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Fusion gene ID: 34969 |
FusionGeneSummary for SMPDL3B_SNX1 |
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Fusion gene information | Fusion gene name: SMPDL3B_SNX1 | Fusion gene ID: 34969 | Hgene | Tgene | Gene symbol | SMPDL3B | SNX1 | Gene ID | 27293 | 6642 |
Gene name | sphingomyelin phosphodiesterase acid like 3B | sorting nexin 1 | |
Synonyms | ASML3B | HsT17379|VPS5 | |
Cytomap | 1p35.3 | 15q22.31 | |
Type of gene | protein-coding | protein-coding | |
Description | acid sphingomyelinase-like phosphodiesterase 3bASM-like phosphodiesterase 3b | sorting nexin-1sorting nexin 1A | |
Modification date | 20180523 | 20180527 | |
UniProtAcc | Q92485 | Q13596 | |
Ensembl transtripts involved in fusion gene | ENST00000373894, ENST00000373888, ENST00000466793, ENST00000549094, | ENST00000560829, ENST00000353874, ENST00000261889, ENST00000559844, ENST00000561026, ENST00000559339, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 6 X 4 X 4=96 |
# samples | 2 | 7 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(7/96*10)=-0.45567948377619 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SMPDL3B [Title/Abstract] AND SNX1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | SNX1 | GO:0072673 | lamellipodium morphogenesis | 20604901 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DA812972 | SMPDL3B | chr1 | 28269989 | + | SNX1 | chr15 | 64404777 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000373894 | ENST00000560829 | SMPDL3B | chr1 | 28269989 | + | SNX1 | chr15 | 64404777 | + |
intron-5UTR | ENST00000373894 | ENST00000353874 | SMPDL3B | chr1 | 28269989 | + | SNX1 | chr15 | 64404777 | + |
intron-5UTR | ENST00000373894 | ENST00000261889 | SMPDL3B | chr1 | 28269989 | + | SNX1 | chr15 | 64404777 | + |
intron-5UTR | ENST00000373894 | ENST00000559844 | SMPDL3B | chr1 | 28269989 | + | SNX1 | chr15 | 64404777 | + |
intron-5UTR | ENST00000373894 | ENST00000561026 | SMPDL3B | chr1 | 28269989 | + | SNX1 | chr15 | 64404777 | + |
intron-intron | ENST00000373894 | ENST00000559339 | SMPDL3B | chr1 | 28269989 | + | SNX1 | chr15 | 64404777 | + |
intron-5UTR | ENST00000373888 | ENST00000560829 | SMPDL3B | chr1 | 28269989 | + | SNX1 | chr15 | 64404777 | + |
intron-5UTR | ENST00000373888 | ENST00000353874 | SMPDL3B | chr1 | 28269989 | + | SNX1 | chr15 | 64404777 | + |
intron-5UTR | ENST00000373888 | ENST00000261889 | SMPDL3B | chr1 | 28269989 | + | SNX1 | chr15 | 64404777 | + |
intron-5UTR | ENST00000373888 | ENST00000559844 | SMPDL3B | chr1 | 28269989 | + | SNX1 | chr15 | 64404777 | + |
intron-5UTR | ENST00000373888 | ENST00000561026 | SMPDL3B | chr1 | 28269989 | + | SNX1 | chr15 | 64404777 | + |
intron-intron | ENST00000373888 | ENST00000559339 | SMPDL3B | chr1 | 28269989 | + | SNX1 | chr15 | 64404777 | + |
intron-5UTR | ENST00000466793 | ENST00000560829 | SMPDL3B | chr1 | 28269989 | + | SNX1 | chr15 | 64404777 | + |
intron-5UTR | ENST00000466793 | ENST00000353874 | SMPDL3B | chr1 | 28269989 | + | SNX1 | chr15 | 64404777 | + |
intron-5UTR | ENST00000466793 | ENST00000261889 | SMPDL3B | chr1 | 28269989 | + | SNX1 | chr15 | 64404777 | + |
intron-5UTR | ENST00000466793 | ENST00000559844 | SMPDL3B | chr1 | 28269989 | + | SNX1 | chr15 | 64404777 | + |
intron-5UTR | ENST00000466793 | ENST00000561026 | SMPDL3B | chr1 | 28269989 | + | SNX1 | chr15 | 64404777 | + |
