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Fusion gene ID: 34972 |
FusionGeneSummary for SMR3B_MAGI1 |
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Fusion gene information | Fusion gene name: SMR3B_MAGI1 | Fusion gene ID: 34972 | Hgene | Tgene | Gene symbol | SMR3B | MAGI1 | Gene ID | 10879 | 154043 |
Gene name | submaxillary gland androgen regulated protein 3B | CNKSR family member 3 | |
Synonyms | P-B|PBII|PRL3|PROL3|SMR1B | CNK3|CNK3/IPCEF1|MAGI1 | |
Cytomap | 4q13.3 | 6q25.2 | |
Type of gene | protein-coding | protein-coding | |
Description | submaxillary gland androgen-regulated protein 3Bproline rich 3proline-rich peptide P-Bproline-rich protein 3salivary proline-rich proteinsubmaxillary gland androgen regulated protein 3 homolog B | connector enhancer of kinase suppressor of ras 3CNK homolog protein 3connector enhancer of KSR 3maguin-like proteinmembrane associated guanylate kinase, WW and PDZ domain containing 1membrane-associated guanylate kinase-interacting protein-like 1 | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | P02814 | Q96QZ7 | |
Ensembl transtripts involved in fusion gene | ENST00000504825, ENST00000304915, | ENST00000330909, ENST00000402939, ENST00000483466, ENST00000497477, ENST00000470990, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 11 X 11 X 2=242 |
# samples | 2 | 12 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(12/242*10)=-1.01197264166608 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SMR3B [Title/Abstract] AND MAGI1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BP333058 | SMR3B | chr4 | 71255923 | + | MAGI1 | chr3 | 65910595 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000504825 | ENST00000330909 | SMR3B | chr4 | 71255923 | + | MAGI1 | chr3 | 65910595 | - |
intron-intron | ENST00000504825 | ENST00000402939 | SMR3B | chr4 | 71255923 | + | MAGI1 | chr3 | 65910595 | - |
intron-intron | ENST00000504825 | ENST00000483466 | SMR3B | chr4 | 71255923 | + | MAGI1 | chr3 | 65910595 | - |
intron-intron | ENST00000504825 | ENST00000497477 | SMR3B | chr4 | 71255923 | + | MAGI1 | chr3 | 65910595 | - |
intron-intron | ENST00000504825 | ENST00000470990 | SMR3B | chr4 | 71255923 | + | MAGI1 | chr3 | 65910595 | - |
3UTR-intron | ENST00000304915 | ENST00000330909 | SMR3B | chr4 | 71255923 | + | MAGI1 | chr3 | 65910595 | - |
3UTR-intron | ENST00000304915 | ENST00000402939 | SMR3B | chr4 | 71255923 | + | MAGI1 | chr3 | 65910595 | - |
3UTR-intron | ENST00000304915 | ENST00000483466 | SMR3B | chr4 | 71255923 | + | MAGI1 | chr3 | 65910595 | - |
3UTR-intron | ENST00000304915 | ENST00000497477 | SMR3B | chr4 | 71255923 | + | MAGI1 | chr3 | 65910595 | - |
3UTR-intron | ENST00000304915 | ENST00000470990 | SMR3B | chr4 | 71255923 | + | MAGI1 | chr3 | 65910595 | - |
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FusionProtFeatures for SMR3B_MAGI1 |
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Hgene | Tgene |
SMR3B | MAGI1 |
May play a role as scaffolding protein at cell-celljunctions. May regulate acid-induced ASIC3 currents by modulatingits expression at the cell surface (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SMR3B_MAGI1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SMR3B_MAGI1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SMR3B_MAGI1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SMR3B_MAGI1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | MAGI1 | C0005586 | Bipolar Disorder | 2 | PSYGENET |
Tgene | MAGI1 | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
Tgene | MAGI1 | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | MAGI1 | C1839839 | MAJOR AFFECTIVE DISORDER 2 | 1 | PSYGENET |