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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 34972

FusionGeneSummary for SMR3B_MAGI1

check button Fusion gene summary
Fusion gene informationFusion gene name: SMR3B_MAGI1
Fusion gene ID: 34972
HgeneTgene
Gene symbol

SMR3B

MAGI1

Gene ID

10879

154043

Gene namesubmaxillary gland androgen regulated protein 3BCNKSR family member 3
SynonymsP-B|PBII|PRL3|PROL3|SMR1BCNK3|CNK3/IPCEF1|MAGI1
Cytomap

4q13.3

6q25.2

Type of geneprotein-codingprotein-coding
Descriptionsubmaxillary gland androgen-regulated protein 3Bproline rich 3proline-rich peptide P-Bproline-rich protein 3salivary proline-rich proteinsubmaxillary gland androgen regulated protein 3 homolog Bconnector enhancer of kinase suppressor of ras 3CNK homolog protein 3connector enhancer of KSR 3maguin-like proteinmembrane associated guanylate kinase, WW and PDZ domain containing 1membrane-associated guanylate kinase-interacting protein-like 1
Modification date2018052320180522
UniProtAcc

P02814

Q96QZ7

Ensembl transtripts involved in fusion geneENST00000504825, ENST00000304915, 
ENST00000330909, ENST00000402939, 
ENST00000483466, ENST00000497477, 
ENST00000470990, 
Fusion gene scores* DoF score2 X 2 X 1=411 X 11 X 2=242
# samples 212
** MAII scorelog2(2/4*10)=2.32192809488736log2(12/242*10)=-1.01197264166608
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SMR3B [Title/Abstract] AND MAGI1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BP333058SMR3Bchr4

71255923

+MAGI1chr3

65910595

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000504825ENST00000330909SMR3Bchr4

71255923

+MAGI1chr3

65910595

-
intron-intronENST00000504825ENST00000402939SMR3Bchr4

71255923

+MAGI1chr3

65910595

-
intron-intronENST00000504825ENST00000483466SMR3Bchr4

71255923

+MAGI1chr3

65910595

-
intron-intronENST00000504825ENST00000497477SMR3Bchr4

71255923

+MAGI1chr3

65910595

-
intron-intronENST00000504825ENST00000470990SMR3Bchr4

71255923

+MAGI1chr3

65910595

-
3UTR-intronENST00000304915ENST00000330909SMR3Bchr4

71255923

+MAGI1chr3

65910595

-
3UTR-intronENST00000304915ENST00000402939SMR3Bchr4

71255923

+MAGI1chr3

65910595

-
3UTR-intronENST00000304915ENST00000483466SMR3Bchr4

71255923

+MAGI1chr3

65910595

-
3UTR-intronENST00000304915ENST00000497477SMR3Bchr4

71255923

+MAGI1chr3

65910595

-
3UTR-intronENST00000304915ENST00000470990SMR3Bchr4

71255923

+MAGI1chr3

65910595

-

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FusionProtFeatures for SMR3B_MAGI1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SMR3B

P02814

MAGI1

Q96QZ7

May play a role as scaffolding protein at cell-celljunctions. May regulate acid-induced ASIC3 currents by modulatingits expression at the cell surface (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SMR3B_MAGI1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SMR3B_MAGI1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SMR3B_MAGI1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SMR3B_MAGI1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMAGI1C0005586Bipolar Disorder2PSYGENET
TgeneMAGI1C0010606Adenoid Cystic Carcinoma1CTD_human
TgeneMAGI1C0036341Schizophrenia1PSYGENET
TgeneMAGI1C1839839MAJOR AFFECTIVE DISORDER 21PSYGENET