intron-intron | ENST00000466793 | ENST00000559339 | SMPDL3B | chr1 | 28269989 | + | SNX1 | chr15 | 64404777 | + |
intron-5UTR | ENST00000549094 | ENST00000560829 | SMPDL3B | chr1 | 28269989 | + | SNX1 | chr15 | 64404777 | + |
intron-5UTR | ENST00000549094 | ENST00000353874 | SMPDL3B | chr1 | 28269989 | + | SNX1 | chr15 | 64404777 | + |
intron-5UTR | ENST00000549094 | ENST00000261889 | SMPDL3B | chr1 | 28269989 | + | SNX1 | chr15 | 64404777 | + |
intron-5UTR | ENST00000549094 | ENST00000559844 | SMPDL3B | chr1 | 28269989 | + | SNX1 | chr15 | 64404777 | + |
intron-5UTR | ENST00000549094 | ENST00000561026 | SMPDL3B | chr1 | 28269989 | + | SNX1 | chr15 | 64404777 | + |
intron-intron | ENST00000549094 | ENST00000559339 | SMPDL3B | chr1 | 28269989 | + | SNX1 | chr15 | 64404777 | + |
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FusionProtFeatures for SMPDL3B_SNX1 |
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Hgene | Tgene |
SMPDL3B | SNX1 |
Lipid-modulating phosphodiesterase (PubMed:26095358).Active on the surface of macrophages and dendritic cells andstrongly influences macrophage lipid composition and membranefluidity. Acts as a negative regulator of Toll-like receptorsignaling (By similarity). {ECO:0000250|UniProtKB:P58242,ECO:0000269|PubMed:26095358}. | Involved in several stages of intracellular trafficking.Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate(PtdIns(3,5)P2) (PubMed:12198132). Acts in part as component ofthe retromer membrane-deforming SNX-BAR subcomplex. The SNX-BARretromer mediates retrograde transport of cargo proteins fromendosomes to the trans-Golgi network (TGN) and is involved inendosome-to-plasma membrane transport for cargo protein recycling.The SNX-BAR subcomplex functions to deform the donor membrane intoa tubular profile called endosome-to-TGN transport carrier (ETC)(Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:19816406,PubMed:23085988). Involved in retrograde endosome-to-TGN transportof lysosomal enzyme receptors (IGF2R, M6PR and SORT1) andShiginella dysenteria toxin stxB. Plays a role in targetingligand-activated EGFR to the lysosomes for degradation afterendocytosis from the cell surface and release from the Golgi(PubMed:12198132, PubMed:15498486, PubMed:17550970,PubMed:17101778, PubMed:18088323, PubMed:21040701). Involvement inretromer-independent endocytic trafficking of P2RY1 and lysosomaldegradation of protease-activated receptor-1/F2R (PubMed:16407403,PubMed:20070609). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation;the function is dependent on GEF activity of KALRN(PubMed:20604901). Required for endocytosis of DRD5 upon agoniststimulation but not for basal receptor trafficking(PubMed:23152498). {ECO:0000269|PubMed:12198132,ECO:0000269|PubMed:15498486, ECO:0000269|PubMed:16407403,ECO:0000269|PubMed:17101778, ECO:0000269|PubMed:17550970,ECO:0000269|PubMed:18088323, ECO:0000269|PubMed:19816406,ECO:0000269|PubMed:20070609, ECO:0000269|PubMed:20604901,ECO:0000269|PubMed:21040701, ECO:0000269|PubMed:23085988,ECO:0000269|PubMed:23152498, ECO:0000303|PubMed:15498486}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SMPDL3B_SNX1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SMPDL3B_SNX1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SMPDL3B_SNX1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SMPDL3B_SNX1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |