|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 35020 |
FusionGeneSummary for SMYD2_ASNA1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SMYD2_ASNA1 | Fusion gene ID: 35020 | Hgene | Tgene | Gene symbol | SMYD2 | ASNA1 | Gene ID | 56950 | 439 |
| Gene name | SET and MYND domain containing 2 | arsA arsenite transporter, ATP-binding, homolog 1 (bacterial) | |
| Synonyms | HSKM-B|KMT3C|ZMYND14 | ARSA-I|ARSA1|ASNA-I|GET3|TRC40 | |
| Cytomap | 1q32.3 | 19p13.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | N-lysine methyltransferase SMYD2SET and MYND domain-containing protein 2histone methyltransferase SMYD2lysine N-methyltransferase 3Czinc finger, MYND domain containing 14 | ATPase ASNA1golgi to ER traffic 3 homologtransmembrane domain recognition complex 40 kDa ATPase subunit | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q9NRG4 | O43681 | |
| Ensembl transtripts involved in fusion gene | ENST00000491455, ENST00000415093, ENST00000366957, | ENST00000591090, ENST00000357332, | |
| Fusion gene scores | * DoF score | 9 X 6 X 7=378 | 6 X 5 X 3=90 |
| # samples | 9 | 6 | |
| ** MAII score | log2(9/378*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SMYD2 [Title/Abstract] AND ASNA1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SMYD2 | GO:0018026 | peptidyl-lysine monomethylation | 17108971|20870719 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BQ374720 | SMYD2 | chr1 | 214507570 | - | ASNA1 | chr19 | 12856514 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000491455 | ENST00000591090 | SMYD2 | chr1 | 214507570 | - | ASNA1 | chr19 | 12856514 | - |
| 3UTR-3CDS | ENST00000491455 | ENST00000357332 | SMYD2 | chr1 | 214507570 | - | ASNA1 | chr19 | 12856514 | - |
| 3UTR-3CDS | ENST00000415093 | ENST00000591090 | SMYD2 | chr1 | 214507570 | - | ASNA1 | chr19 | 12856514 | - |
| 3UTR-3CDS | ENST00000415093 | ENST00000357332 | SMYD2 | chr1 | 214507570 | - | ASNA1 | chr19 | 12856514 | - |
| Frame-shift | ENST00000366957 | ENST00000591090 | SMYD2 | chr1 | 214507570 | - | ASNA1 | chr19 | 12856514 | - |
| Frame-shift | ENST00000366957 | ENST00000357332 | SMYD2 | chr1 | 214507570 | - | ASNA1 | chr19 | 12856514 | - |
Top |
FusionProtFeatures for SMYD2_ASNA1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SMYD2 | ASNA1 |
| Protein-lysine N-methyltransferase that methylates bothhistones and non-histone proteins, including p53/TP53 and RB1.Specifically methylates histone H3 'Lys-4' (H3K4me) anddimethylates histone H3 'Lys-36' (H3K36me2). Shows even highermethyltransferase activity on p53/TP53. Monomethylates 'Lys-370'of p53/TP53, leading to decreased DNA-binding activity andsubsequent transcriptional regulation activity of p53/TP53.Monomethylates RB1 at 'Lys-860'. {ECO:0000269|PubMed:17108971,ECO:0000269|PubMed:17805299, ECO:0000269|PubMed:18065756,ECO:0000269|PubMed:20870719, ECO:0000269|PubMed:21782458,ECO:0000269|PubMed:21880715}. | ATPase required for the post-translational delivery oftail-anchored (TA) proteins to the endoplasmic reticulum.Recognizes and selectively binds the transmembrane domain of TAproteins in the cytosol. This complex then targets to theendoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process isregulated by ATP binding and hydrolysis. ATP binding drives thehomodimer towards the closed dimer state, facilitating recognitionof newly synthesized TA membrane proteins. ATP hydrolysis isrequired for insertion. Subsequently, the homodimer revertstowards the open dimer state, lowering its affinity for themembrane-bound receptor, and returning it to the cytosol toinitiate a new round of targeting (By similarity). May be involvedin insulin signaling. {ECO:0000255|HAMAP-Rule:MF_03112,ECO:0000269|PubMed:17382883, ECO:0000269|PubMed:18477612,ECO:0000269|PubMed:25535373}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for SMYD2_ASNA1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for SMYD2_ASNA1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for SMYD2_ASNA1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for SMYD2_ASNA1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|