56950

439

Gene nameSET and MYND domain containing 2arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)
SynonymsHSKM-B|KMT3C|ZMYND14ARSA-I|ARSA1|ASNA-I|GET3|TRC40
Cytomap

1q32.3

19p13.13

Type of geneprotein-codingprotein-coding
DescriptionN-lysine methyltransferase SMYD2SET and MYND domain-containing protein 2histone methyltransferase SMYD2lysine N-methyltransferase 3Czinc finger, MYND domain containing 14ATPase ASNA1golgi to ER traffic 3 homologtransmembrane domain recognition complex 40 kDa ATPase subunit
Modification date2018052220180523
UniProtAcc

Q9NRG4

O43681

Ensembl transtripts involved in fusion geneENST00000491455, ENST00000415093, 
ENST00000366957, 
ENST00000591090, 
ENST00000357332, 
Fusion gene scores* DoF score9 X 6 X 7=3786 X 5 X 3=90
# samples 96
** MAII scorelog2(9/378*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SMYD2 [Title/Abstract] AND ASNA1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSMYD2

GO:0018026

peptidyl-lysine monomethylation

17108971|20870719


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ374720SMYD2chr1

214507570

-ASNA1chr19

12856514

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000491455ENST00000591090SMYD2chr1

214507570

-ASNA1chr19

12856514

-
3UTR-3CDSENST00000491455ENST00000357332SMYD2chr1

214507570

-ASNA1chr19

12856514

-
3UTR-3CDSENST00000415093ENST00000591090SMYD2chr1

214507570

-ASNA1chr19

12856514

-
3UTR-3CDSENST00000415093ENST00000357332SMYD2chr1

214507570

-ASNA1chr19

12856514

-
Frame-shitENST00000366957ENST00000591090SMYD2chr1

214507570

-ASNA1chr19

12856514

-
Frame-shitENST00000366957ENST00000357332SMYD2chr1

214507570

-ASNA1chr19

12856514

-

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FusionProtFeatures for SMYD2_ASNA1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SMYD2

Q9NRG4

ASNA1

O43681

Protein-lysine N-methyltransferase that methylates bothhistones and non-histone proteins, including p53/TP53 and RB1.Specifically methylates histone H3 'Lys-4' (H3K4me) anddimethylates histone H3 'Lys-36' (H3K36me2). Shows even highermethyltransferase activity on p53/TP53. Monomethylates 'Lys-370'of p53/TP53, leading to decreased DNA-binding activity andsubsequent transcriptional regulation activity of p53/TP53.Monomethylates RB1 at 'Lys-860'. {ECO:0000269|PubMed:17108971,ECO:0000269|PubMed:17805299, ECO:0000269|PubMed:18065756,ECO:0000269|PubMed:20870719, ECO:0000269|PubMed:21782458,ECO:0000269|PubMed:21880715}. ATPase required for the post-translational delivery oftail-anchored (TA) proteins to the endoplasmic reticulum.Recognizes and selectively binds the transmembrane domain of TAproteins in the cytosol. This complex then targets to theendoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process isregulated by ATP binding and hydrolysis. ATP binding drives thehomodimer towards the closed dimer state, facilitating recognitionof newly synthesized TA membrane proteins. ATP hydrolysis isrequired for insertion. Subsequently, the homodimer revertstowards the open dimer state, lowering its affinity for themembrane-bound receptor, and returning it to the cytosol toinitiate a new round of targeting (By similarity). May be involvedin insulin signaling. {ECO:0000255|HAMAP-Rule:MF_03112,ECO:0000269|PubMed:17382883, ECO:0000269|PubMed:18477612,ECO:0000269|PubMed:25535373}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SMYD2_ASNA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SMYD2_ASNA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SMYD2_ASNA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SMYD2_ASNA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource