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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 350

FusionGeneSummary for ACAP2_QKI

check button Fusion gene summary
Fusion gene informationFusion gene name: ACAP2_QKI
Fusion gene ID: 350
HgeneTgene
Gene symbol

ACAP2

QKI

Gene ID

23527

9444

Gene nameArfGAP with coiled-coil, ankyrin repeat and PH domains 2QKI, KH domain containing RNA binding
SynonymsCENTB2|CNT-B2Hqk|QK|QK1|QK3|hqkI
Cytomap

3q29

6q26

Type of geneprotein-codingprotein-coding
Descriptionarf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2Arf GAP with coiled coil, ANK repeat and PH domains 2centaurin-beta-2protein quakingQKI/LOC100132735 fusionRNA binding protein HQKhomolog of mouse quaking QKI (KH domain RNA binding protein)quaking homolog, KH domain RNA binding
Modification date2018052320180522
UniProtAcc

Q15057

Q96PU8

Ensembl transtripts involved in fusion geneENST00000326793, ENST00000472860, 
ENST00000275262, ENST00000392127, 
ENST00000453779, ENST00000361752, 
ENST00000361195, ENST00000424802, 
Fusion gene scores* DoF score9 X 7 X 10=63013 X 14 X 6=1092
# samples 1318
** MAII scorelog2(13/630*10)=-2.27684020535882
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(18/1092*10)=-2.60090404459018
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACAP2 [Title/Abstract] AND QKI [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AK021880ACAP2chr3

195001275

-QKIchr6

163931554

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000326793ENST00000275262ACAP2chr3

195001275

-QKIchr6

163931554

+
intron-intronENST00000326793ENST00000392127ACAP2chr3

195001275

-QKIchr6

163931554

+
intron-intronENST00000326793ENST00000453779ACAP2chr3

195001275

-QKIchr6

163931554

+
intron-intronENST00000326793ENST00000361752ACAP2chr3

195001275

-QKIchr6

163931554

+
intron-intronENST00000326793ENST00000361195ACAP2chr3

195001275

-QKIchr6

163931554

+
intron-intronENST00000326793ENST00000424802ACAP2chr3

195001275

-QKIchr6

163931554

+
intron-intronENST00000472860ENST00000275262ACAP2chr3

195001275

-QKIchr6

163931554

+
intron-intronENST00000472860ENST00000392127ACAP2chr3

195001275

-QKIchr6

163931554

+
intron-intronENST00000472860ENST00000453779ACAP2chr3

195001275

-QKIchr6

163931554

+
intron-intronENST00000472860ENST00000361752ACAP2chr3

195001275

-QKIchr6

163931554

+
intron-intronENST00000472860ENST00000361195ACAP2chr3

195001275

-QKIchr6

163931554

+
intron-intronENST00000472860ENST00000424802ACAP2chr3

195001275

-QKIchr6

163931554

+

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FusionProtFeatures for ACAP2_QKI


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACAP2

Q15057

QKI

Q96PU8

GTPase-activating protein (GAP) for ADP ribosylationfactor 6 (ARF6). {ECO:0000269|PubMed:11062263}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ACAP2_QKI


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ACAP2_QKI


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ACAP2_QKI


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ACAP2_QKI


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneQKIC0036341Schizophrenia5PSYGENET
TgeneQKIC0017638Glioma1CTD_human
TgeneQKIC0041696Unipolar Depression1PSYGENET
TgeneQKIC1269683Major Depressive Disorder1PSYGENET